Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A



GPCRdb(A)
MC5
Human
MC5
Mouse
MC5
Rat
V1B
Human
V1B
Rat
V1B
Bovine
TM1
1x28 - - - D30 D30 D30
1x29 - - - E31 E31 E31
1x30 - - - E32 E32 E32
1x31 - - - L33 L33 L33
1x32 - - - A34 A34 A34
1x33 - - - K35 K35 K35
1x34 - - - V36 V36 V36
1x35 A39 A39 A39 E37 E37 E37
1x36 V40 V40 V40 I38 I38 I38
1x37 E41 E41 E41 G39 G39 G39
1x38 V42 V42 V42 V40 I40 V40
1x39 F43 F43 F43 L41 L41 L41
1x40 L44 L44 L44 A42 A42 A42
1x41 T45 T45 T45 T43 T43 T43
1x42 L46 L46 L46 V44 V44 V44
1x43 G47 G47 G47 L45 L45 L45
1x44 V48 L48 L48 V46 V46 A46
1x45 I49 V49 V49 L47 L47 L47
1x46 S50 S50 S50 A48 A48 A48
1x47 L51 L51 L51 T49 T49 T49
1x48 L52 L52 L52 G50 G50 G50
1x49 E53 E53 E53 G51 G51 G51
1x50 N54 N54 N54 N52 N52 N52
1x51 I55 I55 I55 L53 L53 L53
1x52 L56 L56 L56 A54 A54 T54
1x53 V57 V57 V57 V55 V55 V55
1x54 I58 I58 I58 L56 L56 L56
1x55 G59 G59 G59 L57 L57 L57
1x56 A60 A60 A60 T58 T58 T58
1x57 I61 I61 I61 L59 L59 V59
1x58 V62 V62 V62 G60 G60 G60
1x59 K63 K63 K63 Q61 R61 Q61
1x60 N64 N64 N64 L62 H62 P62
ICL1
12x48 K65 K65 K65 G63 G63 V63
12x49 N66 N66 N66 R64 H64 R64
12x50 L67 L67 L67 K65 K65 K65
12x51 H68 H68 H68 R66 R66 R66
TM2
2x37 S69 S69 S69 S67 S67 S67
2x38 P70 P70 P70 R68 R68 R68
2x39 M71 M71 M71 M69 M69 M69
2x40 Y72 Y72 Y72 H70 H70 Q70
2x41 F73 F73 F73 L71 L71 V71
2x42 F74 F74 F74 F72 F72 F72
2x43 V75 V75 V75 V73 V73 V73
2x44 C76 G76 G76 L74 L74 L74
2x45 S77 S77 S77 H75 H75 H75
2x46 L78 L78 L78 L76 L76 L76
2x47 A79 A79 A79 A77 A77 A77
2x48 V80 V80 V80 L78 L78 L78
2x49 A81 A81 A81 T79 T79 T79
2x50 D82 D82 D82 D80 D80 D80
2x51 M83 M83 M83 L81 L81 L81
2x52 L84 L84 L84 A82 G82 G82
2x53 V85 V85 V85 V83 V83 V83
2x54 S86 S86 S86 A84 A84 A84
2x55 M87 M87 M87 L85 L85 L85
2x551 - - - F86 F86 F86
2x56 S88 S88 S88 Q87 Q87 Q87
2x57 S89 N89 N89 V88 V88 V88
2x58 A90 A90 A90 L89 L89 L89
2x59 W91 W91 W91 P90 P90 P90
2x60 E92 E92 E92 Q91 Q91 Q91
2x61 T93 T93 T93 L92 L92 L92
2x62 I94 V94 I94 L93 L93 L93
2x63 T95 T95 T95 W94 W94 W94
2x64 I96 I96 I96 D95 D95 D95
2x65 Y97 Y97 Y97 I96 I96 I96
2x66 L98 L98 L98 T97 T97 T97
2x67 L99 L99 I99 Y98 Y98 Y98
ECL1
23x49 - - - R99 R99 R99
23x50 - - - F100 F100 F100
23x51 - - - Q101 Q101 R101
23x52 - - - G102 G102 G102
TM3
3x18 D108 D108 D108 - - -
3x19 A109 T109 T109 - - -
3x20 F110 F110 F110 - - -
3x21 V111 V111 V111 P103 S103 P103
3x22 R112 R112 R112 D104 D104 D104
3x23 H113 H113 H113 L105 L105 P105
3x24 I114 I114 I114 L106 L106 L106
3x25 D115 D115 D115 C107 C107 C107
3x26 N116 N116 N116 R108 R108 R108
3x27 V117 V117 V117 A109 A109 A109
3x28 F118 F118 F118 V110 V110 V110
3x29 D119 D119 D119 K111 K111 K111
3x30 S120 S120 S120 Y112 Y112 Y112
3x31 M121 M121 M121 L113 L113 L113
3x32 I122 I122 I122 Q114 Q114 Q114
3x33 C123 C123 C123 V115 V115 V115
3x34 I124 I124 I124 L116 L116 L116
3x35 S125 S125 S125 S117 S117 S117
3x36 V126 V126 V126 M118 M118 M118
3x37 V127 V127 V127 F119 F119 F119
3x38 A128 A128 A128 A120 A120 A120
3x39 S129 S129 S129 S121 S121 S121
3x40 M130 M130 M130 T122 T122 T122
3x41 C131 C131 C131 Y123 Y123 Y123
3x42 S132 S132 S132 M124 M124 M124
3x43 L133 L133 L133 L125 L125 L125
3x44 L134 L134 L134 L126 L126 L126
3x45 A135 A135 A135 A127 A127 A127
3x46 I136 I136 I136 M128 M128 M128
3x47 A137 A137 A137 T129 T129 T129
3x48 V138 V138 V138 L130 L130 L130
3x49 D139 D139 D139 D131 D131 D131
3x50 R140 R140 R140 R132 R132 R132
3x51 Y141 Y141 Y141 Y133 Y133 Y133
3x52 V142 I142 I142 L134 L134 L134
3x53 T143 T143 T143 A135 A135 A135
3x54 I144 I144 I144 V136 V136 V136
3x55 F145 F145 F145 C137 C137 C137
3x56 Y146 Y146 Y146 H138 H138 H138
ICL2
34x50 A147 A147 A147 P139 P139 P139
34x51 L148 L148 L148 L140 L140 L140
34x52 R149 R149 R149 R141 R141 R141
34x53 Y150 Y150 Y150 S142 S142 S142
34x54 H151 H151 H151 L143 L143 L143
34x55 H152 H152 H152 Q144 R144 Q144
34x56 I153 I153 I153 Q145 Q145 Q145
34x57 M154 M154 M154 - - -
TM4
4x38 T155 T155 T155 P146 P146 P146
4x39 A156 A156 A156 G147 S147 S147
4x40 R157 R157 R157 Q148 Q148 R148
4x41 R158 R158 R158 S149 S149 S149
4x42 S159 S159 S159 T150 T150 T150
4x43 G160 G160 G160 Y151 Y151 Y151
4x44 A161 V161 V161 L152 P152 P152
4x45 I162 I162 I162 L153 L153 L153
4x46 I163 I163 I163 I154 I154 I154
4x47 A164 A164 A164 A155 A155 A155
4x48 G165 C165 C165 A156 A156 A156
4x49 I166 I166 I166 P157 P157 P157
4x50 W167 W167 W167 W158 W158 W158
4x51 A168 T168 T168 L159 L159 L159
4x52 F169 F169 F169 L160 L160 L160
4x53 C170 C170 C170 A161 A161 A161
4x54 T171 I171 I171 A162 A162 A162
4x55 G172 S172 S172 I163 I163 V163
4x56 C173 C173 C173 F164 L164 L164
4x57 G174 G174 G174 S165 S165 S165
4x58 I175 I175 I175 - - -
4x59 V176 V176 V176 L166 L166 L166
4x60 F177 F177 F177 P167 P167 P167
4x61 I178 I178 I178 Q168 Q168 Q168
4x62 L179 I179 I179 V169 V169 V169
4x63 Y180 Y180 Y180 F170 F170 F170
4x64 S181 Y181 Y181 I171 I171 I171
4x65 - - - F172 F172 F172
ECL2
45x50 - - - C186 C186 C186
45x51 - - - W187 W187 W187
45x52 - - - A188 A188 A188
TM5
5x34 - - - W194 W194 W194
5x35 - - - G195 G195 G195
5x36 S183 S183 S183 P196 P196 P196
5x37 T184 K184 K184 R197 R197 R197
5x38 Y185 Y185 Y185 A198 A198 A198
5x39 V186 V186 V186 Y199 Y199 Y199
5x40 I187 I187 I187 L200 I200 I200
5x41 L188 I188 V188 T201 T201 T201
5x42 C189 C189 C189 W202 W202 W202
5x43 L190 L190 L190 T203 T203 T203
5x44 I191 I191 I191 T204 T204 T204
5x45 S192 S192 S192 L205 M205 L205
5x46 M193 M193 M193 A206 A206 A206
5x461 - - - I207 I207 I207
5x47 F194 F194 F194 F208 F208 F208
5x48 F195 F195 F195 V209 V209 I209
5x49 A196 T196 T196 L210 L210 L210
5x50 M197 M197 M197 P211 P211 P211
5x51 L198 L198 L198 V212 V212 V212
5x52 F199 F199 F199 T213 A213 A213
5x53 L200 F200 F200 M214 V214 M214
5x54 L201 M201 M201 L215 L215 L215
5x55 V202 V202 V202 T216 S216 T216
5x56 S203 S203 S203 A217 A217 A217
5x57 L204 L204 L204 C218 C218 C218
5x58 Y205 Y205 Y205 Y219 Y219 Y219
5x59 I206 I206 I206 S220 G220 G220
5x60 H207 H207 H207 L221 L221 L221
5x61 M208 M208 M208 I222 I222 I222
5x62 F209 F209 F209 C223 C223 C223
5x63 L210 L210 L210 H224 H224 H224
5x64 L211 L211 L211 E225 E225 E225
5x65 A212 A212 A212 I226 I226 I226
5x66 R213 R213 R213 C227 Y227 C227
5x67 T214 N214 N214 K228 K228 R228
5x68 H215 H215 H215 N229 N229 N229
5x69 V216 V216 V216 L230 L230 L230
5x70 K217 K217 K217 K231 K231 K231
5x71 R218 R218 R218 V232 V232 V232
5x72 I219 I219 I219 K233 K233 K233
5x73 A220 A220 A220 T234 T234 T234
5x74 - - - Q235 Q235 E235
5x75 - - - A236 A236 A236
5x76 - - - W237 G237 G237
TM6
6x24 - - - N270 S271 S270
6x25 - - - T271 T272 A271
6x26 - - - I272 I273 I272
6x27 Q230 Q230 Q230 S273 S274 S273
6x28 R231 R231 R231 R274 R275 R274
6x29 T232 T232 A232 A275 A276 A275
6x30 S233 S233 S233 K276 K277 K276
6x31 M234 M234 M234 I277 I278 I277
6x32 Q235 K235 K235 R278 R279 R278
6x33 G236 G236 G236 T279 T280 T279
6x34 A237 A237 A237 V280 V281 V280
6x35 V238 I238 I238 K281 K282 K281
6x36 T239 T239 T239 M282 M283 M282
6x37 V240 L240 L240 T283 T284 T283
6x38 T241 T241 T241 F284 F285 F284
6x39 M242 M242 M242 V285 V286 V285
6x40 L243 L243 L243 I286 I287 I286
6x41 L244 L244 L244 V287 V288 V287
6x42 G245 G245 G245 L288 L289 L288
6x43 V246 I246 I246 A289 A290 A289
6x44 F247 F247 F247 Y290 Y291 Y290
6x45 T248 I248 I248 I291 I292 I291
6x46 V249 V249 V249 A292 A293 A292
6x47 C250 C250 C250 C293 C294 C293
6x48 W251 W251 W251 W294 W295 W294
6x49 A252 S252 S252 A295 A296 A295
6x50 P253 P253 P253 P296 P297 P296
6x51 F254 F254 F254 F297 F298 F297
6x52 F255 F255 F255 F298 F299 F298
6x53 L256 L256 L256 S299 S300 S299
6x54 H257 H257 H257 V300 V301 V300
6x55 L258 L258 L258 Q301 Q302 Q301
6x56 T259 I259 I259 M302 M303 M302
6x57 L260 L260 L260 W303 W304 W303
6x58 M261 M261 M261 S304 S305 S304
6x59 L262 I262 I262 V305 V306 V305
6x60 S263 S263 S263 W306 W307 W306
6x61 C264 C264 C264 D307 D308 D307
TM7
7x29 - - - S315 S316 S315
7x30 - - - T316 T317 T316
7x31 - - - N317 N318 N317
7x32 - - - V318 V319 V318
7x33 H276 Y276 Y276 A319 A320 A319
7x34 F277 F277 F277 F320 F321 F320
7x35 N278 N278 N278 T321 T322 T321
7x36 M279 M279 M279 I322 I323 I322
7x37 Y280 Y280 Y280 S323 S324 S323
7x38 L281 L281 L281 M324 M325 M324
7x39 I282 I282 I282 L325 L326 L325
7x40 L283 L283 L283 L326 L327 L326
7x41 I284 I284 I284 G327 G328 G327
7x42 M285 M285 M285 N328 N329 N328
7x43 C286 C286 C286 L329 L330 L329
7x45 N287 N287 N287 N330 S331 S330
7x46 S288 S288 S288 S331 S332 S331
7x47 V289 V289 V289 C332 C333 C332
7x48 M290 I290 I290 C333 C334 C333
7x49 D291 D291 D291 N334 N335 N334
7x50 P292 P292 P292 P335 P336 P335
7x51 L293 L293 L293 W336 W337 W336
7x52 I294 I294 I294 I337 I338 I337
7x53 Y295 Y295 Y295 Y338 Y339 Y338
7x54 A296 A296 A296 M339 M340 M339
7x55 F297 L297 L297 G340 G341 G340
7x56 R298 R298 R298 F341 F342 F341
H8
8x47 S299 S299 S299 N342 N343 N342
8x48 Q300 Q300 Q300 S343 S344 S343
8x49 E301 E301 E301 H344 R345 H344
8x50 M302 M302 M302 L345 L346 L345
8x51 R303 R303 R303 L346 L347 W346
8x52 K304 R304 R304 P347 P348 L347
8x53 T305 T305 T305 R348 R349 H348
8x54 F306 F306 F306 P349 S350 A349
8x55 K307 K307 K307 L350 L351 L350
8x56 E308 E308 E308 R351 S352 R351
8x57 I309 I309 I309 H352 H353 R352
8x58 I310 V310 I310 L353 H354 L353
8x59 C311 C311 C311 A354 A355 A354
8x60 C312 C312 C312 C355 C356 C355
8x61 R313 H313 H313 C356 C357 C356
8x62 - - - G357 T358 G357
8x63 - - - G358 G359 G358