GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	122195891	123665	0	None	-269	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	489	7	6	13	-0.1	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.5b00575
	CHEMBL3634182	123665	0	None	-269	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	489	7	6	13	-0.1	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.5b00575
	122195895	123669	0	None	-11	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	477	6	6	12	-0.2	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)S)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL3634186	123669	0	None	-11	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	477	6	6	12	-0.2	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)S)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	73351984	89936	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	457	6	5	12	-1.5	B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	10.1021/jm400197m
	CHEMBL2386492	89936	0	None	-1	2	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	457	6	5	12	-1.5	B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	10.1021/jm400197m
	122195893	123667	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	557	8	7	14	-0.0	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL3634184	123667	0	None	-3	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	557	8	7	14	-0.0	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	23656760	14528	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	974	9	4	10	10.0	O=S(=O)(O)OC(=C\c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)/C(=C/c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)OS(=O)(=O)O	10.1021/jm070043r
	CHEMBL1206193	14528	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	974	9	4	10	10.0	O=S(=O)(O)OC(=C\c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)/C(=C/c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)OS(=O)(=O)O	10.1021/jm070043r
	CHEMBL240681	14528	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	974	9	4	10	10.0	O=S(=O)(O)OC(=C\c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)/C(=C/c1cc(Br)c2oc(-c3ccc(O)c(Br)c3)cc2c1)OS(=O)(=O)O	10.1021/jm070043r
	73353445	89940	0	None	7	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	603	8	6	13	-0.1	B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O	10.1021/jm400197m
	CHEMBL2386496	89940	0	None	7	2	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	603	8	6	13	-0.1	B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O	10.1021/jm400197m
	56941832	76412	0	None	-42	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	908	16	10	25	-2.5	BP(=O)(OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm100597c
	CHEMBL1802094	76412	0	None	-42	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	908	16	10	25	-2.5	BP(=O)(OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm100597c
	CHEMBL2068734	76412	0	None	-42	2	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	908	16	10	25	-2.5	BP(=O)(OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)CP(=O)(O)OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O	10.1021/jm100597c
	122195892	123666	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	477	6	6	12	-0.2	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL3634183	123666	0	None	-3	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	477	6	6	12	-0.2	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	73347374	89939	0	None	-9	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	603	8	6	13	-0.1	B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O	10.1021/jm400197m
	CHEMBL2386495	89939	0	None	-9	2	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	603	8	6	13	-0.1	B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)C(Cl)(Cl)P(=O)(O)O	10.1021/jm400197m
	1756	459	8	None	-38	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	10.1021/jm020046y
	5310954	459	8	None	-38	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	10.1021/jm020046y
	CHEMBL336292	459	8	None	-38	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	10.1021/jm020046y
	73354953	89935	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	577	9	5	14	0.8	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@H](O)[C@H]3OC(=O)c3ccccc3)c2n1	10.1021/jm400197m
	CHEMBL2386490	89935	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	577	9	5	14	0.8	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)O)[C@H](O)[C@H]3OC(=O)c3ccccc3)c2n1	10.1021/jm400197m
	135973538	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	1728	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	2966	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	4261196	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	5361	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	CHEMBL265502	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	DB04786	3641	30	None	-6	7	Human	4.8	pEC50	=	4.8	Functional	The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm020046y
	1712	285	64	None	-41	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	6022	285	64	None	-41	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	CHEMBL14830	285	64	None	-41	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	1712	285	64	None	-41	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	6022	285	64	None	-41	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	CHEMBL14830	285	64	None	-41	6	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	427	6	6	12	-1.7	O[C@@H]1[C@@H](COP(=O)(OP(=O)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	1713	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	5957	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	91	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	CHEMBL14249	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	DB00171	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	10994891	78005	0	None	-194	4	Human	4.8	pEC50	=	4.8	Functional	Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM	ChEMBL	517	8	7	13	-1.0	Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C[C@H]12	10.1021/jm010369e
	CHEMBL2111533	78005	0	None	-194	4	Human	4.8	pEC50	=	4.8	Functional	Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM	ChEMBL	517	8	7	13	-1.0	Nc1ncnc2c1ncn2[C@H]1[C@H](O)[C@H](O)[C@]2(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C[C@H]12	10.1021/jm010369e
	6083	203097	90	None	-34	6	Human	4.8	pEC50	=	4.8	Functional	Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM	ChEMBL	347	4	5	10	-1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm010369e
	CHEMBL1315633	203097	90	None	-34	6	Human	4.8	pEC50	=	4.8	Functional	Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM	ChEMBL	347	4	5	10	-1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm010369e
	CHEMBL752	203097	90	None	-34	6	Human	4.8	pEC50	=	4.8	Functional	Measure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uMMeasure of Agonist Potency at human P2Y purinoceptor 11 (hP2Y11) stably expressed in 131N1 astrocytoma cell at 10 uM	ChEMBL	347	4	5	10	-1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm010369e
	1713	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm010538v
	5957	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm010538v
	91	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm010538v
	CHEMBL14249	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm010538v
	DB00171	516	63	None	-165	10	Human	4.8	pEC50	=	4.8	Functional	Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm010538v
	CHEMBL2181938	208737	0	None	-3	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL		None	None	None		B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	10.1021/jm400197m
	CHEMBL2448332	208737	0	None	-3	3	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL		None	None	None		B[P@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)ncnc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	10.1021/jm400197m
	440317	21533	15	None	2	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	523	8	7	14	-1.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O	10.1021/jm020046y
	CHEMBL131890	21533	15	None	2	4	Human	5.5	pEC50	=	5.5	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	523	8	7	14	-1.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O	10.1021/jm020046y
	1755	286	16	None	-16218	6	Human	4.5	pEC50	=	4.5	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	5310996	286	16	None	-16218	6	Human	4.5	pEC50	=	4.5	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	CHEMBL335206	286	16	None	-16218	6	Human	4.5	pEC50	=	4.5	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm020046y
	122195891	123665	0	None	-269	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	489	7	6	13	-0.1	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.5b00575
	CHEMBL3634182	123665	0	None	-269	2	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	489	7	6	13	-0.1	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.5b00575
	1755	286	16	None	-16218	6	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	5310996	286	16	None	-16218	6	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	CHEMBL335206	286	16	None	-16218	6	Human	4.5	pEC50	=	4.5	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	1713	516	63	None	-165	10	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm100597c
	5957	516	63	None	-165	10	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm100597c
	91	516	63	None	-165	10	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm100597c
	CHEMBL14249	516	63	None	-165	10	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm100597c
	DB00171	516	63	None	-165	10	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysisAgonist activity at GFP tagged-human P2Y11 receptor expressed in human 1321N1 cells assessed as elevation in calcium level after 30 mins by fluorescence spectrophotometric analysis	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm100597c
	118725181	116558	0	None	-524	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	457	6	5	12	-1.5	B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	10.1021/jm400197m
	CHEMBL3392138	116558	0	None	-524	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	457	6	5	12	-1.5	B[P@@](=O)(OC[C@H]1O[C@@H](n2cnc3c(N)nc(Cl)nc32)[C@H](O)[C@@H]1O)OP(=O)(O)O	10.1021/jm400197m
	171069	196529	7	None	-60	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL575257	196529	7	None	-60	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	23656758	14640	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	1018	10	5	11	9.7	O=C(O)c1c(-c2ccc(O)c(Br)c2)oc2c(Br)cc(/C=C(OS(=O)(=O)O)/C(=C/c3cc(Br)c4oc(-c5ccc(O)c(Br)c5)cc4c3)OS(=O)(=O)O)cc12	10.1021/jm070043r
	CHEMBL1207329	14640	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	1018	10	5	11	9.7	O=C(O)c1c(-c2ccc(O)c(Br)c2)oc2c(Br)cc(/C=C(OS(=O)(=O)O)/C(=C/c3cc(Br)c4oc(-c5ccc(O)c(Br)c5)cc4c3)OS(=O)(=O)O)cc12	10.1021/jm070043r
	CHEMBL394381	14640	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	1018	10	5	11	9.7	O=C(O)c1c(-c2ccc(O)c(Br)c2)oc2c(Br)cc(/C=C(OS(=O)(=O)O)/C(=C/c3cc(Br)c4oc(-c5ccc(O)c(Br)c5)cc4c3)OS(=O)(=O)O)cc12	10.1021/jm070043r
	122195892	123666	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	477	6	6	12	-0.2	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL3634183	123666	0	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	477	6	6	12	-0.2	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	1711	77	12	None	-64565	7	Human	4.3	pEC50	=	4.3	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10.1021/jm020046y
	5310983	77	12	None	-64565	7	Human	4.3	pEC50	=	4.3	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10.1021/jm020046y
	CHEMBL336208	77	12	None	-64565	7	Human	4.3	pEC50	=	4.3	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10.1021/jm020046y
	440317	21533	15	None	2	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	523	8	7	14	-1.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O	10.1021/jm070043r
	CHEMBL131890	21533	15	None	2	4	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium levelAgonist activity at P2Y11 receptor expressed in 1321N1 cells assessed as cytosolic calcium level	ChEMBL	523	8	7	14	-1.5	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(O)(O)=S)[C@@H](O)[C@H]1O	10.1021/jm070043r
	1713	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	5957	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	91	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	CHEMBL14249	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	DB00171	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/acs.jmedchem.5b00575
	1713	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	5957	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	91	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	CHEMBL14249	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	DB00171	516	63	None	-165	10	Human	5.2	pEC50	=	5.2	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	ChEMBL	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10.1021/jm400197m
	44353592	116633	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	687	11	6	15	1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1OC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm020046y
	CHEMBL339386	116633	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	687	11	6	15	1.9	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1OC(=O)c1ccc(-c2ccccc2)cc1	10.1021/jm020046y
	171069	196529	7	None	-60	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL575257	196529	7	None	-60	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	443	6	6	12	-0.8	Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	122195894	123668	0	None	-23	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	489	7	6	13	-0.1	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)S)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.5b00575
	CHEMBL3634185	123668	0	None	-23	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	489	7	6	13	-0.1	CSc1nc(N)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)S)[C@@H](O)[C@H]3O)c2n1	10.1021/acs.jmedchem.5b00575
	14753886	111516	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human P2Y11 receptor expressed in human 1321N1 cells assessed as increase of intracellular calcium level after 30 mins using fura-2 AM by fluorescence assayAgonist activity at human P2Y11 receptor expressed in human 1321N1 cells assessed as increase of intracellular calcium level after 30 mins using fura-2 AM by fluorescence assay	ChEMBL	521	8	7	13	-1.4	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](O)(=S)OP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm500196c
	CHEMBL3289393	111516	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human P2Y11 receptor expressed in human 1321N1 cells assessed as increase of intracellular calcium level after 30 mins using fura-2 AM by fluorescence assayAgonist activity at human P2Y11 receptor expressed in human 1321N1 cells assessed as increase of intracellular calcium level after 30 mins using fura-2 AM by fluorescence assay	ChEMBL	521	8	7	13	-1.4	Nc1ncnc2c1ncn2[C@@H]1O[C@H](CO[P@@](O)(=S)OP(=O)(O)CP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/jm500196c
	15993	1295	40	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10.1021/jm020046y
	1760	1295	40	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10.1021/jm020046y
	CHEMBL335538	1295	40	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10.1021/jm020046y
	DB03222	1295	40	None	1	2	Human	5.1	pEC50	=	5.1	Functional	Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)Agonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)	ChEMBL	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10.1021/jm020046y
	122195893	123667	0	None	-3	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	557	8	7	14	-0.0	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	CHEMBL3634184	123667	0	None	-3	2	Human	5.0	pEC50	=	5.0	Functional	Agonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assayAgonist activity at GFP-tagged human P2Y11R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay	ChEMBL	557	8	7	14	-0.0	Nc1nc(Cl)nc2c1ncn2[C@@H]1O[C@H](COP(=O)(S)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O	10.1021/acs.jmedchem.5b00575
	1713	516	63	None	-165	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	Drug Central	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	None
	5957	516	63	None	-165	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	Drug Central	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	None
	91	516	63	None	-165	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	Drug Central	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	None
	CHEMBL14249	516	63	None	-165	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	Drug Central	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	None
	DB00171	516	63	None	-165	10	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assayAgonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay	Drug Central	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	None
	1734	3891	45	None	-1	7	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	None
	3639	3891	45	None	-1	7	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	None
	6133	3891	45	None	-1	7	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	None
	CHEMBL336296	3891	45	None	-1	7	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	None
	DB04005	3891	45	None	-1	7	Human	8.3	pEC50	=	8.3	Functional	NoneNone	Drug Central	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	None
	1755	286	16	None	-16218	6	Human	4.2	pEC50	=	4.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	5310996	286	16	None	-16218	6	Human	4.2	pEC50	=	4.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	CHEMBL335206	286	16	None	-16218	6	Human	4.2	pEC50	=	4.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	443	6	6	12	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=S)(O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	1713	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	1713	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12213051
	1713	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12761346
	5957	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	5957	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12213051
	5957	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12761346
	91	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	91	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12213051
	91	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12761346
	CHEMBL14249	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	CHEMBL14249	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12213051
	CHEMBL14249	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12761346
	DB00171	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	DB00171	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12213051
	DB00171	516	63	None	-165	10	Human	4.9	pEC50	=	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	507	8	7	14	-1.6	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	12761346
	1714	517	0	None	-158	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	519	8	3	18	-4.0	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=S)([O-])[O-])[O-])[O-])O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	44123300	517	0	None	-158	3	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	519	8	3	18	-4.0	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=S)([O-])[O-])[O-])[O-])O[C@H]([C@@H]1O)n1cnc2c1ncnc2N	10578132
	1734	3891	45	None	-1	7	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	12761346
	3639	3891	45	None	-1	7	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	12761346
	6133	3891	45	None	-1	7	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	12761346
	CHEMBL336296	3891	45	None	-1	7	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	12761346
	DB04005	3891	45	None	-1	7	Human	5.2	pEC50	=	5.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	484	8	7	12	-2.5	O[C@@H]1[C@@H](COP(=O)(OP(=O)(OP(=O)(O)O)O)O)O[C@H]([C@@H]1O)n1ccc(=O)[nH]c1=O	12761346
	136861374	2762	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1180	22	10	13	8.1	[Na]OP(=O)(Cc1cc(ccc1NC(=O)c1ccc(c(c1)NC(=O)c1cccc(c1)NC(=O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(cc1CP(=O)(O[Na])O)CP(=O)(O[Na])O)C)CP(=O)(O[Na])O)O	19815812
	4046	2762	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1180	22	10	13	8.1	[Na]OP(=O)(Cc1cc(ccc1NC(=O)c1ccc(c(c1)NC(=O)c1cccc(c1)NC(=O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(cc1CP(=O)(O[Na])O)CP(=O)(O[Na])O)C)CP(=O)(O[Na])O)O	19815812
	73755075	2762	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1180	22	10	13	8.1	[Na]OP(=O)(Cc1cc(ccc1NC(=O)c1ccc(c(c1)NC(=O)c1cccc(c1)NC(=O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(cc1CP(=O)(O[Na])O)CP(=O)(O[Na])O)C)CP(=O)(O[Na])O)O	19815812
	90488895	2762	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1180	22	10	13	8.1	[Na]OP(=O)(Cc1cc(ccc1NC(=O)c1ccc(c(c1)NC(=O)c1cccc(c1)NC(=O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(cc1CP(=O)(O[Na])O)CP(=O)(O[Na])O)C)CP(=O)(O[Na])O)O	19815812
	1762	2761	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	986	14	4	15	3.9	[Na]OS(=O)(=O)c1cc(NC(=O)c2ccc(c(c2)NC(=O)Nc2cc(ccc2C)C(=O)Nc2cc(cc3c2cc(cc3)S(=O)(=O)O[Na])S(=O)(=O)O[Na])C)c2c(c1)ccc(c2)S(=O)(=O)O[Na]	18404494
	73755007	2761	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	986	14	4	15	3.9	[Na]OS(=O)(=O)c1cc(NC(=O)c2ccc(c(c2)NC(=O)Nc2cc(ccc2C)C(=O)Nc2cc(cc3c2cc(cc3)S(=O)(=O)O[Na])S(=O)(=O)O[Na])C)c2c(c1)ccc(c2)S(=O)(=O)O[Na]	18404494
	90488883	2761	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	986	14	4	15	3.9	[Na]OS(=O)(=O)c1cc(NC(=O)c2ccc(c(c2)NC(=O)Nc2cc(ccc2C)C(=O)Nc2cc(cc3c2cc(cc3)S(=O)(=O)O[Na])S(=O)(=O)O[Na])C)c2c(c1)ccc(c2)S(=O)(=O)O[Na]	18404494
	1756	459	8	None	-38	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	10578132
	1756	459	8	None	-38	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	15893764
	5310954	459	8	None	-38	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	10578132
	5310954	459	8	None	-38	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	15893764
	CHEMBL336292	459	8	None	-38	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	10578132
	CHEMBL336292	459	8	None	-38	2	Human	8.5	pEC50	=	8.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	647	11	7	14	1.1	CCCSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(C(P(=O)(O)O)(Cl)Cl)O)O	15893764
	1711	77	12	None	-64565	7	Human	4.0	pEC50	None	4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10578132
	5310983	77	12	None	-64565	7	Human	4.0	pEC50	None	4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10578132
	CHEMBL336208	77	12	None	-64565	7	Human	4.0	pEC50	None	4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	553	9	7	15	-0.9	CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10578132
	15993	1295	40	None	1	2	Human	4.9	pEC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10578132
	1760	1295	40	None	1	2	Human	4.9	pEC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10578132
	CHEMBL335538	1295	40	None	1	2	Human	4.9	pEC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10578132
	DB03222	1295	40	None	1	2	Human	4.9	pEC50	None	4.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	491	8	6	13	-0.6	O[C@H]1C[C@@H](O[C@@H]1COP(=O)(OP(=O)(OP(=O)(O)O)O)O)n1cnc2c1ncnc2N	10578132
	115205	747	0	None	-	1	Human	5.1	pEC50	None	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	715	12	6	16	1.5	O[C@@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c2ccccc2)[C@H](O[C@H]1n1cnc2c1ncnc2N)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10578132
	1757	747	0	None	-	1	Human	5.1	pEC50	None	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	715	12	6	16	1.5	O[C@@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c2ccccc2)[C@H](O[C@H]1n1cnc2c1ncnc2N)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10578132
	CHEMBL2407634	747	0	None	-	1	Human	5.1	pEC50	None	5.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology	715	12	6	16	1.5	O[C@@H]1[C@H](OC(=O)c2ccc(cc2)C(=O)c2ccccc2)[C@H](O[C@H]1n1cnc2c1ncnc2N)COP(=O)(OP(=O)(OP(=O)(O)O)O)O	10578132
	135973538	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	1728	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	2966	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	4261196	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	5361	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	CHEMBL265502	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	DB04786	3641	30	None	-6	7	Human	8.2	pIC50	=	8.2	Functional	NoneNone	Drug Central	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	None
	136677322	3232	22	None	-398	9	Human	5.0	pIC50	=	5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	773	9	7	15	3.9	OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1	10578132
	1739	3232	22	None	-398	9	Human	5.0	pIC50	=	5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	773	9	7	15	3.9	OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1	10578132
	656725	3232	22	None	-398	9	Human	5.0	pIC50	=	5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	773	9	7	15	3.9	OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1	10578132
	CHEMBL1160031	3232	22	None	-398	9	Human	5.0	pIC50	=	5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	773	9	7	15	3.9	OS(=O)(=O)c1cc(Nc2ccc(c(c2)S(=O)(=O)O)Nc2nc(Cl)nc(n2)Nc2cccc(c2)S(=O)(=O)O)c2c(c1N)C(=O)c1c(C2=O)cccc1	10578132
	135973538	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	1728	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	2966	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	4261196	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	5361	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	CHEMBL265502	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	DB04786	3641	30	None	-6	7	Human	5.4	pIC50	=	5.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10578132
	1762	2761	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	986	14	4	15	3.9	[Na]OS(=O)(=O)c1cc(NC(=O)c2ccc(c(c2)NC(=O)Nc2cc(ccc2C)C(=O)Nc2cc(cc3c2cc(cc3)S(=O)(=O)O[Na])S(=O)(=O)O[Na])C)c2c(c1)ccc(c2)S(=O)(=O)O[Na]	19815812
	73755007	2761	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	986	14	4	15	3.9	[Na]OS(=O)(=O)c1cc(NC(=O)c2ccc(c(c2)NC(=O)Nc2cc(ccc2C)C(=O)Nc2cc(cc3c2cc(cc3)S(=O)(=O)O[Na])S(=O)(=O)O[Na])C)c2c(c1)ccc(c2)S(=O)(=O)O[Na]	19815812
	90488883	2761	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	986	14	4	15	3.9	[Na]OS(=O)(=O)c1cc(NC(=O)c2ccc(c(c2)NC(=O)Nc2cc(ccc2C)C(=O)Nc2cc(cc3c2cc(cc3)S(=O)(=O)O[Na])S(=O)(=O)O[Na])C)c2c(c1)ccc(c2)S(=O)(=O)O[Na]	19815812

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	11636757	2760	1	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	136776947	2760	1	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	1761	2760	1	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	CHEMBL1207514	2760	1	None	-	1	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)Inhibitory concentration against P2Y11 receptor expressed in 1321N1 astrocytoma Cells; (n=7)	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	136825091	14778	1	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1324	18	12	17	7.3	CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1	10.1021/jm050301p
	451869	14778	1	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1324	18	12	17	7.3	CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1	10.1021/jm050301p
	CHEMBL1208520	14778	1	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1324	18	12	17	7.3	CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1	10.1021/jm050301p
	CHEMBL276295	14778	1	None	-	1	Human	6.0	pKi	=	6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1324	18	12	17	7.3	CCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3CC)c2)c1	10.1021/jm050301p
	11564437	14680	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1336	16	12	17	7.4	O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1	10.1021/jm050301p
	CHEMBL1207516	14680	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1336	16	12	17	7.4	O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1	10.1021/jm050301p
	CHEMBL413180	14680	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1336	16	12	17	7.4	O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2Cl)c1	10.1021/jm050301p
	135973538	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	1728	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	2966	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	4261196	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	5361	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	CHEMBL265502	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	DB04786	3641	30	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	11679781	14677	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4	ChEMBL	1356	20	12	19	6.4	COCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3COC)c2)c1	10.1021/jm050301p
	CHEMBL1207473	14677	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4	ChEMBL	1356	20	12	19	6.4	COCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3COC)c2)c1	10.1021/jm050301p
	CHEMBL409304	14677	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=4	ChEMBL	1356	20	12	19	6.4	COCc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3COC)c2)c1	10.1021/jm050301p
	16163320	14562	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1420	18	12	17	9.5	O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1	10.1021/jm050301p
	CHEMBL1206368	14562	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1420	18	12	17	9.5	O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1	10.1021/jm050301p
	CHEMBL266646	14562	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1420	18	12	17	9.5	O=C(Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1)Nc1cccc(C(=O)Nc2cc(C(=O)Nc3ccc(S(=O)(=O)O)c4cc(S(=O)(=O)O)cc(S(=O)(=O)O)c34)ccc2-c2ccccc2)c1	10.1021/jm050301p
	135973538	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	1728	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	2966	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	4261196	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	5361	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	CHEMBL265502	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	DB04786	3641	30	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=6	ChEMBL	1296	16	12	17	6.7	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1C)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	11636757	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	136776947	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	1761	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	CHEMBL1207514	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	10.1021/jm050301p
	10080219	14671	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1352	18	12	17	8.4	CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1	10.1021/jm050301p
	136825093	14671	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1352	18	12	17	8.4	CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1	10.1021/jm050301p
	CHEMBL1207434	14671	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1352	18	12	17	8.4	CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1	10.1021/jm050301p
	CHEMBL405500	14671	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1352	18	12	17	8.4	CC(C)c1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C(C)C)c2)c1	10.1021/jm050301p
	16155350	14681	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1328	18	12	19	6.1	COc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3OC)c2)c1	10.1021/jm050301p
	CHEMBL1207525	14681	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1328	18	12	19	6.1	COc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3OC)c2)c1	10.1021/jm050301p
	CHEMBL413910	14681	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=7	ChEMBL	1328	18	12	19	6.1	COc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3OC)c2)c1	10.1021/jm050301p
	136880426	14679	4	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1058	12	10	15	4.2	Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C	10.1021/jm050301p
	369605	14679	4	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1058	12	10	15	4.2	Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C	10.1021/jm050301p
	CHEMBL1207502	14679	4	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1058	12	10	15	4.2	Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C	10.1021/jm050301p
	CHEMBL411554	14679	4	None	-	1	Human	5.1	pKi	=	5.1	Binding	Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3Inhibitory concentration against P2Y purinoceptor 11 expressed in 1321N1 astrocytoma cells; n=3	ChEMBL	1058	12	10	15	4.2	Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)Nc1cc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)ccc1C	10.1021/jm050301p
	11636757	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	16250663
	136776947	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	16250663
	1761	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	16250663
	CHEMBL1207514	2760	1	None	-	1	Human	7.4	pKi	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	1304	16	12	17	6.4	O=C(Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O)Nc1cccc(c1)C(=O)Nc1cc(ccc1F)C(=O)Nc1ccc(c2c1c(cc(c2)S(=O)(=O)O)S(=O)(=O)O)S(=O)(=O)O	16250663

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)