GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	44570962	183265	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480821	183265	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	145950336	162265	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172656	162265	0	None	-	1	Human	10.0	pEC50	=	10	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	3	3	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	156016416	177073	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177073	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94050	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251572	94050	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156014430	176639	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	176639	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016416	177073	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641513	177073	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	6	3	5	3.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	16752684	94050	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	CHEMBL251572	94050	1	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2008.12.042
	44570963	183288	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481013	183288	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	435	4	1	5	2.5	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	156014430	176639	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635542	176639	0	None	-	1	Human	9.8	pEC50	=	9.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444563	154404	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401134	154404	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)cc1)CC2	10.1016/j.bmcl.2007.09.067
	156011926	176816	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	176816	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44571002	190494	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL518774	190494	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H](O)[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44449987	95436	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259166	95436	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	16	4	10	0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCSCCO	10.1016/j.bmcl.2008.03.059
	25010378	158839	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	CHEMBL410074	158839	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	525	16	4	11	-0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(=O)(=O)CCO	10.1016/j.bmcl.2008.03.059
	44449955	158853	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410085	158853	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	509	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	156011926	176816	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638297	176816	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	6	4	5	2.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4Cl)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177222	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177222	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156015100	176988	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	176988	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	156017918	177222	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643530	177222	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	591	7	3	7	2.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44570960	183396	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481796	183396	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	417	4	1	5	2.4	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	24894012	176213	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL460680	176213	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	497	14	4	9	1.6	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	156015100	176988	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640507	176988	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437979	10214	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10214	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44437979	10214	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162065	10214	0	None	-	1	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	655	12	5	5	4.1	NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)c1ccccc1	10.1016/j.bmc.2007.01.057
	44454303	97107	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97107	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	156020725	177521	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	177521	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44570764	183457	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482220	183457	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	481	4	1	4	3.8	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(Cl)ccc3Cl)cc2)C1	10.1016/j.bmcl.2008.12.042
	24803512	88565	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364468	88565	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1Cl	10.6019/CHEMBL2364335
	156020725	177521	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647963	177521	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	9917957	109217	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	CHEMBL322912	109217	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Compound was evaluated for GH release for effect on human GH secretagogue receptorCompound was evaluated for GH release for effect on human GH secretagogue receptor	ChEMBL	683	14	4	5	4.3	NC(=O)CN(CCc1ccccc1)C(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1021/jm970342o
	44447855	193177	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL539929	193177	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	539	15	4	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	178024	1932	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1932	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1932	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	156013414	176888	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	176888	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	176900	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	176900	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44452749	95755	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL260819	95755	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	7	2	6	4.5	COc1ccc(F)c(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44570765	190834	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL519301	190834	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007047	88523	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364427	88523	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1C	10.6019/CHEMBL2364335
	178024	1932	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1932	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1932	30	None	-1	3	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	25022640	97339	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97339	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454337	155051	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155051	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44447839	94537	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254765	94537	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	499	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156013414	176888	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639111	176888	4	None	1905	4	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156013297	176900	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639229	176900	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@H]3CCCN(C)C3)cc2c1	10.1021/acs.jmedchem.0c00828
	44447857	166312	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL428592	166312	0	None	-	1	Human	9.4	pEC50	=	9.4	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156019724	177407	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177407	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888474	63119	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL179823	63119	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	11306502	63296	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63296	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63296	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63296	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11306502	63296	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63296	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888476	122290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	22888476	122290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360547	122290	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	525	9	1	6	5.6	COc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	44454117	155004	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155004	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44444559	93987	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251169	93987	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	451	4	1	5	3.8	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	156011750	176706	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	176706	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156019724	177407	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646219	177407	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	5	2.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453123	97524	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL272753	97524	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	503	6	2	5	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(Cl)ccc2F)cc1	10.1016/j.bmcl.2007.12.021
	44570966	182977	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480037	182977	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	59007062	88525	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364429	88525	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1F	10.6019/CHEMBL2364335
	24803514	88570	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364472	88570	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1Cl	10.6019/CHEMBL2364335
	44447852	155010	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404354	155010	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	477	14	4	10	0.6	Cc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156011750	176706	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636502	176706	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccccc2Cl)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450016	160001	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411259	160001	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	17	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCCO	10.1016/j.bmcl.2008.03.059
	44454367	94804	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94804	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	22867441	10203	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10203	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	16114096	78735	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	78735	1	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	22867441	10203	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161835	10203	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447841	154527	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL401827	154527	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1Cl)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	69195371	88449	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364354	88449	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44450101	158901	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL410135	158901	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	13	4	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCc1cccc(O)c1	10.1016/j.bmcl.2008.03.059
	44391039	131253	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369329	131253	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	540	9	1	7	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc([N+](=O)[O-])c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44449988	160542	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411697	160542	0	None	-	1	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	477	16	4	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCOCCO	10.1016/j.bmcl.2008.03.059
	44447843	94565	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254973	94565	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C(F)(F)F)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	10280020	62747	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178900	62747	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	529	8	1	5	6.2	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(Cl)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156021297	177505	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177505	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444571	93532	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248544	93532	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	10553921	104068	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104068	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	138732	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	138732	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	156012122	176797	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176797	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	177505	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177505	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11584048	97566	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	CHEMBL272993	97566	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1Cl	10.1016/j.bmcl.2007.12.021
	24755624	156746	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL407706	156746	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2007.12.021
	24755624	156746	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	CHEMBL407706	156746	1	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cc1	10.1016/j.bmcl.2008.12.042
	69197353	88503	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364408	88503	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44454060	154781	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154781	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10553921	104068	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL310457	104068	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	517	9	4	4	2.9	CCNC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	10345516	138732	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	CHEMBL379074	138732	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1016/j.bmc.2007.01.057
	127047525	139224	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139224	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	156022162	177622	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	177622	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	156012122	176797	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176797	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	20600693	63111	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179785	63111	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	566	11	1	6	4.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44560945	178513	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL471751	178513	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	391	9	2	7	2.1	CC(C)(N)C(=O)N[C@H](CCC(F)(F)c1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	216208	9620	27	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9620	27	None	-5	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	44449891	96014	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL262358	96014	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	216208	9620	27	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9620	27	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	156021478	177471	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	177471	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	44437955	10212	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10212	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	9807597	182425	3	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL47938	182425	3	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	156018364	177329	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177329	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021478	177471	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647258	177471	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	7	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NC[C@H]3CCCN3)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	177619	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	177619	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156022162	177622	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649634	177622	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	8	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)NC[C@@H]1CCCN1)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	56926175	68656	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	68656	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926356	68662	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	68662	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926461	68679	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	68679	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	68680	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	68680	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57399248	68687	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	68687	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	11664206	68696	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	68696	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926894	68707	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	68707	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	11526745	68711	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	68711	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11526696	71243	13	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71243	13	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71243	13	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	134130631	141829	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	141829	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134137202	142282	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142282	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	142593	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	142593	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133518	142909	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	142909	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134133352	142961	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	142961	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134286	143150	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143150	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135712	143594	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	143594	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	11512561	143824	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	143824	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144022	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144022	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132893	144318	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144318	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132152	144387	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144387	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	144742	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	144742	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	144781	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	144781	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	134142839	144841	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	144841	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143635	145029	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145029	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143366	145215	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145215	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134142204	145392	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145392	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	145646	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	145646	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	145828	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	145828	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134139279	145902	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	145902	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139286	146009	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146009	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	146573	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	146573	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	117812380	147207	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147207	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147210	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147210	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	147470	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	147470	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	147810	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	147810	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149306	147930	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	147930	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145791	148242	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148242	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134145564	148546	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	148546	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147441	148945	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	148945	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134155239	150470	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	150470	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	150548	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	150548	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154079	151859	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	151859	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152176	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152176	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	44570763	189655	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517543	189655	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	449	4	1	4	2.7	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cc(F)ccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	9890504	89296	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	CHEMBL237699	89296	0	None	-	1	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	461	10	3	10	-0.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CC[C@@H](O)C1	10.1021/jm7010595
	24969109	88433	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364338	88433	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cccc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11518200	88448	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364353	88448	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641108	88477	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364382	88477	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197887	88498	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364403	88498	0	None	-	1	Human	9.0	pEC50	=	9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447856	161253	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL414394	161253	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	558	15	4	12	1.6	Cc1noc(C)c1-c1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	156018364	177329	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177329	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156022090	177619	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649603	177619	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10323604	10197	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10197	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10323604	10197	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161828	10197	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44447853	94510	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254565	94510	0	None	-	1	Human	9.0	pEC50	=	9.0	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	493	15	4	11	0.3	COc1ccccc1COC[C@@H](NC(=O)C(C)(C)N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	25022503	155011	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL404355	155011	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	540	15	4	11	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1-c1cccnc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44269035	27110	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13675	27110	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44269039	97876	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL275093	97876	0	None	-	1	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	145956061	162131	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162131	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44570965	189235	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL516602	189235	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	418	4	2	6	0.8	Cc1ccc(-c2ccc(S(=O)(=O)N3CCNC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	69194933	88520	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364424	88520	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	5	2	5	5.0	Cc1csc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3C)cc2)c1	10.6019/CHEMBL2364335
	69198297	88529	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364432	88529	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cc(C)cs3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	44447850	94481	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254363	94481	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	488	14	4	11	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1C#N)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450015	95858	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261358	95858	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	475	16	4	9	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCCO	10.1016/j.bmcl.2008.03.059
	178024	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	178024	1932	30	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	5867	1932	30	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	CHEMBL13817	1932	30	None	1	3	Rat	8.9	pEC50	=	8.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(97)10199-8
	178024	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	5867	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	CHEMBL13817	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/j.bmc.2007.01.057
	145956061	162131	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162131	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	44450104	95344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258761	95344	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	496	14	4	10	-1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(N)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	212334	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL500468	212334	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	22888475	63479	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180246	63479	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	523	9	1	6	5.4	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C=O)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL500468	212334	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.040
	162653916	179953	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	179953	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	212334	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.02.021
	CHEMBL500468	212334	0	None	-	1	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2008.05.100
	178024	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1932	30	None	-1	3	Human	8.9	pEC50	=	8.9	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	156012849	176714	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176714	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390996	63958	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181063	63958	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(C(F)(F)F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	11353414	64270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181764	64270	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	553	11	1	7	4.5	COC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44347919	16182	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122939	16182	0	None	-	1	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	606	14	3	6	4.2	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	16133832	211573	15	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	211573	15	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	145957574	161739	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161739	0	None	57	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	9875705	203580	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	203580	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	156012849	176714	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176714	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013219	176905	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176905	0	None	60	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11648350	88476	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364381	88476	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007043	88479	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364384	88479	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(Cl)cccc2c1	10.6019/CHEMBL2364335
	69197106	88522	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364426	88522	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)s3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	24803348	88527	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364430	88527	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197228	88573	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364475	88573	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.6	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	16114291	190690	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL5190973	190690	1	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/acs.jmedchem.1c02191
	16114292	96473	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96473	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	9875705	203580	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	CHEMBL79263	203580	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1016/j.bmc.2007.01.057
	44436850	91104	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91104	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44447840	94538	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254766	94538	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	497	14	4	10	0.9	CC(C)(N)C(=O)N[C@H](COCc1cccc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44447854	94511	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254566	94511	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	469	14	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCC1CCCCC1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL105462	206716	34	None	12	2	Rat	8.8	pEC50	=	8.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm980197u
	44447844	94423	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253965	94423	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.3	CC(C)(N)C(=O)N[C@H](COCc1cccc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44450017	95886	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL261544	95886	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	15	4	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	10118326	23874	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	23874	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10458218	27265	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13687	27265	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	10745618	112475	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	CHEMBL331093	112475	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	568	13	2	4	4.5	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CC1	10.1021/jm980197u
	10118326	23874	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL133848	23874	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	509	9	4	4	3.7	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1ccc2ccccc2c1)C1CCNCC1	10.1016/j.bmc.2007.01.057
	156010457	176470	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	176470	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	23649669	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL398372	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.03.059
	23649669	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	CHEMBL398372	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1021/jm7010595
	23649669	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	CHEMBL398372	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.05.100
	23649669	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL398372	153421	7	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	463	14	4	10	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44437955	10212	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162063	10212	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	534	11	4	6	2.6	NCC(O)CNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCCN1C(=O)CCSc2ccccc21	10.1016/j.bmc.2007.01.057
	10626337	100742	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	100742	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156010457	176470	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4632657	176470	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	557	7	3	7	2.3	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccc(Cl)cc2)on1	10.1021/acs.jmedchem.0c00828
	156012445	176751	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176751	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	176997	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	176997	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452750	95797	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL261030	95797	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	7	2	6	4.4	COc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.1016/j.bmcl.2007.12.021
	44452932	97125	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	CHEMBL270790	97125	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1F	10.1016/j.bmcl.2007.12.021
	44570700	183367	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	CHEMBL481620	183367	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	486	6	2	6	2.1	COc1cccc(C(=O)Nc2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CC[C@H](N)C3)cc2)c1	10.1016/j.bmcl.2008.12.042
	69197169	88494	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364399	88494	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11641478	88502	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364407	88502	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)s1	10.6019/CHEMBL2364335
	24803350	88538	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364441	88538	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	6	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1C	10.6019/CHEMBL2364335
	11547664	88578	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364480	88578	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)c(F)c1	10.6019/CHEMBL2364335
	44579802	186176	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488965	186176	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44444572	93572	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248745	93572	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	498	5	1	7	4.1	COc1cc2c(cc1N1C[C@@H](C)NC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145962494	161513	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	161513	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145951150	162214	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162214	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44434120	89463	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89463	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	9827234	5249	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL106841	5249	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	498	9	5	4	3.1	O=C(N[C@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CO)Cc1c[nH]c2ccccc12)C1CCNCC1	10.1016/j.bmc.2007.01.057
	44411718	10194	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161825	10194	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10211	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10211	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	44293557	100606	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL294923	100606	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL540001	100606	0	None	1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	127046473	139237	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139237	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	156012203	176750	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	176750	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	156016696	177046	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177046	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11525404	94924	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL256808	94924	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44571004	183454	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL482203	183454	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	5	1	5	2.6	CNC1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccc(C)o3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL105462	206716	34	None	12	2	Rat	8.0	pEC50	=	8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(97)10199-8
	24969294	88438	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364343	88438	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	460	5	3	6	3.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)c[nH]c3=O)cc2F)o1	10.6019/CHEMBL2364335
	69194607	88453	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364358	88453	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1	10.6019/CHEMBL2364335
	69197049	88454	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364359	88454	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	69195141	88472	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364377	88472	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	431	5	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1csc2ccccc12	10.6019/CHEMBL2364335
	11682686	88485	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364390	88485	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc4ccccc34)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198021	88528	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	CHEMBL2364431	88528	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccc(Cl)c12	10.6019/CHEMBL2364335
	11655608	88541	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364444	88541	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194649	88575	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364477	88575	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196750	88577	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364479	88577	0	None	-	1	Human	8.0	pEC50	=	8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	472	6	2	7	4.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)nc1	10.6019/CHEMBL2364335
	23730339	147575	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL393531	147575	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	10	3	10	0.4	CC1(O)CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	156016696	177046	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177046	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145993528	166753	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	166753	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	156012203	176750	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637255	176750	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	558	7	3	8	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1nnc(-c2ccc(F)cc2)s1	10.1021/acs.jmedchem.0c00828
	145950201	162380	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162380	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44281466	168805	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	168805	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44452806	96222	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL263916	96222	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	486	7	2	7	4.6	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	44452885	97352	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271948	97352	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	481	8	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(OCc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	11633712	158776	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410013	158776	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	446	5	2	6	3.9	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	57390496	68698	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68698	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	56926782	68700	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	68700	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	68703	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	68703	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	68705	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	68705	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926893	68706	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	68706	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	134131183	141924	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	141924	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133488	142692	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	142692	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134870	143847	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	143847	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144116	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144116	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132265	144426	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144426	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	76460236	144915	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	144915	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134141159	146184	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146184	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	147909	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	147909	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134146570	148236	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148236	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145820	148490	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	148490	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155024	150468	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	150468	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	150798	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	150798	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152627	151004	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151004	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150696	151535	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	151535	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150029	151571	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	151571	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	151826	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	151826	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154022	152281	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152281	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151899	152773	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	152773	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134156625	153105	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153105	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	16040587	178794	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	CHEMBL473921	178794	0	None	-14	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human Ghrelin receptorAgonist activity at human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm801332q
	44576247	212441	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	212441	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	212441	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	212441	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL3578015	210009	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	210012	0	None	-15	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69198097	88459	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364364	88459	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)cc1	10.6019/CHEMBL2364335
	69198438	88461	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364366	88461	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccnc2)s1	10.6019/CHEMBL2364335
	69196473	88470	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364375	88470	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	452	5	2	6	4.3	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)ccc2C#N)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197657	88471	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364376	88471	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	497	8	2	7	4.5	COc1ccc(Oc2cccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)c2)cc1	10.6019/CHEMBL2364335
	69195983	88492	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364397	88492	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196844	88509	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364414	88509	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647817	88513	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	CHEMBL2364418	88513	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	437	4	2	4	3.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.6019/CHEMBL2364335
	69196864	88531	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364434	88531	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(F)cc2F)cc1	10.6019/CHEMBL2364335
	69198407	88560	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364463	88560	0	None	-	1	Human	7.0	pEC50	=	7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	5	2	5	3.6	COc1cc(Br)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	44579958	190738	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519171	190738	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	156020713	177504	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	177504	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	134139753	145491	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	145491	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44449923	95878	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL261497	95878	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	601	17	4	11	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1cccc(S(=O)(=O)CCO)c1	10.1016/j.bmcl.2008.03.059
	156020713	177504	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647751	177504	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	477	6	3	7	0.7	Cc1csc(C(=O)N[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2C(=O)N[C@H]2CCCNC2)n1	10.1021/acs.jmedchem.0c00828
	44434110	88070	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88070	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578018	210012	0	None	-15	2	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44450102	95314	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL258550	95314	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1ccccc1C(=O)NCCO	10.1016/j.bmcl.2008.03.059
	16114290	136671	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	136671	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11664206	68696	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	68696	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	71453489	207613	13	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Val mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	9870965	63968	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181092	63968	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	509	9	1	5	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44434051	88971	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	88971	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	44434053	146313	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	CHEMBL392522	146313	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1cccc(NS(C)(=O)=O)c1	10.1016/j.bmcl.2007.07.099
	145988557	166696	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	166696	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL2170775	207608	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434083	89586	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	89586	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44436884	91107	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91107	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114098	141067	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141067	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113246	94226	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94226	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	22888486	63972	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL181108	63972	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	552	9	2	6	5.5	CC(=O)Nc1cccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	71453489	207613	13	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	CHEMBL2170781	207613	13	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.9b02122
	156018539	177225	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177225	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145949755	162372	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162372	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	156013970	176656	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	176656	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156018539	177225	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4643595	177225	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	2	7	2.6	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1NC(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	69197178	88431	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364336	88431	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(Cl)s2)cc1	10.6019/CHEMBL2364335
	69194396	88482	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364387	88482	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	7	2	6	4.8	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	69195258	88514	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364419	88514	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	6	2	7	4.0	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11604627	88530	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364433	88530	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(NS(=O)(=O)c2ccc(-c3ccoc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197381	88548	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364451	88548	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	486	6	2	7	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2cccc(C)n2)s1	10.6019/CHEMBL2364335
	11576185	88555	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364458	88555	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2nccs2)cc1	10.6019/CHEMBL2364335
	11633856	88581	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364483	88581	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ncccn2)cc1	10.6019/CHEMBL2364335
	59007104	88584	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364486	88584	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	1	6	4.8	COc1ccc(N2C[C@H](C)N(C)[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2170779	207611	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579824	183518	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482623	183518	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44579883	186245	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489403	186245	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579861	192908	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL528332	192908	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	44579906	192009	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL521612	192009	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	145992125	166186	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166186	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016682	177182	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177182	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170776	207609	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	16752689	187774	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	CHEMBL501315	187774	0	None	-5	3	Rabbit	6.9	pEC50	=	6.9	Functional	Activity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assayActivity at ghrelin receptor in New Zealand White rabbit gastric antral smooth muscle by calcium mobilization-based FLIPR assay	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1016/j.bmcl.2008.10.071
	44444557	154136	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL399704	154136	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	493	4	0	5	3.7	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1cccc(Br)c1)CC2	10.1016/j.bmcl.2007.09.067
	145957404	161488	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	161488	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	161962	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	161962	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	145950261	162167	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162167	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156014569	176648	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	176648	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452776	95868	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL261466	95868	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)cc1	10.1016/j.bmcl.2007.12.021
	69196695	88444	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364349	88444	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	7	2	6	4.5	COc1ccc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	59007058	88452	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	CHEMBL2364357	88452	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Br)s1	10.6019/CHEMBL2364335
	156016682	177182	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4642860	177182	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44579842	184158	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL485091	184158	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	145986461	166649	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	166649	0	None	-	1	Human	5.9	pEC50	=	5.9	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145950261	162167	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162167	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	10602593	112331	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330860	112331	0	None	-	1	Rat	7.9	pEC50	=	7.9	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	542	12	2	4	4.1	CCNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391038	64239	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181627	64239	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	13	1	4	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170783	207615	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)[C@@H](N)CCCCN)C(c1ccccc1)c1ccccc1)C(N)=O	10.1021/jm300414b
	CHEMBL2170779	207611	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013970	176656	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635743	176656	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	624	7	3	6	3.9	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1ccc(-c2cc(C(F)(F)F)ccc2Cl)o1	10.1021/acs.jmedchem.0c00828
	156014569	176648	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4635694	176648	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	599	7	2	7	2.5	CC(=O)N1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	56926173	68655	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	68655	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	134138625	147486	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	147486	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	155526063	170459	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	170459	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145957404	161488	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4160261	161488	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)c(F)cc21	10.1021/acs.jmedchem.8b00322
	145955250	161962	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167776	161962	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	4	4	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCOC3)cc2c1	10.1021/acs.jmedchem.8b00322
	44454060	154781	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154781	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	57399248	68687	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	68687	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at ghrelin receptor by cell based assayAgonist activity at ghrelin receptor by cell based assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	145949755	162372	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162372	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44434109	145736	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	145736	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9890375	97805	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	97805	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	97805	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44436876	146474	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	146474	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9890375	97805	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL274599	97805	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL558802	97805	0	None	-1	3	Rat	7.9	pEC50	=	7.9	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	9890375	97805	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL274599	97805	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL558802	97805	0	None	1	3	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	44281466	168805	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL442151	168805	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	436	8	2	4	2.9	Cc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	162672839	182430	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	182430	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	22888428	64004	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181247	64004	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	508	9	2	4	4.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)NC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	23730227	147329	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	CHEMBL393330	147329	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	15	4	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO	10.1021/jm7010595
	44450133	159834	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL411122	159834	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	481	13	3	10	-0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44579821	183636	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL483455	183636	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	44579879	186402	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490627	186402	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)c1	10.1016/j.bmcl.2008.07.120
	44450071	96124	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263141	96124	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	489	15	3	10	0.6	CCOC(=O)CCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	16113906	136686	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	136686	0	None	-	1	Human	6.9	pEC50	=	6.9	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44579752	186367	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490390	186367	0	None	-	1	Human	4.9	pEC50	=	4.9	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	377	8	1	4	3.7	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	44436887	90514	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90514	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44434076	89333	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89333	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	145952740	161939	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161939	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	23648250	78738	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	78738	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16113577	84498	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84498	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	162657465	180449	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	180449	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	44444574	93573	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248746	93573	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	484	5	1	7	3.8	COc1cc2c(cc1N1CCNC(C)(C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145952740	161939	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161939	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	11532288	96459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL265950	96459	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	7	2.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-n2cccn2)cc1	10.1016/j.bmcl.2007.12.021
	11576186	154674	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	CHEMBL402632	154674	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	7	3.8	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccn3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.1016/j.bmcl.2007.12.021
	44570964	183289	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL481014	183289	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	407	4	1	5	1.7	Cc1ccc(-c2ccc(S(=O)(=O)N3CC[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	44570921	183363	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481601	183363	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	59007073	88432	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364337	88432	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)nc1	10.6019/CHEMBL2364335
	69197749	88441	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364346	88441	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc3ccccc3c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11682796	88443	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364348	88443	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	6	2	5	3.3	COc1ccc(NS(=O)(=O)/C=C/c2ccccc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198460	88455	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	CHEMBL2364360	88455	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Cl)c1Cl	10.6019/CHEMBL2364335
	69198360	88463	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364368	88463	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	466	6	2	6	4.1	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)n3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11683967	88475	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364380	88475	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cccs2)c1	10.6019/CHEMBL2364335
	69195261	88483	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364388	88483	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	7	2	6	5.2	CC(C)Oc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11516766	88487	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364392	88487	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	395	4	2	4	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc4ccccc4c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11525161	88544	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364447	88544	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	447	5	2	5	4.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)c(F)c3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194533	88574	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364476	88574	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(F)c(-c2ccco2)cc1F	10.6019/CHEMBL2364335
	69197165	88586	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364488	88586	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	3	6	3.6	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccco4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44579777	186391	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490601	186391	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44454432	154707	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154707	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44434112	168283	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168283	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44579908	186281	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489610	186281	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145954311	161924	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161924	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44434124	88216	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235817	88216	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC#N)n1	10.1016/j.bmcl.2007.07.099
	162659161	180799	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	180799	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44444556	93953	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	CHEMBL250973	93953	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	471	6	0	5	4.4	CCOc1ccc(CC(=O)N2CCc3cc(OC)c(N4C[C@H](C)N(C)[C@H](C)C4)cc32)cc1Cl	10.1016/j.bmcl.2007.09.067
	145950963	162244	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162244	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952396	162441	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162441	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	156011695	176771	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	176771	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	44452887	159019	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL410282	159019	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccccc2)c1	10.1016/j.bmcl.2007.12.021
	46882522	5621	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078208	5621	0	None	-39	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	440	7	2	5	3.6	CC(C)Oc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	69195349	88466	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	CHEMBL2364371	88466	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	5	2	5	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(Br)c1	10.6019/CHEMBL2364335
	69198352	88587	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364489	88587	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	44446188	154840	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	154840	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145954311	161924	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161924	0	None	-	1	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882521	5620	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078207	5620	0	None	-158	2	Human	5.8	pEC50	=	5.8	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	458	6	2	4	4.5	O=S(=O)(Nc1ccc2c(c1)CCN(Cc1cc[nH]n1)CC2)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2009.09.027
	44445620	154128	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154128	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	22862453	97994	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL275795	97994	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	490	5	4	5	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	10675061	96083	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL262889	96083	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	10026738	162207	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162207	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162207	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	56926464	68682	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	68682	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	155540883	172378	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172378	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.36 +/- 0.01 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	10210658	10213	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10213	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	145952396	162441	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162441	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL2170784	207616	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134139080	147138	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147138	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	156011695	176771	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637585	176771	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	8	2	7	2.2	O=CN1CCC[C@H](NC(=O)[C@H]2CN(S(=O)(=O)c3ccccc3)C[C@@H]2NC(=O)c2cc(-c3ccccc3Cl)on2)C1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170697	207602	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(=O)c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434080	89467	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434080	89467	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89467	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89467	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	10210658	10213	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	CHEMBL1162064	10213	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	593	13	5	5	3.6	NCCCCNC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1	10.1016/j.bmc.2007.01.057
	10026738	162207	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL417182	162207	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL557206	162207	0	None	1	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	10530983	167810	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL434609	167810	0	None	-	1	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	564	11	2	4	4.0	CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391003	122792	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL361612	122792	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	531	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170780	207612	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145950963	162244	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162244	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	127047409	139088	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139088	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	10745533	139577	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	139577	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	200824	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	200824	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	16113693	137476	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	137476	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	11692516	68691	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	68691	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	155557019	174005	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174005	0	None	-	1	Human	7.8	pEC50	=	7.8	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.34 +/- 0.12 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	9810101	98779	12	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL281764	98779	12	None	-5	2	Rat	7.8	pEC50	=	7.8	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10745533	139577	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL380096	139577	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	44437971	200824	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611489	200824	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	7	2	4	3.9	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44579909	186310	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186310	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44436882	145471	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	145471	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2170698	207603	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434122	89067	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237302	89067	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCCC#N)n1	10.1016/j.bmcl.2007.07.099
	145992142	166207	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166207	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL3578006	210003	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	145953016	162025	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162025	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	44454304	97141	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97141	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97187	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97187	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454338	97373	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97373	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	22867310	29812	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	CHEMBL13891	29812	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	4	4	2.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2O	10.1016/s0960-894x(97)10199-8
	162653802	179939	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	179939	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44436886	161394	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161394	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	9987037	11912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	11912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	11912	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	44391008	64521	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182137	64521	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	9	1	5	4.6	CCN(CC)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	22888379	167739	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL434152	167739	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	584	12	2	5	4.8	CC(=O)NC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	44444564	94023	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251366	94023	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	478	5	1	6	3.7	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1cccc(-c3ccccn3)c1)CC2	10.1016/j.bmcl.2007.09.067
	145961213	161602	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	161602	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145953016	162025	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162025	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949595	162162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	162462	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162462	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44452929	97081	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	CHEMBL270573	97081	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccco2)c1	10.1016/j.bmcl.2007.12.021
	46882396	5752	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079187	5752	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc(C)[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570698	183366	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481619	183366	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	456	5	2	5	2.0	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	24969292	88435	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364340	88435	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	2	6	3.8	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccn3)cc2F)o1	10.6019/CHEMBL2364335
	69194665	88468	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364373	88468	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	3.9	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.6019/CHEMBL2364335
	11524465	88488	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364393	88488	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	413	4	2	4	4.0	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cccc(Cl)c3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11576404	88499	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364404	88499	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(F)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194865	88518	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364422	88518	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2ccccc12	10.6019/CHEMBL2364335
	11712498	88532	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364435	88532	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	469	6	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2F)cc1	10.6019/CHEMBL2364335
	69195296	88537	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364440	88537	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3F)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11518242	88540	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364443	88540	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.9	Cc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	69197366	88545	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364448	88545	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	5	4.7	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11503413	88562	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	CHEMBL2364465	88562	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	454	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccn2C)cc1	10.6019/CHEMBL2364335
	11647900	88568	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364470	88568	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1cc(-c2ccco2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	11669734	88569	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364471	88569	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1cc(-c2cccs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	44391007	64520	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182136	64520	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	480	9	1	4	4.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	145994050	166780	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	166780	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	156016392	177062	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177062	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578006	210003	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)O	10.1021/jm501702q
	25098836	190852	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	190852	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957574	161739	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161739	0	None	57	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10196	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10196	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	10626337	100742	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL295984	100742	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1016/j.bmc.2007.01.057
	156013219	176905	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176905	0	None	60	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	22888352	63591	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63591	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888352	63591	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180659	63591	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vivo effective concentration against human growth hormone secretagoguesIn vivo effective concentration against human growth hormone secretagogues	ChEMBL	537	11	1	6	4.9	CC(=O)C(C)(C)OC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	10649999	16910	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL125498	16910	0	None	-	1	Rat	8.7	pEC50	=	8.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156015928	176997	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	176997	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012445	176751	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176751	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44411634	10193	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10193	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44411634	10193	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161824	10193	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44390986	64323	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181832	64323	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccccc1CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL2170695	207600	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156011766	176724	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	176724	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	44281449	112882	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	112882	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	44281449	112882	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33182	112882	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	559	12	4	7	1.4	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(=O)(=O)CC(=O)O)CC1	10.1016/j.bmc.2007.01.057
	23648249	78737	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	78737	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	10166594	64290	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181786	64290	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	563	8	1	5	6.6	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccc(C(F)(F)F)cc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391010	64528	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL182158	64528	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	9	1	6	6.3	CSc1ccc(Oc2ccc3c(c2)CCN(C(=O)OC(C)(C)C)C3C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	23648244	91568	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	91568	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	155557019	174005	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174005	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)Antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM by measuring ghrelin EC50 after 30 mins by HTRF assay (Rvb = 0.40 +/- 0.05 nM)	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44444565	94051	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251573	94051	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	474	5	1	8	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccon3)s1)CC2	10.1016/j.bmcl.2007.09.067
	145957075	161717	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161717	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44411745	10196	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161827	10196	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	156013684	176681	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	176681	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156011766	176724	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636780	176724	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	569	6	2	7	2.2	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N1C[C@H]2CCNC[C@H]21)c1cc(-c2ccccc2Cl)on1	10.1021/acs.jmedchem.0c00828
	11539642	97466	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL272540	97466	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	448	6	2	8	3.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)s1	10.1016/j.bmcl.2007.12.021
	44570702	183244	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL480639	183244	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	463	4	1	5	3.1	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	11683968	88474	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364379	88474	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(NS(=O)(=O)c2ccc(-c3ccsc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197883	88497	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364402	88497	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)cc2F)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69195597	88510	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	CHEMBL2364415	88510	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2Cl)s1	10.6019/CHEMBL2364335
	59007081	88524	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364428	88524	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	5	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(Cl)c2)cc1	10.6019/CHEMBL2364335
	11648834	88579	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364481	88579	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1F	10.6019/CHEMBL2364335
	44411753	10198	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10198	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411753	10198	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161829	10198	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	10415000	167493	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	167493	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	71453489	207613	13	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Phe119:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	156013684	176681	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636178	176681	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	571	7	3	7	2.6	Cc1oc(-c2ccc(Cl)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	10415000	167493	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL432461	167493	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	543	11	3	6	2.7	CC(C)S(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	156019457	177358	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177358	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449922	95761	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL260849	95761	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	615	17	3	11	1.0	CN(CCc1cccc(S(=O)(=O)CCO)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44269019	97761	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL274340	97761	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44579840	184156	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL485090	184156	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579907	186455	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	186455	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579805	186473	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491221	186473	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434113	88207	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88207	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127048060	139318	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139318	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	57399248	68687	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	68687	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44268965	23843	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13383	23843	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2=O)C1	10.1016/s0960-894x(97)10199-8
	10675800	113282	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL332414	113282	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	654	11	2	4	4.3	CNC(=O)[C@@H](Cc1ccc(I)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391002	123379	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL362798	123379	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	507	10	1	4	5.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44579857	186331	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL490009	186331	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44434018	88050	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235012	88050	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	399	8	3	8	0.9	COC(=O)CCn1nnnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44579641	186304	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489794	186304	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	370	7	1	4	4.0	CSc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579996	186543	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491835	186543	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	367	7	2	4	2.8	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)COc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	44579919	190745	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	CHEMBL519196	190745	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	444	9	1	4	5.3	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(-c2ccccc2)c1OC	10.1016/j.bmcl.2008.07.120
	44454092	97187	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97187	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44450070	158093	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	CHEMBL409258	158093	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	461	14	4	9	0.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(=O)O	10.1016/j.bmcl.2008.03.059
	156016392	177062	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177062	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145961213	161602	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162174	161602	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	3	4	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@H]3COCCN(C)C3)cc2c1	10.1021/acs.jmedchem.8b00322
	145949595	162162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162162	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145974293	162462	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162462	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44390905	64111	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181337	64111	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	544	10	1	6	3.4	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)N(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391040	64115	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181352	64115	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	577	10	1	6	5.0	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10579444	113731	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	CHEMBL332987	113731	0	None	-	1	Rat	7.7	pEC50	=	7.7	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	598	13	2	5	4.3	CN(C(=O)/C=C/CC(C)(C)N)[C@H](Cc1cccc2ccccc12)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NCC1CCCO1	10.1021/jm980197u
	162645413	179136	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179136	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44293091	187593	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	187593	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	16114011	137597	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	137597	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	145981343	166145	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166145	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44391048	62604	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178502	62604	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	8	2	5	4.2	CC(C)NCCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44454399	154588	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	154588	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44293091	187593	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL49884	187593	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1016/j.bmc.2007.01.057
	155540883	172378	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172378	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44579801	186568	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL492028	186568	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	168276220	189817	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5177954	189817	0	None	-	1	Human	5.7	pEC50	=	5.7	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	261	6	1	1	4.2	CCCCCCCc1cc(=O)c2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	145958774	161704	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161704	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145950877	162433	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162433	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44450135	158145	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL409327	158145	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44454302	158821	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	158821	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	16203237	96490	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96490	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	56926462	68680	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	68680	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162660604	180627	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	180627	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956753	161596	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	161596	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	71453489	207613	13	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Phe119:Ser mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44446190	94107	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94107	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446189	154823	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	154823	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	10744738	16013	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122420	16013	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1cccc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL2170699	207604	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44454432	154707	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154707	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	44454397	154972	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL404227	154972	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC(C#N)Cc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145949381	162153	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162153	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	22862431	30255	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13930	30255	0	None	-	1	Rat	7.6	pEC50	=	7.6	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	474	5	3	4	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc3O2)CC1	10.1016/s0960-894x(97)10199-8
	162653781	179890	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	179890	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	156013764	176687	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	176687	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	145958317	161751	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161751	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949381	162153	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162153	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950877	162433	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162433	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	156013764	176687	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636229	176687	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	585	7	1	7	3.0	CN(C(=O)[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1N(C)C(=O)c1cc(-c2ccccc2Cl)on1)[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156020452	177450	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	177450	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	24969201	88439	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364344	88439	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	476	6	2	7	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1Cl	10.6019/CHEMBL2364335
	69197403	88464	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	CHEMBL2364369	88464	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	5	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc2cc(Cl)ccc2s1	10.6019/CHEMBL2364335
	59007071	88478	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364383	88478	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	444	5	3	7	3.5	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11547135	88491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364396	88491	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	2	5	5.1	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccc(Cl)s4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11567764	88495	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364400	88495	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	411	5	2	6	2.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-n4cccn4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11511157	88505	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	CHEMBL2364410	88505	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2C)s1	10.6019/CHEMBL2364335
	11547599	88507	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364412	88507	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(NS(=O)(=O)c2ccc(-c3c(C)cccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197133	88517	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	CHEMBL2364421	88517	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	477	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)s1	10.6019/CHEMBL2364335
	69197849	88542	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364445	88542	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	429	5	2	5	4.1	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccoc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69198350	88549	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	CHEMBL2364452	88549	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	9	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csnn2)s1	10.6019/CHEMBL2364335
	156020452	177450	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4646979	177450	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	6	4	5	2.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@]3(C)C(=O)N[C@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	44579860	188304	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL507551	188304	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145956415	161502	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161502	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956415	161502	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161502	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145956753	161596	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4162000	161596	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145958774	161704	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161704	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145955718	161973	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	161973	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145952404	162174	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162174	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	210008	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44436816	91359	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91359	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44391028	63952	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181051	63952	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	451	9	1	4	3.9	CC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44390906	131568	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL369571	131568	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	467	7	2	5	4.2	CC(C)(CN)CNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	44434052	88972	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237059	88972	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccc(NS(C)(=O)=O)cc1	10.1016/j.bmcl.2007.07.099
	44450169	159191	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	CHEMBL410499	159191	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	471	12	3	8	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCC(F)(F)F	10.1016/j.bmcl.2008.03.059
	56926894	68707	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	68707	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	44391027	128268	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL366916	128268	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	12	1	4	5.6	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)CCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579803	186177	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488966	186177	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145952404	162174	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171300	162174	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578014	210008	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11526696	71243	13	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1923502	71243	13	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	CHEMBL1963249	71243	13	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm1012374
	44450045	158678	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL409894	158678	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCO	10.1016/j.bmcl.2008.03.059
	44434012	88631	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	88631	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44454398	97136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97136	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	11526745	68711	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	68711	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44391020	63518	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180337	63518	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OCc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	162643920	181188	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181188	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172378	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172378	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)Antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM by measuring ghrelin EC50 after 15 mins by Fluo 4-AM dye-based fluorescence assay (Rvb = 0.41 +/- 0.13 nM)	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145955718	161973	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167965	161973	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	432	4	2	5	2.0	CN1CCO[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	23648236	78727	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	78727	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	145958317	161751	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161751	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	162649014	179351	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179351	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	44434123	145005	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145005	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	11526696	71243	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71243	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71243	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	122178179	120737	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	120737	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	145980382	166079	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166079	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71453489	207613	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Tyr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	134149793	148061	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148061	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release by aequorin assay	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	145980333	166017	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166017	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44579823	183489	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	183489	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	145957075	161717	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161717	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145951150	162214	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162214	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	44449864	158272	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL409462	158272	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	539	16	4	10	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCCCO)c1	10.1016/j.bmcl.2008.03.059
	10005618	10210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77376	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77376	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	98779	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	98779	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	140666	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	140666	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	206935	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	16114292	96473	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96473	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	16114292	96473	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96473	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	23730225	153630	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	CHEMBL398570	153630	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	435	12	4	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCO	10.1021/jm7010595
	10530781	15387	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL122108	15387	0	None	-	1	Rat	8.5	pEC50	=	8.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	554	12	2	4	4.2	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10005618	10210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	CHEMBL1162058	10210	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	485	11	1	3	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1	10.1016/j.bmc.2007.01.057
	15481181	77376	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL209020	77376	2	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	9810101	98779	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL281764	98779	12	None	5	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	15481188	140666	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL382844	140666	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1016/j.bmc.2007.01.057
	CHEMBL130229	206935	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1016/j.bmc.2007.01.057
	156011385	176794	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	176794	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44449956	96154	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL263389	96154	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	523	14	3	9	2.0	CN(CCc1cccc(O)c1)C(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	44447846	94445	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254166	94445	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1cccc(OC(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44444566	154217	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400124	154217	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156011385	176794	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637916	176794	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	518	8	3	5	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCCCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156019457	177358	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177358	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570961	191952	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521246	191952	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	421	4	1	5	2.2	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)c(F)c2)C1	10.1016/j.bmcl.2008.12.042
	69195095	88521	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364425	88521	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccs3)c(F)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69194503	88557	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364460	88557	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	491	6	2	6	5.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1Cl	10.6019/CHEMBL2364335
	59007103	88583	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	CHEMBL2364485	88583	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)cn1	10.6019/CHEMBL2364335
	69197358	88589	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364491	88589	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	3	6	4.1	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2F)o1	10.6019/CHEMBL2364335
	44450046	95399	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	CHEMBL259016	95399	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	501	14	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCN1CCNC1=O	10.1016/j.bmcl.2008.03.059
	23730341	89298	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	CHEMBL237701	89298	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	502	11	3	10	0.1	CC(=O)N[C@@H]1CCN(C(=O)OCCn2nnnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)C1	10.1021/jm7010595
	71453489	207613	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Asp mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44390914	63292	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180093	63292	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	11	1	5	4.9	CCCOC(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888424	122469	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL360877	122469	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	541	11	1	4	5.7	CC(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	71453489	207613	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	162671996	182239	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182239	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	23730228	89148	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237492	89148	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	477	14	3	10	0.6	CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	71453489	207613	13	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444568	93531	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL248542	93531	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	470	5	1	7	3.4	COc1cc2c(cc1N1CCN[C@H](C)C1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	15481185	76893	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	76893	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	156011736	176839	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	176839	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	25022506	94810	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL256263	94810	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.1016/j.bmcl.2007.12.021
	24803347	154477	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401548	154477	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccco2)cc1	10.1016/j.bmcl.2007.12.021
	46882394	5750	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079185	5750	0	None	1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cnc[nH]2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	46882395	5751	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1079186	5751	0	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	452	8	2	4	4.5	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2[nH]cnc2C)CC3)cc1	10.1016/j.bmcl.2009.09.027
	44570699	190701	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL519121	190701	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	474	5	2	5	2.2	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(NC(=O)c3ccccc3F)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196498	88469	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	CHEMBL2364374	88469	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)s1	10.6019/CHEMBL2364335
	69197028	88508	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364413	88508	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(C)c3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198238	88519	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364423	88519	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	2	5	4.7	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11712867	88556	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364459	88556	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)cc1F	10.6019/CHEMBL2364335
	69194471	88571	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364473	88571	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(F)c1	10.6019/CHEMBL2364335
	11698505	88580	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364482	88580	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)c2)cc1	10.6019/CHEMBL2364335
	9950632	88264	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	CHEMBL236038	88264	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHS receptorAgonist activity at GHS receptor	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.05.100
	44579880	186243	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186243	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	44579841	191945	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL521176	191945	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44434010	88331	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	CHEMBL236311	88331	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2008.03.059
	9950632	88264	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	9950632	88264	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88264	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88264	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44434010	88331	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88331	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44437966	200399	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	200399	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	200823	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	200823	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437966	200399	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL608827	200399	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	607	8	1	5	4.8	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N1CCOCC1)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44437969	200823	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	CHEMBL611488	200823	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	565	8	1	4	5.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c1cc(C#CCCC(=O)N(C)C)cc2C(F)(F)F	10.1016/j.bmc.2007.01.057
	44454368	94805	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL256236	94805	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCC(C#N)c2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	145987684	166713	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	166713	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44444560	154403	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL401133	154403	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	541	5	1	5	3.4	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)Cc1cccc(I)c1)CC2	10.1016/j.bmcl.2007.09.067
	145953855	161953	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161953	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44570923	183364	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481602	183364	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	403	4	1	5	2.0	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccco3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44570761	189369	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL517081	189369	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	NC1CCN(C(=O)C2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	122178179	120737	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578008	120737	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1002	29	10	9	3.8	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	24969112	88434	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	CHEMBL2364339	88434	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	7	3.2	Cc1ccc(-c2ccc(S(=O)(=O)Nc3ccnc(N4C[C@H](C)N[C@H](C)C4)n3)cc2F)o1	10.6019/CHEMBL2364335
	11540248	88440	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364345	88440	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	6	4.9	COc1ccc(NS(=O)(=O)c2sc3ccc(Cl)cc3c2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11647560	88442	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364347	88442	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2cccc3ccccc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196005	88473	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	CHEMBL2364378	88473	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	5	2	6	4.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1sc2ccc(F)cc2c1C	10.6019/CHEMBL2364335
	69198434	88481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	CHEMBL2364386	88481	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	488	7	2	8	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccc2OC)s1	10.6019/CHEMBL2364335
	69198286	88489	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364394	88489	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	401	4	2	5	3.9	C[C@H]1CN(c2cccc(NS(=O)(=O)c3cc4ccccc4s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11562181	88500	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364405	88500	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(NS(=O)(=O)c2ccc(-c3cccc(F)c3F)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196132	88511	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	CHEMBL2364416	88511	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2)s1	10.6019/CHEMBL2364335
	69197703	88512	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364417	88512	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)cc2)s1	10.6019/CHEMBL2364335
	69194443	88533	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	CHEMBL2364436	88533	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	487	6	2	5	4.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(F)c2F)cc1	10.6019/CHEMBL2364335
	11503069	88536	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364439	88536	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	439	5	2	4	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4ccccc4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	11647941	88543	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	CHEMBL2364446	88543	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.4	Cc1cc(-c2ccoc2)ccc1S(=O)(=O)Nc1cc(N2C[C@H](C)N[C@H](C)C2)ccc1F	10.6019/CHEMBL2364335
	11576203	88550	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	CHEMBL2364453	88550	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	6	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)CCC(C)(C)O2	10.6019/CHEMBL2364335
	11683891	88564	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364467	88564	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnccn2)cc1	10.6019/CHEMBL2364335
	69194380	88588	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364490	88588	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	6	2	6	4.0	COc1ccc(N2CCN[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	56926783	68701	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	68701	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	156021183	177540	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	177540	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177066	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177066	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021183	177540	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648308	177540	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)CC[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44453070	94637	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL255401	94637	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	6	2	7	3.1	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cncnc2)cc1	10.1016/j.bmcl.2007.12.021
	44453097	154542	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL401891	154542	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	452	6	2	6	3.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccncc2)cc1	10.1016/j.bmcl.2007.12.021
	44570762	182836	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL479865	182836	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	414	4	1	5	1.9	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3cccnc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578013	210007	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156017268	177066	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177066	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44434114	88974	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237060	88974	0	None	-	1	Human	5.5	pEC50	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnc([C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)n1	10.1016/j.bmcl.2007.07.099
	44450134	161331	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL415095	161331	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	479	13	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44446177	94197	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94197	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500468	212334	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	44450105	95345	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL258762	95345	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	507	15	3	8	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2008.03.059
	44447848	94446	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254167	94446	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	547	15	4	11	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(OC(F)(F)F)cc1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44580031	192458	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL522446	192458	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	381	7	2	4	3.2	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL3578013	210007	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44447845	94424	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL253966	94424	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	599	14	4	10	2.3	CC(C)(N)C(=O)N[C@H](COCc1cc(C(F)(F)F)cc(C(F)(F)F)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44434119	89462	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89462	0	None	-	1	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	145953855	161953	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161953	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44434121	89464	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89464	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	162646324	179146	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179146	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	10721075	15363	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121960	15363	0	None	-	1	Rat	7.5	pEC50	=	7.5	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	534	11	2	5	3.8	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1csc2ccccc12)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	145959787	161723	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114289	98199	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98199	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	56926892	68705	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	68705	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145984632	165827	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	165827	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	155551597	173367	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173367	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	22862448	96717	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	CHEMBL268231	96717	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CC(=O)c1ccccc1O2	10.1016/s0960-894x(97)10199-8
	22867465	96757	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	CHEMBL268518	96757	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2	10.1016/s0960-894x(97)10199-8
	44301387	11144	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11144	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11144	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56926356	68662	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	68662	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	10143731	63982	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181156	63982	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	543	11	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44444558	167203	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL430398	167203	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	465	4	0	5	4.1	COc1cc2c(cc1N1C[C@H](C)N(C)[C@H](C)C1)N(S(=O)(=O)c1ccc3ccccc3c1)CC2	10.1016/j.bmcl.2007.09.067
	145959007	161695	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161695	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	161723	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156021766	177543	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177543	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44452826	94925	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL256809	94925	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	428	5	2	6	3.8	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452777	95760	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL260831	95760	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	470	6	2	7	4.0	CC(=O)c1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	11554351	96079	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL262879	96079	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	458	6	2	6	2.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(N2CCCC2=O)cc1	10.1016/j.bmcl.2007.12.021
	11605061	96253	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL264170	96253	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	462	5	2	6	4.5	C[C@H]1CN(c2ccc(Cl)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	44452825	154699	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL402772	154699	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	472	7	2	7	4.2	CCOc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccn2)s1	10.1016/j.bmcl.2007.12.021
	CHEMBL3578017	210011	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	69197033	88465	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364370	88465	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197513	88480	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364385	88480	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	448	6	2	8	3.4	COc1ccc(NS(=O)(=O)c2ccc(-c3cnco3)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196509	88484	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364389	88484	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)cc2C)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11669948	88496	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364401	88496	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	467	5	2	5	3.8	COc1ccc(NS(=O)(=O)c2ccc(Br)c(C)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69196071	88554	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	CHEMBL2364457	88554	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	478	6	2	8	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2csc(C)n2)s1	10.6019/CHEMBL2364335
	69194899	88558	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364461	88558	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2ccoc2)c1	10.6019/CHEMBL2364335
	44434055	88861	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	88861	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44436889	152511	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	152511	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44570922	191954	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL521264	191954	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	415	3	1	4	1.6	N[C@@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(Br)cc2)C1	10.1016/j.bmcl.2008.12.042
	69196838	88445	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364350	88445	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(NS(=O)(=O)c2cccc3cccnc23)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	25211977	186309	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186309	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	16113580	137340	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137340	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at GHSR1a expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	44434111	145738	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	145738	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	15481185	76893	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	CHEMBL207970	76893	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1016/j.bmc.2007.01.057
	127048059	139023	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139023	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	16113580	137340	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137340	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44450103	95315	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL258551	95315	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	495	14	3	10	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCS(C)(=O)=O	10.1016/j.bmcl.2008.03.059
	44391032	64499	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL182050	64499	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	8	1	5	5.7	CC(C)N(CCNC(=O)C1c2ccc(Oc3cccc(F)c3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	156011736	176839	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4638566	176839	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	605	7	3	7	3.0	Cc1oc(-c2ccc(C(F)(F)F)cc2)nc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	44450132	95553	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL259712	95553	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	447	14	4	9	0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCNC(=O)CCCCO	10.1016/j.bmcl.2008.03.059
	145948725	166925	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	166925	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	44281450	99171	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99171	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44281450	99171	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL284295	99171	0	None	-	1	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	573	12	3	8	1.5	COC(=O)CS(=O)(=O)Nc1ccccc1N1CCN(C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)CC1	10.1016/j.bmc.2007.01.057
	44411584	10191	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10191	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	156015766	176984	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	176984	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44411584	10191	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161822	10191	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888433	64267	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181735	64267	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	535	10	1	5	5.9	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC1CCCCC1)C(C)C	10.1016/j.bmcl.2005.02.040
	44579775	186587	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL492230	186587	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1ccccc1	10.1016/j.bmcl.2008.07.120
	11258291	188505	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL510195	188505	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1Cl)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579882	192454	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL522426	192454	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44450044	160543	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	CHEMBL411699	160543	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	433	13	4	9	-0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCO	10.1016/j.bmcl.2008.03.059
	56926463	68681	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	68681	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	145981687	166013	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166013	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44579640	186303	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489793	186303	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	354	7	1	4	3.2	COc1cccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	44579686	186398	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490614	186398	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	395	8	2	4	3.6	CCC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(NC(C)=O)cc1	10.1016/j.bmcl.2008.07.120
	16203238	136572	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	136572	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	44390997	122472	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360891	122472	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	481	8	1	5	4.6	CC(C)N(C)CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL3578017	210011	0	None	-3	2	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	23661656	168467	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	CHEMBL439560	168467	0	None	-7	2	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	564	8	1	4	5.3	CC(C)C[C@H](N)c1cc(C(F)(F)F)ccc1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2)N2CCCC2=O)CC1	10.1016/j.bmc.2007.05.026
	44434074	154123	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154123	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434009	166882	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	166882	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	22867312	23651	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	CHEMBL13366	23651	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	4	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)Cc1ccccc1C2=O	10.1016/s0960-894x(97)10199-8
	162665952	181787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	181787	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44434056	144450	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391088	144450	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434007	88133	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88133	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	156021766	177543	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177543	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44391035	122080	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL360247	122080	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	545	11	1	4	5.3	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1F)C(C)C	10.1016/j.bmcl.2005.02.040
	44301512	11902	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	11902	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	11902	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	145979268	166100	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166100	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145959007	161695	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161695	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	44580030	186377	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490422	186377	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	324	6	1	3	3.2	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccccc1	10.1016/j.bmcl.2008.07.120
	118718706	114867	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	114867	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	44301462	11142	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11142	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11142	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113800	137274	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137274	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44391015	123025	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	CHEMBL361802	123025	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1ccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)cc1	10.1016/j.bmcl.2005.02.040
	162677268	182981	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	182981	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	10507433	16275	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL123430	16275	0	None	-	1	Rat	7.4	pEC50	=	7.4	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	578	13	3	6	3.5	C[C@H](O)CNC(=O)[C@@H](Cc1cccs1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	23730458	146027	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	CHEMBL392296	146027	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	499	14	3	11	0.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCn1ccnc1	10.1021/jm7010595
	44576247	212441	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL506986	212441	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	168285897	191051	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5196194	191051	0	None	-	1	Human	5.4	pEC50	=	5.4	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	273	7	1	2	4.1	CCCCCCCc1cc(=O)c2cc(OC)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	155529391	170864	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	170864	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145956659	161494	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161494	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	155537651	171740	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	171740	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	145981196	165972	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	165972	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	145979819	165909	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	165909	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434016	89748	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	89748	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	16113692	136699	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	136699	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	24970113	68699	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	68699	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170777	207610	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CCC[C@H](NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm300414b
	145956026	162100	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162100	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10202	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10202	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	137648	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	137648	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	138993	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	138993	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	168707	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	168707	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	11526696	71243	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923502	71243	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1963249	71243	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assayAgonist activity at human GSHR1a transfected in CHOK1 cells co-expressing Galpha16 assessed as increase in Ca2+ release incubated for 3 mins by FLIPR assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	10649323	15340	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL121803	15340	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	508	13	2	5	2.5	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](COCc1ccccc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	10841400	16657	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL124831	16657	0	None	-	1	Rat	8.3	pEC50	=	8.3	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	608	13	3	5	3.7	C[C@H](O)CNC(=O)[C@@H](Cc1ccc(F)c(F)c1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	156009875	176539	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176539	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44444562	94022	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL251365	94022	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	463	6	1	5	3.5	COc1cc2c(cc1N1C[C@H](C)N[C@H](C)C1)N(S(=O)(=O)CCc1ccccc1Cl)CC2	10.1016/j.bmcl.2007.09.067
	145956026	162100	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162100	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	22862436	10202	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161834	10202	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10602640	137648	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	CHEMBL376970	137648	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1016/j.bmc.2007.01.057
	10791616	138993	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL379564	138993	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10029990	168707	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL441360	168707	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	156009875	176539	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176539	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015766	176984	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640438	176984	0	None	407	3	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	523	7	3	7	1.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(-c2ccccc2)on1	10.1021/acs.jmedchem.0c00828
	44570967	189566	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL517391	189566	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	437	4	2	6	1.1	Cc1ccc(-c2ccc(S(=O)(=O)N3C[C@@H](O)C[C@H]3C(=O)N3CC[C@@H](N)C3)cc2F)o1	10.1016/j.bmcl.2008.12.042
	24969114	88437	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	CHEMBL2364342	88437	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	506	6	2	7	4.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)nc1NS(=O)(=O)c1ccc(-c2cc(C)cs2)cc1Cl	10.6019/CHEMBL2364335
	59007076	88460	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364365	88460	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	457	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1	10.6019/CHEMBL2364335
	69197196	88462	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	CHEMBL2364367	88462	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	463	6	2	7	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)s1	10.6019/CHEMBL2364335
	69197071	88501	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364406	88501	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	445	5	2	5	4.5	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69194482	88516	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364420	88516	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	409	4	2	4	4.1	Cc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	11719784	88553	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364456	88553	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)cc1C	10.6019/CHEMBL2364335
	59007054	88585	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	CHEMBL2364487	88585	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	5	3	6	3.9	Cc1ccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3O)cc2)o1	10.6019/CHEMBL2364335
	16114097	78732	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	78732	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	16113710	78736	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	78736	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	23730226	147327	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	CHEMBL393329	147327	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	449	13	4	10	-0.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCO	10.1021/jm7010595
	71453489	207613	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	207613	13	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	44411632	10192	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10192	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	22888425	62180	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL178216	62180	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	2	5	4.7	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)C(CO)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	44411632	10192	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161823	10192	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL2170782	207614	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44579858	186332	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL490010	186332	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)cc1	10.1016/j.bmcl.2008.07.120
	44579778	186426	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490801	186426	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1ccccc1)C(=O)N(Cc1cccc(Cl)c1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162657606	180525	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	180525	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	145956659	161494	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161494	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950987	162278	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162278	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	69198313	88456	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	CHEMBL2364361	88456	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	426	5	2	6	3.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc2cccnc12	10.6019/CHEMBL2364335
	69195692	88457	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	CHEMBL2364362	88457	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c(Cl)c1	10.6019/CHEMBL2364335
	69196612	88458	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364363	88458	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	442	6	2	7	3.3	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cnco2)cc1	10.6019/CHEMBL2364335
	11511158	88506	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364411	88506	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccccc3C)s2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198054	88559	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	CHEMBL2364462	88559	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cccc(-c2cc(C)cs2)c1	10.6019/CHEMBL2364335
	69195074	88572	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364474	88572	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	7	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)nc1	10.6019/CHEMBL2364335
	69195546	88582	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	CHEMBL2364484	88582	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	459	5	2	5	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Cl)c2ccccc12	10.6019/CHEMBL2364335
	44580028	192637	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	CHEMBL523786	192637	0	None	-	1	Human	5.3	pEC50	=	5.3	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	416	8	1	4	4.5	COc1c(-c2ccccc2)cccc1N(C[C@H]1CCCN1)C(=O)COc1ccccc1	10.1016/j.bmcl.2008.07.120
	44434011	147319	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147319	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	57390496	68698	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68698	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	145988894	166580	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	166580	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44434086	148311	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL394130	148311	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C/C=C/c2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	145950987	162278	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4172848	162278	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	418	4	3	5	1.7	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CNCCO3)ccc21	10.1021/acs.jmedchem.8b00322
	44449924	159386	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	CHEMBL410730	159386	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	487	12	4	9	1.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)N[C@H]1CC[C@H](O)CC1	10.1016/j.bmcl.2008.03.059
	56926785	68703	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	68703	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434078	89466	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237932	89466	0	None	-	1	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	513	10	2	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CC2Cc3ccccc3N2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44434008	145989	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	145989	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44411913	10201	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10201	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44268939	30218	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL13926	30218	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	488	5	3	5	3.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC[C@]2(CC(=O)c3ccccc3O2)C1	10.1016/s0960-894x(97)10199-8
	44411913	10201	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161833	10201	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1016/j.bmc.2007.01.057
	44434015	88049	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88049	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44411905	10200	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10200	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	10506325	100758	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	100758	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	16113371	78728	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	78728	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	162676229	182712	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	182712	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL3578005	210002	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	44348031	112577	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL331303	112577	0	None	-	1	Rat	8.2	pEC50	=	8.2	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	618	14	3	5	4.3	C[C@@H](O)CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](CC1=CCC(c2ccccc2)C=C1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44411905	10200	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161832	10200	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1016/j.bmc.2007.01.057
	44437953	10211	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	CHEMBL1162062	10211	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	522	9	3	6	1.5	NCCNC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)CCN1C(=O)CCS(=O)(=O)c2ccccc21	10.1016/j.bmc.2007.01.057
	10506325	100758	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	CHEMBL296104	100758	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1016/j.bmc.2007.01.057
	44436857	145111	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145111	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	156021787	177559	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	177559	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	10006735	116499	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	116499	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	10006735	116499	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	CHEMBL33892	116499	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	515	10	3	6	2.0	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCN(c2ccccc2NS(C)(=O)=O)CC1	10.1016/j.bmc.2007.01.057
	156021787	177559	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648799	177559	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	509	6	4	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)N[C@@H]3CCCNC3)cc2c1	10.1021/acs.jmedchem.0c00828
	11712108	160749	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL412303	160749	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	451	6	2	5	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	44571003	191979	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL521439	191979	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	445	4	1	5	3.0	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3C[C@H](C)N[C@H](C)C3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL3578005	210002	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(N)=O)C(N)=O	10.1021/jm501702q
	69196876	88447	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364352	88447	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	7	2.9	COc1ccc(NS(=O)(=O)c2ccc(-n3cccn3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11562329	88486	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	CHEMBL2364391	88486	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	495	8	2	6	4.5	COCc1cccc(-c2ccc(S(=O)(=O)Nc3cc(N4C[C@H](C)N[C@H](C)C4)ccc3OC)cc2)c1	10.6019/CHEMBL2364335
	69196868	88490	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364395	88490	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	427	5	2	5	4.4	C[C@H]1CN(c2cccc(NS(=O)(=O)c3ccc(-c4cccs4)cc3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69196990	88546	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	CHEMBL2364449	88546	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	480	6	2	6	4.4	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1C	10.6019/CHEMBL2364335
	69195880	88563	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364466	88563	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	485	6	2	6	5.0	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)s2)c(C)c1	10.6019/CHEMBL2364335
	11518463	88566	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	CHEMBL2364469	88566	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1cc(-c2cc(C)cs2)ccc1S(=O)(=O)Nc1cccc(N2C[C@H](C)N[C@H](C)C2)c1	10.6019/CHEMBL2364335
	69195024	88590	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364492	88590	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	461	5	3	6	4.2	C[C@H]1CN(c2ccc(O)c(NS(=O)(=O)c3ccc(-c4ccccc4F)s3)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	44390922	121619	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	CHEMBL359686	121619	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	557	12	1	5	5.2	COc1cccc(CC(=O)N2CCc3cc(OCc4ccccc4)ccc3C2C(=O)NCCN(C(C)C)C(C)C)c1	10.1016/j.bmcl.2005.02.040
	23631026	166885	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL429817	166885	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelinAgonist activity at human recombinant GHSR1a expressed in HEK293F cells assessed as stimulation of [35S]GTP-gamma-S binding relative to ghrelin	ChEMBL	443	5	1	5	5.3	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1CC1CCCNC1	10.1021/jm070071+
	CHEMBL2170779	207611	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor Ser123:Ala mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44447842	94564	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	CHEMBL254972	94564	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Inhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assayInhibition of human growth hormone secretagogue receptor assessed as measuring intracellular calcium level by FLIPR assay	ChEMBL	531	14	4	10	1.6	CC(C)(N)C(=O)N[C@H](COCc1cc(Cl)cc(Cl)c1)c1nnnn1CCOC(=O)NCCCCO	10.1016/j.bmcl.2008.02.021
	44579804	186472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL491220	186472	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	406	7	1	3	4.5	CC(Oc1ccccc1Cl)C(=O)N(Cc1ccc(Cl)cc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145948708	166924	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	166924	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	121879	2195	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	5868	2195	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	CHEMBL308716	2195	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1016/s0960-894x(97)10199-8
	44268996	165899	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL427806	165899	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(Cc3ccccc3C2)C1	10.1016/s0960-894x(97)10199-8
	122178180	120738	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	120738	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	44579959	183680	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL483865	183680	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(Cl)cc1	10.1016/j.bmcl.2008.07.120
	44454117	155004	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155004	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	162677361	182917	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	182917	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170700	207605	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc(C(C)(C)C)cc1)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44444570	154218	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	CHEMBL400125	154218	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at GSHR by FLIPR assayAgonist activity at GSHR by FLIPR assay	ChEMBL	456	5	1	7	3.0	COc1cc2c(cc1N1CCNCC1)N(S(=O)(=O)c1ccc(-c3ccccn3)s1)CC2	10.1016/j.bmcl.2007.09.067
	156017532	177324	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177324	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11662746	97351	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	CHEMBL271947	97351	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	467	7	2	6	4.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(Oc2ccccc2)cc1	10.1016/j.bmcl.2007.12.021
	122178180	120738	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578009	120738	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL	1130	35	12	11	3.4	CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)CCC(=O)O)C(N)=O	10.1021/jm501702q
	CHEMBL3578007	210004	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	16750162	88436	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364341	88436	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	474	6	2	7	3.8	COc1ncc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)c(F)c1	10.6019/CHEMBL2364335
	11568467	88446	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364351	88446	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	443	5	2	5	4.0	COc1ccc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69197136	88547	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	CHEMBL2364450	88547	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	489	6	2	6	4.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1cc(C)c(-c2ccccc2F)s1	10.6019/CHEMBL2364335
	69195304	88561	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	CHEMBL2364464	88561	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	455	4	2	4	3.9	Cc1cc(S(=O)(=O)Nc2cc(N3C[C@H](C)N[C@H](C)C3)ccc2F)ccc1Br	10.6019/CHEMBL2364335
	145949880	162229	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162229	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16114099	136687	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	136687	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44269018	96886	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	CHEMBL269447	96886	0	None	-	1	Rat	6.2	pEC50	=	6.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCCC2(CCc3ccccc32)C1	10.1016/s0960-894x(97)10199-8
	145949880	162229	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162229	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	156015598	176993	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	176993	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	44452827	94969	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL257019	94969	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	453	5	2	7	3.7	C[C@H]1CN(c2cc(NS(=O)(=O)c3ccc(-c4ccccn4)s3)ccc2C#N)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	46882582	5663	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	CHEMBL1078490	5663	0	None	-125	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	466	5	2	5	3.9	CC1(C)CCc2cc(S(=O)(=O)Nc3ccc4c(c3)CCN(Cc3cc[nH]n3)CC4)ccc2O1	10.1016/j.bmcl.2009.09.027
	145988647	166508	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	166508	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44454367	94804	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94804	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	16113691	136183	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136183	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	16113691	136183	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136183	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	22867380	29192	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	CHEMBL13841	29192	0	None	-	1	Rat	7.2	pEC50	=	7.2	Functional	In vitro growth hormone release was determined in rat pituitary cell assayIn vitro growth hormone release was determined in rat pituitary cell assay	ChEMBL	472	5	3	3	3.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCCc3ccccc32)CC1	10.1016/s0960-894x(97)10199-8
	2098	3625	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	36511	3625	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3805	3625	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	3835	3625	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	CHEMBL235363	3625	31	None	-128	11	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL		None	None	None		None	10.1021/acs.jmedchem.9b02122
	155561671	175081	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175081	0	None	-	1	Human	5.2	pEC50	=	5.2	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	44434073	89156	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89156	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	145981794	166132	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166132	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56926173	68655	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	CHEMBL1923501	68655	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm1012374
	44301389	11155	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11155	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11155	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	156015598	176993	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640573	176993	0	None	-	1	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	486	7	4	6	0.6	O=C(N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1)c1cc(C2CC2)n[nH]1	10.1021/acs.jmedchem.0c00828
	156017532	177324	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177324	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10100708	11914	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	11914	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	11914	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44579756	186231	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186231	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	145958487	161623	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	161623	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156016840	177047	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177047	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL2170779	207611	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayAgonist activity at FLAG-tagged human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453489	207613	13	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at FLAG-tagged human ghrelin receptor Ser123:Thr mutant expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10209618	63154	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL179978	63154	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	555	11	1	5	5.4	CC(=O)c1ccccc1C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	44391041	63975	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL181123	63975	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	591	11	1	6	5.1	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)S(=O)(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10600702	140792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	140792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	10600702	140792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	CHEMBL383526	140792	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1016/j.bmc.2007.01.057
	9868878	96081	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	CHEMBL262884	96081	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	460	14	4	9	-0.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)NCCC(N)=O	10.1016/j.bmcl.2008.03.059
	11306502	63296	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180094	63296	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	495	8	1	5	5.5	CC(C)N(CCNC(=O)C1c2ccc(Oc3ccccc3)cc2CCN1C(=O)OC(C)(C)C)C(C)C	10.1016/j.bmcl.2005.02.040
	22888395	63559	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180540	63559	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	513	10	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)c1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	156021942	177639	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177639	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16113248	78739	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	78739	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	23730342	89458	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	CHEMBL237916	89458	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	511	13	4	10	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1	10.1021/jm7010595
	145958487	161623	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	CHEMBL4162545	161623	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	443	4	3	5	3.1	Cn1ccc2cc(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc(F)c21	10.1021/acs.jmedchem.8b00322
	156010733	176496	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176496	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156013130	176918	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176918	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016840	177047	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641215	177047	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	621	7	3	7	3.4	Cc1nc(-c2cccc(C(F)(F)F)c2)sc1C(=O)N[C@H]1CN(S(=O)(=O)c2ccccc2)C[C@@H]1C(=O)N[C@H]1CCCNC1	10.1021/acs.jmedchem.0c00828
	156021942	177639	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177639	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44570920	183341	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	CHEMBL481408	183341	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	413	4	1	4	2.5	N[C@H]1CCN(C(=O)[C@@H]2CCCCN2S(=O)(=O)c2ccc(-c3ccccc3)cc2)C1	10.1016/j.bmcl.2008.12.042
	44571005	183455	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	CHEMBL482204	183455	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human ghrelin receptor by cell based BACMAM FLIPR assayAgonist activity at human ghrelin receptor by cell based BACMAM FLIPR assay	ChEMBL	431	4	1	5	2.6	Cc1ccc(-c2ccc(S(=O)(=O)N3CCCC[C@H]3C(=O)N3CCCNCC3)cc2)o1	10.1016/j.bmcl.2008.12.042
	11539144	88451	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	CHEMBL2364356	88451	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	425	5	2	5	3.8	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2ccccc2c1	10.6019/CHEMBL2364335
	69197315	88467	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364372	88467	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	475	6	2	6	4.6	COc1cc(F)c(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccs2)cc1	10.6019/CHEMBL2364335
	11683663	88493	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	CHEMBL2364398	88493	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	441	6	2	6	3.9	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccoc2)cc1	10.6019/CHEMBL2364335
	11583902	88534	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	CHEMBL2364437	88534	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)cc1F	10.6019/CHEMBL2364335
	69198030	88539	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	CHEMBL2364442	88539	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	479	5	2	5	5.2	C[C@H]1CN(c2ccc(F)c(NS(=O)(=O)c3ccc(-c4cccs4)cc3Cl)c2)C[C@@H](C)N1	10.6019/CHEMBL2364335
	69197149	88551	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	CHEMBL2364454	88551	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	471	6	2	6	4.7	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccsc2)c(C)c1	10.6019/CHEMBL2364335
	69196669	88576	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	CHEMBL2364478	88576	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	456	6	2	7	3.6	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2ccc(C)o2)nc1	10.6019/CHEMBL2364335
	10032659	11931	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	11931	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	11931	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	44450137	95841	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	CHEMBL261234	95841	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	465	12	3	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCC(=O)Nc1ccccc1	10.1016/j.bmcl.2008.03.059
	127046472	139151	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139151	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127046472	139151	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139151	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayInverse agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	145988286	166642	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	166642	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL3578007	210004	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)O	10.1021/jm501702q
	CHEMBL61663	214052	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Functional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1aFunctional potency measured as intracellular calcium elevation in Hek-293 cells expressing hGHSR1a	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	24180592	96552	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96552	0	None	1	2	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	162663868	181396	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181396	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	145986080	165888	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	165888	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	168274297	189975	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	CHEMBL5180310	189975	0	None	-	1	Human	4.1	pEC50	=	4.1	Functional	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	299	6	1	1	5.3	CCCCCCCc1cc(=O)c2cc(C(C)(C)C)ccc2[nH]1	10.1021/acs.jmedchem.1c02191
	127047523	139520	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	139520	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	44434118	147634	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL393570	147634	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	467	14	3	9	0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	44446187	94171	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94171	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	145959787	161723	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	155557019	174005	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174005	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926893	68706	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	68706	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	44437963	200398	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	200398	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44437963	200398	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	CHEMBL608826	200398	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	452	6	1	3	4.5	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc3ccccc3c2)c2c(Br)cccc21	10.1016/j.bmc.2007.01.057
	44579881	186244	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	CHEMBL489402	186244	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	392	6	1	3	4.5	CC(Oc1cccc(Cl)c1)C(=O)N(C[C@H]1CCCN1)c1ccccc1Cl	10.1016/j.bmcl.2008.07.120
	24180646	147638	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	147638	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	24180646	147638	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	CHEMBL393576	147638	0	None	-3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1016/j.bmcl.2007.07.097
	145959787	161723	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysisAgonist activity at human GHS receptor assessed as intracellular myo-IP1 secretion after 90 mins by HTRF analysis	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882520	5764	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	CHEMBL1079311	5764	0	None	-1	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	430	5	2	4	3.8	Cc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1Cl	10.1016/j.bmcl.2009.09.027
	46882458	5886	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL1080046	5886	0	None	-31	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human ghrelin receptorAgonist activity at human ghrelin receptor	ChEMBL	438	8	2	4	4.2	CCCCc1ccc(S(=O)(=O)Nc2ccc3c(c2)CCN(Cc2cc[nH]n2)CC3)cc1	10.1016/j.bmcl.2009.09.027
	CHEMBL3578016	210010	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	59007057	88450	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364355	88450	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	458	6	2	6	2.8	COc1ccc(NS(=O)(=O)c2ccc(N3CCCC3=O)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	11597905	88504	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	CHEMBL2364409	88504	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	465	6	2	5	4.7	COc1ccc(NS(=O)(=O)c2ccc(-c3ccc(C)cc3)cc2)cc1N1C[C@H](C)N[C@H](C)C1	10.6019/CHEMBL2364335
	69198135	88535	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	CHEMBL2364438	88535	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	484	6	2	6	4.2	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc(-c2cccc(C)n2)c(F)c1	10.6019/CHEMBL2364335
	11711997	88552	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	CHEMBL2364455	88552	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945SUPPLEMENTARY: Agonist activity at GSHR by FLIPR assay. Same assay as CHEMBL941945	ChEMBL	446	5	2	7	2.5	COc1ccc(N2C[C@H](C)N[C@H](C)C2)cc1NS(=O)(=O)c1ccc2c(c1)OCCN2C	10.6019/CHEMBL2364335
	44452778	159219	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	CHEMBL410527	159219	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHSR1a by FLIPR assayAgonist activity at human GHSR1a by FLIPR assay	ChEMBL	499	6	2	7	3.5	C[C@H]1CN(c2ccc(C(=O)N(C)C)c(NS(=O)(=O)c3ccc(-c4ccccn4)s3)c2)C[C@@H](C)N1	10.1016/j.bmcl.2007.12.021
	10437444	112370	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL330989	112370	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	546	11	2	4	3.8	CNC(=O)[C@@H](Cc1ccc(F)cc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	24969603	68697	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	68697	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	162649450	179464	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	179464	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	156013130	176918	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176918	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44450100	160096	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	CHEMBL411330	160096	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 cells by FLIPR assayAgonist activity at human GHS receptor expressed in H4 cells by FLIPR assay	ChEMBL	511	14	4	10	0.6	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOc1cccc(C(=O)NCCO)c1	10.1016/j.bmcl.2008.03.059
	44411720	10195	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10195	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	44411720	10195	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161826	10195	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1016/j.bmc.2007.01.057
	44411902	10199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	CHEMBL1161831	10199	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS-R1Agonist activity at human GHS-R1	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1016/j.bmc.2007.01.057
	162656896	180268	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180268	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44436883	145608	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	145608	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	156010733	176496	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176496	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assayAgonist activity at human GHSR expressed in HEK293 cells assessed as increase in IP1 accumulation measured after 90 mins in presence of LiCl by HTRF assay	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10745674	167380	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167380	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44579776	192638	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL523795	192638	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	7	1	3	3.5	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2)c1	10.1016/j.bmcl.2008.07.120
	127048061	139193	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139193	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assayAgonist activity at human GHS-R1a expressed in HEK293T cells after 45 mins by HTRF-based IP3 turnover assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	23730340	89297	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	CHEMBL237700	89297	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	504	15	4	10	0.4	CC(=O)NCCCCNC(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1021/jm7010595
	56926175	68656	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	68656	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	145992835	166270	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166270	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56925343	68709	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	68709	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assayAgonist activity at human GRLN receptor expressed in HEK293 cells assessed as calcium binding by Ca2+ bioluminescence aequorin assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	145986870	166576	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	166576	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44434054	88860	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL236857	88860	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2cccc(NS(C)(=O)=O)c2)n1	10.1016/j.bmcl.2007.07.099
	44446178	154572	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	154572	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilizationAgonist activity at human GHSR1a receptor expressed in CHO cells assessed as intracellular calcium mobilization	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3578016	210010	0	None	-15	2	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	162648837	179248	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179248	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293 cells assessed as inhibition of ghrelin-induced IP1 response measured after 30 mins by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44391024	63939	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180992	63939	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	527	11	1	4	5.2	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)Cc1ccccc1)C(C)C	10.1016/j.bmcl.2005.02.040
	10745674	167380	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	CHEMBL431668	167380	0	None	-	1	Rat	8.1	pEC50	=	8.1	Functional	Tested for GH-releasing property using classical rat pituitary cell assayTested for GH-releasing property using classical rat pituitary cell assay	ChEMBL	572	13	3	5	3.5	C[C@@H](O)CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm980197u
	44391021	19238	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL129637	19238	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	569	12	1	5	5.3	CC(=O)C(C(=O)N1CCc2cc(OCc3ccccc3)ccc2C1C(=O)NCCN(C(C)C)C(C)C)c1ccccc1	10.1016/j.bmcl.2005.02.040
	CHEMBL2170696	207601	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	23730343	89459	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	CHEMBL237917	89459	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assayIntrinsic activity at human GHS receptor in H4 glioma cells assessed by measuring intracellular calcium concentration by FLIPR assay	ChEMBL	475	12	3	10	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NC[C@H]1CCCO1	10.1021/jm7010595
	22888359	63570	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	CHEMBL180591	63570	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	In vitro effective concentration against human growth hormone secretagoguesIn vitro effective concentration against human growth hormone secretagogues	ChEMBL	520	10	1	6	4.8	CC(C)N(CCNC(=O)C1c2ccc(OCc3ccccc3)cc2CCN1C(=O)OC(C)(C)C#N)C(C)C	10.1016/j.bmcl.2005.02.040
	16114514	78733	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	78733	0	None	-	1	Human	8.0	pEC50	=	8	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium levelAgonist activity at human GHS1a receptor expressed in CHO cells assessed as accumulation of intracellular calcium level	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	44579843	184160	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL485092	184160	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	358	6	1	3	3.9	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44579643	186179	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL488971	186179	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	338	7	1	3	3.2	CC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44579822	191916	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL520953	191916	0	None	-	1	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	386	7	1	3	4.2	Cc1cccc(CN(C[C@H]2CCCN2)C(=O)C(C)Oc2ccccc2Cl)c1	10.1016/j.bmcl.2008.07.120
	44579755	186350	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL490186	186350	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	352	8	1	3	3.6	CCC(Oc1ccccc1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	44580032	186242	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489398	186242	0	None	-	1	Human	5.1	pEC50	=	5.1	Functional	Agonist activity at GHSRAgonist activity at GHSR	ChEMBL	363	7	1	4	3.3	CC(Oc1ccccc1)C(=O)N(C[C@H]1CCCN1)c1ccc(CC#N)cc1	10.1016/j.bmcl.2008.07.120
	145991945	166251	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166251	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	145992253	166364	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166364	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL2170702	207607	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assayInverse agonist activity at human ghrelin receptor expressed in COS 7 cells using [2-3H]myo-inositol by inositol triphosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	145993313	166328	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166328	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Inverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assayInverse agonist at recombinant human GHSR1a expressed in HEK293 cells assessed as decrease in IP1 accumulation after 1 hr by IP1-d2-based HTRF assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16114008	84408	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84408	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilizationAgonist activity at human GHS1a receptor expressed in CHO cells assessed as induction of intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL501261	212354	19	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Inverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assayInverse agonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in inositol phosphate production after 30 mins by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	9848305	144907	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL391429	144907	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccc(NS(C)(=O)=O)cc2)n1	10.1016/j.bmcl.2007.07.099
	44434050	144905	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	144905	0	None	-	1	Human	7.0	pEC50	=	7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assayAgonist activity at human GHS receptor expressed in H4 glioma cells assessed as intracellular calcium concentration by FLIPR assay	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL3578015	210009	0	None	-33	2	Human	7.0	pEC50	=	7	Functional	Inverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatographyInverse agonist activity at human GHSR1a receptor expressed in COS-7 cells assessed as inositol phosphate accumulation after 2 hrs by anion exchange chromatography	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL369482	210406	0	None	-	0	Rat	8.0	pED50	=	8	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cn1ccnc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/S0960-894X(01)80239-0
	44269087	97762	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	CHEMBL274341	97762	0	None	-	1	Rat	6.7	pED50	=	6.7	Functional	In vitro effective dose was measured for the growth hormone release in rat pituitary cellsIn vitro effective dose was measured for the growth hormone release in rat pituitary cells	ChEMBL	553	10	4	7	3.2	CC(C)(NCCCO)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/S0960-894X(01)80239-0
	70691550	72838	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011825	72838	0	None	-	1	Human	9.7	pIC50	=	9.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	572	8	2	5	5.1	Cc1cc(F)ccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	16114292	96473	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96473	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL509976	213794	0	None	-	1	Human	9.5	pIC50	=	9.5	Functional	Agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	25260901	112968	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319405	112968	1	None	-	1	Human	9.1	pIC50	=	9.1	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	71456897	81424	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81424	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70691551	72839	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011826	72839	0	None	-	1	Human	9.0	pIC50	=	9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.3	Cc1cccc(C)c1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	25261382	112929	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319215	112929	0	None	-	1	Human	8.9	pIC50	=	8.9	Functional	Partial agonist activity at GHS-R1a (unknown origin)Partial agonist activity at GHS-R1a (unknown origin)	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11431274	76976	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	76976	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11577349	64885	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	64885	1	None	-	1	Human	8.0	pIC50	=	8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	11351838	77282	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	CHEMBL208842	77282	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	8	4	6	4.9	CC(NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1)c1ccccc1	10.1021/jm060461g
	11712151	75625	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75625	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11713497	122708	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	122708	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409757	140780	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383454	140780	0	None	-	1	Human	8.0	pIC50	=	8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	506	8	3	8	4.1	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccc(F)cc1	10.1016/j.bmcl.2006.01.012
	127046807	139397	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139397	0	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	3676358	5444	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1076586	5444	4	None	-	1	Human	7.0	pIC50	=	7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	409	3	1	2	4.4	O=C(c1ccc(-c2ccccc2)cc1)N1CCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	122182047	121475	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121475	0	None	-67	2	Rat	7.0	pIC50	=	7	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122178603	120812	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	120812	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	11649248	66322	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66322	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44395020	123501	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	123501	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	44389262	121505	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	121505	0	None	-	1	Human	5.0	pIC50	=	5.0	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	145993628	166826	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4295148	166826	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	483	4	1	2	6.1	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11211892	79791	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	79791	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122178611	120821	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	120821	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	11846624	77548	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77548	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11846463	138699	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	138699	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	11430392	76356	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76356	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57797614	72830	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011817	72830	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	558	8	2	5	4.8	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44409801	76365	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206638	76365	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	5	3	7	3.6	CC(C)(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11523411	75189	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75189	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	11537800	75201	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75201	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	71453392	81421	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164504	81421	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71456910	81475	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81475	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	71460578	81482	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164830	81482	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	122178612	120822	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	120822	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL507636	212652	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	56942387	139119	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139119	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145991822	166395	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287267	166395	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	6.8	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11676995	65816	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	65816	1	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	127048038	139429	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139429	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	71458746	81411	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164493	81411	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1ccc2c(c1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	145992142	166207	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283858	166207	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	475	4	2	3	5.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(O)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	71460565	81413	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164495	81413	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1cccc(Cl)c1	10.1016/j.bmc.2012.07.018
	11538533	74636	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	74636	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	46880462	6175	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081648	6175	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	70693641	72841	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011828	72841	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	538	8	2	5	4.4	O=C1CN([C@@H](C(=O)NC2CCN(Cc3ccccc3)CC2)C2CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	44409756	76399	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76399	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46865987	7501	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087908	7501	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880772	5819	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079624	5819	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11538534	74649	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	74649	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	145986870	166576	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290627	166576	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	505	6	1	4	5.9	COc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(OC)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	127046806	139390	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139390	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178613	120823	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	120823	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	145981196	165972	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4279344	165972	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	627	5	1	6	7.1	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)N[C@@H](C)c4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	46880814	6285	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082190	6285	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	413	3	2	3	3.5	C[C@H]1CN(C(=O)c2ccc(-c3cn[nH]c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178616	120825	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	120825	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	145986461	166649	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4291926	166649	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71451551	81425	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81425	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	46880727	6053	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080939	6053	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122182190	121482	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121482	0	None	-8	2	Rat	7.9	pIC50	=	7.9	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409840	75974	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205896	75974	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc43)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127047362	139176	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139176	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145989916	166182	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4283454	166182	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	491	5	2	4	5.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(O)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	127048038	139429	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139429	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880673	6013	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080755	6013	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3ccc(OC(F)(F)F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11455251	160755	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	160755	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409611	74323	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203019	74323	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	463	6	3	7	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC4CCC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11221946	140302	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140302	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409839	75890	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	75890	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71460576	81479	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164828	81479	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3c(Cl)cc(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL509976	213794	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11692087	62648	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62648	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409758	75606	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75606	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409661	75628	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205484	75628	0	None	-	1	Human	7.9	pIC50	=	7.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	423	6	3	7	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880724	6166	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081611	6166	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1cc(-c2ccccc2)ccc1C(=O)N1CCN(C(=O)c2ccc3cc[nH]c3c2)[C@@H](C)C1	10.1016/j.bmcl.2010.01.043
	71455105	81478	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164827	81478	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	432	4	2	4	2.6	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)ccc32)CC1	10.1016/j.bmc.2012.07.018
	11221946	140302	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140302	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	44410003	75813	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	75813	0	None	-	1	Human	5.9	pIC50	=	5.9	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880811	5906	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080162	5906	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3cccnc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687379	72836	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011823	72836	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1cccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)c1	10.1016/j.bmcl.2012.01.014
	44394974	66662	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	66662	1	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	210044	4	None	-	1	Rat	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	46880567	6295	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082210	6295	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3cccc(F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71460564	81410	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164492	81410	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	488	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(C(C)(C)C)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	145992854	166302	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4285747	166302	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C2)ncn1	10.1021/acs.jmedchem.8b00794
	44394833	126291	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126291	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL509976	213794	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	213794	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL509976	213794	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	127047654	139434	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139434	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	145993758	166751	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294024	166751	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	490	5	2	4	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(N)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	145993528	166753	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4294083	166753	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	561	5	1	4	6.6	C#Cc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL444131	212171	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	11476589	75620	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75620	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11329138	64114	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL181350	64114	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1016/j.bmcl.2012.01.014
	70681022	72845	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011833	72845	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	568	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NC(C)(C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL509976	213794	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178611	120821	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	120821	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	46880675	6051	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080927	6051	0	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2F)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11612155	140465	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	140465	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	328912	62232	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62232	1	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	70685218	72833	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011820	72833	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3cccc(Cl)c3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145981794	166132	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4282394	166132	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	567	6	1	5	6.6	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11649239	65993	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	65993	1	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL501261	212354	19	None	-	1	Human	7.8	pIC50	=	7.8	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	1744826	62654	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62654	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	11282247	165362	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165362	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11282247	165362	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165362	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62654	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62654	17	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409831	75331	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204776	75331	0	None	-	1	Human	6.8	pIC50	=	6.8	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	503	6	3	9	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3COc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145979268	166100	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4281647	166100	0	None	-	1	Human	5.8	pIC50	=	5.8	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	607	8	1	5	7.4	COc1ccc([C@H](CC2CC2)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44409678	140673	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	140673	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11349789	78348	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78348	1	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11692087	62648	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62648	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11677781	124525	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	124525	1	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	11538533	74636	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	74636	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	11154823	75661	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	75661	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942244	124664	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	124664	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44409994	75814	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205796	75814	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	409	6	3	7	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212441	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe5:12Ala(Phe220) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44395002	65840	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	65840	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	11646276	75566	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75566	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	127046807	139397	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139397	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113695	136490	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	136490	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	145987684	166713	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4293331	166713	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CC[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	122178602	120811	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	120811	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	70681020	72842	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011829	72842	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	56942098	124660	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	124660	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	124662	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	124662	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139414	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139414	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	66788278	124659	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	124659	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046956	139414	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139414	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	57797640	72864	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011892	72864	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	510	9	1	3	7.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880628	5940	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	5940	0	None	4	2	Rat	8.7	pIC50	=	8.7	Functional	Inhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayInhibition of rat GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	120815	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	120815	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880629	5966	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080556	5966	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	457	3	1	2	5.5	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178606	120815	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	120815	0	None	-	1	Human	8.7	pIC50	=	8.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	70681021	72844	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011832	72844	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.2	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)c2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70691552	72846	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011834	72846	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	8	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(N[C@H](C)C2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	44576247	212441	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Inverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	122178607	120817	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	120817	0	None	-	1	Human	8.6	pIC50	=	8.6	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	46880631	6043	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080907	6043	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	437	3	1	2	5.1	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	46880726	6052	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080938	6052	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)nc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70689441	72863	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011891	72863	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.1	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	145988582	166727	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4293608	166727	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	555	4	1	2	7.4	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#C[Si](C)(C)C)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	122178610	120820	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	120820	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409666	75519	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204897	75519	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	437	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212441	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL500703	212339	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	44409802	76376	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76376	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178613	120823	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	120823	0	None	-	1	Human	5.7	pIC50	=	5.7	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	71458747	81412	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81412	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	56942244	124664	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	124664	0	None	-	1	Human	7.7	pIC50	=	7.7	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11537683	75161	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75161	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	71449740	81414	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	CHEMBL2164497	81414	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	480	4	2	4	3.5	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)c(Cl)c1	10.1016/j.bmc.2012.07.018
	122178601	120810	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	120810	0	None	-	1	Human	6.7	pIC50	=	6.7	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	11337482	76272	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76272	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122178614	120824	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	120824	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	44389168	64527	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64527	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	145991389	166440	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4288108	166440	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	6	1	6	6.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	145990051	166391	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4287218	166391	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	499	5	1	2	7.0	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44410012	137858	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	137858	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	71462272	81419	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164502	81419	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	4.6	CN(C)C1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	71451563	81484	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164832	81484	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	145988286	166642	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4291718	166642	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	542	6	1	6	5.4	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-n5nccn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	46880813	6284	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082189	6284	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	4	4.4	Cc1noc(C)c1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	44409761	75498	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75498	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11846625	77516	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77516	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	122178610	120820	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	120820	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	46880461	6143	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081483	6143	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	439	4	1	3	4.4	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)CC3)cc2)c1	10.1016/j.bmcl.2010.01.043
	71453391	81420	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164503	81420	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.2	CN(C)[C@@H]1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	1221269	121507	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	121507	12	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389151	62161	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62161	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	71451564	81486	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	CHEMBL2164834	81486	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)C(NC(=O)CN1CCN(C)CC1)(c1ccc(Cl)cc1)C(=O)N2	10.1016/j.bmc.2012.07.018
	71449753	81476	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164825	81476	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	465	4	2	3	4.7	CC1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44409871	75031	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75031	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880569	6097	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081212	6097	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1	10.1016/j.bmcl.2010.01.043
	70693640	72835	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011822	72835	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL449590	212202	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	44576247	212441	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Inverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Val5:08Ala(Val216) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145994299	166831	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4295212	166831	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	5	1	4	6.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)NCc3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	71460577	81480	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164829	81480	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	500	4	2	4	3.9	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)c(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	16113902	137138	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137138	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	71462274	81423	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL2164506	81423	0	None	-	1	Human	5.6	pIC50	=	5.6	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	528	5	2	4	3.8	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1=O	10.1016/j.bmc.2012.07.018
	CHEMBL509976	213794	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Agonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser3:08Ala(Ser123) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	70683143	72834	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011821	72834	0	None	-	1	Human	7.6	pIC50	=	7.6	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	574	8	2	5	5.3	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(Cl)cc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	46880495	6277	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082162	6277	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	11697618	62255	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62255	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145988557	166696	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4292914	166696	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	523	4	1	2	6.9	Cc1ccc2c(c1)CCC2N1CCC(N(C)C(=O)N[C@@H](C)c2ccc(C#CC3CC3)c(Cl)c2Cl)CC1	10.1021/acs.jmedchem.8b00794
	44409771	140709	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383073	140709	0	None	-	1	Human	6.6	pIC50	=	6.6	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145980333	166017	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4280040	166017	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	6	1	4	7.5	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11329138	64114	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64114	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium levelAntagonist activity at GHSR expressed in CHOK cells assessed as inhibition of ghrelin-induced increase in intracellular calcium level	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	44576247	212441	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Met5:05Ala(Met213) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11568561	168976	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	168976	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	145991945	166251	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	CHEMBL4284715	166251	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	4	7.8	CCN(C(=O)N[C@@H](C)c1ccc(C#CC2CC2)c(Cl)c1Cl)C1CCN(C2CCc3cc(-c4cc(C)ncn4)ccc32)CC1	10.1021/acs.jmedchem.8b00794
	44394982	65792	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	65792	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cellsAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	66788278	124659	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	124659	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942099	124661	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	124661	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942243	124663	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	124663	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139319	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139319	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	70681018	72832	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	CHEMBL2011819	72832	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccccc1Oc1ccc2c(c1)C(=O)N([C@@H](C(=O)NC1CCN(Cc3ccccc3)CC1)C(C)C)CC(=O)N2	10.1016/j.bmcl.2012.01.014
	70685225	72866	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011894	72866	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	576	8	2	5	5.0	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11410373	137993	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	137993	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	11339816	75639	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	75639	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992253	166364	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4286849	166364	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	595	6	1	6	6.4	COC(=O)c1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(-c5cc(C)ncn5)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11503585	64858	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	64858	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	44409762	75518	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75518	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180026	121060	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121060	0	None	8	2	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium responseAntagonist activity against ghrelin receptor (unknown origin) expressed in CHO cells assessed as inhibition of ghrelin-induced calcium response	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	46880846	7516	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088038	7516	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	442	3	1	3	4.4	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44389248	121641	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	121641	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	70695749	72848	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011836	72848	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	562	9	2	6	4.3	CC(C)[C@H](C(=O)N1CCC(NCCC2CCOCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178614	120824	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	120824	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	70695748	72840	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011827	72840	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	498	7	2	5	3.7	O=C1CN(CC(=O)NC2CCN(Cc3ccccc3)CC2)C(=O)c2cc(Oc3ccccc3)ccc2N1	10.1016/j.bmcl.2012.01.014
	145981687	166013	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4279987	166013	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	5	1	3	6.5	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(Cl)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11508639	76167	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76167	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	44409683	75891	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	75891	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11626181	123849	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	123849	1	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11690097	76304	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76304	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409775	75657	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	75657	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212441	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human wild type ghrelin receptor expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11655355	74057	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74057	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	127047654	139434	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139434	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	16113799	168137	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168137	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145986080	165888	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4277793	165888	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	489	5	1	3	6.2	COc1ccc([C@H](C)NC(=O)N(C)C2CCN(C3CCc4cc(C)ccc43)CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	56942385	124665	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	124665	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	46880771	5818	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079623	5818	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	448	3	1	4	4.4	C[C@H]1CN(C(=O)c2csc(-c3ccccc3F)n2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11654867	75833	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	75833	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	122178600	120809	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	120809	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	46880844	7500	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1087907	7500	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	432	3	1	4	3.0	C[C@H]1CN(C(=O)c2ccc(N3CCOCC3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	11248021	138712	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378989	138712	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	454	8	4	6	4.3	Nc1nc(N)c(-c2ccc(NC(=O)NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122182189	121481	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121481	0	None	-7	2	Rat	7.5	pIC50	=	7.5	Functional	Antagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assayAntagonist activity at rat ghrelin receptor expressed in CHO cells assessed as blocking of human ghrelin-induced response by FLIPR based intracellular Ca2+ mobilization assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	44409865	140174	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381759	140174	0	None	-	1	Human	7.5	pIC50	=	7.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	500	7	3	8	3.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3Cc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11751384	140962	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	140962	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409679	75142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75142	0	None	-	1	Human	5.5	pIC50	=	5.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409868	76374	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76374	0	None	-	1	Human	6.5	pIC50	=	6.5	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409667	75601	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205294	75601	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	451	6	3	7	4.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3CCCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44576247	212441	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	56942388	139400	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139400	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	11166495	75184	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75184	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	145994050	166780	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4294493	166780	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	615	6	1	6	7.1	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11538533	74636	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	74636	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46880770	5817	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1079622	5817	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	458	3	1	3	4.9	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3Cl)cn2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71453390	81417	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81417	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	44409763	140821	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383757	140821	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	487	6	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3C3Cc4ccccc4O3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165262	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165262	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44410008	140707	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	140707	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11178309	79476	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79476	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	167764	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	167764	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	127047655	139071	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139071	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139164	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139164	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139319	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139319	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	56942098	124660	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	124660	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127046957	139164	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139164	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	46880630	6006	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080735	6006	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3C(F)(F)F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70685219	72847	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011835	72847	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	560	9	2	5	5.4	CC(C)[C@H](C(=O)N1CCC(NCCC2CCCCC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	120807	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	120807	0	None	-	1	Human	8.4	pIC50	=	8.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	122178607	120817	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	120817	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	11452801	138755	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	138755	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	46882763	5537	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5537	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilizationAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-stimulated intracellular calcium mobilization	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409776	76775	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	76775	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145991797	166352	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286597	166352	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	613	5	1	6	6.5	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)NCc4ccc(-c5cnccn5)c(Cl)c4Cl)CC3)C2)ncn1	10.1021/acs.jmedchem.8b00794
	122178616	120825	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	120825	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	11430583	79792	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	79792	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL509976	213794	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	11669486	64268	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64268	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409946	139272	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL379887	139272	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	514	7	3	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN3CCc4ccccc4C3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	127046806	139390	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139390	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	122178600	120809	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	120809	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	11605333	76357	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76357	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	46880845	7515	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1088037	7515	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	460	3	1	3	4.5	C[C@H]1CN(C(=O)c2ccc(-c3ccncc3F)c(F)c2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880773	6115	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081301	6115	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	424	3	1	3	4.2	C[C@H]1CN(C(=O)c2ccc(-c3ccccn3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178604	120813	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	120813	0	None	-	1	Human	6.4	pIC50	=	6.4	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	56942387	139119	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139119	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	212441	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Inverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ile4:20Ala(Ile178) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	11683469	76338	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76338	0	None	-	1	Human	7.4	pIC50	=	7.4	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	44389216	123323	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123323	0	None	-	1	Human	5.4	pIC50	=	5.4	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	145979819	165909	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4278185	165909	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	655	8	1	6	7.9	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3ccc(-c4cnccn4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880498	5903	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080155	5903	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	507	4	1	3	5.7	C[C@H]1CN(C(=O)c2ccc(-c3cccc(OC(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71462273	81422	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	CHEMBL2164505	81422	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	513	5	2	3	5.7	CCN1CCCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)C1	10.1016/j.bmc.2012.07.018
	71453404	81477	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81477	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	44389283	62601	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62601	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11179347	76985	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	76985	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44409764	76781	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	76781	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11606121	64230	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64230	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	11539587	66727	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	66727	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL3586019	210044	4	None	-	1	Rat	8.3	pIC50	=	8.3	Functional	Inverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assayInverse agonist activity at rat ghrelin receptor by inositol phosphate turnover assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122178608	120818	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	120818	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409821	75669	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	75669	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11340044	140791	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	140791	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70683149	72861	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011887	72861	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	504	8	2	5	3.9	CC(C)[C@H](C(=O)N1CCC(NCC2CC2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	71452183	83102	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83102	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assayAntagonist activity at ghrelin receptor assessed as inhibition of ghrelin-induced Ca2+ release by cell based assay	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	122178602	120811	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	120811	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	11582836	62569	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62569	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389192	168070	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168070	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	71455106	81487	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164835	81487	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	442	5	2	5	2.2	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(C)cc32)cc1	10.1016/j.bmc.2012.07.018
	44409998	137994	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	137994	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145984632	165827	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4276775	165827	0	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	629	5	1	4	8.0	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)C(C)(C)C2)ncn1	10.1021/acs.jmedchem.8b00794
	10415364	126233	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126233	0	None	-5	3	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	15949382	74484	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203158	74484	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145993313	166328	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4286101	166328	0	None	-	1	Human	5.3	pIC50	=	5.3	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	577	7	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](CC3CC3)c3cccc(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	11605822	123856	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	123856	1	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11154001	79463	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL212354	79463	0	None	-	1	Human	7.3	pIC50	=	7.3	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	406	7	4	6	3.6	CC(C)NC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	44394930	65985	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	65985	1	None	-	1	Human	6.3	pIC50	=	6.3	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11699004	65856	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	65856	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11618705	166374	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166374	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44409785	75435	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204852	75435	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	439	6	3	8	3.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CCCO3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409990	76149	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76149	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145992125	166186	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4283504	166186	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	552	5	2	5	6.2	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(N)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	46880568	6296	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082211	6296	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	70687383	72862	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011890	72862	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	525	9	2	4	6.6	CC(C)[C@H](C[C@H]1CC[C@@H](NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	16113245	120807	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	120807	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL509976	213794	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Agonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Ser4:16Ala(Ser174) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	57422817	112937	13	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	CHEMBL3319223	112937	13	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inverse agonist activity at GHS-R1a (unknown origin)Inverse agonist activity at GHS-R1a (unknown origin)	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/acs.jmedchem.1c02191
	11190594	75617	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75617	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	56942385	124665	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	124665	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44576247	212441	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Phe3:04Ser(phe119) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	16113904	136499	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	136499	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44389215	62734	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	62734	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44576247	212441	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Asn7:02Ala(Asn305) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409809	74700	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	74700	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113468	141256	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141256	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11531313	62160	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62160	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389167	123327	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123327	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880674	6050	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080926	6050	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccc(F)cc3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	71455085	81418	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164501	81418	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	4	2	4	4.3	CN1CCCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	46880463	6176	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081649	6176	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@H](C)C3)cc2)c1	10.1016/j.bmcl.2010.01.043
	46880812	5929	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080320	5929	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	430	3	1	4	4.3	C[C@H]1CN(C(=O)c2ccc(-c3cncs3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	46880497	6279	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082164	6279	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	423	3	1	2	4.8	O=C(c1ccc(-c2ccccc2)cc1)N1CCCN(C(=O)c2ccc3cc[nH]c3c2)CC1	10.1016/j.bmcl.2010.01.043
	44409770	140824	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383766	140824	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	461	6	3	7	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3[C@H]3CC4C=CC3C4)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	120813	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	120813	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	46880496	6278	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082163	6278	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1cccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)C[C@H]3C)cc2)c1	10.1016/j.bmcl.2010.01.043
	CHEMBL502208	212369	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	145980382	166079	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4281310	166079	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	44389186	64269	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64269	0	None	-	1	Human	5.2	pIC50	=	5.2	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409864	75133	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75133	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409975	75423	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75423	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409455	75600	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75600	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	11441554	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	5871	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	CHEMBL212761	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	10.1021/jm060461g
	11340329	79177	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211454	79177	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	468	9	4	6	4.4	Nc1nc(N)c(-c2ccc(NC(=O)NCCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178605	120814	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	120814	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	127047655	139071	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139071	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	46880672	6104	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	CHEMBL1081254	6104	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	453	4	1	3	4.8	COc1ccc(-c2ccc(C(=O)N3CCN(C(=O)c4ccc5cc[nH]c5c4)[C@@H](C)C3)cc2)cc1	10.1016/j.bmcl.2010.01.043
	66601728	81415	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81415	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	70689440	72831	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011818	72831	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	554	8	2	5	5.0	Cc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	70693644	72865	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011893	72865	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	496	9	1	3	6.7	CC(C)[C@H](C[C@H]1CC[C@@H](NCC2CC2)CC1)N1CCc2ccc(Oc3ccc(F)cc3F)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70695747	72829	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	72829	0	None	1	2	Mouse	8.2	pIC50	=	8.2	Functional	Antagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at mouse GHSR1 receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	11225576	165473	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	165473	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11225576	165473	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	165473	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122178608	120818	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	120818	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	120819	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	120819	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	56942388	139400	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139400	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139218	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139218	0	None	-	1	Human	7.2	pIC50	=	7.2	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	11176805	76966	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	76966	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	71453405	81485	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164833	81485	0	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	462	5	2	5	2.6	COc1ccc(C2(NC(=O)CN3CCN(C)CC3)C(=O)Nc3cc(Cl)c(Cl)cc32)cc1	10.1016/j.bmc.2012.07.018
	44394913	126639	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	126639	1	None	-	1	Human	6.2	pIC50	=	6.2	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	44409832	76042	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76042	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25190383	81483	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81483	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assayAntagonist activity at human GHSR1 expressed in CHO-CREluc cells after 4 hrs by Luciferase reporter assay	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	122178615	120777	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	120777	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44410013	76685	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	76685	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44389243	64237	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64237	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	753168	122710	33	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	122710	33	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Inhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assayInhibition of ghrelin-induced increase of intracellular [Ca2+] in CHO K cell FLIPR assay	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	46880566	6294	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1082209	6294	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	491	3	1	2	5.8	C[C@H]1CN(C(=O)c2ccc(-c3cccc(C(F)(F)F)c3)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	122178603	120812	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	120812	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	44409979	140016	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140016	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11256439	75014	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75014	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	11655578	169455	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	169455	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	70681019	72837	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL2011824	72837	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	570	9	2	6	4.7	COc1ccc(Oc2ccc3c(c2)C(=O)N([C@@H](C(=O)NC2CCN(Cc4ccccc4)CC2)C(C)C)CC(=O)N3)cc1	10.1016/j.bmcl.2012.01.014
	122178612	120822	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	120822	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	11617435	75629	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75629	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	145988647	166508	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4289530	166508	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4ncccn4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11663710	123935	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	123935	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	56942099	124661	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	124661	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	56942242	124662	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	124662	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	11663710	123935	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	CHEMBL363995	123935	1	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilizationAntagonist activity at human GHSR1a receptor assessed as blockade of intracellular Ca2+ mobilization	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2012.01.014
	70695747	72829	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	72829	0	None	-1	2	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	70687380	72843	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011831	72843	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assayAntagonist activity at human GHSR1a receptor assessed as intracellular Ca2+ concentration by aequorin luminescent assay	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)N1CCC(NCc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	122178605	120814	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	120814	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	145988894	166580	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4290680	166580	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	601	5	1	4	7.4	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@@H](C)c3ccc(C#CC4CC4)c(Cl)c3Cl)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	16203569	141189	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141189	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	145981343	166145	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL4282719	166145	0	None	-	1	Human	5.1	pIC50	=	5.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	669	6	1	6	7.6	Cc1cc(-c2ccc3c(c2)CCC3N2CCC(N(C)C(=O)N[C@H](c3ccc(-c4cnccn4)c(Cl)c3Cl)C(F)(F)F)CC2)ncn1	10.1021/acs.jmedchem.8b00794
	CHEMBL509976	213794	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Agonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulationAgonist activity at human ghrelin receptor Phe7:06Leu(Phe306) mutant expressed in african green monkey COS7 cells assessed as stimulation of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	122178615	120777	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	120777	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	44409810	140356	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382138	140356	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	469	9	3	9	2.8	CCOC(=O)CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113124	120808	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	120808	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44576247	212441	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Inverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor Ser5:09Ala(Ser217) mutant expressed in african green monkey COS7 cells assessed as inhibition of constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	44409536	75143	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75143	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145992835	166270	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4285075	166270	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	587	5	1	4	7.1	C[C@H](NC(=O)N(C)C1CCN(C2CCc3cc(-c4cncnc4)ccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	11327400	75007	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75007	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11539588	66564	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66564	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	16113796	84244	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84244	0	None	-	1	Human	6.1	pIC50	=	6.1	Functional	Antagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilizationAntagonist activity at human GHSR1a receptor expressed in CHO cells assessed as reduction of ghrelin-induced intracellular calcium mobilization	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	11442040	78126	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211211	78126	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Activity at GHS receptor by calcium flux assay in CHO-K cellsActivity at GHS receptor by calcium flux assay in CHO-K cells	ChEMBL	440	7	4	6	4.7	Nc1nc(N)c(-c2ccc(NC(=O)Nc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122178601	120810	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	120810	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilizationAntagonist activity at GHSR1a (unknown origin) assessed as inhibition of ghrelin-induced intracellular calcium mobilization	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	56942243	124663	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	124663	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipramAntagonist activity at human GHS-R1a transfected in mouse LTK cells after 6 hrs by CRE/luciferase reporter gene assay in presence of ghrelin and rolipram	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	46880725	6167	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	CHEMBL1081612	6167	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	455	3	1	2	5.3	Cc1ccccc1-c1ccc(C(=O)N2CCN(C(=O)c3ccc4cc[nH]c4c3)[C@@H](C)C2)cc1F	10.1016/j.bmcl.2010.01.043
	122178609	120819	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	120819	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Antagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assayAntagonist activity at human GSHR1a expressed in mouse LTK cells assessed as inhibition of ghrelin-induced reporter gene expression after 6 hrs by CRE/luciferase reporter gene assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	11454617	140775	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	140775	0	None	-	1	Human	8.1	pIC50	=	8.1	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	46880628	5940	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	CHEMBL1080389	5940	0	None	-4	2	Human	8.0	pIC50	=	8.0	Functional	Antagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assayAntagonist activity at human GHSR expressed in CHOK1 cells assessed as inhibition of ghrelin-induced intracellular calcium flux by aequorin flash luminescence assay	ChEMBL	441	3	1	2	5.0	C[C@H]1CN(C(=O)c2ccc(-c3ccccc3F)cc2)CCN1C(=O)c1ccc2cc[nH]c2c1	10.1016/j.bmcl.2010.01.043
	44409684	140341	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140341	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409672	139944	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	139944	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409673	76382	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76382	0	None	-	1	Human	8.0	pIC50	=	8.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	11453509	75810	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	75810	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	127047362	139176	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139176	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139218	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139218	0	None	-	1	Human	7.1	pIC50	=	7.1	Functional	Antagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric methodAntagonist activity at human GHS-R1a transfected in CHO cells assessed as inhibition of ghrelin-induced intracellular calcium mobilization measured over 60 secs by fluo-4AM dye-based fluorometric method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	145990956	166457	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	CHEMBL4288441	166457	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assayAntagonist activity at recombinant human GHSR1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced intracellular calcium release incubated for 20 secs and measured after 2 mins by FLIPR assay	ChEMBL	509	4	1	2	6.6	C[C@H](NC(=O)N(C)C1CCN(C2CCc3ccccc32)CC1)c1ccc(C#CC2CC2)c(Cl)c1Cl	10.1021/acs.jmedchem.8b00794
	44394947	168646	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	168646	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	44410007	76059	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76059	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Inhibition of human GHS receptor by FLIPRInhibition of human GHS receptor by FLIPR	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75619	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75619	0	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11576960	66764	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	66764	1	None	-	1	Human	7.0	pIC50	=	7.0	Functional	Ability to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assayAbility to inhibit ghrelin induced increase in intracellular [Ca2+] in CHO-K cells was determined by FLIPR assay	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11281346	75650	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	75650	0	None	-	1	Human	6.0	pIC50	=	6.0	Functional	Antagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cellsAntagonist activity at human GHS receptor by inhibition of ghrelin-induced intracellular calcium flux in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL499371	212314	0	None	-	1	Human	6.0	pIC50	=	6	Functional	Inverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulationInverse agonist activity at human ghrelin receptor expressed in african green monkey COS7 cells assessed as constitutively stimulated inositol phosphate accumulation	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	155540883	172378	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172378	0	None	-	1	Human	8.8	pKd	=	8.8	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155540883	172378	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172378	0	None	-	1	Human	8.0	pKd	=	8.0	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174005	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174005	0	None	-	1	Human	7.5	pKd	=	7.5	Functional	Competitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assayCompetitive antagonist activity at SNAP-tagged human GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced inositol phosphate production at 1 uM after 30 mins by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	155557019	174005	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174005	0	None	-	1	Human	7.1	pKd	=	7.1	Functional	Competitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assayCompetitive antagonist activity at human SNAP-tagged GHSR expressed in HEK293T cells assessed as reduction in ghrelin-induced calcium production at 1 uM after 15 mins by Fluo 4-AM dye-based fluorescence assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57399248	68687	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923617	68687	0	None	-	1	Human	9.0	pKi	=	9	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	71452183	83102	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	CHEMBL2203623	83102	0	None	-	1	Human	7.0	pKi	=	7	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	10.1021/jm1012374
	44454117	155004	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155004	0	None	-	1	Human	7.9	pKi	=	7.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	44454060	154781	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154781	0	None	-	1	Human	5.9	pKi	=	5.9	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	94804	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94804	0	None	-	1	Human	7.8	pKi	=	7.8	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454338	97373	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL272085	97373	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44434080	89467	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL237933	89467	0	None	-	1	Human	6.7	pKi	=	6.7	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454302	158821	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL410060	158821	0	None	-	1	Human	6.6	pKi	=	6.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454092	97187	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97187	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454432	154707	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154707	0	None	-	1	Human	5.6	pKi	=	5.6	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	9950632	88264	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL236038	88264	0	None	-	1	Human	5.5	pKi	=	5.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2008.01.100
	44454399	154588	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL402086	154588	0	None	-	1	Human	6.5	pKi	=	6.5	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC(C#N)Cc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454432	154707	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL402808	154707	0	None	-	1	Human	5.4	pKi	=	5.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(CC#N)CCc2ccccc2)n1	10.1016/j.bmcl.2008.01.100
	25022640	97339	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL271876	97339	0	None	-	1	Human	7.4	pKi	=	7.4	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	44454092	97187	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	CHEMBL271082	97187	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(C(/C=C/c2ccccc2)CC#N)n1	10.1016/j.bmcl.2008.01.100
	44454303	97107	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	CHEMBL270666	97107	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	479	12	3	10	2.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1O	10.1016/j.bmcl.2008.01.100
	44454304	97141	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	CHEMBL270876	97141	0	None	-	1	Human	6.3	pKi	=	6.3	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	464	12	2	10	1.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@@H](CC#N)COc1ccccn1	10.1016/j.bmcl.2008.01.100
	56926461	68679	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	CHEMBL1923609	68679	0	None	-	1	Human	8.2	pKi	=	8.2	Functional	Agonist activity at ghrelin receptorAgonist activity at ghrelin receptor	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm1012374
	44454398	97136	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL270851	97136	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	447	11	2	8	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(C#N)c1ccccc1	10.1016/j.bmcl.2008.01.100
	44454060	154781	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL403180	154781	0	None	-	1	Human	7.2	pKi	=	7.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	461	12	2	8	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)CCc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454367	94804	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	CHEMBL256235	94804	0	None	-	1	Human	6.2	pKi	=	6.2	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	481	12	2	9	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(CC#N)COc1ccccc1F	10.1016/j.bmcl.2008.01.100
	44454337	155051	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	CHEMBL404545	155051	0	None	-	1	Human	8.1	pKi	=	8.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	463	12	2	9	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1[C@H](CC#N)COc1ccccc1	10.1016/j.bmcl.2008.01.100
	44454117	155004	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	CHEMBL404336	155004	0	None	-	1	Human	6.1	pKi	=	6.1	Functional	Agonist activity at human GHS receptor expressed in H4 glioma cellsAgonist activity at human GHS receptor expressed in H4 glioma cells	ChEMBL	459	11	2	8	3.0	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C(/C=C/c1ccccc1)CC#N	10.1016/j.bmcl.2008.01.100
	1099	1749	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.Measuring ghrelin-induced GHSR activation detected by β-arrestin recruitment in cells stably expressing hGHSR.	Guide to Pharmacology		None	None	None		None	29233536
	121879	2195	19	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2195	19	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2195	19	None	-3	5	Human	7.0	pEC50	=	7	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5869	4005	0	None	-	1	Human	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	121879	2195	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	5868	2195	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	CHEMBL308716	2195	19	None	1	5	Rat	7.2	pEC50	=	7.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	8503009
	1099	1749	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	10628755
	1099	1749	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	121879	2195	19	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	5868	2195	19	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	CHEMBL308716	2195	19	None	-3	5	Human	7.5	pEC50	=	7.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	15905359
	1093	1756	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1756	0	None	-	1	Human	8.3	pEC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1756	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1756	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	178024	1932	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	178024	1932	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	5867	1932	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1932	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	CHEMBL13817	1932	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1932	30	None	-1	3	Human	9.2	pEC50	=	9.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	15905359
	1099	1749	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1749	0	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	21402696
	5866	3554	3	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9804743	3554	3	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	CHEMBL360227	3554	3	None	-	1	Human	9.5	pEC50	=	9.5	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	18923064
	9734	2289	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.IC<sub>50</sub> for LEAP2 antagonism of GHSR activation in the presence of ghrelin.	Guide to Pharmacology		None	None	None		None	29233536
	11441554	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5871	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	CHEMBL212761	218	0	None	-	1	Human	8.2	pIC50	=	8.2	Functional	UnclassifiedUnclassified	Guide to Pharmacology	420	6	4	6	3.9	O=C(NC(C)(C)C)Nc1ccc(cc1)c1c(N)nc(nc1COCc1ccccc1)N	16854051
	5872	2084	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	74015851	2084	0	None	-	1	Human	8.3	pIC50	=	8.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	603	10	3	8	5.4	COc1ccc(c(c1)OC)n1c(nnc1n1cc(c2c1cccc2)CC)[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@@H]1CCCN1	17927165
	25124566	1836	6	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5870	1836	6	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	CHEMBL3358452	1836	6	None	2	2	Human	8.4	pIC50	=	8.4	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	20593439
	5866	3554	3	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	9804743	3554	3	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	CHEMBL360227	3554	3	None	-	1	Human	8.9	pIC50	=	8.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	11741481
	25124566	1836	6	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	5870	1836	6	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740
	CHEMBL3358452	1836	6	None	-2	2	Rat	8.0	pKB	=	8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	21034740

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Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	178024	1932	30	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	5867	1932	30	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	CHEMBL13817	1932	30	None	-	1	Human	9.7	pEC50	=	9.7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm301653f
	22867441	10203	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161835	10203	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	67457995	91387	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
	CHEMBL2413152	91387	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@H](O)c1ccccc12	10.1016/j.bmc.2013.06.006
	22867441	10203	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161835	10203	0	None	-	0	Human	9.2	pEC50	=	9.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	474	5	4	4	2.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	71716660	85561	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL2304221	85561	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10345516	138732	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	CHEMBL379074	138732	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	71716660	85561	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL2304221	85561	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	5	5	2.7	CCNC(O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10345516	138732	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	CHEMBL379074	138732	0	None	-	0	Human	9.1	pEC50	=	9.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	11	1	4	4.9	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1cccs1	10.1021/jm058053k
	9807597	182425	3	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL47938	182425	3	None	-	0	Human	9.0	pEC50	=	9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	513	7	4	4	3.5	CNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	10323604	10197	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161828	10197	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10323604	10197	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161828	10197	0	None	-	0	Human	9.0	pEC50	=	9.0	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	497	7	2	5	2.6	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411920	77510	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL209360	77510	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	162662316	180931	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
	CHEMBL4765101	180931	0	None	-	0	Rat	8.9	pEC50	=	8.9	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	542	8	3	6	2.6	CC(C)(N)NC(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CC(S(C)(=O)=O)c1ccccc12	10.1021/acs.jmedchem.0c00829
	90666017	108799	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218890	108799	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Agonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assayAgonist activity at GSH-R1a in human U2OS cells after 2 hrs by FLIPR assay	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44411920	77510	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	CHEMBL209360	77510	0	None	-	0	Human	8.9	pEC50	=	8.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	3	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[C@@H](O)c1ccccc12	10.1021/jm058053k
	10625750	167580	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL433087	167580	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10625750	167580	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	CHEMBL433087	167580	0	None	-	0	Human	8.8	pEC50	=	8.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	518	9	3	5	3.3	CCOC(=O)[C@@]1(Cc2ccccc2)CCCN(C(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)C1	10.1021/jm058053k
	10626337	100742	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	CHEMBL295984	100742	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	44411718	10194	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161825	10194	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	467	7	2	5	3.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44293557	100606	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL294923	100606	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL540001	100606	0	None	-	0	Human	8.0	pEC50	=	8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	447	7	2	3	3.7	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	16040587	178794	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
	CHEMBL473921	178794	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1021/jm301653f
	16040587	178794	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL473921	178794	0	None	-	0	Human	7.0	pEC50	=	7	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	501	6	2	5	4.8	C[C@H]1CN(Cc2ccc(-c3cccnc3C(=O)N3CCC(Nc4ccc(F)cc4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	16752689	187774	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
	CHEMBL501315	187774	0	None	-	0	Human	6.9	pEC50	=	6.9	Binding	Agonist activity at GHSR (unknown origin)Agonist activity at GHSR (unknown origin)	ChEMBL	568	10	2	4	6.6	COc1cccc(CCN(Cc2ccccc2-c2ccc(CN3C[C@H](C)N[C@H](C)C3)cc2)C(=O)NC2CCCCC2)c1	10.1021/jm301653f
	9890375	97805	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL274599	97805	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL558802	97805	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	9890375	97805	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL274599	97805	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL558802	97805	0	None	-	0	Human	7.9	pEC50	=	7.9	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	458	5	3	3	3.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10026738	162207	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL417182	162207	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL557206	162207	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10026738	162207	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL417182	162207	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL557206	162207	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	10745533	139577	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL380096	139577	0	None	-	0	Human	7.8	pEC50	=	7.8	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10745533	139577	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL380096	139577	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	564	12	2	5	4.0	CN(CCc1ccccc1NS(C)(=O)=O)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	44411745	10196	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161827	10196	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	10626337	100742	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	CHEMBL295984	100742	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	543	9	5	5	2.8	CC(C)(N)C(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3CNC(=O)NCCO)cc2)C1=O	10.1021/jm058053k
	44411634	10193	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161824	10193	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411634	10193	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161824	10193	0	None	-	0	Human	8.7	pEC50	=	8.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	508	5	3	5	2.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	44411745	10196	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161827	10196	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	481	7	2	4	2.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411753	10198	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161829	10198	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44411753	10198	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161829	10198	0	None	-	0	Human	8.6	pEC50	=	8.6	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	449	7	2	4	3.2	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44293091	187593	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL49884	187593	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	44293091	187593	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	CHEMBL49884	187593	0	None	-	0	Human	7.7	pEC50	=	7.7	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	433	6	2	3	3.3	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CCc3ccccc32)CC1	10.1021/jm058053k
	46905972	10296	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	CHEMBL1162926	10296	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	15481181	77376	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL209020	77376	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	9810101	98779	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL281764	98779	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	15481188	140666	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL382844	140666	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL1793862	207175	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
	216208	9620	27	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
	CHEMBL113313	9620	27	None	-	1	Rat	8.5	pEC50	=	8.5	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.0c00829
	46905972	10296	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	CHEMBL1162926	10296	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	471	10	1	3	4.8	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)Cc1ccccc1	10.1021/jm058053k
	15481181	77376	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL209020	77376	2	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	9810101	98779	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL281764	98779	12	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	528	11	2	4	3.7	CNC(=O)[C@@H](Cc1ccccc1)N(C)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	15481188	140666	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL382844	140666	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	491	9	3	6	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2=NNC(=O)[C@@]2(Cc2ccccc2)C1	10.1021/jm058053k
	CHEMBL1793862	207175	0	None	-	0	Human	8.5	pEC50	=	8.5	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL		None	None	None		CCOC(=O)[C@@H](CCc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm058053k
	15481185	76893	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL207970	76893	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	15481185	76893	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	CHEMBL207970	76893	0	None	-	0	Human	8.4	pEC50	=	8.4	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	519	10	2	6	2.1	CCN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@]2(Cc2ccccc2)C1=O	10.1021/jm058053k
	44411584	10191	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161822	10191	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411584	10191	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161822	10191	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	465	7	2	4	3.9	CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	22862436	10202	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161834	10202	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10602640	137648	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	CHEMBL376970	137648	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	10791616	138993	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL379564	138993	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10029990	168707	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL441360	168707	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	22862436	10202	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161834	10202	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	499	7	2	6	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10602640	137648	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	CHEMBL376970	137648	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	545	14	2	5	4.2	CNC(C)(C)C/C=C/C(=O)N(C)[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)CCc1ccccc1OCCO	10.1021/jm058053k
	10791616	138993	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL379564	138993	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	503	11	1	4	5.2	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc(-c2ccccc2)cc1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10029990	168707	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL441360	168707	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	531	13	2	5	4.0	CN(CCc1ccccc1OCCO)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	44411632	10192	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161823	10192	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411632	10192	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161823	10192	0	None	-	0	Human	8.3	pEC50	=	8.3	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	476	5	3	4	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	23529194	101708	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
	CHEMBL302810	101708	0	None	-	0	Rat	7.3	pEC50	=	7.3	Binding	Agonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIAAgonist activity at GHSR in Wistar rat pituitary gland cells assessed as induction of GH release by RIA	ChEMBL	525	5	3	3	4.0	O=C(NC(Cc1c[nH]c2ccccc12)C(=O)N1CCC2(CCc3ccccc32)CC1)NC1CN2CCC1CC2	10.1021/acs.jmedchem.0c00829
	16041292	183019	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	CHEMBL480219	183019	0	None	-	0	Human	6.3	pEC50	=	6.3	Binding	Inhibition of human Ghrelin receptorInhibition of human Ghrelin receptor	ChEMBL	490	6	2	6	3.9	C[C@H]1CN(Cc2ccc(-n3ccnc3C(=O)N3CCC(Nc4cccc(F)c4)CC3)cc2)C[C@@H](C)N1	10.1016/j.bmcl.2008.10.072
	44411913	10201	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161833	10201	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411913	10201	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	CHEMBL1161833	10201	0	None	-	0	Human	7.2	pEC50	=	7.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	6	2	4	3.5	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CSc1ccccc12	10.1021/jm058053k
	44411905	10200	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161832	10200	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10506325	100758	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL296104	100758	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	44411905	10200	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	CHEMBL1161832	10200	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	6	2	5	2.2	CC(C)(N)C(=O)N[C@H](CCc1ccccc1)C(=O)N1CCC2(CC1)CS(=O)(=O)c1ccccc12	10.1021/jm058053k
	10506325	100758	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	CHEMBL296104	100758	0	None	-	0	Human	8.2	pEC50	=	8.2	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	527	8	4	4	3.9	CCNC(=O)NCc1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)C(C)(C)N)CCc3ccccc32)cc1	10.1021/jm058053k
	10600702	140792	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL383526	140792	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	10600702	140792	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL383526	140792	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	477	10	1	4	4.7	CN(CCc1cccs1)C(=O)[C@@H](Cc1ccc2ccccc2c1)N(C)C(=O)/C=C/CC(C)(C)N	10.1021/jm058053k
	CHEMBL335799	209808	0	None	-	0	Human	7.1	pEC50	=	7.1	Binding	Agonist activity at GHS-R1a (unknown origin)Agonist activity at GHS-R1a (unknown origin)	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1016/j.bmc.2013.06.006
	44411720	10195	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161826	10195	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411902	10199	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161831	10199	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44411720	10195	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	CHEMBL1161826	10195	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	483	7	2	5	2.1	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)C[S+]([O-])c1ccccc12	10.1021/jm058053k
	44411902	10199	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	CHEMBL1161831	10199	0	None	-	0	Human	8.1	pEC50	=	8.1	Binding	Activity at human GHS-R1a receptor in rat pituitary cells assessed as GH releaseActivity at human GHS-R1a receptor in rat pituitary cells assessed as GH release	ChEMBL	451	7	2	5	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)COc1ccccc12	10.1021/jm058053k
	44390849	62571	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL178475	62571	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	25227441	112931	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319217	112931	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	563	8	2	8	3.9	CCc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL501253	212352	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	44582528	192803	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	91935097	192803	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	CHEMBL525994	192803	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm0001727
	CHEMBL2310891	207740	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	90665845	108771	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218645	108771	0	None	-	0	Human	9.9	pIC50	=	9.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	485	5	0	4	6.8	Cc1ccccc1-c1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL500468	212334	0	None	-	1	Human	9.9	pIC50	=	9.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/j.bmcl.2005.02.042
	57422686	112935	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319221	112935	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	600	8	2	9	4.1	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccc5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL2310888	207738	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O)C(C)C	10.1021/jm0001727
	11340044	140791	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL383522	140791	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(NCc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44336274	108070	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
	CHEMBL320289	108070	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Inhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 bindingInhibitory concentration (biotinylated probe) is evaluated for [35S]- MK-0677 binding	ChEMBL	896	22	6	10	2.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)C(=O)N1CCC2(CC1)CN(S(=O)(=O)CC(=O)NCCCCCCNC(=O)CCCC[C@@H]1SCC3NC(=O)NC31)c1ccccc12	10.1021/jm970342o
	122180027	121061	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586033	121061	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	118709502	112960	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319398	112960	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390862	63521	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180349	63521	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cc(Cl)ccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	16133832	211573	15	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL425281	211573	15	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL500468	212334	0	None	-	1	Human	9.6	pIC50	=	9.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1016/s0960-894x(01)00324-9
	90665847	108773	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218647	108773	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3ccc(Cl)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	122182190	121482	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121482	0	None	-	0	Rat	9.6	pIC50	=	9.6	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	57422687	112936	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319222	112936	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	604	8	2	9	3.9	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	16114292	96473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL266063	96473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	16114292	96473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL266063	96473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	11225576	165473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL425594	165473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	122182047	121475	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121475	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	11225576	165473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL425594	165473	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	489	9	3	8	4.0	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	25260749	112934	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319220	112934	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	579	9	2	9	3.7	CCOc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	57422792	112959	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319397	112959	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	635	8	2	10	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)c(Cl)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	57422692	112933	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319219	112933	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	575	8	2	8	4.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(C5CC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL500468	212334	0	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
	122182043	121471	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121471	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	118709506	112970	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319407	112970	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	586	5	2	9	4.3	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)c(C#N)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	178024	1932	30	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	5867	1932	30	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	CHEMBL13817	1932	30	None	-	1	Human	9.4	pIC50	=	9.4	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm0309452
	11431274	76976	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL208424	76976	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	9	3	8	3.8	CC(C)=CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11410373	137993	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	CHEMBL377514	137993	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	558	10	4	8	4.2	Cc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)c1	10.1016/j.bmcl.2006.01.012
	44582531	188126	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	91935100	188126	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL504776	188126	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	122182046	121474	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121474	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	25260745	112963	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319400	112963	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	573	10	2	8	5.2	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	122182190	121482	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121482	0	None	-	0	Human	9.4	pIC50	=	9.4	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	57422768	112942	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
	CHEMBL3319228	112942	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c(Cl)c2)n1	10.1021/jm500610n
	16114096	78735	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113324	78735	1	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)c(OC)c1	10.1021/jm0704550
	178024	1932	30	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	5867	1932	30	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	CHEMBL13817	1932	30	None	-	1	Human	9.3	pIC50	=	9.3	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cells	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020424z
	57422690	112941	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	CHEMBL3319227	112941	0	None	-	0	Human	9.3	pIC50	=	9.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	615	8	2	10	3.8	Cc1ccn(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	118709503	112961	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319399	112961	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	588	7	2	9	3.8	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(ccn5C)cc4Cl)sc3c2)CC1	10.1021/jm500610n
	66788278	124659	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645254	124659	0	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	16114292	96473	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	CHEMBL266063	96473	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm701292s
	44436850	91104	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240509	91104	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	6	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	57422793	112958	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
	CHEMBL3319396	112958	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	631	9	2	11	3.5	COc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1021/jm500610n
	178024	1932	30	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	5867	1932	30	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	CHEMBL13817	1932	30	None	-	1	Human	9.2	pIC50	=	9.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(01)00324-9
	57422688	112939	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319225	112939	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	57785733	112938	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319224	112938	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	612	8	2	9	4.4	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-c5ccccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	16113245	120807	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581030	120807	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2014.11.031
	44445600	154238	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL400175	154238	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL437713	211973	0	None	-	0	Human	9.2	pIC50	=	9.2	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm020424z
	178024	1932	30	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	5867	1932	30	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL13817	1932	30	None	-	1	Human	9.1	pIC50	=	9.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL412799	211268	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(N)=O)C(C)C	10.1021/jm0001727
	57422817	112937	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319223	112937	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	620	8	2	10	3.2	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	11476589	75620	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205451	75620	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	456	9	3	8	4.5	Nc1nc(N)c(-c2ccc(CNc3ccc([N+](=O)[O-])cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL526723	213911	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44436857	145111	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL391588	145111	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	594	12	4	7	4.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	90666039	108821	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218912	108821	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	8	0	9	4.2	CCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	118709505	112969	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319406	112969	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	561	5	2	8	4.4	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL2310887	207737	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCC(CCC)C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	122180026	121060	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121060	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	122182043	121471	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121471	0	None	-	0	Rat	9.0	pIC50	=	9.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL2310890	207739	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		C/C=C/C=C/C=C/C(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44409536	75143	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL204325	75143	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	579	9	3	8	5.2	Nc1nc(N)c(-c2ccc(NCc3cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44445595	93954	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL250974	93954	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90665850	108776	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218650	108776	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	7	0	7	4.6	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cn(-c4ccc(Cl)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	90665851	108777	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218651	108777	0	None	-	0	Human	9.0	pIC50	=	9.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	459	5	0	6	4.8	Cc1ccccc1-c1nc2cn(-c3ccc(F)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	11134880	98959	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL282891	98959	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	5866	3554	3	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	9804743	3554	3	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	CHEMBL360227	3554	3	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1021/jm040103i
	11712151	75625	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205470	75625	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	453	9	3	7	4.8	CC(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	56942098	124660	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645255	124660	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	25261382	112929	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319215	112929	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	535	7	2	8	3.3	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	57422789	112943	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	CHEMBL3319229	112943	0	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	629	8	2	10	4.1	Cc1cc(C)n(-c2ccc(Cl)c(C(=O)NC(=O)Nc3nc4ccc(S(=O)(=O)CCCN5CCN(C)CC5)cc4s3)c2)n1	10.1021/jm500610n
	56942244	124664	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL3645259	124664	0	None	-	1	Human	8.9	pIC50	=	8.9	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	90665846	108772	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218646	108772	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	491	5	0	5	6.9	Cc1ccccc1-c1nc2cc(-c3ccc(Cl)cc3)sc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	11339816	75639	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205521	75639	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	446	8	3	7	4.7	Nc1nc(N)c(-c2ccc(NCc3ccnc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44409756	76399	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206820	76399	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	492	8	4	8	4.1	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccc(F)cc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	90666012	108794	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218885	108794	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	475	5	0	6	5.3	Cc1ccccc1-c1nc2cn(-c3cccc(Cl)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666031	108813	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218904	108813	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	498	7	0	8	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44390840	123026	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL361804	123026	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	90666017	108799	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218890	108799	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	472	6	0	8	4.1	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666027	108809	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218900	108809	0	None	-	0	Human	8.8	pIC50	=	8.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	502	8	0	9	3.7	COC[C@H](C)N1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	44445594	154093	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399447	154093	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	611	11	3	7	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90666013	108795	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218886	108795	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1cccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44445599	93737	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL249639	93737	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	581	10	3	6	6.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44446187	94171	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252255	94171	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	178024	1932	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1932	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1932	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	23648244	91568	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241775	91568	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	44409776	76775	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207754	76775	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	3	7	3.5	CC(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178616	120825	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581048	120825	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc3ccccc3cn2)cc1	10.1016/j.bmcl.2014.11.031
	16113471	84283	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL222789	84283	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	623	10	4	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	156021766	177543	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177543	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145959787	161723	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145953855	161953	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161953	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	16113585	136698	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL375161	136698	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	145958774	161704	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161704	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	156016073	177071	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4641503	177071	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@@H](C)C1	10.1016/j.bmcl.2020.126953
	162646061	178941	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
	CHEMBL4741413	178941	0	None	-	0	Human	4.0	pIC50	=	4	Binding	Inhibition of GHSR-1A (unknown origin)Inhibition of GHSR-1A (unknown origin)	ChEMBL	729	18	11	12	-5.4	C[C@@H](O)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccc2ccccc12)NC(=O)[C@H](CN)NC(=O)[C@H](CO)NC(=O)CN)C(N)=O	10.1039/d0md00210k
	70692600	75506	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048813	75506	0	None	-	1	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2310886	207736	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCNC(=O)CCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	156021766	177543	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4648355	177543	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445601	93738	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	CHEMBL249640	93738	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	498	8	2	5	5.4	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	44390901	63733	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180755	63733	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(OC)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	145959787	161723	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	70694648	75504	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048811	75504	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	44445591	154092	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399446	154092	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	591	11	4	7	5.0	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113468	141256	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL386218	141256	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	16113468	141256	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL386218	141256	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	46882103	5862	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079872	5862	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	72190450	91829	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426679	91829	0	None	-	1	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	11441978	129920	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL368034	129920	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	8	2	4	4.8	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL2310894	207742	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)c1ccccc1)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O	10.1021/jm0001727
	122180017	121051	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586023	121051	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44445592	93736	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL249638	93736	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113577	84498	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL223725	84498	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	573	12	4	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	16113902	137138	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375859	137138	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90666041	108823	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218914	108823	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	8	0	9	4.6	Cc1ncccc1-c1nc2cn(-c3cccc(OC(C)C)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	16113902	137138	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL375859	137138	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	15945877	146394	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392593	146394	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	11337482	76272	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL206399	76272	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	44409775	75657	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205605	75657	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122182190	121482	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121482	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44445620	154128	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399651	154128	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	571	11	2	6	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	11676995	65816	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184258	65816	1	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCOC)cc1	10.1016/j.bmcl.2004.06.060
	16203930	83904	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	CHEMBL221674	83904	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1cc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	11537683	75161	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL204352	75161	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	354	5	3	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccnc(Cl)c2)cc1	10.1021/jm0510934
	122180020	121054	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586026	121054	0	None	-	0	Rat	7.0	pIC50	=	7.0	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44338247	7830	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL109035	7830	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	549	11	1	6	4.8	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCC1	10.1016/j.bmcl.2003.11.012
	44445622	154129	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399653	154129	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	11	4	7	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccc2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	59446139	81175	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163449	81175	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436812	91318	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241033	91318	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	11	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11731384	162158	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	CHEMBL417092	162158	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	44390888	64070	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL181312	64070	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	435	7	2	4	2.7	CCN(CC)CCN1C(=O)C(O)(c2ccccc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	60195112	81180	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163466	81180	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	875	21	10	8	2.6	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2370788	208166	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
	16113904	136499	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374655	136499	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90665852	108778	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218652	108778	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666032	108814	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218905	108814	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	512	7	0	8	4.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113904	136499	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374655	136499	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	5.1	COc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL500703	212339	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	10415364	126233	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126233	0	None	-	0	Rat	7.9	pIC50	=	7.9	Binding	Inhibitory concentration against rat Growth hormone secretagogue receptorInhibitory concentration against rat Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	53390181	91825	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426675	91825	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	145957075	161717	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161717	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145956026	162100	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162100	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145956061	162131	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162131	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	145951150	162214	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162214	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	11328064	159753	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL411055	159753	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	437	6	2	4	4.9	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OC(C)(C)C)CCc3ccccc3C2)cc1	10.1021/jm0491750
	44445607	166166	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL428314	166166	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.4	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113581	84699	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL224921	84699	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1cccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	90666022	108804	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218895	108804	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	528	7	0	9	4.2	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666028	108810	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218901	108810	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	511	7	0	10	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5cnco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	70682036	75510	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048817	75510	0	None	-	1	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	16113796	84244	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL222518	84244	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	57422697	112949	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319276	112949	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	44582528	192803	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	91935097	192803	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	CHEMBL525994	192803	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3419	113	48	48	-14.7	CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CC12CC3CC(CC(C3)C1)C2)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	CHEMBL499371	212314	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCC(N)=O)C(N)=O	10.1074/jbc.m609796200
	59446101	81190	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163477	81190	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446101	81190	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163477	81190	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	915	23	11	9	2.1	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44389262	121505	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359506	121505	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	479	6	2	4	6.1	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccccc1	10.1016/j.bmcl.2004.11.075
	16113796	84244	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL222518	84244	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11576960	66764	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187427	66764	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	500	8	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	11124146	98683	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL281173	98683	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	122178600	120809	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581033	120809	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2)cc1	10.1016/j.bmcl.2014.11.031
	44409679	75142	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204322	75142	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	466	8	4	8	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	9745	2410	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	9804938	2410	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	CHEMBL278623	2410	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	DB13074	2410	20	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	16113579	84499	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL223726	84499	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	10	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL3578015	210009	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	145954311	161924	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161924	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL3578015	210009	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	11373823	78079	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211188	78079	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)c3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	145954311	161924	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167267	161924	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44301389	11155	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179118	11155	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL61292	11155	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	46882236	5680	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078608	5680	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	8	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16114514	78733	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	CHEMBL2113322	78733	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCCNC1	10.1021/jm0704550
	11523411	75189	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	CHEMBL204511	75189	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	363	6	4	6	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)O)cc2)cc1	10.1021/jm0510934
	57422730	112926	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319212	112926	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	508	9	2	7	4.4	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	46882763	5537	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077617	5537	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK0677 from human GHS-R1aDisplacement of [35S]MK0677 from human GHS-R1a	ChEMBL	612	17	6	7	5.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NC[C@H](O)COc3ccc(O)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44576247	212441	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	CHEMBL506986	212441	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1074/jbc.m609796200
	145951150	162214	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4171914	162214	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	443	4	3	5	3.1	Cn1ccc2c(F)c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)ccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL433540	211884	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsAbility to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cells	ChEMBL		None	None	None		C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020424z
	1744826	62654	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
	CHEMBL178668	62654	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1021/jm0491750
	1744826	62654	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178668	62654	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Binding affinity to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.06.060
	122178603	120812	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581036	120812	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	590	11	2	6	6.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(Cl)nc2)cc1	10.1016/j.bmcl.2014.11.031
	16114009	136657	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374921	136657	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	556	10	3	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	23648246	161227	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL414132	161227	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	11655578	169455	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL444277	169455	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	462	8	3	7	5.2	Nc1nc(N)c(-c2ccc(NCc3cnc4ccccc4c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	1744826	62654	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178668	62654	17	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	417	6	1	4	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	156021336	177583	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4649089	177583	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	467	5	1	6	5.2	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	44446190	94107	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL251855	94107	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44389167	123327	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL362612	123327	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	425	7	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338240	108639	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL321403	108639	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2cc(-c3ccccc3-c3nn[nH]n3)cs2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	11539587	66727	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL187271	66727	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	8	1	4	6.7	CCCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	11503585	64858	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182542	64858	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	461	9	2	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCCO)cc1	10.1016/j.bmcl.2004.06.060
	23656300	148222	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
	CHEMBL394054	148222	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	592	12	3	7	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)c(OC)c1	10.1021/jm0704550
	59446107	81193	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163480	81193	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446107	81193	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163480	81193	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(-c2ccccc2)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436807	147767	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL393692	147767	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	547	11	3	7	4.6	COc1ccc(Cn2c(CCC3C=Nc4ccccc43)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	46882237	5688	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078677	5688	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	9	4	4	4.1	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44395002	65840	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184368	65840	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	534	9	1	5	5.6	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)CC1	10.1016/j.bmcl.2004.06.060
	44445627	154389	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401084	154389	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	543	10	2	7	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113906	136686	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL375102	136686	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	612	12	5	5	6.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	70692601	75507	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048814	75507	0	None	-	1	Human	7.9	pIC50	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	145957075	161717	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164040	161717	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	447	4	4	4	3.2	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2c(F)cc(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	145956026	162100	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4169979	162100	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	418	6	2	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)N(C)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	145956061	162131	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170481	162131	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	3	4	2.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)[C@@H]3CN(C)CCO3)cc2c1	10.1021/acs.jmedchem.8b00322
	46882271	5717	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078899	5717	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	466	8	4	4	5.0	CCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	156018364	177329	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177329	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445624	154355	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400879	154355	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	631	11	4	7	5.8	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)[C@H]2CCCC[C@H]2N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16203238	136572	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	CHEMBL374757	136572	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	531	9	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1	10.1021/jm070024h
	16113694	136656	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374920	136656	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	609	11	4	5	6.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1cccc2ccccc12	10.1021/jm070024h
	16114181	141396	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL387109	141396	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	10	3	5	5.0	Cc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44446137	154866	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403682	154866	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	122180017	121051	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586023	121051	0	None	-	0	Rat	6.9	pIC50	=	6.9	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	525	9	2	8	4.5	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44379072	12674	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188124	12674	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL535353	12674	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	492	8	2	5	4.2	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	16113905	84259	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL222622	84259	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11626181	123849	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363896	123849	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	431	7	1	4	6.3	CCc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccc(N(CC)CC)cc1	10.1016/j.bmcl.2004.06.060
	42624369	188266	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582535	188266	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935102	188266	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL506930	188266	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1713	58	25	24	-9.3	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	16113691	136183	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL374073	136183	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	90666023	108805	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218896	108805	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113691	136183	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	CHEMBL374073	136183	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm0704550
	57422696	112966	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319403	112966	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	558	5	2	9	4.0	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(-n5cccn5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	156012849	176714	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176714	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44390860	63298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL180096	63298	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(Cl)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	73347725	91824	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426674	91824	0	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	476	6	0	5	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4ncccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2013.07.044
	156012849	176714	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4636571	176714	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.3	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnc(C)c4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156015928	176997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	176997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156018364	177329	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645148	177329	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	498	8	3	6	1.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145949595	162162	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162162	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	1100	1572	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	6918297	1572	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	CHEMBL108335	1572	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		None	10.1021/jm300557t
	11539588	66564	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186540	66564	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	445	7	1	4	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C(C)C)cc1	10.1016/j.bmcl.2004.06.060
	122180015	121049	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586021	121049	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122178615	120777	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3580668	120777	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	606	11	2	6	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2nccc3ccccc23)cc1	10.1016/j.bmcl.2014.11.031
	16113798	83902	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL221662	83902	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	598	11	5	5	5.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	16113797	137596	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL376735	137596	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	637	11	4	5	6.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	16113903	167802	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	CHEMBL434573	167802	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1cc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc(OC)c1	10.1021/jm070024h
	44338241	6448	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL108287	6448	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	569	11	1	7	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)s2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	44410012	137858	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377305	137858	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113122	147624	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	CHEMBL393565	147624	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	538	12	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	11556937	81196	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163484	81196	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11556937	81196	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163484	81196	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	9956908	12970	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190326	12970	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540604	12970	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	482	12	2	5	4.5	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11329138	64114	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	CHEMBL181350	64114	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	481	9	1	5	5.1	CCN(CC)c1ccc(NC(=O)C2(N(C)C(=O)OCC(C)C)CCc3cccc(OC)c3C2)cc1	10.1021/jm0491750
	90665848	108774	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218648	108774	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	507	7	0	6	6.1	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3cc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	23648245	91569	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL241776	91569	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCNC2)cc1	10.1021/jm0704550
	145949595	162162	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171040	162162	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	11846625	77516	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209394	77516	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	498	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(-c1ccccc1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	44409683	75891	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205848	75891	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	480	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCC3CCCC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46882305	5736	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079091	5736	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	7	4	4	5.7	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccc(C(C)(C)C)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11124146	98683	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL281173	98683	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	518	10	6	5	2.8	CCOC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	56942855	124666	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
	CHEMBL3645261	124666	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	601	10	2	6	7.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccc3ccccc3c2)NC(=O)OC(C)(C)C)cc1	nan
	11016748	97885	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275141	97885	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44445602	93739	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	CHEMBL249659	93739	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	537	8	3	5	5.9	O=C(N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)c1ccccn1	10.1021/jm701292s
	11256439	75014	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	CHEMBL203843	75014	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	344	5	3	6	3.4	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C#N)cc2)cc1	10.1021/jm0510934
	44390881	65757	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL183916	65757	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2ccccc2OC)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	44338151	109248	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL323026	109248	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	6	5.3	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2F)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	46882238	5691	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078699	5691	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccccc1NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	59446133	174452	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4567432	174452	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195284	81184	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163471	81184	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)N(Cc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44394930	65985	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185028	65985	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2cccc3c2OCO3)cc1	10.1016/j.bmcl.2004.06.060
	11016748	97885	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275141	97885	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	517	10	7	4	2.4	CCNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	59446115	173728	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4550305	173728	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195379	81188	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163475	81188	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	910	22	10	9	2.6	C[C@H](NC(=O)N(Cc1ccc(-c2ccccc2)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	46882155	5617	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078114	5617	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	8	4	4	3.3	CCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11145720	66988	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
	CHEMBL18853	66988	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	11	6	4	2.9	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)NC	10.1021/jm020985q
	11846628	77344	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL208930	77344	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	431	7	2	6	4.2	CN(C(=O)C1CCCC1)c1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	156015928	176997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4640615	176997	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	512	8	3	6	1.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16114012	167824	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL434738	167824	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	510	9	3	5	4.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	122180018	121052	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586024	121052	0	None	-	0	Rat	6.8	pIC50	=	6.8	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	16113582	136103	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL373995	136103	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	7	4	5	3.5	Cn1c(Cc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	46882807	5672	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078533	5672	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	10	4	4	3.6	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16114184	149946	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
	CHEMBL395441	149946	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	564	11	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2C[C@@H](O)CN2)cc1	10.1021/jm0704550
	44446188	154840	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403542	154840	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	611	11	3	7	6.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)Oc2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	44436817	166205	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL428383	166205	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	600	13	4	6	5.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](N)Cc3ccccc3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44445618	161337	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL415134	161337	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	570	12	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)CCc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44436887	90514	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239464	90514	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	5	6	3.7	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	10907396	98680	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	CHEMBL281147	98680	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	11649239	65993	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185057	65993	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	514	9	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	1100	1572	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	6918297	1572	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	CHEMBL108335	1572	41	None	-	1	Human	7.8	pIC50	=	7.8	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		None	10.1021/jm020985q
	16113580	137340	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	CHEMBL376258	137340	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm701292s
	16113580	137340	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376258	137340	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1cccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	44436883	145608	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	CHEMBL391980	145608	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	604	11	6	7	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)cc1	10.1021/jm0704550
	44436889	152511	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397594	152511	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	11	3	5	6.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCCCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11452801	138755	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL379191	138755	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	417	7	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44445625	154269	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400381	154269	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	612	11	3	8	5.4	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	122180019	121053	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586025	121053	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	145957443	161528	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160928	161528	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	10864048	97923	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275373	97923	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44389187	63676	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL180722	63676	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3cccc(Cl)c3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44409871	75031	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203948	75031	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	426	7	3	8	2.4	CN(C)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145959007	161695	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161695	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145956659	161494	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161494	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145959787	161723	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16113248	78739	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113328	78739	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	560	11	3	5	5.6	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	11282247	165362	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL425048	165362	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	11282247	165362	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL425048	165362	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	6	5.3	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	44409802	76376	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206687	76376	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	439	9	3	7	4.1	CCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	156019457	177358	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177358	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	216208	9620	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9620	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	90666037	108819	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218910	108819	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	484	6	0	8	3.8	Cc1ncccc1-c1nc2cn(-c3ccccc3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	23648236	78727	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	CHEMBL2113317	78727	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	13	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NCCN)c(OC)c1	10.1021/jm0704550
	44383343	119823	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
	CHEMBL353007	119823	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	606	6	2	5	3.4	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)C3Cc4ccccc4CN3)CC2)c2ccccc21	10.1021/jm0309452
	156014693	176608	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4635089	176608	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	530	6	2	8	2.9	CCOc1cc(Cl)c(-c2ccc(-c3nc4c(s3)CN(C(=O)CO)CC4)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	44389151	62161	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178138	62161	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	6	1	4	5.7	CCN(CC)C(=O)c1ccccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	44409979	140016	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL381159	140016	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	7	2	7	3.4	CCc1nc(N)nc(N(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44395020	123501	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL363021	123501	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	507	9	1	5	6.1	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)CC1	10.1016/j.bmcl.2004.06.060
	16114530	84302	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222912	84302	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	539	13	4	5	5.7	CCCCCCn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	59446130	81192	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163479	81192	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446130	81192	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163479	81192	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	800	21	10	9	0.4	CC(C)CN(NC(=O)[C@H](C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409761	75498	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204880	75498	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	3	7	4.4	CCc1nc(N)nc(NCC(C)C)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145956659	161494	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160434	161494	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	406	4	4	3	2.4	O=C(N[C@H]1Cc2ccccc2[C@@H]1NC(=O)[C@H]1CCNC1)c1cc2cc(F)ccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145957443	161528	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160928	161528	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145959007	161695	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163623	161695	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	436	4	4	5	2.8	N#Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	145959787	161723	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164107	161723	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	444	4	2	4	3.4	CN1CCCCC(C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11328920	143498	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
	CHEMBL390308	143498	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	471	8	2	4	5.4	CCN(CC)c1ccc(NC(=O)C2(NC(=O)OCC(C)C)CCc3cccc(Cl)c3C2)cc1	10.1021/jm0491750
	122178606	120815	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581039	120815	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(F)n2)cc1	10.1016/j.bmcl.2014.11.031
	122178609	120819	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581042	120819	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	586	12	2	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(OC)n2)cc1	10.1016/j.bmcl.2014.11.031
	178024	1932	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	5867	1932	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	CHEMBL13817	1932	30	None	-	1	Human	8.7	pIC50	=	8.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/acs.jmedchem.8b00322
	44409821	75669	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205711	75669	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	564	10	4	8	4.2	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CCC(=O)NCc3cccc(Cl)c3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	46882307	5738	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079108	5738	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	530	8	4	4	6.0	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NC(C)(C)c3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	122182044	121472	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593633	121472	0	None	-	0	Rat	8.7	pIC50	=	8.7	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	5866	3554	3	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	9804743	3554	3	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	CHEMBL360227	3554	3	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CCN1c2cc(cc(c2[C@](C1=O)(O)c1ccccc1Cl)C(F)(F)F)C(=O)N)CC	10.1016/j.bmcl.2005.02.042
	CHEMBL500468	212334	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
	CHEMBL500468	212334	0	None	-	1	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm501702q
	11683469	76338	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL206486	76338	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	433	6	3	7	3.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(C)(=O)=O)c(F)c2)cc1	10.1021/jm0510934
	11454617	140775	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383411	140775	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	8	3	8	4.0	CN(Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1)c1ccccc1	10.1016/j.bmcl.2006.01.012
	90666029	108811	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218902	108811	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	510	7	0	9	4.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(Cc5ccco5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44409672	139944	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL380971	139944	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	479	9	3	9	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccco3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11154823	75661	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205660	75661	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	436	8	3	7	4.5	N#Cc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	11190594	75617	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205445	75617	0	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	469	10	3	8	3.9	CC(C)CCOCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	11583811	75619	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205450	75619	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	479	8	3	6	5.7	Nc1nc(N)c(-c2ccc(NCc3ccc(C(F)(F)F)cc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	25260900	112965	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319402	112965	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	593	10	2	9	4.3	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(N4CCOCC4)ccc3Cl)sc2c1	10.1021/jm500610n
	10918326	98502	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	CHEMBL279822	98502	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	44378981	13842	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1196773	13842	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL558181	13842	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	504	10	2	5	5.5	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	90666033	108815	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218906	108815	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	526	7	0	8	5.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCCC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16113472	168429	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL439251	168429	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	66813470	76464	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
	CHEMBL2069411	76464	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]ghrelin from GHS receptorDisplacement of [125I]ghrelin from GHS receptor	ChEMBL	459	6	2	6	3.3	O=C(N[C@@H]1COc2cccc(-c3ccc(CO)nc3)c2C1)c1ccc(OCC(F)(F)F)nc1	10.1016/j.bmcl.2012.06.105
	122180022	121056	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586028	121056	0	None	-	0	Rat	5.7	pIC50	=	5.7	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	70694649	75516	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048823	75516	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	10100708	11914	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183387	11914	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL294408	11914	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	530	9	3	7	0.3	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@@H](N)CO)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	11577349	64885	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL182655	64885	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	529	9	1	5	5.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCN(C)C2=O)cc1	10.1016/j.bmcl.2004.06.060
	16114098	141067	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL385131	141067	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.4	Cc1ccc(Cn2c(CCCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11327400	75007	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL203782	75007	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	412	8	3	7	4.0	Nc1nc(N)c(-c2ccc(NCc3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	44409455	75600	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	CHEMBL205286	75600	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	487	6	3	7	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2cc(F)c(S(=O)(=O)C(F)(F)F)c(F)c2)cc1	10.1021/jm0510934
	156019457	177358	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645625	177358	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	515	8	3	7	0.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cn(C)nc4C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	46882306	5737	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079107	5737	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	502	8	4	4	5.2	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)NCc3cccc4ccccc34)cc2)cc1	10.1016/j.bmcl.2009.08.076
	11731384	162158	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	CHEMBL417092	162158	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	557	10	7	5	2.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCCCN1	10.1021/jm020985q
	118709470	112947	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319274	112947	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	395	3	2	5	4.6	COc1ccc2nc(NC(=O)NC(=O)c3c(Cl)cccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL507636	212652	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCCNC(=N)N)NC(=O)[C@H]1CCCN1C(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	156021885	177631	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4649741	177631	0	None	-	0	Human	4.7	pIC50	=	4.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	635	10	1	10	4.2	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1CCO[C@H](C)C1	10.1016/j.bmcl.2020.126953
	70688404	75499	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048807	75499	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	11114279	97784	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	CHEMBL274460	97784	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	70688404	75499	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048807	75499	0	None	-	1	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2013.07.044
	16113693	137476	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL376471	137476	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	589	12	4	6	5.6	COc1cccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	216208	9620	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	CHEMBL113313	9620	27	None	-	1	Human	7.7	pIC50	=	7.7	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1021/acs.jmedchem.8b00322
	11827047	98750	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	CHEMBL281578	98750	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	9745	2410	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	9804938	2410	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	CHEMBL278623	2410	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	DB13074	2410	20	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	10.1021/jm020985q
	16113124	120808	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581032	120808	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	556	11	2	6	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccncc2)cc1	10.1016/j.bmcl.2014.11.031
	44445605	154430	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401260	154430	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	542	10	2	6	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113578	136655	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	CHEMBL374919	136655	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	542	9	3	5	5.7	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1cccc2ccccc12	10.1021/jm070024h
	16113584	137056	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
	CHEMBL375568	137056	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	441	7	5	4	3.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)[nH]1	10.1021/jm070024h
	44389168	64527	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL182154	64527	0	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	457	4	1	4	5.8	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCC1	10.1016/j.bmcl.2004.11.075
	11314908	141268	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL386290	141268	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	377	7	3	6	3.4	CCC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	11846627	79299	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL211581	79299	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	363	6	3	6	3.0	CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	10929048	68450	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL19220	68450	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	90666020	108802	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218893	108802	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	500	7	0	9	3.5	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	16114403	146642	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392805	146642	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCCN2)cc1	10.1021/jm0704550
	57422673	112954	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319282	112954	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	474	4	2	7	4.1	CS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccc4)ccc3Cl)sc2c1	10.1021/jm500610n
	70684154	75501	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048809	75501	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	122180020	121054	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586026	121054	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	16113710	78736	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113325	78736	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.5	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1)C1CCNCC1	10.1021/jm0704550
	122178611	120821	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581044	120821	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	3	7	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2O)cc1	10.1016/j.bmcl.2014.11.031
	122178614	120824	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581047	120824	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	660	13	2	7	6.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2C(=O)c2ccccc2)cc1	10.1016/j.bmcl.2014.11.031
	16114531	84238	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222498	84238	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	553	14	4	5	6.1	CCCCCCn1c(CCCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	145974293	162462	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162462	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	46882197	5650	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078403	5650	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	10	4	4	4.1	CCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44409980	75812	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205790	75812	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	425	8	3	7	3.7	CCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145952740	161939	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161939	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	44409868	76374	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206673	76374	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	487	9	3	7	4.9	CCc1nc(N)nc(NCc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	156017532	177324	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177324	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11605822	123856	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363930	123856	1	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	503	9	1	6	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCO2)cc1	10.1016/j.bmcl.2004.06.060
	162651761	179619	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	CHEMBL4749698	179619	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	798	19	7	8	3.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccncc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	70686292	75512	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048819	75512	0	None	-	1	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	10186158	97977	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL275660	97977	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	122178602	120811	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581035	120811	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2Br)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL500468	212334	0	None	-	1	Human	6.6	pIC50	=	6.6	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm8014519
	CHEMBL3586019	210044	4	None	-	0	Rat	6.6	pIC50	=	6.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCCNC(=N)N)C(N)=O	10.1016/j.bmcl.2015.04.040
	122180025	121059	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586031	121059	0	None	-	0	Rat	5.6	pIC50	=	5.6	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	156017532	177324	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4645072	177324	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145952740	161939	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	CHEMBL4167481	161939	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	3	5	3.0	Cn1c(C(=O)N[C@H]2Cc3ccccc3[C@@H]2NC(=O)c2cnccc2N)cc2ccccc21	10.1021/acs.jmedchem.8b00322
	145974293	162462	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175823	162462	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	432	4	2	5	2.0	CN1CCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44436881	91142	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
	CHEMBL240746	91142	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	540	10	4	6	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1cccs1)C1CCNCC1	10.1021/jm0704550
	122182189	121481	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121481	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	122180016	121050	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586022	121050	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	46882199	5669	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078498	5669	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	438	7	4	4	4.4	CC(C)(N)Cc1ccc(NS(=O)(=O)c2ccc(NC(=O)Nc3ccccc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44301462	11142	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179075	11142	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL58758	11142	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	623	15	4	9	0.2	CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	90666042	108824	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	CHEMBL3218915	108824	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	550	8	0	9	4.4	Cc1ncccc1-c1nc2cn(-c3cccc(OC(F)F)c3)nc2c(=O)n1C[C@H]1CCCN(C[C@H]2CCCO2)C1	10.1039/C2MD20340E
	25262771	112952	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319280	112952	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	3	7	3.7	CC(C)NCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	42624370	188240	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582537	188240	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935104	188240	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL506624	188240	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1797	64	25	24	-7.0	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44445617	154126	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399649	154126	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	11163070	65222	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
	CHEMBL183123	65222	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	322	5	1	2	4.3	CCN(CC)c1ccc(NC(=O)C2CCc3ccccc3C2)cc1	10.1021/jm0491750
	156012428	176726	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
	CHEMBL4636832	176726	0	None	-	0	Human	4.6	pIC50	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	649	10	1	10	4.6	CCOc1cc(Cl)c(C(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)cc1N1C[C@H](C)O[C@H](C)C1	10.1016/j.bmcl.2020.126953
	46882766	5581	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077839	5581	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44436813	146762	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL392902	146762	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	11	4	5	4.5	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](C)N)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44410013	76685	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207268	76685	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.5	CCCCNc1nc(N)nc(CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44235473	81191	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163478	81191	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	44235473	81191	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163478	81191	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	10	9	0.9	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409839	75890	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205847	75890	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	412	7	4	8	2.0	CNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16114099	136687	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL375103	136687	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	10	4	5	5.5	Cc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113372	78729	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113319	78729	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCN2)cc1	10.1021/jm0704550
	46882273	5726	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078982	5726	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	494	10	4	4	5.8	CCCCc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	122182044	121472	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593633	121472	0	None	-	0	Rat	7.6	pIC50	=	7.6	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	552	9	2	6	4.9	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	121879	2195	19	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2195	19	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2195	19	None	-	1	Human	5.6	pIC50	=	5.6	Binding	Inhibition against human growth hormone secretagogue (GHS) receptorInhibition against human growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL2370788	208166	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm020985q
	145950261	162167	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162167	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44394974	66662	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL186974	66662	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCOCC2)cc1	10.1016/j.bmcl.2004.06.060
	44445615	161308	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL414929	161308	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113370	78734	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL2113323	78734	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H]2CCCCN2)cc1	10.1021/jm0704550
	145953016	162025	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162025	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	156012445	176751	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176751	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	10186158	97977	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL275660	97977	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N(C)[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	11617435	75629	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	CHEMBL205486	75629	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	359	5	3	6	4.2	CCc1nc(N)nc(N)c1-c1ccc(NCc2csc(Cl)c2)cc1	10.1021/jm0510934
	70696689	75514	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048821	75514	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	70694647	75500	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048808	75500	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	380	6	0	4	3.2	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	56942242	124662	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
	CHEMBL3645257	124662	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	nan
	122178605	120814	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581038	120814	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	574	11	2	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2014.11.031
	44445611	154125	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399648	154125	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	556	11	2	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	122182189	121481	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121481	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from human ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	56942385	124665	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL3645260	124665	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	nan
	CHEMBL501261	212354	19	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1074/jbc.m609796200
	56942099	124661	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	CHEMBL3645256	124661	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	nan
	56942243	124663	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
	CHEMBL3645258	124663	0	None	-	1	Human	8.5	pIC50	=	8.5	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	nan
	122178608	120818	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581041	120818	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	570	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(C)n2)cc1	10.1016/j.bmcl.2014.11.031
	44409673	76382	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL206741	76382	0	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	493	9	3	9	3.9	Cc1ccc(COCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(S(C)(=O)=O)cc3)cc2)o1	10.1016/j.bmcl.2006.01.012
	CHEMBL105462	206716	34	None	-	1	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11690097	76304	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL206446	76304	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	6	2	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(N(C)Cc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	57422695	112964	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319401	112964	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	574	10	2	9	4.6	CCN(CC)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3cc(-n4cccn4)ccc3Cl)sc2c1	10.1021/jm500610n
	25124566	1836	6	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	5870	1836	6	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	CHEMBL3358452	1836	6	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	487	5	2	5	4.1	O=C([C@@H](c1cccnc1)N1CCN2[C@@H](C1)CCC2)NNc1cc(cc(c1)C(F)(F)F)C(F)(F)F	10.1021/jm5003183
	156013219	176905	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176905	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145957574	161739	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161739	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	46882805	5732	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079046	5732	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	474	13	4	4	5.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC)cc2)cc1	10.1016/j.bmcl.2009.08.076
	53390538	91831	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426681	91831	0	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	178024	1932	30	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	5867	1932	30	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	CHEMBL13817	1932	30	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1016/s0960-894x(99)00584-3
	44445629	161339	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL415136	161339	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	559	10	2	8	4.9	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16204239	135748	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL373393	135748	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	11508639	76167	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL206091	76167	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	216208	9620	27	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL113313	9620	27	None	-	1	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(99)00584-3
	11846630	138393	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378438	138393	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	426	7	3	7	3.7	Nc1nc(N)c(-c2ccc(NC(=O)c3ccncc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	156012445	176751	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637284	176751	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4cnccn4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145953016	162025	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4168863	162025	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	5	2	4	3.2	CN1CCC[C@H]1CC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1ccc2c(ccn2C)c1	10.1021/acs.jmedchem.8b00322
	145949755	162372	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162372	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	16204241	83993	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL221996	83993	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	11	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1CCc1ccccc1	10.1021/jm070024h
	11221946	140302	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	CHEMBL381942	140302	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm0510934
	11221946	140302	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	CHEMBL381942	140302	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	353	5	3	5	4.1	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(Cl)cc2)cc1	10.1021/jm060461g
	46882104	5863	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079873	5863	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CCC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	145956415	161502	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161502	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145950261	162167	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4171137	162167	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11654867	75833	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205833	75833	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	429	7	3	5	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)cc3)cc2)c(CCc2ccccc2)n1	10.1021/jm0510934
	10415364	126233	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126233	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	178024	1932	30	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	5867	1932	30	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	CHEMBL13817	1932	30	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm020985q
	16114404	154346	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL400814	154346	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1016/j.bmcl.2014.11.031
	90666014	108796	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL3218887	108796	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	466	5	0	7	4.6	Cc1ccccc1-c1nc2cn(-c3cccc(C#N)c3)nc2c(=O)n1CC1CCCN(C(C)C)C1	10.1039/C2MD20340E
	44436885	145884	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
	CHEMBL392191	145884	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	634	12	6	8	3.6	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2c[nH]c3ccccc23)c(OC)c1	10.1021/jm0704550
	44436829	151934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397109	151934	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	16114404	154346	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL400814	154346	18	None	-	1	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	122182047	121475	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121475	0	None	-	0	Rat	7.5	pIC50	=	7.5	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	70684155	75517	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048824	75517	0	None	-	1	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2163483	207570	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163483	207570	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44409872	74701	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203581	74701	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	7	2	8	3.1	CCc1nc(N)nc(N2CCOCC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44445596	154094	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL399448	154094	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	558	10	2	7	5.5	COc1ccc(-n2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16113692	136699	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL375162	136699	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm070024h
	118709504	112967	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319404	112967	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	572	5	2	9	4.3	Cc1ccnn1-c1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	10907396	98680	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	CHEMBL281147	98680	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	515	10	7	5	1.2	NC1(C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)N[C@H](Cc2c[nH]c3ccccc23)NC=O)CCNCC1	10.1021/jm020985q
	11677781	124525	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL364430	124525	1	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	502	9	1	5	5.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN(C)C(C)=O)cc1	10.1016/j.bmcl.2004.06.060
	44445606	154463	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL401467	154463	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	625	12	3	7	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	44379034	12800	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1189120	12800	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL538068	12800	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	490	9	2	5	5.1	NCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44378986	12969	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190325	12969	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540603	12969	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	470	10	2	5	3.2	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11697618	62255	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178289	62255	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	427	6	1	4	5.5	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Br)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145956415	161502	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160541	161502	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	416	4	2	4	2.6	CN1CC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44436886	161394	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL415674	161394	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	595	12	5	8	3.2	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	145949755	162372	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174302	162372	0	None	-	0	Human	7.5	pIC50	=	7.5	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	425	4	4	4	3.3	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3NC(=O)c3cnccc3N)cc2c1	10.1021/acs.jmedchem.8b00322
	23648242	78731	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113320	78731	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	571	10	4	5	5.7	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	11606121	64230	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	CHEMBL181584	64230	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	523	6	2	6	5.9	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2004.11.075
	122180023	121057	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586029	121057	0	None	-	0	Rat	6.5	pIC50	=	6.5	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	44379301	12934	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1190091	12934	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL540093	12934	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	7	3.7	COC(=O)C(CCCCN)NC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Cl)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44338300	167269	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL430882	167269	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	525	10	1	6	4.0	CN(C)CCCN1C(=O)[C@H](Cc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44338239	167324	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL431245	167324	0	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	511	9	1	6	4.2	CN(C)CCCN1C(=O)[C@H](c2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44409762	75518	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204884	75518	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	441	9	4	8	2.7	CCc1nc(N)nc(NCCO)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180018	121052	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586024	121052	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	527	9	2	9	4.3	CCCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122182189	121481	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121481	0	None	-	0	Rat	7.4	pIC50	=	7.4	Binding	Antagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA methodAntagonist activity at ghrelin receptor in Sprague-Dawley rat primary pituitary cells assessed as inhibition of ghrelin-induced growth hormone secretion incubated for 15 mins by ELISA method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	10032659	11931	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL1183505	11931	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	CHEMBL301259	11931	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	587	11	4	8	-0.5	CS(=O)(=O)N1CC2(CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)[C@H](CO)NC(=O)CN)CC2)c2ccccc21	10.1016/s0960-894x(01)00324-9
	60195019	81178	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163464	81178	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	849	21	10	8	2.2	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](C)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	156009875	176539	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176539	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	11430583	79792	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL213704	79792	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	439	8	3	6	4.2	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11517629	167764	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL434330	167764	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	6	1	4	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C)c1	10.1016/j.bmcl.2004.11.075
	44409975	75423	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204835	75423	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	7	3	7	3.3	CCc1nc(N)nc(NC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	53391301	91828	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426678	91828	0	None	-	1	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN(C2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	90666019	108801	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218892	108801	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	464	7	0	8	3.8	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(C4CCCCC4)nc3c2=O)C1	10.1039/C2MD20340E
	11669486	64268	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	CHEMBL181736	64268	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	445	7	1	4	6.6	CCc1cc(N(CC)CC)ccc1NC(=O)c1c(-c2c(Cl)cccc2Cl)noc1C	10.1016/j.bmcl.2004.11.075
	59446141	81194	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163481	81194	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446141	81194	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163481	81194	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CCc1ccccc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436917	90204	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL239007	90204	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	4	5	5.3	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CCCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	60165265	115685	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
	CHEMBL3358453	115685	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	453	5	1	2	6.0	CC(NC(=O)N(Cc1ccccc1Cl)C1CCN(C)CC1)c1cccc(Cl)c1Cl	10.1021/jm5003183
	16113002	147769	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	CHEMBL393693	147769	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	577	12	4	7	4.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)c(OC)c1	10.1021/jm0704550
	44409678	140673	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382853	140673	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	490	9	3	9	3.4	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3cccnc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122178604	120813	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581037	120813	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccnc2N)cc1	10.1016/j.bmcl.2014.11.031
	10929048	68450	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL19220	68450	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	9	6	4	2.2	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	60195018	81177	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163463	81177	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	834	21	9	7	3.2	CCC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NN(CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44394913	126639	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365721	126639	1	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	537	10	1	5	7.5	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccccc2OC)cc1	10.1016/j.bmcl.2004.06.060
	11649248	66322	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL185399	66322	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	515	9	1	5	7.2	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	44394833	126291	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL365460	126291	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	542	9	1	5	6.7	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2C(=O)CCC2(C)C)cc1	10.1016/j.bmcl.2004.06.060
	11827047	98750	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	CHEMBL281578	98750	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	488	11	6	4	2.1	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC=O	10.1021/jm020985q
	42624359	192788	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	44582536	192788	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	91935103	192788	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	CHEMBL525751	192788	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cellsDisplacement of [125I]ghrelin from human growth hormone secretagogue receptor expressed in CHO-K1 cells	ChEMBL	1755	61	25	24	-8.1	CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CNC(=O)CCCCCCCCF)NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)C(C)C	10.1021/jm8014519
	156009875	176539	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633695	176539	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	499	8	3	7	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccnnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021942	177639	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177639	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	122180021	121055	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586027	121055	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	11134880	98959	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL282891	98959	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	500	10	6	4	2.1	O=CN[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	11846629	138277	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL378118	138277	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	419	7	3	7	3.1	Nc1nc(N)c(-c2ccc(NC(=O)C3CCCO3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	11114279	97784	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	CHEMBL274460	97784	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	544	12	6	4	3.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(=O)CC(C)C	10.1021/jm020985q
	145952396	162441	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162441	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	122178607	120817	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581040	120817	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	592	11	2	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncc(F)cc2F)cc1	10.1016/j.bmcl.2014.11.031
	156013219	176905	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639379	176905	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	404	6	3	3	2.6	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145957574	161739	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164328	161739	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	11846463	138699	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL378909	138699	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	422	5	2	8	2.7	CCc1nc(N)nc(N)c1-c1ccc2c(c1)ncn2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	9890863	131457	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL369533	131457	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)C(O)(c2ccccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	44409864	75133	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL204266	75133	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	502	9	3	8	4.0	CN(Cc1ccccc1)Cc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180027	121061	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586033	121061	0	None	-	0	Rat	8.4	pIC50	=	8.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	8	2	7	5.2	CC(C)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	11430392	76356	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	CHEMBL206588	76356	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	431	6	3	7	3.5	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Cl)c1	10.1021/jm0510934
	57785737	112930	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319216	112930	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	549	7	2	8	3.7	CN1CCCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390871	64496	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL182035	64496	0	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	503	7	2	4	4.0	CCN(CC)CCN1C(=O)[C@@](O)(c2c(Cl)cccc2Cl)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	70682037	75513	14	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048820	75513	14	None	43	2	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	156021297	177505	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177505	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	90666040	108822	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218913	108822	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	542	9	0	9	4.6	CCCOc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	90666026	108808	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218899	108808	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	16204021	84269	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL222710	84269	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	3	5	4.9	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(F)cc1	10.1021/jm070024h
	122180014	121048	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586020	121048	0	None	-	0	Rat	6.4	pIC50	=	6.4	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	90666016	108798	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
	CHEMBL3218889	108798	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	481	5	0	9	2.9	Cc1ncccc1-c1nc2cn(-c3ccc(C#N)cc3)nc2c(=O)n1CC1CCCN(C2COC2)C1	10.1039/C2MD20340E
	44389186	64269	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL181739	64269	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	379	7	1	5	4.8	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3OC)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338266	109831	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
	CHEMBL323974	109831	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	523	11	1	6	4.3	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=O	10.1016/j.bmcl.2003.11.012
	70692602	75508	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048815	75508	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	11455251	160755	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL412362	160755	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	523	8	3	7	5.0	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3Br)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	156021942	177639	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4649860	177639	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	475	8	3	5	1.1	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)C4CC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	16204037	136696	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL375150	136696	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	522	10	3	6	4.5	COc1ccccc1Cn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	11582836	62569	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178463	62569	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	431	7	1	4	6.4	CCCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389131	63117	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL179812	63117	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	485	6	1	4	7.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C(F)(F)F)c1	10.1016/j.bmcl.2004.11.075
	122180025	121059	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586031	121059	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	542	7	2	8	3.6	CC(=O)N1CC=C(c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)CC1	10.1016/j.bmcl.2015.04.040
	122178612	120822	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581045	120822	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	572	11	2	6	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc[n+]2[O-])cc1	10.1016/j.bmcl.2014.11.031
	16203237	96490	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	CHEMBL266199	96490	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	496	10	3	6	4.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccco1	10.1021/jm070024h
	44582531	188126	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	91935100	188126	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	CHEMBL504776	188126	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL	3368	117	49	47	-15.3	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	59446148	174467	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4567800	174467	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(CC1CCCCC1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	46882152	5763	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079302	5763	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	432	12	4	4	4.1	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	11655355	74057	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL202642	74057	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3ccc(Cl)s3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145952396	162441	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	CHEMBL4175534	162441	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	434	9	3	5	2.3	COCCNCCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2n1C	10.1021/acs.jmedchem.8b00322
	46882764	5540	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1077716	5540	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	375	9	3	3	4.2	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccccc2)cc1	10.1016/j.bmcl.2009.08.076
	16114290	136671	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374992	136671	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	534	11	3	5	5.3	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	90666015	108797	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218888	108797	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	483	7	0	9	3.2	COCCN1CCCC(Cn2c(-c3cccnc3C)nc3cn(-c4ccc(C#N)cc4)nc3c2=O)C1	10.1039/C2MD20340E
	44436831	151452	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL396681	151452	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	12	4	7	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	25262608	112951	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
	CHEMBL3319279	112951	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	6	2	7	3.8	O=C(NC(=O)c1ccccc1Cl)Nc1nc2ccc(S(=O)(=O)CCN3CCCC3)cc2s1	10.1021/jm500610n
	10918326	98502	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	CHEMBL279822	98502	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	516	10	5	4	2.8	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N(C)C	10.1021/jm020985q
	16203918	84349	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	CHEMBL223239	84349	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	570	9	3	5	5.3	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccc(Br)cc1	10.1021/jm070024h
	70696687	75505	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048812	75505	0	None	-	1	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	46882105	6259	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1082044	6259	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)CN)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44446189	154823	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL403426	154823	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	618	11	3	7	6.3	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OC2CCOCC2)cc1	10.1016/j.bmcl.2007.10.113
	44446157	94202	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252501	94202	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	594	13	3	8	4.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](CC(=O)OCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	44446148	154867	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL403683	154867	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	44410008	140707	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL383058	140707	0	None	-	0	Human	6.4	pIC50	=	6.4	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	9	2	7	4.2	CCc1nc(N)nc(N(CC)CC)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	59446143	81174	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	CHEMBL2163448	81174	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	59446143	81174	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163448	81174	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	802	17	11	8	0.6	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	44338221	7951	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL109094	7951	0	None	-	0	Human	4.4	pIC50	=	4.4	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	581	11	1	7	4.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=S)N1CCCN1CCOCC1	10.1016/j.bmcl.2003.11.012
	60195113	81181	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
	CHEMBL2163467	81181	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	787	17	9	7	2.5	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(N)=O	10.1021/jm300557t
	46882804	5731	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079045	5731	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	446	11	4	4	4.5	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	10864048	97923	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL275373	97923	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.6	CCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	156016110	177114	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4642043	177114	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	628	7	1	9	5.1	CCOc1cc(Cl)c(-c2ccc(-c3nc4ccc(S(=O)(=O)C5CCN(C)CC5)cc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	156017268	177066	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177066	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	59446118	174118	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4559602	174118	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195285	81186	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163473	81186	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)N(Cc1cccc2ccccc12)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44436868	145538	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391922	145538	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	520	9	4	5	4.6	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1c1ccccc1)C1CCNCC1	10.1021/jm0704550
	44394947	168646	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL440939	168646	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	551	9	1	6	7.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)cc1	10.1016/j.bmcl.2004.06.060
	122180022	121056	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586028	121056	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	504	7	2	9	2.8	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2CCOCC2)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	11751384	140962	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL384524	140962	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	453	9	3	6	4.6	Nc1nc(N)c(-c2ccc(NC(=O)CCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	122180026	121060	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586032	121060	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	566	7	2	7	4.4	CC(=O)N1[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmcl.2015.04.040
	122182043	121471	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593632	121471	0	None	-	0	Rat	7.3	pIC50	=	7.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	580	7	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCC5)c(C(=O)NC[C@H]4COc5ccccc5O4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	16204226	84361	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223323	84361	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	486	12	3	5	5.1	CCCCCCn1c(Cc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	118709472	112950	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
	CHEMBL3319277	112950	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	409	3	2	6	3.3	CS(=O)(=O)c1ccc2sc(NC(=O)NC(=O)c3ccccc3Cl)nc2c1	10.1021/jm500610n
	46882196	5649	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078402	5649	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	9	4	4	3.7	CCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	44379303	12715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188529	12715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL536706	12715	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	468	11	2	5	4.1	NCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(-c3ccccc3)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL2310893	207741	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)C(C)C	10.1021/jm0001727
	44445614	168732	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL441567	168732	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2cccnc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	44445598	93927	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL250807	93927	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	9	3	5	6.5	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	145949381	162153	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162153	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	44436832	151454	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL396682	151454	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	548	11	4	5	4.9	CCc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	44445626	96606	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL267197	96606	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	573	11	2	8	4.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	90666025	108807	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218898	108807	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	516	9	0	9	4.1	CCO[C@@H](C)CN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	156012122	176797	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176797	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156012122	176797	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4637980	176797	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156021297	177505	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4647797	177505	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	511	8	3	5	2.0	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)c4ccccc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	90666024	108806	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218897	108806	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	57422776	112932	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	CHEMBL3319218	112932	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	559	7	2	8	3.3	C#Cc1ccc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)CCCN4CCN(C)CC4)cc3s2)c1	10.1021/jm500610n
	162657463	180448	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	CHEMBL4759415	180448	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting methodDisplacement of [125I-His9]-ghrelin from GHS-R1a (unknown origin) expressed in human HEK293 cells incubated for 20 mins by gamma scintillation counting method	ChEMBL	783	20	7	7	4.0	NCCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC[C@@H](Cc1ccc2ccccc2c1)NC(=O)C1CCNCC1)C(N)=O	10.1016/j.ejmech.2016.07.078
	44409990	76149	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205995	76149	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	481	12	3	7	5.2	CCCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122180024	121058	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586030	121058	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	44409758	75606	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205374	75606	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	411	6	3	7	3.4	CC(C)c1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	122182190	121482	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	CHEMBL3593815	121482	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	507	7	3	6	4.7	Cc1ccc(CNC(=O)c2cc(C#CC(C)(C)O)cnc2NCc2ccc3c(c2)OCO3)cc1C(F)F	10.1016/j.bmc.2015.05.047
	44409684	140341	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL382033	140341	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	474	8	4	8	3.9	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16113003	94296	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
	CHEMBL253126	94296	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm701292s
	16113003	94296	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
	CHEMBL253126	94296	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	617	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)c(OC)c1	10.1021/jm0704550
	122182047	121475	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121475	0	None	-	0	Rat	8.3	pIC50	=	8.3	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	90666030	108812	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218903	108812	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	486	7	0	8	4.3	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC(C)C)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	11605333	76357	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	CHEMBL206589	76357	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	475	6	3	7	3.6	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)c(Br)c1	10.1021/jm0510934
	122182046	121474	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121474	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	11281346	75650	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL205568	75650	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	411	8	3	6	4.6	Nc1nc(N)c(-c2ccc(NCc3ccccc3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	145949381	162153	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4170865	162153	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	411	4	4	4	3.0	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	16204145	136016	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
	CHEMBL373772	136016	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	492	9	3	5	4.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1Cc1ccccc1	10.1021/jm070024h
	90666036	108818	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218909	108818	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	479	8	0	8	3.7	COc1cccc(-n2cc3nc(CC(C)C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	44338235	109161	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL322499	109161	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	546	7	3	6	4.1	O=C1[C@H](Cc2c[nH]c3ccccc23)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1C1CCNCC1	10.1016/j.bmcl.2003.11.012
	156016392	177062	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177062	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156017268	177066	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641472	177066	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	497	8	3	5	1.6	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)c4ccccc4)C[C@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145958317	161751	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161751	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145949880	162229	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162229	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	145950963	162244	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162244	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	156016392	177062	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641386	177062	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	476	7	3	5	1.8	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(C(=O)c4cccnc4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	44445608	154464	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL401468	154464	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	554	11	2	5	6.0	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	59446116	81172	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163439	81172	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	777	17	9	8	0.8	C[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)N(Cc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	23631387	92821	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	CHEMBL244936	92821	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	409	4	0	4	5.1	Cc1nc2ccc(-c3ccc(Cl)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1039/C2MD20340E
	90666038	108820	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	CHEMBL3218911	108820	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1ccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	44421230	84353	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL223269	84353	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	546	8	3	5	5.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1-c1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	156018460	177293	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	CHEMBL4644587	177293	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	468	5	1	7	4.6	CCOc1cc(Cl)c(-c2ncc(-c3nc4ccccc4s3)c(=O)[nH]2)cc1N1CCOCC1	10.1016/j.bmcl.2020.126953
	145950963	162244	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172411	162244	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	11618705	166374	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL428698	166374	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	423	6	1	4	5.3	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)CC1	10.1016/j.bmcl.2004.06.060
	44436842	146393	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL392592	146393	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.6	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCCN2)cc1	10.1021/jm0704550
	CHEMBL509976	213794	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)N)C(N)=O	10.1074/jbc.m609796200
	CHEMBL450217	212203	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrsDisplacement of [35S]MK677 from human ghrelin receptor expressed in COS-7 cells incubated for 3 hrs	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300414b
	CHEMBL450217	212203	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12)C(N)=O	10.1074/jbc.m609796200
	10984270	98042	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL276137	98042	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44436884	91107	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL240522	91107	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	5	7	3.1	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CNCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL444131	212171	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		NC(=O)CNC(=O)CNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](N)Cc1c[nH]c2ccccc12	10.1074/jbc.m609796200
	60195020	81179	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163465	81179	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	835	21	10	8	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	59446112	172395	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4517723	172395	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	840	21	10	9	1.3	C[C@H](NC(=O)N(CC1CCCCC1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL422461	211528	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm0001727
	16114010	135747	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL373392	135747	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	613	10	4	5	6.5	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	16203349	165726	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL427076	165726	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	12	3	6	4.9	COc1ccc(CCn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	11531313	62160	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178137	62160	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	394	7	1	6	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3[N+](=O)[O-])noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44389283	62601	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178494	62601	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	403	5	1	4	5.7	CCN(C)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	122180019	121053	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586025	121053	0	None	-	0	Rat	5.3	pIC50	=	5.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	513	8	2	9	3.9	CCn1cc(-c2cnc(NCc3ccc4c(c3)OCO4)c(C(=O)NC[C@@H]3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL447282	212190	0	None	-	0	Human	4.3	pIC50	=	4.3	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(N)=O	10.1021/jm8014519
	145958317	161751	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4164531	161751	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	430	4	2	4	3.0	CN1CCC[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	16114008	84408	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL223532	84408	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1ccccc1Cn1c(CCc2ccccc2)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	16112910	135841	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL373507	135841	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	16112910	135841	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL373507	135841	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	44436882	145471	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	CHEMBL391859	145471	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	10	4	6	4.2	O=C(N[C@H](Cc1c[nH]c2ccccc12)C1=NNC(CCc2ccccc2)N1Cc1ccco1)C1CCNCC1	10.1021/jm0704550
	145949880	162229	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4172217	162229	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	390	6	3	3	2.3	CN(C)CCNC(=O)[C@@H]1c2ccccc2C[C@H]1NC(=O)c1cc2ccccc2[nH]1	10.1021/acs.jmedchem.8b00322
	122180024	121058	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586030	121058	0	None	-	0	Rat	6.3	pIC50	=	6.3	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	530	7	2	9	3.4	O=C(NC[C@H]1COc2ccccc2O1)c1cc(N2C[C@@H]3CC[C@H](C2)O3)cnc1NCc1ccc2c(c1)OCO2	10.1016/j.bmcl.2015.04.040
	46882154	5769	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079323	5769	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	390	7	4	4	2.9	CCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	59446145	81173	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163444	81173	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446145	81173	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163444	81173	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	793	19	11	8	0.8	C[C@H](N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)NNC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	11699004	65856	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL184429	65856	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	501	9	1	5	6.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2CCCO2)cc1	10.1016/j.bmcl.2004.06.060
	11537800	75201	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL204564	75201	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	361	6	3	6	3.7	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(C(C)=O)cc2)cc1	10.1021/jm0510934
	16203236	165698	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
	CHEMBL426905	165698	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	512	10	3	6	4.8	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1cccs1	10.1021/jm070024h
	10207327	66721	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL18725	66721	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	44445603	154429	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL401259	154429	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	572	11	2	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccncc2)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL502208	212369	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1074/jbc.m609796200
	16113583	161190	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL413856	161190	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	469	8	4	5	3.7	Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	90665849	108775	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218649	108775	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	508	7	0	7	5.5	COCCN1CCC[C@@H](Cn2c(-c3ccccc3C)nc3nc(-c4ccc(Cl)cc4)sc3c2=O)C1	10.1039/C2MD20340E
	70696688	75511	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048818	75511	0	None	-	1	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	44436816	91359	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241242	91359	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	524	12	4	6	3.9	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CCN)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	10984270	98042	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	CHEMBL276137	98042	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	530	11	6	4	3.3	CC(C)CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm020985q
	44301387	11144	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1179088	11144	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL59572	11144	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	11692087	62648	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL178610	62648	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.06.060
	122178610	120820	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581043	120820	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	571	11	3	7	5.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cccc(N)n2)cc1	10.1016/j.bmcl.2014.11.031
	16113695	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
	CHEMBL374643	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm701292s
	16113695	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL374643	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	16113695	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL374643	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	16113695	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
	CHEMBL374643	136490	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm0704550
	44436888	152510	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL397593	152510	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	565	11	3	6	5.0	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCOCC3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	11692087	62648	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178610	62648	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	517	9	1	6	6.4	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)cc1	10.1016/j.bmcl.2004.11.075
	44409809	74700	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203578	74700	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	453	10	3	7	4.4	CCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44409989	165262	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL424860	165262	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	467	11	3	7	4.8	CCCCCCCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL105462	206716	34	None	-	1	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	90666018	108800	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	CHEMBL3218891	108800	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	488	8	0	9	3.3	COCCN1CCC[C@H](Cn2c(-c3cccnc3C)nc3cn(-c4cccc(OC)c4)nc3c2=O)C1	10.1039/C2MD20340E
	11612155	140465	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	CHEMBL382375	140465	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	451	8	3	7	5.4	Nc1nc(N)c(-c2ccc(NCc3csc(Cl)c3)cc2)c(COCc2ccccc2)n1	10.1021/jm0510934
	118722878	115684	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
	CHEMBL3358451	115684	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Antagonist activity against human ghrelin receptor by FLIPR assayAntagonist activity against human ghrelin receptor by FLIPR assay	ChEMBL	494	5	2	4	4.8	CN1CCN([C@@H](C(=O)NNc2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccccc2Cl)CC1	10.1021/jm5003183
	16114097	78732	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	CHEMBL2113321	78732	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	631	12	4	7	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCCNC2)c(OC)c1	10.1021/jm0704550
	122182189	121481	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593814	121481	0	None	-	0	Rat	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	548	8	3	7	4.3	COc1ccc(CNC(=O)c2cc(C#CC(C)(C)NC(C)=O)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	25260901	112968	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319405	112968	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	577	5	2	9	3.6	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(N5CCOCC5)ccc4Cl)sc3c2)CC1	10.1021/jm500610n
	122180021	121055	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	CHEMBL3586027	121055	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	528	7	2	7	4.9	O=C(NCC1COc2ccccc2O1)c1cc(-c2ccnc(Cl)c2)cnc1NCc1ccc2c(c1)OCC2	10.1016/j.bmcl.2015.04.040
	11179347	76985	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL208477	76985	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	490	9	2	8	4.0	CS(=O)(=O)c1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44445593	154237	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	CHEMBL400174	154237	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	552	11	3	7	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)C(C)(C)N)c2c[nH]c3ccccc23)c(OC)c1	10.1021/jm701292s
	16203569	141189	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL385803	141189	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	90666034	108816	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218907	108816	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.7	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCOC5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL449590	212202	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cellsDisplacement of [35S]MK677 from human ghrelin receptor expressed in african green monkey COS7 cells	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(=O)O)C(N)=O	10.1074/jbc.m609796200
	121879	2195	19	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2195	19	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2195	19	None	-	1	Rat	7.2	pIC50	=	7.2	Binding	Inhibition against rat growth hormone secretagogue (GHS) receptorInhibition against rat growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	11568561	168976	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL443560	168976	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	447	7	1	5	6.1	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(OC)c1	10.1016/j.bmcl.2004.11.075
	44338246	98385	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL278909	98385	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	563	11	1	6	5.2	O=C1[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C(=O)N1CCCN1CCCCC1	10.1016/j.bmcl.2003.11.012
	CHEMBL105462	206716	34	None	-	1	Human	5.2	pIC50	=	5.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1016/s0960-894x(99)00584-3
	44409767	156688	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL407647	156688	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	437	8	3	7	3.9	CCc1nc(N)nc(NC2CC2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44445612	96580	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
	CHEMBL266964	96580	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	565	10	3	5	5.9	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccccc1	10.1021/jm701292s
	44410003	75813	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205794	75813	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	468	10	4	8	3.5	CC(C)CCNCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16203569	141189	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL385803	141189	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	12	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL18872	207304	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H](Cc1c(C)[nH]c2ccccc12)NC(=O)C(C)(C)N)C(N)=O	10.1021/jm300557t
	46882106	5770	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079340	5770	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	418	11	4	4	3.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2cccc(CCN)c2)cc1	10.1016/j.bmcl.2009.08.076
	44436876	146474	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	CHEMBL392663	146474	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	580	11	4	7	4.6	COc1ccc(N2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)=NNC2CCc2ccccc2)c(OC)c1	10.1021/jm0704550
	121879	2195	19	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	5868	2195	19	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	CHEMBL308716	2195	19	None	-	1	Pig	7.2	pIC50	=	7.2	Binding	Inhibition against pig growth hormone secretagogue (GHS) receptorInhibition against pig growth hormone secretagogue (GHS) receptor	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm0309452
	156010733	176496	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176496	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145962494	161513	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	161513	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	145950201	162380	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162380	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44409832	76042	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205955	76042	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	398	6	4	8	1.8	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CN)cc2)cc1	10.1016/j.bmcl.2006.01.012
	16204237	84459	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	CHEMBL223638	84459	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	574	10	3	5	6.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(Cl)c(Cl)c1	10.1021/jm070024h
	16204343	136654	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
	CHEMBL374918	136654	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	635	12	4	5	7.0	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CC(c1ccccc1)c1ccccc1	10.1021/jm070024h
	122178613	120823	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581046	120823	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	625	12	2	7	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccc(N3CCCC3)cn2)cc1	10.1016/j.bmcl.2014.11.031
	57422749	112927	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319213	112927	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	492	4	2	7	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44410007	76059	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL205963	76059	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	438	8	4	8	2.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNC3CC3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	118718706	114867	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL3350011	114867	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	89768546	148473	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
	CHEMBL3942511	148473	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of ghrelin receptor (unknown origin) by radioligand binding assayInhibition of ghrelin receptor (unknown origin) by radioligand binding assay	ChEMBL	438	4	2	5	5.5	Cc1nnc2sc(C(=O)NCc3ccc(S(F)(F)(F)(F)F)cc3)c(N)c2c1C	10.1016/j.bmcl.2016.11.086
	16114011	137597	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	CHEMBL376736	137597	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	563	10	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1Cc1ccc(F)cc1	10.1021/jm070024h
	11349789	78348	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL211265	78348	1	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	389	7	3	6	3.4	Nc1nc(N)c(-c2ccc(NC(=O)C3CC3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	16112909	143737	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL390503	143737	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	561	10	4	6	5.0	COc1ccc(Cn2c(Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	44378837	12896	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1189851	12896	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL539575	12896	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	484	11	2	5	3.6	NCCCCCCNC(=O)Cn1c(CCc2ccccc2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	44445597	94067	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL251640	94067	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	540	10	2	5	6.1	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	11176805	76966	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	CHEMBL208374	76966	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	391	7	3	6	4.5	CC(C)(C)CNc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm0510934
	156010733	176496	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4633062	176496	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	520	8	3	6	0.2	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	46882153	5768	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1079322	5768	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	528	13	4	4	5.7	CCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)NCC(F)(F)F)cc2)cc1	10.1016/j.bmcl.2009.08.076
	145950201	162380	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4174476	162380	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	46882239	5692	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078700	5692	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1cccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)c1	10.1016/j.bmcl.2009.08.076
	1221269	121507	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359530	121507	12	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44446177	94197	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252448	94197	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	601	11	4	6	5.5	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1016/j.bmcl.2007.10.113
	16114289	98199	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	CHEMBL277376	98199	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	562	11	3	6	5.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCNC2)cc1	10.1021/jm0704550
	11538533	74636	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	CHEMBL203280	74636	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm060461g
	10415364	126233	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL365294	126233	0	None	-	0	Mouse	8.2	pIC50	=	8.2	Binding	Inhibitory concentration against mouse Growth hormone secretagogue receptorInhibitory concentration against mouse Growth hormone secretagogue receptor	ChEMBL	557	9	1	6	6.5	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCc2ccc3c(c2)OCO3)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL263544	208820	0	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(N)=O	10.1021/jm0001727
	122180023	121057	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586029	121057	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	530	7	2	8	3.8	C[C@H]1CN(c2cnc(NCc3ccc4c(c3)OCC4)c(C(=O)NC[C@H]3COc4ccccc4O3)c2)C[C@@H](C)O1	10.1016/j.bmcl.2015.04.040
	118709507	112971	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319408	112971	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	547	4	2	8	3.8	CN1CCC(S(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc5c(cc4Cl)CCN5C)sc3c2)CC1	10.1021/jm500610n
	90666011	108793	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	CHEMBL3218884	108793	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	471	6	0	7	4.7	COc1ccc(-n2cc3nc(-c4ccccc4C)n(CC4CCCN(C(C)C)C4)c(=O)c3n2)cc1	10.1039/C2MD20340E
	11538533	74636	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203280	74636	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	44409998	137994	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL377515	137994	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	413	7	3	8	2.5	COCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	90666021	108803	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218894	108803	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	514	7	0	9	3.9	COc1cccc(-n2cc3nc(-c4cccnc4C)n(C[C@H]4CCCN(CC5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	11453509	75810	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL205784	75810	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	441	9	3	7	4.6	COc1ccc(CNc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	44445610	161162	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL413608	161162	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	23648249	78737	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	CHEMBL2113326	78737	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	557	9	4	5	5.4	O=C(N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1-c1ccccc1)C1CCNCC1	10.1021/jm0704550
	11178309	79476	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL212415	79476	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	445	8	3	7	4.3	Nc1nc(N)c(-c2ccc(NC(=O)Cc3ccsc3)cc2)c(COCc2ccccc2)n1	10.1021/jm060461g
	CHEMBL3578018	210012	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578018	210012	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	44445613	93740	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
	CHEMBL249662	93740	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	512	9	2	5	5.4	O=C(Cc1ccccn1)N[C@H](c1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1-c1ccccc1	10.1021/jm701292s
	16204229	83886	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL221569	83886	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	545	10	4	5	5.2	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(Cc2ccccc2)n1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	44409867	76373	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL206672	76373	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	473	8	3	7	5.0	CCc1nc(N)nc(Nc2ccccc2)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	145962494	161513	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	CHEMBL4160705	161513	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	446	4	2	5	2.4	CN1CCCO[C@H](C(=O)N[C@H]2c3ccccc3C[C@@H]2NC(=O)c2ccc3c(ccn3C)c2)C1	10.1021/acs.jmedchem.8b00322
	44389215	62734	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL178838	62734	0	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	383	6	1	4	5.4	CCN(CC)c1ccc(NC(=O)c2c(-c3ccc(Cl)cc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	11211892	79791	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	CHEMBL213703	79791	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	405	8	3	6	4.0	CC(C)CC(=O)Nc1ccc(-c2c(N)nc(N)nc2COCc2ccccc2)cc1	10.1021/jm060461g
	122180015	121049	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586021	121049	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	523	9	2	8	5.3	CCCn1cc(-c2cnc(NCc3ccc4occc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	59446138	81195	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163482	81195	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	59446138	81195	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163482	81195	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	884	21	10	9	2.1	C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)NN(Cc1cccc2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	59446127	172457	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4518972	172457	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	60195286	81187	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163474	81187	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	848	22	10	9	1.0	C[C@H](NC(=O)N(CCc1ccccc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	10207327	66721	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	CHEMBL18725	66721	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL	502	10	6	4	2.5	CNC(C)(C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1c[nH]c2ccccc12)NC(C)=O	10.1021/jm020985q
	16112911	84291	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	CHEMBL222835	84291	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	619	13	4	7	5.6	COc1ccc(Cn2c(CCCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1021/jm070024h
	5311280	81183	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163470	81183	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	1035	25	11	10	2.4	Cc1[nH]c2ccccc2c1C[C@@H](NC(=O)[C@@H]1Cc2cccc3c2N1C(=O)[C@@H](N)CC3)C(=O)N[C@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	44389243	64237	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	CHEMBL181619	64237	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	557	7	1	6	6.2	O=C(Nc1ccccc1C(=O)N1CCCCC1)c1c(-c2c(Cl)cccc2Cl)noc1CCC1OCCCO1	10.1016/j.bmcl.2004.11.075
	23648232	90798	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	CHEMBL240179	90798	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	11	3	5	4.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/jm0704550
	44445616	161309	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL414930	161309	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	595	11	3	6	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccncc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	118709471	112948	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319275	112948	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	361	3	2	5	3.9	COc1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	44390889	64077	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL181313	64077	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	465	8	2	5	2.7	CCN(CC)CCN1C(=O)[C@@](O)(c2cccc(OC)c2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	46882270	5725	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078960	5725	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	452	7	4	4	4.7	Cc1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	156016696	177046	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177046	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL3578016	210010	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL2163348	207569	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL2163348	207569	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	16113800	137274	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL375972	137274	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	536	11	3	6	4.7	COc1cccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c1	10.1021/jm070024h
	CHEMBL3578016	210010	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)N[C@@H](CCCCNC(=O)CCCCCNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	156013130	176918	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176918	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	156016696	177046	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4641201	177046	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	478	8	3	5	0.4	Cc1ccc2[nH]c(C(=O)N[C@H]3CCN(S(=O)(=O)N(C)C)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	145950877	162433	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162433	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	44358041	160772	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	91931457	160772	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	CHEMBL412565	160772	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL	1724	59	24	24	-8.1	CCCCCCCC(=O)NC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	57422810	177077	2	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
	CHEMBL4641579	177077	2	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	602	7	2	10	4.4	CCOc1cc(Cl)c(C(=O)NC(=O)Nc2nc3ccc(S(=O)(=O)C4CCN(C)CC4)cc3s2)cc1-n1cccn1	10.1016/j.bmcl.2020.126953
	16113246	94226	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL252643	94226	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	11846624	77548	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	CHEMBL209443	77548	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of [125I]ghrelin binding to GHS receptor in CHO-K cellsInhibition of [125I]ghrelin binding to GHS receptor in CHO-K cells	ChEMBL	490	6	2	8	4.3	CCc1nc(N)nc(N)c1-c1ccc2c(c1)nc(C1CCCC1)n2Cc1ccc(S(C)(=O)=O)cc1	10.1021/jm060461g
	46882272	5718	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078900	5718	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	480	8	4	4	5.5	CC(C)c1ccc(NC(=O)Nc2ccc(S(=O)(=O)Nc3ccc(CC(C)(C)N)cc3)cc2)cc1	10.1016/j.bmcl.2009.08.076
	9987037	11912	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183385	11912	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL294324	11912	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	564	12	2	7	2.5	CCCCCCCC(=O)OC[C@@H](NC(=O)C(C)(C)N)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	56942537	124667	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
	CHEMBL3645262	124667	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Competitive Binding Assay: Competitive binding assay using ghrelin receptor.Competitive Binding Assay: Competitive binding assay using ghrelin receptor.	ChEMBL	551	12	2	6	6.3	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)OCC(C)C)cc1	nan
	57422761	112928	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319214	112928	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	510	10	3	8	3.3	COCCNCCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	57422760	112925	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	CHEMBL3319211	112925	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	480	7	2	7	3.6	CN(C)CCCS(=O)(=O)c1ccc2nc(NC(=O)NC(=O)c3ccccc3Cl)sc2c1	10.1021/jm500610n
	57422791	112940	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319226	112940	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	601	8	2	10	3.5	CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cccc(-n5cccn5)c4Cl)sc3c2)CC1	10.1021/jm500610n
	44445619	154127	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL399650	154127	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	5	6.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2ccccc2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16113469	136964	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL375408	136964	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	559	11	4	5	5.4	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2c[nH]c3ccccc23)n1CCc1ccccc1	10.1021/jm070024h
	CHEMBL501253	212352	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](COC(=O)CCCCCCCBr)NC(=O)[C@H](CO)NC(=O)CN)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O	10.1021/jm8014519
	122182045	121473	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593634	121473	0	None	-	0	Rat	7.1	pIC50	=	7.1	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	44446175	94533	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL254741	94533	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	566	13	3	7	4.7	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](COCc2ccccc2)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2007.10.113
	10994861	66920	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	CHEMBL18815	66920	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	514	9	6	4	2.5	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1CCNCC1	10.1021/jm020985q
	10984260	167779	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
	CHEMBL434391	167779	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligandBinding affinity towards cloned human Growth hormone secretagogue receptor type I in LLC PK-1 cells using [125I][His9]-ghrelin as radioligand	ChEMBL	529	9	7	5	1.6	CC(=O)N[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C1(N)CCNCC1	10.1021/jm020985q
	59446135	81189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	CHEMBL2163476	81189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	nan
	59446135	81189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	CHEMBL2163476	81189	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	859	21	12	9	0.7	NCCCC[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)NNC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(N)=O	10.1021/jm300557t
	59446154	81176	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
	CHEMBL2163453	81176	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	nan
	59446154	81176	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
	CHEMBL2163453	81176	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	858	19	10	8	2.0	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](C)C(N)=O	10.1021/jm300557t
	44446178	154572	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL402023	154572	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	595	11	3	6	6.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2007.10.113
	753168	122710	33	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL361366	122710	33	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	349	6	1	4	4.7	CCN(CC)c1ccc(NC(=O)c2c(-c3ccccc3)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	44338253	9182	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	CHEMBL110900	9182	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cellsInhibition of ghrelin binding to Growth hormone secretagogue receptor expressed in BHK cells	ChEMBL	539	11	1	6	4.4	CN(C)CCCN1C(=O)[C@H](CCc2ccccc2)N(Cc2ccc(-c3ccccc3-c3nn[nH]n3)cc2)C1=S	10.1016/j.bmcl.2003.11.012
	44301512	11902	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL1183340	11902	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	CHEMBL291333	11902	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL	566	13	3	8	1.0	CCCCCCCC(=O)OC[C@@H](NC(=O)[C@@H](N)CO)C(=O)N1CCC2(CC1)CN(S(C)(=O)=O)c1ccccc12	10.1016/s0960-894x(01)00324-9
	16113799	168137	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	CHEMBL436849	168137	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	605	12	4	7	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)c(OC)c1	10.1016/j.bmcl.2007.10.113
	11166495	75184	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	CHEMBL204474	75184	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	437	8	2	7	4.5	N#Cc1ccc(COc2ccc(-c3c(N)nc(N)nc3COCc3ccccc3)cc2)cc1	10.1021/jm0510934
	25262772	112953	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	CHEMBL3319281	112953	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting methodDisplacement of [125I]human ghrelin from human GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method	ChEMBL	521	6	2	8	2.9	CN1CCN(CCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4ccccc4Cl)sc3c2)CC1	10.1021/jm500610n
	44390869	121815	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	CHEMBL359922	121815	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Inhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparationInhibition of [125I]ghrelin binding to human recombinant ghrelin receptor membrane preparation	ChEMBL	469	7	2	4	3.4	CCN(CC)CCN1C(=O)[C@@](O)(c2ccc(Cl)cc2)c2c1cc(C(N)=O)cc2C(F)(F)F	10.1016/j.bmcl.2005.02.042
	156013130	176918	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	CHEMBL4639514	176918	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting methodDisplacement of [His[125I]]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes measured after 1 hr by microbeta counting method	ChEMBL	505	8	3	6	0.7	Cc1ccc2[nH]c(C(=O)N[C@H]3CN(S(=O)(=O)C4CCOCC4)C[C@@H]3C(=O)NCCN(C)C)cc2c1	10.1021/acs.jmedchem.0c00828
	122180014	121048	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586020	121048	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to ghrelin receptor (unknown origin)Binding affinity to ghrelin receptor (unknown origin)	ChEMBL	539	9	2	8	5.8	CCCn1cc(-c2cnc(NCc3ccc4sccc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	122178601	120810	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	CHEMBL3581034	120810	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assayDisplacement of 125I-[His9]-ghrelin from human GHSR1a expressed in LLC-PK1 cells by competitive binding assay	ChEMBL	634	11	2	6	6.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cncc(Br)c2)cc1	10.1016/j.bmcl.2014.11.031
	16202767	84558	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	CHEMBL223810	84558	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	506	9	3	5	4.8	Cc1ccc(Cn2c(Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1021/jm070024h
	46882156	5618	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078115	5618	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	404	7	4	4	3.3	CC(C)NC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	16113474	136097	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	CHEMBL373993	136097	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	455	8	4	5	3.6	CC(C)(N)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nncn1CCc1c[nH]c2ccccc12	10.1021/jm070024h
	59446105	172242	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	CHEMBL4514053	172242	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter methodDisplacement of [125I]-ghrelin (1 to 28 residues) from human GHS-R1a expressed in pig LLC-PK1 cell membranes by LKB gamma counter method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	nan
	11556936	81185	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	CHEMBL2163472	81185	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	850	21	11	10	0.7	C[C@H](NC(=O)N(Cc1ccc(O)cc1)NC(=O)C(N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm300557t
	60195114	81182	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
	CHEMBL2163468	81182	0	None	-	0	Human	4.1	pIC50	=	4.1	Binding	Displacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting methodDisplacement of [125I]ghrelin expressed in in LLC-PK1 cells incubated for 1 hr by gamma counting method	ChEMBL	640	13	8	6	1.8	CC(C)CN(NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1cnc[nH]1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O	10.1021/jm300557t
	70690449	75503	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048810	75503	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	70692603	75509	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048816	75509	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	44389192	168070	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	CHEMBL436275	168070	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	471	4	1	4	6.2	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1C(=O)N1CCCCCC1	10.1016/j.bmcl.2004.11.075
	44394982	65792	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL184093	65792	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	523	9	1	6	5.7	CCN(CC)[C@H]1CC[C@H](NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)CC1	10.1016/j.bmcl.2004.06.060
	CHEMBL526723	213911	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCCCCCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/jm8014519
	CHEMBL335799	209808	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(N)=O	10.1021/jm0001727
	CHEMBL61663	214052	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50Binding affinity towards human Growth hormone secretagogue receptor type 1 using competitive binding assay with radiolabeled [35S]-MK-0677 expressed as IC50	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O	10.1016/s0960-894x(01)00324-9
	44445628	161338	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL415135	161338	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	541	10	2	6	5.5	CCc1ccc(Cn2c(CCc3ccccc3)nnc2[C@H](NC(=O)c2cnccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	145950877	162433	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4175360	162433	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	448	4	4	5	2.6	Nc1ccncc1C(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1nc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	11663710	123935	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	CHEMBL363995	123935	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)Ability to displace [125I]ghrelin from cloned human GHS-R expressed in CHO-K cells was determined (Kd of ghrelin is 0.4 nM)	ChEMBL	528	9	1	5	6.3	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCN2CCCCC2=O)cc1	10.1016/j.bmcl.2004.06.060
	16113371	78728	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	CHEMBL2113318	78728	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human GHSR1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1016/j.bmcl.2007.10.113
	16113371	78728	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	CHEMBL2113318	78728	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	587	11	4	6	5.2	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CCCN2)cc1	10.1021/jm0704550
	11713497	122708	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL361349	122708	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	531	9	1	6	6.8	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2CCC2OCCCO2)c(C)c1	10.1016/j.bmcl.2004.11.075
	122182045	121473	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	CHEMBL3593634	121473	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Displacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting methodDisplacement of [125I]human ghrelin from rat ghrelin receptor expressed in CHO cell membranes incubated for 30 mins by scintillation counting method	ChEMBL	554	9	2	7	4.6	CC(=O)N1C[C@@H]2C=C(c3cnc(NCc4ccc5c(c4)OCO5)c(C(=O)NCCOc4ccccc4)c3)C[C@H]1CC2	10.1016/j.bmc.2015.05.047
	11646276	75566	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	CHEMBL205136	75566	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	364	6	3	7	3.4	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc([N+](=O)[O-])cc2)cc1	10.1021/jm0510934
	122182046	121474	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593635	121474	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	586	8	2	6	5.6	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCC3)cc1Cl	10.1016/j.bmc.2015.05.047
	44436828	91554	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL241664	91554	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	550	11	4	6	4.3	COc1ccc(CN2C([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H]3CCCN3)=NNC2CCc2ccccc2)cc1	10.1021/jm0704550
	CHEMBL410108	211042	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligandBinding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]MK-0677 as a radiolabeled ligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm0001727
	11538533	74636	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL203280	74636	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(NCc2ccc(S(C)(=O)=O)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL500468	212334	0	None	-	1	Human	8.0	pIC50	=	8.0	Binding	Binding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligandBinding affinity towards human pituitary Growth hormone secretagogue receptor using [125I][Tyr4]-ghrelin as radioligand	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm020985q
	11538534	74649	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	CHEMBL203373	74649	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Displacement of [125I]ghrelin from human GHS receptor expressed in CHOK cellsDisplacement of [125I]ghrelin from human GHS receptor expressed in CHOK cells	ChEMBL	397	6	3	7	2.9	CCc1nc(N)nc(N)c1-c1ccc(CNc2ccc(S(C)(=O)=O)cc2)cc1	10.1021/jm0510934
	122182047	121475	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	CHEMBL3593636	121475	0	None	-	0	Rat	8.0	pIC50	=	8.0	Binding	Inverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assayInverse agonist activity rat ghrelin receptor expressed in HEK293 cells by luciferase reporter gene assay	ChEMBL	588	8	2	7	5.4	COc1ccc(CNC(=O)c2cc(C3=C[C@@H]4CC[C@H](C3)N(C(C)=O)C4)cnc2NCc2ccc3c(c2)OCO3)cc1Cl	10.1016/j.bmc.2015.05.047
	70686293	75515	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048822	75515	0	None	-	1	Human	7.1	pIC50	=	7.1	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPADisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	122180016	121050	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	CHEMBL3586022	121050	0	None	-	0	Rat	6.1	pIC50	=	6.1	Binding	Inverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assayInverse agonist activity at rat ghrelin receptor expressed in HEK293 cells by NFAT-RE-luciferase reporter gene assay	ChEMBL	540	9	2	9	5.1	CCCn1cc(-c2cnc(NCc3ccc4ncsc4c3)c(C(=O)NCC3COc4ccccc4O3)c2)cn1	10.1016/j.bmcl.2015.04.040
	44389216	123323	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	CHEMBL362595	123323	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	442	6	1	5	5.9	CCN(CC)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)c(C#N)c1	10.1016/j.bmcl.2004.11.075
	44389248	121641	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	CHEMBL359714	121641	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	433	7	2	5	5.0	CCN(CCO)c1ccc(NC(=O)c2c(-c3c(Cl)cccc3Cl)noc2C)cc1	10.1016/j.bmcl.2004.11.075
	145958774	161704	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	CHEMBL4163811	161704	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	404	6	3	3	2.9	Cc1ccc2[nH]c(C(=O)N[C@@H]3Cc4ccccc4[C@H]3NC(=O)CCN(C)C)cc2c1	10.1021/acs.jmedchem.8b00322
	44445609	96579	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	CHEMBL266961	96579	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cellsDisplacement of 125I]-His9-ghrelin from human GHSR1a expressed in LLCPK1 cells	ChEMBL	579	10	3	5	6.4	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@H](NC(=O)Cc2ccccn2)c2c[nH]c3ccccc23)cc1	10.1021/jm701292s
	16114532	84258	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	CHEMBL222610	84258	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I-His9]ghrelin from human GHS1a receptor expressed in LLC PK1 cells	ChEMBL	575	11	4	6	5.2	COc1ccccc1Cn1c(CCc2c[nH]c3ccccc23)nnc1[C@@H](Cc1c[nH]c2ccccc12)NC(=O)C(C)(C)N	10.1021/jm070024h
	23648250	78738	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	CHEMBL2113327	78738	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cellsDisplacement of [125I]His9-ghrelin from human cloned GHS1a receptor expressed in LLC PK1 cells	ChEMBL	585	10	4	5	6.0	CCc1ccc(-n2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2CCNCC2)cc1	10.1021/jm0704550
	44409764	76781	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	CHEMBL207792	76781	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS receptor by binding assayInhibition of human GHS receptor by binding assay	ChEMBL	488	9	4	8	3.6	CS(=O)(=O)c1ccc(CNc2ccc(-c3c(N)nc(N)nc3CNCc3ccccc3)cc2)cc1	10.1016/j.bmcl.2006.01.012
	44378979	12720	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL1188586	12720	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	CHEMBL536779	12720	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Binding affinity for human growth hormone GH secretagogue (hGHsr) receptorBinding affinity for human growth hormone GH secretagogue (hGHsr) receptor	ChEMBL	506	9	2	5	4.6	NCCCCCCNC(=O)Cn1c(-c2ccc3ccccc3c2)nc2ccc(Br)cc2c1=O	10.1016/s0960-894x(99)00584-3
	11197	1046	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	154699458	1046	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	CHEMBL4632411	1046	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter methodDisplacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method	ChEMBL	572	7	2	9	3.9	CCOc1cc(Cl)c(cc1N1CCOCC1)C(=O)NC(=O)Nc1nc2c(s1)cc(cc2)CN1CCN(CC1)C	10.1016/j.bmcl.2020.126953
	CHEMBL498956	212307	0	None	-	0	Human	5.0	pIC50	=	5.0	Binding	Displacement of [35S]MK-0677 from human growth hormone secretagogue receptorDisplacement of [35S]MK-0677 from human growth hormone secretagogue receptor	ChEMBL		None	None	None		CCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C	10.1021/jm8014519
	46882198	5668	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL1078497	5668	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Inhibition of human GHS-R1aInhibition of human GHS-R1a	ChEMBL	460	12	4	4	4.9	CCCCCCCNC(=O)Nc1ccc(S(=O)(=O)Nc2ccc(CC(C)(C)N)cc2)cc1	10.1016/j.bmcl.2009.08.076
	CHEMBL3578017	210011	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	CHEMBL3578017	210011	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assayDisplacement of [125I]ghrelin from human eYFP-fused ghrelin receptor expressed in COS7 cells after 75 mins by competitive receptor binding assay	ChEMBL		None	None	None		CC(=O)NC(CNC(=O)CCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](Cc1cccc2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O	10.1021/jm501702q
	145953855	161953	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	CHEMBL4167669	161953	0	None	-	0	Human	7.0	pIC50	=	7.0	Binding	Displacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assayDisplacement of human [125I]-ghrelin from GHS-R1a (unknown origin) expressed in HEK293 cell membranes after 1 hr by radioligand binding assay	ChEMBL	426	6	3	3	2.9	CN(C)CCC(=O)N[C@H]1c2ccccc2C[C@@H]1NC(=O)c1cc2cc(F)c(F)cc2[nH]1	10.1021/acs.jmedchem.8b00322
	90666035	108817	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	CHEMBL3218908	108817	0	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Displacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysisDisplacement of [125I]-ghrelin from GSH-R1a (unknown origin) overexpressed in HEK cells after 60 mins by gamma counting analysis	ChEMBL	437	6	0	8	2.8	COc1cccc(-n2cc3nc(C)n(C[C@H]4CCCN(C[C@H]5CCCO5)C4)c(=O)c3n2)c1	10.1039/C2MD20340E
	328912	62232	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	CHEMBL178266	62232	1	None	-	0	Human	6.0	pIC50	=	6.0	Binding	Inhibition of binding to human growth hormone secretagogue receptorInhibition of binding to human growth hormone secretagogue receptor	ChEMBL	505	5	1	4	7.0	Cc1onc(-c2c(Cl)cccc2Cl)c1C(=O)Nc1ccccc1CC1c2ccccc2CCN1C	10.1016/j.bmcl.2004.11.075
	178024	1932	30	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	5867	1932	30	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	CHEMBL13817	1932	30	None	-	1	Human	9.9	pKd	=	9.9	Binding	Compound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activityCompound was evaluated for binding affinity using [35S]MK-0677 (800-1100 Ci/mmol), as radioligand having specific high activity	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm970342o
	57398340	70917	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956993	70917	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2ccc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57400002	70918	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956994	70918	0	None	-	1	Human	11.0	pKi	=	11	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ccc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57394881	70934	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957010	70934	0	None	-	1	Human	10.3	pKi	=	10.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	489	5	0	7	4.3	Cc1nc2ncc(Oc3ccc(Br)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57393073	70925	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957001	70925	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	449	5	0	8	4.6	Cc1nc2cnc(Oc3ccc4ncsc4c3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56926461	68679	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923609	68679	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926462	68680	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923610	68680	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926680	68693	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923623	68693	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926682	68695	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923625	68695	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11664206	68696	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923626	68696	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926893	68706	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	CHEMBL1923637	68706	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	nan
	11526745	68711	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923642	68711	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134137202	142282	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3893048	142282	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	5	3	6	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(OC)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137257	142593	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3895776	142593	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134133352	142961	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3898794	142961	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2Cl)NC(=O)[C@@H](C)N(C)C1=O	nan
	11527086	143506	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3903118	143506	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)c(Cl)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	11512561	143824	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3905791	143824	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	574	3	3	5	3.4	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2Cl)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134133037	144022	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3907497	144022	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132670	144069	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3907891	144069	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132152	144387	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3910300	144387	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	572	4	3	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc3ccccc23)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142839	144841	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913855	144841	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142553	144902	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3914259	144902	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134143635	145029	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3915269	145029	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2Cl)NC(=O)C2(CCCC2)NC1=O	nan
	134143096	145388	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3918009	145388	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	584	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Br)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134142204	145392	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3918046	145392	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11584702	145646	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3920049	145646	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	540	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139279	145902	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922056	145902	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	5	4.1	CCC(C)[C@H]1NCCOc2ccccc2[C@H]2C[C@@H]2CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134138445	146832	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3929593	146832	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C/c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138218	147465	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934367	147465	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148686	147627	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3935670	147627	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)c(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134149719	148143	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
	CHEMBL3939872	148143	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	2	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C(C)(C)C)C(=O)N1C	nan
	134145791	148242	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3940705	148242	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	3	3	5	2.8	C[C@@H]1C(=O)N[C@H](Cc2c(F)c(F)c(F)c(F)c2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134143746	150055	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
	CHEMBL3955179	150055	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	2	4	5	3.9	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1cccc(Cl)c1	nan
	134145221	150087	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3955437	150087	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NC[C@H](C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134155656	150650	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959816	150650	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155282	150798	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961108	150798	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153496	151741	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3969367	151741	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153654	152222	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3973513	152222	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	632	3	3	5	2.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(I)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134157569	153490	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3984338	153490	0	None	-	1	Human	10.0	pKi	=	10	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2cc(F)c(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	57345600	70914	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956990	70914	0	None	-	1	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	488	5	0	6	4.9	Cc1nc2ncc(Oc3ccc(Br)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57345599	70915	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956991	70915	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2ccc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57398341	70923	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956999	70923	0	None	-	1	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	444	5	0	6	4.8	Cc1nc2cnc(Oc3ccc(Cl)cc3F)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	178024	1932	30	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	5867	1932	30	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	CHEMBL13817	1932	30	None	-	1	Human	9.6	pKi	=	9.6	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10.1021/jm960054c
	57398342	70931	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957007	70931	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	450	5	0	9	4.0	Cc1nc2ncc(Oc3ccc4ncsc4c3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401803	70933	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957009	70933	0	None	-	1	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	469	6	0	7	5.1	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401799	70924	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957000	70924	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2cnc(Oc3ccc4c(c3)OCO4)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57399248	68687	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923617	68687	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	44340008	112876	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL331801	112876	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	583	9	2	6	3.2	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(C(C)(C)C)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	57399248	68687	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923617	68687	0	None	-	1	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	4	3	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(Cl)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	24970113	68699	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923629	68699	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	580	3	3	5	3.8	C[C@@H]1CN[C@@H](C2CCCCC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	57391293	70921	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956997	70921	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ccc(Oc3ccc(-c4ccccc4)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162659411	180633	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761419	180633	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	575	13	3	7	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CC#N)cc1	10.1021/acs.jmedchem.9b02122
	44340268	110019	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL325062	110019	0	None	-	1	Human	9.4	pKi	=	9.4	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	609	10	2	6	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)c(F)c1)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)C2(Cc2ccccc2)C1	10.1016/s0960-894x(02)00734-5
	57401800	70927	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957003	70927	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	446	5	0	8	3.9	Cc1nc2cnc(Oc3ccc4c(c3)ncn4C)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162657606	180525	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760409	180525	0	None	-	1	Human	9.3	pKi	=	9.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	693	15	3	8	5.7	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	57401801	70929	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957005	70929	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	445	5	0	7	4.2	Cc1nc2ncc(Oc3ccc(Cl)cc3F)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162672839	182430	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4793824	182430	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	681	14	3	7	5.9	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL500468	212334	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)CNC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)O	10.1021/jm300414b
	56942242	124662	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645257	124662	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	566	12	4	7	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CO)cc1	10.1016/j.bmcl.2016.04.003
	56925343	68709	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923640	68709	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	57398339	70916	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956992	70916	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	436	5	0	8	3.7	Cc1nc2ccc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162645413	179136	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744051	179136	0	None	-	1	Human	9.0	pKi	=	9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	677	14	3	7	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155540883	172378	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4517399	172378	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	4548	115	75	66	-23.9	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C)C(=O)N[C@H](CO)C(=O)N[C@@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CSSC[C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)C(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC2=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CC(=O)O)NC(=O)[C@@H](CCCNC(=N)N)NC1=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	16133832	211573	15	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	CHEMBL425281	211573	15	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CCCCCCCC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(C)C	10.1021/acs.jmedchem.8b01644
	162653781	179890	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753046	179890	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	732	15	4	8	6.2	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3c[nH]c4ccccc34)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	57401802	70930	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957006	70930	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	437	5	0	9	3.1	Cc1nc2ncc(Oc3ccc4c(c3)OCO4)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57401797	70910	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956987	70910	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	468	6	0	6	5.7	Cc1nc2ncc(Oc3ccc(-c4ccccc4)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	57398343	70932	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957008	70932	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	462	5	0	8	4.1	Cc1nc2ncc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56926175	68656	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923504	68656	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926360	68678	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923608	68678	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926582	68686	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923616	68686	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926681	68694	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923624	68694	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	56926891	68704	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923635	68704	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926892	68705	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923636	68705	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926894	68707	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	CHEMBL1923638	68707	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	nan
	56925345	68712	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL1923643	68712	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134130631	141829	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	CHEMBL3889512	141829	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	COc1ccc(C[C@@H]2NC(=O)C3(CCCC3)NC(=O)[C@H](CC(C)C)NCCOc3ccccc3/C=C\CNC2=O)cc1	nan
	134131442	141852	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3889678	141852	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134131183	141924	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890296	141924	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134136433	141963	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890602	141963	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(OC)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134137008	141999	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3890889	141999	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134137012	142058	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3891381	142058	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	3	3	6	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccsc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134137398	142332	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3893476	142332	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	4	4	4	4.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134136665	142355	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
	CHEMBL3893697	142355	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	5	6	3.9	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(O)cc1	nan
	134133488	142692	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3896536	142692	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	600	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccc(F)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134248	142807	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3897510	142807	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(c2ccccc2)c2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134556	142808	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3897527	142808	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134133518	142909	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3898348	142909	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134134286	143150	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900284	143150	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	5	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134135296	143467	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902856	143467	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	4	5	3.0	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132958	144116	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	CHEMBL3908264	144116	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	C[C@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCN[C@H](C2CC2)C(=O)N1C	nan
	134132137	144268	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3909431	144268	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)cc2)NC(=O)C(C)N(C)C1=O	nan
	134132893	144318	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3909834	144318	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	4	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	24969783	144319	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
	CHEMBL3909838	144319	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc(F)cc2O1	nan
	130334810	144615	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
	CHEMBL3912211	144615	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C2=O)N(C)C1=O	nan
	134132394	144639	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3912375	144639	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134142218	144742	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3913052	144742	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	4	5	3.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134142433	144781	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3913335	144781	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	6	1.8	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOC2)NC1=O	nan
	59778970	144830	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3913763	144830	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	6	1.8	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143366	145215	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3916659	145215	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	117812386	145313	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3917385	145313	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139489	145517	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3919021	145517	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2cc(F)cc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134140270	145828	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3921499	145828	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	5	3.1	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134140007	145859	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3921750	145859	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)c(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139286	146009	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3922810	146009	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134139113	146108	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
	CHEMBL3923633	146108	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)N(C)C1=O	nan
	134141159	146184	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3924192	146184	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134140968	146245	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3924635	146245	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	3	3	5	2.4	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NC[C@H]2C[C@@H]2c2ccccc2OCCNC(C2CC2)C(=O)N1C	nan
	134141782	146449	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3926434	146449	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	4	4.6	CCC(C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134141886	146573	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3927481	146573	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134138234	146868	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3929852	146868	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	3	3	5	2.4	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccc3c(c2)OC(CC3)CN[C@@H](C2CC2)C(=O)N1C	nan
	117812380	147207	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3932408	147207	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(NS(C)(=O)=O)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134138595	147210	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	CHEMBL3932434	147210	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	2	4	5	3.3	O=C1NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccccc1	nan
	134138824	147470	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3934402	147470	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134148504	147810	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3937200	147810	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.4	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134149092	147909	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3937924	147909	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	4	5	2.5	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134149306	147930	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3938104	147930	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	3	3	5	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC#Cc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134149407	147976	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3938452	147976	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	571	4	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C#N)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148639	147999	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
	CHEMBL3938683	147999	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	5	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCNC2)NC1=O	nan
	134146570	148236	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940653	148236	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	4	4	5	3.3	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145552	148475	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
	CHEMBL3942528	148475	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(CC)C1=O	nan
	134145564	148546	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3943086	148546	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	72574018	148560	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943159	148560	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CCC(C)C1NCC(C)Oc2ccccc2CCCNC(=O)C(Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134146319	148582	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943294	148582	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CC(C)CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147809	148905	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3946007	148905	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147441	148945	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3946348	148945	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134146888	149219	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948268	149219	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	624	4	4	5	4.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Br)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147381	149241	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948472	149241	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147802	149547	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3950904	149547	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145064	149605	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951476	149605	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	4	5	3.4	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144205	149729	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3952596	149729	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144429	149741	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3952699	149741	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144211	149786	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3953033	149786	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	4	4	5	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2C#CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144606	149790	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3953053	149790	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	134155024	150468	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3958451	150468	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.6	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155239	150470	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3958460	150470	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	5	3.4	O=C1NC/C=C\c2ccccc2OCCN[C@@H](C2CC2)C(=O)NC2(CCCC2)C(=O)N[C@H]1Cc1ccc(Cl)cc1	nan
	134155132	150548	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3959108	150548	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	502	4	3	5	2.9	CC[C@H](C)[C@]1(C)NCCOc2ccccc2CCCNC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134155178	150835	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3961456	150835	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	525	3	3	6	1.6	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCCc2ncccc2OCCNC(C2CC2)C(=O)N1C	nan
	134150646	151102	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963865	151102	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	5	3	6	2.6	CSCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150029	151571	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967783	151571	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	3	4	3.3	CC[C@H](C)C1NCCCc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134150729	151612	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3968175	151612	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	2.1	CC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154254	151755	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3969506	151755	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	3	4	3.5	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154486	151898	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	CHEMBL3970827	151898	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	134154392	151988	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3971540	151988	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134153247	152176	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3973085	152176	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	134153772	152354	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3974701	152354	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cccs2)NC(=O)[C@@H](C)N(C)C1=O	nan
	52911621	152515	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3975975	152515	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	531	3	3	6	1.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(C#N)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134151758	152558	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3976294	152558	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	558	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(Cl)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134152984	152622	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3976853	152622	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	6	2.9	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(Cl)cc2)NC(=O)C2(CCOC2)NC1=O	nan
	134151899	152773	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3978207	152773	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134152339	152913	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3979468	152913	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	545	3	4	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2c[nH]c3ccccc23)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134152133	152977	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3979911	152977	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	578	3	4	6	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(O)c(C(C)(C)C)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134157813	153126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981238	153126	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	524	4	3	6	1.7	COC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134156963	153312	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3982825	153312	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528321	153411	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
	CHEMBL3983626	153411	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	2	2	5	2.6	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCCC[C@H]2C(=O)N1C	nan
	134156579	153508	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3984464	153508	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134156405	153716	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
	CHEMBL3986375	153716	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	620	4	4	6	4.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccsc1	nan
	134156453	153754	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3986628	153754	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	4	3	6	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccncc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56942098	124660	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645255	124660	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	162646324	179146	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4744139	179146	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	17	3	9	4.8	CCN(CC)CCc1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(OC)cc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	162665018	181543	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4782214	181543	0	None	-	1	Human	8.0	pKi	=	8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	550	12	3	6	4.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(C)=O)cc1	10.1021/acs.jmedchem.9b02122
	58438451	91839	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426689	91839	0	None	2089	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	442	4	0	6	3.1	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	90644553	111230	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287214	111230	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	540	5	1	7	4.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ccc(C(N)=O)nc6)ccc53)C4)nc2s1	10.1021/ml400473x
	56926177	68658	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923506	68658	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926268	68660	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
	CHEMBL1923510	68660	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	nan
	56926269	68661	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
	CHEMBL1923511	68661	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	nan
	56926356	68662	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923512	68662	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	nan
	56926465	68683	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL1923613	68683	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	56926782	68700	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923631	68700	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926784	68702	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923633	68702	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	56926785	68703	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL1923634	68703	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	71452183	83102	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
	CHEMBL2203623	83102	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CO)N(C)C1=O	nan
	134131439	141851	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
	CHEMBL3889672	141851	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	527	4	4	6	1.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCN)C(=O)N1C	nan
	134137460	142091	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3891657	142091	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	134136637	142176	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
	CHEMBL3892319	142176	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	541	5	4	6	1.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCN)C(=O)N1C	nan
	134136946	142210	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3892517	142210	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	4	6	2.4	CC[C@H](C)[C@@H]1NCCOc2ccc(C(=O)O)cc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134136405	142375	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3893850	142375	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	616	4	4	5	4.6	CC[C@H](C)[C@@H]1NCCOc2ccc(Cl)cc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134133771	142797	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
	CHEMBL3897387	142797	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	4	3	5	2.3	CCC[C@H]1NC(=O)[C@@H](C)N(C)C(=O)[C@H]([C@@H](C)CC)NCCOc2ccccc2CCCNC1=O	nan
	134133353	142975	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
	CHEMBL3898864	142975	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C(C)C)N(C)C1=O	nan
	134134505	143124	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3900035	143124	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	4	4.3	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134605	143133	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3900122	143133	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	2.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](C(C)C)NC(=O)[C@@H](C)N(C)C1=O	nan
	134134099	143187	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3900636	143187	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	639	4	4	6	4.1	N#Cc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134135897	143450	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902804	143450	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	530	4	4	4	4.0	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134134825	143535	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3903351	143535	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	476	3	3	5	1.4	C[C@@H]1C(=O)N[C@@H](Cc2ccc(F)cc2)C(=O)NCCCCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	72989837	143571	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
	CHEMBL3903647	143571	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	5	4	6	1.7	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)NC(=O)C(CO)N(C)C1=O	nan
	134135712	143594	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	CHEMBL3903845	143594	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	533	4	4	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C1=O	nan
	134136025	143788	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3905495	143788	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134134870	143847	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3905987	143847	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	3	4	5	2.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134135261	143940	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
	CHEMBL3906788	143940	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC)N(C)C1=O	nan
	134134893	143966	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	CHEMBL3907031	143966	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	2	3	5	3.3	C[C@H]1C(=O)N[C@H](Cc2cccc(Cl)c2)C(=O)NC/C=C\c2ccccc2OCCNC2(CCCC2)C(=O)N1C	nan
	134132666	144020	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3907480	144020	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132519	144104	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3908156	144104	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccsc2)NC(=O)C2(CCCC2)NC1=O	nan
	134132427	144156	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3908583	144156	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	622	5	4	5	5.0	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(-c3ccccc3)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134131971	144383	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3910288	144383	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134132265	144426	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	CHEMBL3910661	144426	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	3	4	6	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCOCC2)NC1=O	nan
	134131903	144593	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3912034	144593	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	529	4	3	7	2.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2cscn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134132099	144665	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3912534	144665	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	4	4	6	3.4	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccs2)NC(=O)C2(CCCC2)NC1=O	nan
	134142223	144798	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
	CHEMBL3913486	144798	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	480	4	4	5	1.7	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CNC1=O	nan
	134142139	144857	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
	CHEMBL3913981	144857	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	5	4	6	3.6	COc1ccc(C[C@@H]2NCCOc3ccccc3/C=C\CNC(=O)[C@H](Cc3ccccc3)NC(=O)C3(CCCC3)NC2=O)cc1	nan
	76460236	144915	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3914338	144915	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	4	3.0	CCC(C)C1NCCCCCCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134143044	144928	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3914467	144928	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143657	145191	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3916501	145191	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	528	4	3	6	1.4	COC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134143398	145389	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3918022	145389	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	552	3	3	5	2.9	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCC(C)(C)c2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134139992	145794	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
	CHEMBL3921227	145794	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccccc1Cl	nan
	134140213	146075	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
	CHEMBL3923324	146075	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	513	3	4	6	0.8	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CN)C(=O)N1C	nan
	134140762	146120	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
	CHEMBL3923718	146120	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	2	5	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@@H](C1=O)C2=O	nan
	134141057	146150	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3923918	146150	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	3	4	5	2.7	CCC1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134140844	146680	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
	CHEMBL3928367	146680	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc(Cl)c1	nan
	68186750	146842	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
	CHEMBL3929656	146842	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.8	CC1CCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc21	nan
	134138656	147009	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3930811	147009	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCc2ccccc2/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134138764	147091	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
	CHEMBL3931402	147091	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	566	5	3	7	2.1	COc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1OC	nan
	134138160	147120	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3931716	147120	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	6	1.4	CCC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134137758	147429	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	CHEMBL3934093	147429	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	500	7	4	5	3.2	CCCC[C@@H]1NC(=O)[C@H](CCCC)NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	134137945	147441	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
	CHEMBL3934184	147441	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	3	4	5	3.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(Cc3ccccc3C2)NC1=O	nan
	134149048	147532	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
	CHEMBL3934901	147532	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	3	5	6	1.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1CO	nan
	134149058	147590	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
	CHEMBL3935422	147590	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	586	4	4	6	3.6	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccs1	nan
	134149451	147621	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3935626	147621	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134148804	147774	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
	CHEMBL3936957	147774	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	3	4	6	2.9	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCSCC2)NC1=O	nan
	58012657	147821	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3937314	147821	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	544	4	3	5	3.9	CCC[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	134149772	147935	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3938132	147935	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	4	4	4	5.0	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134149793	148061	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	CHEMBL3939196	148061	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(CC)C1=O	nan
	134148754	148155	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
	CHEMBL3939993	148155	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	646	8	3	6	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)C(COCc2ccccc2)N(C)C1=O	nan
	134145258	148258	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3940860	148258	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	4	4.8	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145652	148479	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3942543	148479	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	576	6	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](COCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145920	148482	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3942554	148482	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	4	5	2.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134146710	148486	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
	CHEMBL3942610	148486	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	4	7	3.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cscn1	nan
	134145820	148490	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3942642	148490	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134146617	148571	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3943228	148571	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.0	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134145420	148769	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
	CHEMBL3944936	148769	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]([C@@H](C)CC)N(C)C1=O	nan
	134147617	148891	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3945918	148891	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134147244	148902	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3945984	148902	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	4	4	6	2.0	CC[C@H](C)[C@@H]1NCCOCCOCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148131	149154	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3947758	149154	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	568	4	4	6	2.6	COC[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134147387	149273	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3948746	149273	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	518	4	4	4	3.9	CC[C@H](C)[C@@H]1NCCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134147861	149313	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3949023	149313	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	2	4	5	2.9	CC1(C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C(C)(C)NC1=O	nan
	134147972	149394	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3949704	149394	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	488	4	3	5	2.5	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H]([C@H](C)CC)NC(=O)[C@@H](C)N(C)C1=O	nan
	134147412	149422	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3949926	149422	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.4	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cccc(C(F)(F)F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134148083	149567	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
	CHEMBL3951110	149567	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	546	3	4	5	3.4	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCCC2)NC1=O	nan
	134144491	149596	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951362	149596	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	4	4	3.5	CC[C@H](C)[C@@H]1NCCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134143693	149612	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3951593	149612	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	4	5	3.1	CC[C@H](C)[C@@H]1NCCOCCCCCNC(=O)[C@@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134145200	149907	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3954124	149907	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	6	4	6	2.8	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(COCc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134144043	149944	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
	CHEMBL3954394	149944	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	4	5	6	2.3	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1c[nH]cn1	nan
	134144941	149982	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3954620	149982	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2cc(F)cc(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134144060	150112	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3955632	150112	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	4	4	5	4.0	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134155541	150493	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3958657	150493	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CCC(C)C1NCCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134155247	150506	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
	CHEMBL3958739	150506	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc2ccccc2c1	nan
	117812381	150807	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3961160	150807	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	592	3	3	5	3.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(C(F)(F)F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134155292	150858	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3961641	150858	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	458	4	3	5	1.3	CC[C@H](C)[C@@H]1NCCOC/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154704	150866	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3961696	150866	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	2	4	5	3.1	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)C2(CCCC2)NC(=O)C2(CCCC2)NC1=O	nan
	134152627	151004	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3963078	151004	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	4	3	4	3.0	CC[C@H](C)[C@@H]1NCc2ccccc2C/C=C\CNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134150950	151061	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
	CHEMBL3963523	151061	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	5	4	5	2.8	CCC[C@@H]1NC(=O)[C@@H](C(C)C)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC1=O	nan
	57528212	151279	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
	CHEMBL3965338	151279	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	2	2	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN2CCC[C@H]2C(=O)N1C	nan
	134150767	151282	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	CHEMBL3965351	151282	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	2	4	5	3.0	C[C@@H]1NC(=O)C2(CCCC2)NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC1=O	nan
	134150369	151312	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	CHEMBL3965516	151312	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	3	5	4.4	CC[C@H](C)[C@@H]1NCCOc2cc(F)ccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	134150388	151381	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3966251	151381	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	617	5	4	7	1.6	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(NS(C)(=O)=O)cc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134150696	151535	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3967506	151535	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CCC(C)C1NCc2ccccc2CCCCNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134153608	151826	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970180	151826	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	4	3	4	3.2	CC[C@H](C)[C@@H]1NCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134154369	151850	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3970414	151850	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134153972	151858	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3970491	151858	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	526	3	3	6	1.7	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	nan
	134154079	151859	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970499	151859	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	512	4	4	5	3.2	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](CC(C)C)NC(=O)C2(CCCC2)NC1=O	nan
	134153529	151904	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3970856	151904	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	548	5	4	5	3.4	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134154612	151967	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
	CHEMBL3971356	151967	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)N2CC[C@H](C2=O)N(C)C1=O	nan
	134153232	152035	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
	CHEMBL3971845	152035	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.5	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@H]1Cc1ccccc1	nan
	134154534	152200	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3973254	152200	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	474	3	3	5	1.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCC/C=C\COCCN[C@@H](C2CC2)C(=O)N1C	nan
	134154022	152281	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3973940	152281	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134151581	152662	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3977241	152662	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	610	4	4	5	4.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2C(C)(C)CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528347	152666	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	CHEMBL3977265	152666	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	134152388	152672	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
	CHEMBL3977294	152672	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	594	5	4	5	4.0	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1CCc1ccccc1	nan
	134151706	152808	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	CHEMBL3978455	152808	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	3	5	2.4	CC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccccc2)NC(=O)C(C)N(C)C1=O	nan
	134151524	152834	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3978661	152834	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	644	5	4	6	4.2	COc1ccccc1C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134152209	152856	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3978864	152856	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	510	3	4	6	1.0	CC(O)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134152547	152937	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3979606	152937	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	532	4	4	5	2.9	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	11421086	153020	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
	CHEMBL3980276	153020	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	2	5	2.8	CCC[C@H]1C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN1C	nan
	134157913	153085	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3980873	153085	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	504	3	4	5	2.2	CC(C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134156625	153105	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	CHEMBL3981072	153105	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	472	4	3	5	1.7	CC[C@H](C)[C@@H]1NCCOC/C=C\CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	nan
	134157438	153202	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981843	153202	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	505	4	5	5	1.9	CC[C@H](C)[C@@H]1NCCCNCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134157625	153215	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981960	153215	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	582	4	4	5	3.6	CCC(C)C1NCCOc2ccccc2/C=C\CNC(=O)C(Cc2ccc(F)c(F)c2)NC(=O)C2(CCCC2)NC1=O	nan
	59834193	153606	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
	CHEMBL3985477	153606	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	538	3	3	5	2.5	CC1CNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)NCCOc2ccccc2C1	nan
	134156443	153800	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
	CHEMBL3986906	153800	0	None	-	1	Human	7.0	pKi	=	7	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	550	5	3	5	3.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)N(C)C1=O	nan
	56926176	68657	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL1923505	68657	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	56926266	68659	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
	CHEMBL1923508	68659	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	nan
	134133634	143090	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3899825	143090	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	549	4	4	6	2.7	CC(C)C[C@@H]1NCCOc2cccnc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	57722117	143140	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3900193	143140	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	466	2	3	5	1.3	C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	57722068	143389	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	CHEMBL3902231	143389	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCOCCOCCN[C@@H](C2CC2)C(=O)N1C	nan
	134135595	143420	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3902597	143420	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	598	4	4	5	5.1	CC(C)C[C@@H]1NCc2ccccc2Sc2ccccc2CNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	134139160	145664	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
	CHEMBL3920156	145664	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	560	4	3	5	3.7	CC(C)C[C@H]1C(=O)NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN1C	nan
	134140250	145701	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3920479	145701	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	562	5	4	5	3.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](CCc2ccccc2)NC(=O)C2(CCCC2)NC1=O	nan
	57951693	145732	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	CHEMBL3920711	145732	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	134140177	145825	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3921493	145825	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	5	4.3	CC(C)C[C@H]1NC[C@H](C)Oc2ccccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134139639	146094	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	CHEMBL3923467	146094	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	556	6	4	7	2.5	CCOC(=O)CC[C@@H]1NC(=O)C2(CCCC2)NC(=O)[C@H](CC(C)C)NCCOc2ccccc2/C=C\CNC1=O	nan
	134140216	146099	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3923508	146099	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	587	4	5	5	3.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)C2(CCCC2)NC1=O	nan
	134141155	146183	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
	CHEMBL3924187	146183	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	596	4	4	6	3.3	CC[C@H](C)[C@@H]1NC[C@H](C)Oc2ccccc2/C=C\CNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCOC2)NC1=O	nan
	134137626	146938	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3930400	146938	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	4	5	6	3.0	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)C2(CCCC2)NC1=O	nan
	134148332	147737	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3936664	147737	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	583	4	4	6	3.3	CC[C@H](C)[C@@H]1NCCOc2ncccc2CCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	57528213	147940	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	CHEMBL3938163	147940	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H]2CCCN2C1=O	nan
	134149424	148092	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3939431	148092	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](C(C)c2ccccc2)NC(=O)CN(C)C1=O	nan
	57951672	149050	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3946954	149050	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	134147008	149392	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	CHEMBL3949653	149392	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	522	4	4	5	2.8	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C(C)(C)NC1=O	nan
	134155726	150474	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
	CHEMBL3958492	150474	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	478	3	3	6	0.2	CC1C(=O)NC(Cc2ccc(F)cc2)C(=O)NCCOCCOCCNC(C2CC2)C(=O)N1C	nan
	134155844	150544	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
	CHEMBL3959055	150544	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	570	6	4	5	3.3	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](Cc2ccccc2)NC1=O	nan
	57528307	150583	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	CHEMBL3959346	150583	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	520	4	3	5	2.6	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	134156186	150806	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3961157	150806	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	490	4	4	4	3.1	CC[C@H](C)[C@@H]1NCCCCCNC(=O)[C@H](Cc2cccc(Cl)c2)NC(=O)C2(CCCC2)NC1=O	nan
	134150525	151020	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
	CHEMBL3963236	151020	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	551	8	5	6	2.2	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCCCN)NC1=O	nan
	134149894	151290	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
	CHEMBL3965402	151290	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	614	4	4	5	4.2	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1ccc(Cl)cc1	nan
	134150119	151503	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
	CHEMBL3967266	151503	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	580	6	4	6	3.2	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](COC(C)(C)C)NC1=O	nan
	134150914	151536	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
	CHEMBL3967522	151536	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	564	6	3	5	3.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H]([C@H](C)CC)N(C)C1=O	nan
	57722047	152322	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3974323	152322	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	436	4	3	4	1.8	CCC[C@@H]1NCc2cccc(c2)CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	57951687	152327	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	CHEMBL3974356	152327	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)NC1=O	nan
	57528291	152371	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	CHEMBL3974776	152371	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	3	5	2.9	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H]2CCCN2C1=O	nan
	134152485	152630	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	CHEMBL3976941	152630	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	604	5	4	6	3.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccc(C(=O)O)cc2)NC(=O)C2(CCCC2)N(C)C1=O	nan
	134151873	152654	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
	CHEMBL3977166	152654	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	630	4	4	5	4.7	O=C1NC2(CCCC2)C(=O)N[C@@H](Cc2ccccc2)C(=O)NC/C=C\c2ccccc2OCCN[C@H]1Cc1cccc2ccccc12	nan
	76556607	153009	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
	CHEMBL3980176	153009	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	534	4	2	5	2.8	CCC(C)C1NCCOc2ccccc2CCCNC(=O)C(Cc2ccccc2)N2CCC(C2=O)N(C)C1=O	nan
	134157812	153124	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	CHEMBL3981235	153124	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	506	3	4	5	2.1	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CC2)NC1=O	nan
	134156737	153153	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
	CHEMBL3981446	153153	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	547	4	4	6	2.8	CC(C)C[C@@H]1NCCOc2ccccc2/C=C\CNC(=O)[C@H](Cc2ccncc2)NC(=O)C2(CCCC2)NC1=O	nan
	134156806	153548	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
	CHEMBL3984892	153548	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	536	6	4	5	3.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CC(C)C)NC1=O	nan
	134157124	153660	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
	CHEMBL3985913	153660	0	None	-	1	Human	6.0	pKi	=	6	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	492	2	4	5	1.9	O=C1CNCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)C2(CCCC2)N1	nan
	11706547	68689	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923619	68689	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	3	3	5	2.8	CC(C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	134138625	147486	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3934561	147486	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	494	3	3	5	1.9	CC(C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	44434011	147319	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL393321	147319	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	465	12	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCc1ccccc1	10.1016/j.bmcl.2007.07.099
	70692601	75507	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048814	75507	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	481	7	0	7	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	127046957	139164	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798155	139164	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	649	12	3	7	5.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2cc(F)cc(F)n2)cc1	10.1016/j.bmcl.2016.04.003
	127046472	139151	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798056	139151	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	56926266	68659	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
	CHEMBL1923508	68659	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	523	6	4	6	1.4	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](CCCCN)C1=O	10.1021/jm2007062
	73352329	91819	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426669	91819	0	None	1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	70692602	75508	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048815	75508	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	423	8	0	5	3.5	CCCOc1ccc(CN2CC3(CCN(C(=O)Cc4ccc(OC)cc4)CC3)C2)cn1	10.1016/j.bmcl.2012.05.024
	162665974	181643	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4783347	181643	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	612	13	3	6	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	44396381	67176	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL189625	67176	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	558	13	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NCc1ccc(F)cc1)c1ccc(F)cc1	10.1021/jm040103i
	44396377	66594	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
	CHEMBL186647	66594	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	13	2	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(Cc1ccc(C)o1)C(=O)NC1CCCCC1	10.1021/jm040103i
	44396269	67004	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
	CHEMBL188586	67004	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	426	10	2	3	4.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC(C)(C)C	10.1021/jm040103i
	56926895	68708	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923639	68708	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	3.0	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OC(C)(C)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	56942244	124664	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645259	124664	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	632	12	5	7	4.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	162648546	179288	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745666	179288	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC=O)cc1	10.1021/acs.jmedchem.9b02122
	58438460	111233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287217	111233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	56926356	68662	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923512	68662	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	510	4	4	6	1.8	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	56926176	68657	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923505	68657	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	71453390	81417	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164500	81417	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	526	6	2	4	4.4	C=CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162663952	181560	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4782383	181560	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	13	2	7	6.6	COc1ccc(/C=C(\C#N)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	118725963	116679	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394203	116679	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	541	7	1	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	44434112	168283	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL438154	168283	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2cc3ccccc3n2S(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	3174463	66420	3	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL185876	66420	3	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	532	12	2	3	6.2	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	56926464	68682	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	CHEMBL1923612	68682	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	nan
	118725960	116675	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	CHEMBL3394199	116675	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	5	0	6	4.5	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	162657547	180391	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4758721	180391	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	694	15	2	9	6.2	COc1ccc(/C=C(\C#N)C(=O)OCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162658148	180556	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4760746	180556	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	565	13	4	7	3.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	162662164	180818	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763700	180818	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	636	12	3	6	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	127047362	139176	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798204	139176	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	590	11	5	7	4.7	COc1ccc(Cn2c([C@H](N)Cc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	3154000	123738	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
	CHEMBL363467	123738	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	530	12	3	4	5.8	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(O)cc1	10.1021/jm040103i
	162651277	179606	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4749525	179606	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	598	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	3180629	67001	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL188582	67001	5	None	-	1	Human	5.9	pKi	=	5.9	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	518	11	2	3	5.8	CCN(CC)CCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	44434016	89748	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL238228	89748	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	415	12	3	7	1.5	CCCCNC(=O)CCn1nnnc1[C@@H](CCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	72190452	91832	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426682	91832	0	None	1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	118725964	116680	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394204	116680	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	7	1	6	4.1	COc1ccc(CCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	70692600	75506	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048813	75506	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	447	7	0	7	2.8	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4nccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	70682036	75510	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048817	75510	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	1	4	4.3	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4n[nH]c5ccccc45)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	70686293	75515	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048822	75515	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	472	5	0	7	3.8	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-c5ncccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	58438460	111233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	CHEMBL3287217	111233	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	162660604	180627	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4761319	180627	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	700	15	3	9	5.0	COc1ccc(/C=C(\C#N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCN3CCCCC3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162671996	182239	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4791255	182239	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	16	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)NCCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	25032438	115683	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
	CHEMBL3358450	115683	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Binding affinity to human ghrelin receptor by receptor binding assayBinding affinity to human ghrelin receptor by receptor binding assay	ChEMBL	485	14	2	6	3.8	CCN(CC)CCCS(=O)(=O)N[C@H](CCc1ccccc1)c1nc(-c2ccc(OC)cc2)n[nH]1	10.1021/jm5003183
	11692516	68691	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923621	68691	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	3	3	5	3.1	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(Cl)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	67407161	91838	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426688	91838	0	None	1819	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	467	5	0	5	4.3	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	67410074	111232	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287216	111232	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	56926782	68700	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923631	68700	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	472	4	3	4	3.0	CC[C@H](C)[C@@H]1NCCCCCCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70696687	75505	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048812	75505	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	446	7	0	6	3.4	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-n4cccn4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	127046806	139390	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799604	139390	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	638	13	4	7	5.4	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127048038	139429	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799862	139429	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	551	11	4	7	4.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	44434076	89333	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	CHEMBL237717	89333	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	513	10	2	9	1.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC1CN(S(C)(=O)=O)c2ccccc21	10.1016/j.bmcl.2007.07.099
	56926463	68681	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923611	68681	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	11526696	71243	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923502	71243	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1963249	71243	13	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	72191051	91816	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426666	91816	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	456	5	0	6	3.4	CCc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	58438460	111233	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287217	111233	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml400473x
	56926783	68701	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923632	68701	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	470	4	3	4	2.8	CC[C@H](C)[C@@H]1NCCCC/C=C/CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	162658631	180491	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759983	180491	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	561	12	3	7	3.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C#N)cc1	10.1021/acs.jmedchem.9b02122
	118725958	116674	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
	CHEMBL3394197	116674	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	507	4	0	7	3.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4nn(C)c5ncccc45)CC3)C2)ncn1	10.1021/ml500414n
	162659337	180724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4762631	180724	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	665	15	3	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C#N)Cc2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	73355325	91821	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426671	91821	0	None	1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN(C(C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	70696688	75511	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048818	75511	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	487	9	0	6	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cn1	10.1016/j.bmcl.2012.05.024
	127048060	139318	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799222	139318	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	789	20	6	10	5.4	COC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	56942388	139400	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799687	139400	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	613	12	3	7	5.3	COc1ccc(Cn2c([C@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	162677361	182917	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4799766	182917	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	685	16	4	8	4.7	COc1ccc(C[C@@H](N)C(=O)NCC(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	58438475	91827	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	CHEMBL2426677	91827	0	None	1548	2	Human	7.8	pKi	=	7.8	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	44434109	145736	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392076	145736	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	529	13	2	9	1.8	CN(c1ccccc1CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N)S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	134139080	147138	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	CHEMBL3931856	147138	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	4	4	5	2.4	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	nan
	44434010	88331	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL236311	88331	0	None	-	1	Human	5.8	pKi	=	5.8	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	445	14	3	8	1.5	CCCCNC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	127047655	139071	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797531	139071	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	44340007	9209	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	CHEMBL111026	9209	0	None	-	1	Human	7.8	pKi	=	7.8	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	541	9	2	6	2.0	CN1N=C2CCN(C(=O)[C@@H](COCc3ccc(F)c(F)c3)NC(=O)C(C)(C)N)CC2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	56925344	68710	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923641	68710	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	3	3	5	2.5	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cccc3c2O[C@@H](CC3)CN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	44434083	89586	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL238155	89586	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	420	10	2	7	2.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1C/C=C/c1ccccc1	10.1016/j.bmcl.2007.07.099
	44434050	144905	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL391428	144905	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1	10.1016/j.bmcl.2007.07.099
	44396306	66926	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
	CHEMBL188173	66926	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	452	11	2	3	4.7	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C)C(=O)NC1CCCCC1	10.1021/jm040103i
	145948725	166925	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299615	166925	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	885	20	7	9	6.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)C3CCNCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	57345597	70911	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956988	70911	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ccc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	56942243	124663	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645258	124663	0	None	-	1	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	621	12	4	8	3.6	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H]2CNCCO2)cc1	10.1016/j.bmcl.2016.04.003
	162648837	179248	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745116	179248	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	706	15	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	127048059	139023	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797225	139023	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	675	16	6	8	4.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	11526745	68711	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923642	68711	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	57400003	70920	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956996	70920	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2ccc(Oc3ccc(F)c4cccnc34)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	155529391	170864	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4463042	170864	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1427	41	20	17	-3.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	70690449	75503	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048810	75503	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	9	0	5	4.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(OCC(C)C)cc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	118725965	116681	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
	CHEMBL3394205	116681	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.0	CNC(=O)c1cc(OC)ccc1CC(=O)N1CCC2(CC1)CN([C@@H]1CCc3cc(-c4cc(C)ncn4)ccc31)C2	10.1021/ml500414n
	44434080	89467	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237933	89467	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	422	11	2	7	2.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	162647450	179281	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4745548	179281	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	12	2	6	4.6	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN(C)C)cc1	10.1021/acs.jmedchem.9b02122
	71456910	81475	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164823	81475	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	480	5	2	4	3.6	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	3154005	66425	4	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	CHEMBL185887	66425	4	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	550	13	1	4	5.7	CCN(CC)CCCN(C(=O)CCN1CCCc2ccccc21)C(C(=O)NC1CCCCC1)c1ccc(F)cc1	10.1021/jm040103i
	70696689	75514	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048821	75514	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	460	5	0	7	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5cccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	56926681	68694	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923624	68694	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2cccc(F)c2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	127047409	139088	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797639	139088	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	888	24	8	10	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)C(CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	56926785	68703	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923634	68703	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.3	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70688404	75499	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	CHEMBL2048807	75499	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	44434009	166882	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL429799	166882	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	431	13	3	8	1.1	CCCCNC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	53248756	60838	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
	CHEMBL1765654	60838	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Inhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometryInhibition of [125I]Ghrelin binding to human Ghrelin receptor expressed in CHO-K1 cells after 60 mins by liquid scintillation spectrometry	ChEMBL	457	5	0	5	5.6	Cc1ccccc1-c1nc2ccc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C)C1	10.1016/j.bmc.2011.02.021
	CHEMBL2170701	207606	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cn(C)c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	10253999	123263	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL362303	123263	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	466	12	2	3	5.1	CCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	127048061	139193	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798337	139193	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	903	24	7	11	5.9	COC(=O)[C@H](CC(C)C)NC(=O)C(CC(C)C)C(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc([C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)n1Cc1ccc(OC)cc1	10.1016/j.bmcl.2016.04.003
	162662593	181378	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780100	181378	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	591	12	3	7	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN2CCC(N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	44579909	186310	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL489819	186310	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44434073	89156	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL237507	89156	0	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	70694649	75516	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048823	75516	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	475	5	0	7	3.2	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-n3nccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	162659161	180799	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763471	180799	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	642	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)Cc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162652815	179785	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4751674	179785	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	564	14	2	6	5.3	CCN(CC)CC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170779	207611	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434008	145989	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL392268	145989	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	404	11	2	9	0.7	COC(=O)CCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44434110	88070	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL235135	88070	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	515	13	3	9	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	44577060	187459	0	None	-69	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL497746	187459	0	None	-69	7	Human	6.6	pKi	=	6.6	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	530	10	1	4	4.8	CC(C)[C@H](NC(=O)CCN(C)C)c1cccc(F)c1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1016/j.bmc.2008.03.072
	CHEMBL2170780	207612	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	71453404	81477	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164826	81477	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)N[C@]2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(Cl)cc32)CC1	10.1016/j.bmc.2012.07.018
	70692603	75509	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048816	75509	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	463	7	0	5	5.0	CC(C)COc1ccc(CN2CC3(CCN(C(=O)Cc4nc5ccccc5s4)CC3)C2)cc1	10.1016/j.bmcl.2012.05.024
	56926360	68678	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923608	68678	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC(C)C[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	72190451	91830	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426680	91830	0	None	524	2	Human	7.6	pKi	=	7.6	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	44579907	186455	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL491044	186455	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)[C@H](C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	73350846	91820	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426670	91820	0	None	-1	2	Human	4.6	pKi	=	4.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	6	0	6	3.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H](C)c2ccc(-c4ncccn4)cc2)C3)nc1	10.1016/j.bmcl.2013.07.044
	44576247	212441	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	CHEMBL506986	212441	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.1c02191
	44576247	212441	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	CHEMBL506986	212441	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1016/j.bmcl.2016.04.003
	44579880	186243	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	CHEMBL489401	186243	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	415	7	2	4	3.9	CC(=O)Nc1ccc(N(C[C@H]2CCCN2)C(=O)C(C)Oc2cccc(Cl)c2)cc1	10.1016/j.bmcl.2008.07.120
	118725962	116678	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
	CHEMBL3394202	116678	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	526	6	1	7	3.1	COc1cc(C(N)=O)c(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)cn1	10.1021/ml500414n
	44396384	67056	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
	CHEMBL188839	67056	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	574	14	2	5	6.1	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccc(OC)c(OC)c1	10.1021/jm040103i
	44434074	154123	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL399625	154123	0	None	-	1	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	501	12	3	9	1.4	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(CCc2ccccc2NS(C)(=O)=O)n1	10.1016/j.bmcl.2007.07.099
	70684155	75517	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	CHEMBL2048824	75517	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	486	5	0	6	4.1	O=C(Cc1cn2cc(Cl)ccc2n1)N1CCC2(CC1)CN(Cc1ccc(-c3ncccn3)cc1)C2	10.1016/j.bmcl.2012.05.024
	72191050	91817	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426667	91817	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	453	4	0	5	4.0	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	72190449	91826	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426676	91826	0	None	4	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	118725966	116682	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
	CHEMBL3394206	116682	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	539	6	1	6	4.6	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(NC(C)=O)c1	10.1021/ml500414n
	162675268	182766	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797685	182766	0	None	-	1	Human	7.6	pKi	=	7.6	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	645	13	3	8	4.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2(C#N)CCOCC2)cc1	10.1021/acs.jmedchem.9b02122
	3153999	126297	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL365489	126297	3	None	-	1	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	494	14	2	3	5.9	CCCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	71451551	81425	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164508	81425	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	460	5	2	4	3.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)c(C)cc32)CC1	10.1016/j.bmc.2012.07.018
	72190451	91830	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426680	91830	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	72190451	91830	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426680	91830	0	None	524	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)nc1	10.1021/ml400473x
	9950632	88264	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL236038	88264	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	357	9	2	8	0.7	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC#N	10.1016/j.bmcl.2007.07.099
	127046472	139151	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798056	139151	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	902	24	8	10	5.6	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@@H](N)CCCCN)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127045859	139156	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	CHEMBL3798095	139156	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Binding affinity at GHS-R1a (unknown origin) assessed as inhibition constantBinding affinity at GHS-R1a (unknown origin) assessed as inhibition constant	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1021/acs.jmedchem.1c02191
	127045859	139156	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798095	139156	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	831	20	7	9	5.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)CO)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	127047523	139520	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3800422	139520	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	859	20	7	9	6.0	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)O)cc1	10.1016/j.bmcl.2016.04.003
	71456897	81424	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164507	81424	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	513	5	2	3	5.7	CCN1CCC(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162653916	179953	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753794	179953	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	707	15	3	8	6.1	COc1ccc(/C=C(\C#N)C(=O)N[C@@H](C)C(=O)N[C@H](Cc2c[nH]c3ccccc23)c2nnc(CCc3ccccc3)n2Cc2ccc(OC)cc2)cc1	10.1021/acs.jmedchem.9b02122
	162643920	181188	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4777792	181188	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	679	14	4	8	5.4	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	155537651	171740	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4475293	171740	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1597	47	22	19	-3.8	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(N)=O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57391292	70919	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956995	70919	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	473	6	0	8	4.6	COc1ccc2cccc(Oc3ccc4nc(C)n(C[C@H]5CCCN(C(C)C)C5)c(=O)c4n3)c2n1	10.1016/j.bmcl.2012.01.078
	57345598	70928	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957004	70928	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	411	5	0	7	3.5	Cc1nc2ncc(Oc3ccc(F)cc3)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	53373577	91836	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426686	91836	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	458	5	0	7	2.8	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	57391294	70922	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956998	70922	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2cnc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	155526063	170459	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4456830	170459	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1174	34	16	14	-2.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	162663004	181457	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4781141	181457	0	None	-	1	Human	8.5	pKi	=	8.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	603	13	3	7	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C(C)(C)C#N)cc1	10.1021/acs.jmedchem.9b02122
	155557019	174005	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4556887	174005	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	1598	47	22	19	-3.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)CC)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	71453489	207613	13	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	CHEMBL2170781	207613	13	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/acs.jmedchem.8b01644
	67405379	91833	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426683	91833	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	474	5	0	6	4.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccs5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	25211977	186309	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489818	186309	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	C[C@H](Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	25098836	190852	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL519322	190852	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)[C@H](C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	127047525	139224	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798559	139224	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	858	20	7	9	5.9	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	162653309	179881	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4752936	179881	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	718	14	5	8	5.9	COc1ccc(Cn2c(CCc3c[nH]c4ccccc34)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	44579756	186231	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	CHEMBL489370	186231	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	372	7	1	3	3.9	CC(Oc1cccc(Cl)c1)C(=O)N(Cc1ccccc1)C[C@H]1CCCN1	10.1016/j.bmcl.2008.07.120
	162666964	181918	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4787023	181918	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	536	13	3	6	4.6	CCNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL2170693	207598	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1csc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	44434121	89464	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL237927	89464	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	385	11	2	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCC#N	10.1016/j.bmcl.2007.07.099
	56926584	68690	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923620	68690	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	554	4	3	5	3.2	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434120	89463	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL237926	89463	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	523	15	3	9	2.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCCCCNC(=O)OCc1ccccc1	10.1016/j.bmcl.2007.07.099
	44434007	88133	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235446	88133	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	390	10	2	9	0.3	COC(=O)CCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	11541143	68688	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923618	68688	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	540	4	3	5	3.0	CCC[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	24969520	68692	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923622	68692	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.5	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL2170694	207599	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	56926580	68684	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
	CHEMBL1923614	68684	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	4	5	3.1	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](CC)NC1=O	10.1021/jm2007062
	162653802	179939	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4753592	179939	0	None	-	1	Human	7.5	pKi	=	7.5	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	15	4	7	5.5	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)CCc2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	73346226	91818	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426668	91818	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	487	8	0	7	3.4	COCC(c1ccc(-c2ncccn2)cc1)N1CC2(CCN(C(=O)Cc3ccc(OC)cn3)CC2)C1	10.1016/j.bmcl.2013.07.044
	162674738	182795	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797988	182795	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	14	3	6	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	56926177	68658	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923506	68658	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	56926581	68685	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
	CHEMBL1923615	68685	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	550	5	4	5	3.4	CC[C@H](C)[C@@H]1NC[C@@H](C)Oc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C(C)C)NC1=O	10.1021/jm2007062
	71458747	81412	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	CHEMBL2164494	81412	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	446	4	2	4	2.9	Cc1cc2c(cc1Cl)NC(=O)C2(NC(=O)CN1CCN(C)CC1)c1ccc(Cl)cc1	10.1016/j.bmc.2012.07.018
	23631116	4037	19	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	3538	4037	19	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	CHEMBL243001	4037	19	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	10.1016/j.bmcl.2012.01.078
	127046956	139414	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799776	139414	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	631	12	3	7	5.5	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ncccc2F)cc1	10.1016/j.bmcl.2016.04.003
	118725961	116676	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	CHEMBL3394200	116676	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	523	6	0	7	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C#N)c1	10.1021/ml500414n
	162663407	181438	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780843	181438	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	562	13	3	6	4.3	C=CC(=O)NCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	56926462	68680	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923610	68680	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	3	3	5	2.1	C[C@@H]1C(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	70695747	72829	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	CHEMBL2011816	72829	0	None	-	1	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]Ghrelin from human GHSR1a receptorDisplacement of [125I]Ghrelin from human GHSR1a receptor	ChEMBL	540	8	2	5	4.7	CC(C)[C@H](C(=O)NC1CCN(Cc2ccccc2)CC1)N1CC(=O)Nc2ccc(Oc3ccccc3)cc2C1=O	10.1016/j.bmcl.2012.01.014
	67406334	111229	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287213	111229	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	57390496	68698	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68698	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	71453489	207613	13	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	CHEMBL2170781	207613	13	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assayDisplacement of [125I]-His-ghrelin from human ghrelin receptor expressed in COS7 cells incubated for 75 mins by scintillation counting based assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1cccc2ccccc12)NC(=O)[C@@H](N)CCCCN)C(N)=O	10.1021/jm300414b
	56926269	68661	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
	CHEMBL1923511	68661	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	460	5	3	5	2.0	CCCC[C@H]1NC(=O)CN(C)C(=O)[C@H](CCC)NCCOc2ccccc2CCCNC1=O	10.1021/jm2007062
	56926784	68702	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923633	68702	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	506	4	3	4	2.9	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	70688404	75499	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	CHEMBL2048807	75499	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1021/ml400473x
	70688404	75499	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048807	75499	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	464	6	0	5	4.3	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc4c(c2)CCC(C)(C)O4)C3)cc1	10.1016/j.bmcl.2012.05.024
	44434123	145005	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	CHEMBL391510	145005	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	343	8	2	8	0.3	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CC#N	10.1016/j.bmcl.2007.07.099
	56926582	68686	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923616	68686	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	536	5	3	5	3.1	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](CCc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	16114404	154346	18	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL400814	154346	18	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	508	11	3	6	4.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CN)cc1	10.1021/acs.jmedchem.9b02122
	25190383	81483	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164831	81483	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	466	4	2	4	3.2	CN1CCN(CC(=O)NC2(c3ccc(Cl)cc3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	11683187	198240	35	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
	CHEMBL594828	198240	35	None	-457	5	Human	5.4	pKi	=	5.4	Binding	Binding affinity to ghrelin receptorBinding affinity to ghrelin receptor	ChEMBL	419	7	0	8	2.9	COCc1nnc(N2CC(Oc3ccc(F)cc3Cl)C2)n1-c1ccc(OC)nc1	10.1016/j.bmcl.2009.11.097
	70684154	75501	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048809	75501	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	414	6	0	4	3.9	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccccc2Cl)C3)cc1	10.1016/j.bmcl.2012.05.024
	44434055	88861	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL236858	88861	0	None	-	1	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	487	11	3	9	1.2	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1Cc1ccccc1NS(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	56942385	124665	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645260	124665	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	13	5	7	4.5	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	56942535	139218	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798525	139218	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	593	12	4	7	4.4	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	24180592	96552	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	CHEMBL266647	96552	0	None	-134	6	Human	6.3	pKi	=	6.3	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	560	11	1	4	5.7	CC(C)C[C@H](NC(=O)CCN(C)C)c1cc(Cl)ccc1N1CCN(C(=O)[C@H](C)Cc2ccc(Cl)cc2)CC1	10.1021/jm701137s
	44434113	88207	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	CHEMBL235793	88207	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	452	10	2	9	1.5	COC(=O)C(c1ccccc1)n1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N	10.1016/j.bmcl.2007.07.099
	44434051	88971	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	CHEMBL237058	88971	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	394	9	2	7	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnn(Cc2ccccc2)n1	10.1016/j.bmcl.2007.07.099
	118725954	116672	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	CHEMBL3394193	116672	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	467	4	0	5	4.3	Cc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)nc1	10.1021/ml500414n
	24969603	68697	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	CHEMBL1923627	68697	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	3	3	5	2.4	Cc1ccc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NCCOc3ccccc3CCCNC2=O)cc1	10.1021/jm2007062
	57394882	70935	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957011	70935	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	447	5	0	9	3.3	Cc1nc2ncc(Oc3ccc4c(c3)ncn4C)nc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	9876514	9037	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
	CHEMBL109980	9037	2	None	-	1	Human	8.3	pKi	=	8.3	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	610	10	2	7	2.3	CC(C)(N)C(=O)N[C@H](COCc1ccc(F)cc1F)C(=O)N1CCC2=NN(CC(F)(F)F)C(=O)[C@]2(Cc2ccccn2)C1	10.1016/s0960-894x(02)00734-5
	70682037	75513	14	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	CHEMBL2048820	75513	14	None	43	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2013.07.044
	145948708	166924	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL4299606	166924	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	886	20	7	10	5.2	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(=O)[C@H]3CNCCO3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(C)=O)cc1	10.1016/j.bmcl.2016.04.003
	67410074	111232	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287216	111232	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5nccc(C)n5)ccc42)C3)nc1	10.1021/ml400473x
	56926465	68683	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
	CHEMBL1923613	68683	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	4	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)NC1=O	10.1021/jm2007062
	44434119	89462	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	CHEMBL237925	89462	0	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	400	10	3	10	-0.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1nnn[nH]1	10.1016/j.bmcl.2007.07.099
	70694648	75504	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048811	75504	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	462	7	0	7	3.6	COc1ccc(OCC(=O)N2CCC3(CC2)CN(Cc2ccc(-c4nnc(C)o4)cc2)C3)cc1	10.1016/j.bmcl.2012.05.024
	155561671	175081	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4581511	175081	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	817	22	11	9	-0.5	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(N)=O)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	56926894	68707	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	CHEMBL1923638	68707	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	C[C@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2O1	10.1021/jm2007062
	162672372	182494	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4794448	182494	0	None	-	1	Human	7.3	pKi	=	7.3	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	656	14	3	6	6.0	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C=C/c2ccc(F)cc2)cc1	10.1021/acs.jmedchem.9b02122
	56925345	68712	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923643	68712	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	3	3	5	2.3	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2cc(F)ccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	56926464	68682	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923612	68682	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	508	4	3	5	2.5	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](C)N(C)C1=O	10.1021/jm2007062
	56942387	139119	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3797857	139119	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	579	13	4	7	4.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C(C)(C)N)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL105462	206716	34	None	-	1	Human	8.2	pKi	=	8.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL		None	None	None		C[C@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(N)=O	10.1021/jm960054c
	56926680	68693	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923623	68693	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccccc2F)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	162649014	179351	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4746362	179351	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	702	14	4	7	6.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2c[nH]c3ccccc23)cc1	10.1021/acs.jmedchem.9b02122
	162666112	181722	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4784240	181722	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	638	13	3	8	4.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)c2ccc(C#N)nc2)cc1	10.1021/acs.jmedchem.9b02122
	162676229	182712	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4797064	182712	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	715	15	3	10	3.9	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(N(C)C)cc2)cc1	10.1021/acs.jmedchem.9b02122
	58438475	91827	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426677	91827	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	58438475	91827	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	CHEMBL2426677	91827	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml400473x
	56926461	68679	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923609	68679	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	522	4	3	5	2.7	CC[C@H](C)[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	118725956	116673	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
	CHEMBL3394195	116673	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	493	5	0	5	4.9	Cc1cc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(C5CC5)cn4)CC3)C2)ncn1	10.1021/ml500414n
	155551597	173367	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	CHEMBL4541252	173367	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL	974	27	13	11	-1.2	CCCC[C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@H](C(N)=O)C(C)C)[C@@H](C)O	10.1021/acs.jmedchem.8b01644
	57394797	70926	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1957002	70926	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	461	5	0	7	4.7	Cc1nc2cnc(Oc3ccc(F)c4cccnc34)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	162649450	179464	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4747770	179464	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	725	14	3	10	5.2	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)C2CCN(c3oc(C)nc3C#N)CC2)cc1	10.1021/acs.jmedchem.9b02122
	58438464	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	58438464	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	9060	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	CHEMBL3287218	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	DB14870	3004	28	None	1	3	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	10.1021/ml400473x
	67406334	111229	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	CHEMBL3287213	111229	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	498	4	0	7	4.3	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN([C@@H]3CCc5cc(-c6ncccn6)ccc53)C4)nc2s1	10.1021/ml400473x
	57401798	70912	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	CHEMBL1956989	70912	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation countingDisplacement of [125I]-Ghrelin from human GHSR membranes overexpressing GSH-R1a by scintillation counting	ChEMBL	410	5	0	6	4.2	Cc1nc2ncc(Oc3ccc(F)cc3)cc2c(=O)n1C[C@H]1CCCN(C(C)C)C1	10.1016/j.bmcl.2012.01.078
	58438475	91827	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	CHEMBL2426677	91827	0	None	1548	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	468	5	0	5	4.3	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncccn5)ccc42)C3)cc1	10.1021/ml500414n
	11541319	68713	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
	CHEMBL1923644	68713	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	556	3	3	5	2.7	C[C@@H]1CN[C@@H](C2CC2)C(=O)N(C)[C@H](C)C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccc(F)cc2O1	10.1021/jm2007062
	162659375	180759	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4763077	180759	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	566	14	4	7	3.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNCC(=O)O)cc1	10.1021/acs.jmedchem.9b02122
	127046807	139397	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799671	139397	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127047654	139434	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799883	139434	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	571	11	3	7	5.2	COc1ccc(Cn2c([C@@H](N)Cc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	121879	2195	19	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	5868	2195	19	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	CHEMBL308716	2195	19	None	-	1	Human	7.2	pKi	=	7.2	Binding	Binding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligandBinding Affinity against Growth hormone secretagogue receptor of swine using [35S]MK-0677 as radioligand	ChEMBL	509	7	3	6	3.6	O=C(CC(N)(C)C)N[C@@H]1CCc2c(N(C1=O)Cc1ccc(cc1)c1ccccc1c1nnn[nH]1)cccc2	10.1021/jm960054c
	162665952	181787	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4785149	181787	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	688	14	4	10	3.5	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc(O)cc2)cc1	10.1021/acs.jmedchem.9b02122
	134139753	145491	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	CHEMBL3918783	145491	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting methodDisplacement of [125I]-Ghrelin from human GSHR1a transfected in HEK293 cell membranes after 30 mins by microplate scintillation and luminescence counting method	ChEMBL	508	5	3	5	2.5	CCCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	nan
	162663868	181396	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4780408	181396	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	672	14	3	9	3.8	COc1ccc(Cn2c(CCN3CCOCC3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	56926268	68660	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
	CHEMBL1923510	68660	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	542	4	3	5	2.5	CN1CC(=O)N[C@H](Cc2ccccc2)C(=O)NCCCc2ccccc2OCCN[C@@H](Cc2ccccc2)C1=O	10.1021/jm2007062
	56926175	68656	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923504	68656	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	494	4	3	5	2.1	CCC[C@@H]1NCCOc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	23635235	165937	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	CHEMBL427860	165937	0	None	-239	5	Human	6.2	pKi	=	6.2	Binding	Inhibition of ghrelin receptorInhibition of ghrelin receptor	ChEMBL	526	10	1	4	4.9	Cc1ccc(N2CCN(C(=O)[C@H](C)Cc3ccc(Cl)cc3)CC2)c([C@@H](NC(=O)CCN(C)C)C(C)C)c1	10.1016/j.bmc.2008.03.072
	70686292	75512	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048819	75512	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	461	5	0	8	3.0	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	90644554	111231	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL3287215	111231	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	469	5	0	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ccncn5)ccc42)C3)nc1	10.1021/ml400473x
	70682037	75513	14	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	CHEMBL2048820	75513	14	None	43	2	Human	8.2	pKi	=	8.2	Binding	Antagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIAAntagonist activity at human GHS-R1a expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP binding by DELFIA	ChEMBL	495	5	0	8	3.6	Cc1cn2cc(CC(=O)N3CCC4(CC3)CN(Cc3ccc(-n5nccn5)cc3Cl)C4)nc2s1	10.1016/j.bmcl.2012.05.024
	11664206	68696	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923626	68696	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	574	3	3	5	3.1	C[C@@H]1C(=O)N[C@H](Cc2ccc(C(F)(F)F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	216208	9620	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	CHEMBL113313	9620	27	None	-	1	Human	8.2	pKi	=	8.2	Binding	In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.In vitro binding affinity against human type 1a growth hormone secretagogue receptor (hGHS-R1a), using [125I]ghrelin as radioligand.	ChEMBL	505	9	2	6	1.7	CN1N=C2CCN(C(=O)[C@@H](COCc3ccccc3)NC(=O)C(C)(C)N)C[C@@]2(Cc2ccccc2)C1=O	10.1016/s0960-894x(02)00734-5
	56926682	68695	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	CHEMBL1923625	68695	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	524	3	3	5	2.2	C[C@@H]1C(=O)N[C@H](Cc2ccc(F)cc2)C(=O)NCCCc2ccccc2OCCN[C@@H](C2CC2)C(=O)N1C	10.1021/jm2007062
	67408128	91834	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426684	91834	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	457	5	0	6	3.4	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-n5nccn5)ccc42)C3)cc1	10.1016/j.bmcl.2013.07.044
	24180646	147638	0	None	-1023	7	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	CHEMBL393576	147638	0	None	-1023	7	Human	6.1	pKi	=	6.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	591	11	2	5	4.7	CC(C)C[C@H](NCCN)c1cccc(F)c1N1CCN(C(=O)[C@@H](Cc2ccc(Cl)cc2Cl)N2CCCC2=O)CC1	10.1021/jm701137s
	57390496	68698	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL1923628	68698	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	552	3	3	5	2.9	Cc1cc(C[C@H]2NC(=O)[C@@H](C)N(C)C(=O)[C@H](C3CC3)NC[C@@H](C)Oc3ccccc3CCCNC2=O)ccc1F	10.1021/jm2007062
	CHEMBL501261	212354	19	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assayDisplacement of [125I]-His9 ghrelin from SNAP-tagged human GHSR expressed in HEK293T cells after 3 hrs by HTRF assay	ChEMBL		None	None	None		CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](N)CCCNC(=N)N)C(N)=O	10.1021/acs.jmedchem.8b01644
	56926892	68705	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923636	68705	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	534	4	3	4	3.7	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434012	88631	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL236513	88631	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	479	13	3	8	1.5	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	127046473	139237	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3798645	139237	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Competitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assayCompetitive binding affinity to human SNAP-tagged GHS-R1a expressed in HEK293T cells incubated at 4 degC for 3 hrs or at room temperature for 1 hr by Tag-lite assay	ChEMBL	661	17	6	8	4.2	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@@H](N)CCCCN)cc1	10.1016/j.bmcl.2016.04.003
	56942099	124661	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645256	124661	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	599	13	3	7	5.0	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	66601728	81415	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	CHEMBL2164499	81415	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation countingDisplacement of [125I]-ghrelin from human GHSR1 expressed in CHO-CREluc cells after 1 hr by scintillation counting	ChEMBL	514	5	2	4	4.3	CCN1CCN(CC(=O)NC2(c3ccc(Cl)c(Cl)c3)C(=O)Nc3cc(Cl)cc(Cl)c32)CC1	10.1016/j.bmc.2012.07.018
	162657465	180449	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4759418	180449	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	652	14	4	7	5.1	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccc[nH]2)cc1	10.1021/acs.jmedchem.9b02122
	56926891	68704	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	CHEMBL1923635	68704	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	520	4	3	4	3.3	CC[C@H](C)[C@@H]1NCCCc2ccccc2CCCNC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@@H](C)N(C)C1=O	10.1021/jm2007062
	44434015	88049	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	CHEMBL235011	88049	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	493	14	3	8	1.9	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCC(=O)NCCCc1ccccc1	10.1016/j.bmcl.2007.07.099
	67407808	91837	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426687	91837	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Inverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIAInverse agonist activity at human ghrelin receptor expressed in HEK293 cells assessed as inhibition of ghrelin-induced europium-labeled GTP-gamma-S binding by DELFIA	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	56926173	68655	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	CHEMBL1923501	68655	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	492	4	3	5	2.2	CCC[C@@H]1NCCOc2ccccc2/C=C/CNC(=O)[C@@H](Cc2ccccc2)NC(=O)CN(C)C1=O	10.1021/jm2007062
	3153998	67166	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	CHEMBL189561	67166	3	None	-	1	Human	6.1	pKi	=	6.1	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	480	13	2	3	5.5	CCCC(C(=O)NC1CCCCC1)N(CCCN(CC)CC)C(=O)c1ccc(-c2ccccc2)[nH]1	10.1021/jm040103i
	56926893	68706	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	CHEMBL1923637	68706	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assayDisplacement of [125I-His9]-ghrelin from human GRLN receptor by radioligand binding assay	ChEMBL	538	3	3	5	2.6	CC1COc2ccccc2CCCNC(=O)[C@@H](Cc2ccc(F)cc2)NC(=O)[C@@H](C)N(C)C(=O)[C@H](C2CC2)N1	10.1021/jm2007062
	66788278	124659	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3645254	124659	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	652	12	4	7	5.8	COc1ccc(Cn2c([C@@H](Cc3c[nH]c4ccccc34)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)c2ccccn2)cc1	10.1016/j.bmcl.2016.04.003
	127045858	139319	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	CHEMBL3799225	139319	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting methodDisplacement of [125I]-His9-ghrelin from human GHS-R1a transfected in pig LLC PK-1 cell membranes after 60 mins by gamma counting method	ChEMBL	618	12	3	7	5.3	COc1ccc(Cn2c([C@@H](Cc3ccccc3)NC(C)=O)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)C2=CCCCO2)cc1	10.1016/j.bmcl.2016.04.003
	162677268	182981	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4800459	182981	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	663	14	3	7	5.7	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2ccccc2)cc1	10.1021/acs.jmedchem.9b02122
	58438487	91835	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426685	91835	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	497	6	0	6	4.3	CCc1cnc(-c2ccc3c(c2)CC[C@H]3N2CC3(CCN(C(=O)Cc4ccc(OC)cn4)CC3)C2)nc1	10.1016/j.bmcl.2013.07.044
	67407808	91837	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	CHEMBL2426687	91837	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation countingDisplacement of [125I]-ghrelin from human GHS-R1a expressed in tetracycline inducible HEK293 cells after 8 hrs by liquid scintillation counting	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1016/j.bmcl.2013.07.044
	67407808	91837	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	CHEMBL2426687	91837	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assayDisplacement of [125I]ghrelin from human ghrelin receptor expressed in HEK293 cells after 8 hrs by scintillation proximity assay	ChEMBL	483	5	0	6	4.0	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5ncc(C)cn5)ccc42)C3)nc1	10.1021/ml400473x
	67406727	116677	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	CHEMBL3394201	116677	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA methodDisplacement of [125I]Ghrelin from human GHS-R1a expressed in HEK293 cells after 8 hrs by SPA method	ChEMBL	525	6	1	6	3.7	COc1ccc(CC(=O)N2CCC3(CC2)CN([C@@H]2CCc4cc(-c5cc(C)ncn5)ccc42)C3)c(C(N)=O)c1	10.1021/ml500414n
	162656896	180268	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4757313	180268	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	669	14	3	8	5.8	COc1ccc(Cn2c(CCc3ccccc3)nnc2[C@@H](Cc2c[nH]c3ccccc23)NC(=O)CNC(=O)/C(C#N)=C/c2cccs2)cc1	10.1021/acs.jmedchem.9b02122
	44579823	183489	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	CHEMBL482420	183489	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to GHSRBinding affinity to GHSR	ChEMBL	386	7	1	3	4.2	Cc1ccccc1CN(C[C@H]1CCCN1)C(=O)C(C)Oc1cccc(Cl)c1	10.1016/j.bmcl.2008.07.120
	44396320	66468	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
	CHEMBL186045	66468	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Binding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelinBinding affinity for human growth hormone secretagogue receptor was determined using [125I]ghrelin	ChEMBL	515	12	2	4	5.4	CCN(CC)CCCN(C(=O)c1ccc(-c2ccccc2)[nH]1)C(C(=O)NC1CCCCC1)c1ccncc1	10.1021/jm040103i
	162674996	182797	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	CHEMBL4798018	182797	0	None	-	1	Human	7.0	pKi	=	7.0	Binding	Displacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assayDisplacement of red-ghrelin from SNAP-tagged human GHSR expressed in HEK293 cells incubated for 3 hrs at 4 degC or for 1 hr at room temperature by HTRF assay	ChEMBL	522	12	3	6	4.2	CNCC(=O)N[C@H](Cc1c[nH]c2ccccc12)c1nnc(CCc2ccccc2)n1Cc1ccc(OC)cc1	10.1021/acs.jmedchem.9b02122
	44434111	145738	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	CHEMBL392077	145738	0	None	-	1	Human	6.0	pKi	=	6.0	Binding	Displacement of [125I]ghrelin from human GHSR1a after 1 hrDisplacement of [125I]ghrelin from human GHSR1a after 1 hr	ChEMBL	525	11	2	10	1.8	CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCc1cc2ccccc2n1S(C)(=O)=O	10.1016/j.bmcl.2007.07.099
	9745	2410	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	9804938	2410	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	CHEMBL278623	2410	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	DB13074	2410	20	None	-	0	Human	8.1	pIC50	=	8.1	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Drug Central	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	None
	9745	2410	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	9804938	2410	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	CHEMBL278623	2410	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	DB13074	2410	20	None	-	0	Human	7.8	pIC50	=	7.8	Binding	In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.In a radioligand displacement assay using <sup>125</sup>I-labeled ghrelin as the probe, and human pituitary gland samples.	Guide to Pharmacology	474	10	6	4	1.8	O=CN[C@@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](NC(=O)C(N)(C)C)Cc1c[nH]c2c1cccc2	12240910
	1102	1289	0	None	-	1	Human	7.4	pKd	=	7.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1093	1756	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1093	1756	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	4345065	1756	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	4345065	1756	0	None	-12	2	Human	7.7	pKd	=	7.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	1100	1572	41	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	6918297	1572	41	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	CHEMBL108335	1572	41	None	-	1	Human	7.9	pKd	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11061542
	1099	1749	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	12907757
	1099	1749	0	None	-	1	Human	9.0	pKd	=	9.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15905359
	1092	3097	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	134715446	3097	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	2232	3097	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	6918245	3097	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	CHEMBL106593	3097	0	None	-	1	Rat	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central		None	None	None		None	None
	58438464	3004	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3004	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3004	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3004	28	None	-2	3	Mouse	8.1	pKi	=	8.1	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	58438464	3004	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3004	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3004	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3004	28	None	-1	3	Rat	8.5	pKi	=	8.5	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cellsMeasured <i>in vitro</i> in recombinant receptor over-expressing cells	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	58438464	3004	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	9060	3004	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	CHEMBL3287218	3004	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	DB14870	3004	28	None	1	3	Human	8.9	pKi	=	8.9	Binding	Measured <i>in vitro</i> in recombinant receptor over-expressing cells.Measured <i>in vitro</i> in recombinant receptor over-expressing cells.	Guide to Pharmacology	512	4	0	7	4.6	Cc1ncnc(c1)c1ccc2c(c1)CC[C@H]2N1CC2(C1)CCN(CC2)C(=O)Cc1nc2n(c1)cc(s2)C	26784385
	12413	3009	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	164946906	3009	0	None	-3	2	Rat	6.6	pKi	=	6.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	12413	3009	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	164946906	3009	0	None	3	2	Human	7.1	pKi	=	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	4	1	8	4.3	CC1=CN2C=C(CC(=O)N3CCC4(CN(C4)[C@@H]5CCC6=CC(=CC=C56)C7=CC(C)=NC(O)=N7)CC3)N=C2S1	36631279
	23631116	4037	19	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	3538	4037	19	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	CHEMBL243001	4037	19	None	-	1	Human	7.8	pKi	=	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	409	5	0	5	4.8	Fc1ccc(cc1)Oc1ccc2c(c1)c(=O)n(c(n2)C)C[C@H]1CCCN(C1)C(C)C	17656463
	1098	1359	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
	1098	1359	0	None	-	1	Rat	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	14763915
	1101	650	0	None	-	1	Human	8.1	pKi	=	8.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	15339248
	10740	1899	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
	146170991	1899	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	401	4	1	3	4.4	COc1ccc(c(c1Cl)Cl)[C@@H](NC(=O)N([C@@H]1CCN(CC1(C)C)C)C)C	25327342
	1092	3097	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	134715446	3097	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	2232	3097	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	6918245	3097	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	CHEMBL106593	3097	0	None	-	1	Rat	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	178024	1932	30	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	5867	1932	30	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	CHEMBL13817	1932	30	None	-	1	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	528	8	2	6	1.8	O=C([C@H](NC(=O)C(N)(C)C)COCc1ccccc1)N1CCC2(CC1)CN(c1c2cccc1)S(=O)(=O)C	10427162
	1099	1749	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	11314756
	1093	1756	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793
	4345065	1756	0	None	12	2	Rat	8.8	pKi	None	8.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology		None	None	None		None	9092793

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Ligand source activities (1 row/activity)