GPCRdb

Ligand source activities (1 row/activity)

Potency
Affinity

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Potency)	# tested GPCRs (Potency)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	57781216	125313	0	None	8	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	125313	0	None	8	2	Human	10.8	pEC50	=	10.8	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	24954989	1497	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	1497	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	1497	1	None	25	2	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	1357	2440	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	2440	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	2440	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	2440	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	2440	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	2440	133	None	1	3	Human	10.7	pEC50	=	10.7	Functional	Agonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assayAgonist activity at human MT1 expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30 mins by AlphaScreen assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1357	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	2440	133	None	1	3	Human	10.6	pEC50	=	10.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate readerAgonist activity at human MT1 receptor expressed in CHO cells assessed as decrease in forskolin-stimulated cAMP release after 30 mins by multilabel plate reader	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	139451757	184238	0	None	3	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184238	0	None	3	2	Human	10.5	pEC50	=	10.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451761	184004	0	None	4	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184004	0	None	4	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451781	184265	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184265	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	139451795	184737	0	None	2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	184737	0	None	2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451767	184411	0	None	5	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	184411	0	None	5	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451764	185675	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	185675	0	None	-2	2	Human	10.4	pEC50	=	10.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	145981769	166103	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4281712	166103	0	None	-	1	Human	10.3	pEC50	=	10.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	139451790	184704	13	None	6	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	184704	13	None	6	2	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	2440	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	2440	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	2440	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	2440	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	2440	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	2440	133	None	1	3	Human	10.2	pEC50	=	10.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1357	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1357	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	2440	133	None	1	3	Human	10.0	pEC50	=	10.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	139451757	184238	0	None	3	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184238	0	None	3	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451763	185741	0	None	-1	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	185741	0	None	-1	2	Human	9.9	pEC50	=	9.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	9839629	99641	0	None	-1	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	99641	0	None	-1	2	Human	9.8	pEC50	=	9.8	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	139451761	184004	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184004	0	None	4	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	198	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	310	120	None	-3	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	145982070	165911	0	None	1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	165911	0	None	1	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145993214	166187	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4283539	166187	0	None	-	1	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	139451767	184411	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	184411	0	None	5	2	Human	9.7	pEC50	=	9.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451776	184418	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	184418	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451799	185247	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	185247	0	None	3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	139451790	184704	13	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	184704	13	None	6	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	164946945	189625	1	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189625	1	None	-3	2	Human	9.6	pEC50	=	9.6	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	139451781	184265	0	None	-2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184265	0	None	-2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	139451795	184737	0	None	2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	184737	0	None	2	2	Human	9.5	pEC50	=	9.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451764	185675	0	None	-2	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	185675	0	None	-2	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	168296374	191910	0	None	9	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191910	0	None	9	2	Human	9.4	pEC50	=	9.4	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	53237951	61675	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774518	61675	0	None	-	1	Human	9.3	pEC50	=	9.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	168296374	191910	0	None	9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191910	0	None	9	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	44394435	66578	0	None	34	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	66578	0	None	34	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulationAgonist activity towards human Melatonin receptor type 1A was determined by its ability to inhibit forskolin stimulated cAMP accumulation	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	168274836	189544	0	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189544	0	None	17	2	Human	9.2	pEC50	=	9.2	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins in presence of light-activated compounds by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	139451780	185352	0	None	-1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	185352	0	None	-1	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	137660333	158961	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	158961	0	None	-3	2	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	145979585	165926	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4278446	165926	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	145986532	166717	0	None	-4	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	166717	0	None	-4	2	Human	9.1	pEC50	=	9.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	122188347	122634	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612604	122634	0	None	-	1	Human	9.1	pEC50	=	9.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	139451766	183855	0	None	-4	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	183855	0	None	-4	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assayAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451769	185550	0	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	185550	0	None	-5	2	Human	9.0	pEC50	=	9.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	1357	2440	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	1672	2440	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	224	2440	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	896	2440	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	CHEMBL45	2440	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	DB01065	2440	133	None	1	3	Human	9.0	pEC50	=	9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by Fluo-8 dye-based calcium assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2019.06.008
	127026427	137146	0	None	-1	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	137146	0	None	-1	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127026425	137282	0	None	8	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	137282	0	None	8	2	Human	9.0	pEC50	=	9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	168274836	189544	0	None	17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189544	0	None	17	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	198	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	198	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	198	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	310	120	None	-3	2	Human	8.9	pEC50	=	8.9	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	1357	2440	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	2440	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	2440	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	2440	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	2440	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	2440	133	None	1	3	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	198	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	198	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	198	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	82148	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	99	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	CHEMBL10878	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	DB06594	310	120	None	-3	2	Human	8.8	pEC50	=	8.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2010.04.008
	122188346	122633	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612603	122633	0	None	-	1	Human	8.8	pEC50	=	8.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	139451776	184418	0	None	3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	184418	0	None	3	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	1357	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	18360658	8787	0	None	10	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	8787	0	None	10	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	145979282	166111	0	None	-1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166111	0	None	-1	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145986700	166655	0	None	-5	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	166655	0	None	-5	2	Human	8.0	pEC50	=	8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122220128	159116	0	None	-27	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	159116	0	None	-27	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	145992795	166227	0	None	-25	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	166227	0	None	-25	2	Human	7.0	pEC50	=	7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145991111	166348	0	None	-10	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	166348	0	None	-10	2	Human	5.0	pEC50	=	5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	23658143	155824	1	None	-41	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	155824	1	None	-41	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	46888492	8740	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1096991	8740	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	122188231	122619	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612462	122619	0	None	-	1	Human	7.0	pEC50	=	7.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	19703063	28687	1	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	28687	1	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	46888520	8541	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095195	8541	0	None	-	1	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	21581654	60413	1	None	-10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	60413	1	None	-10	2	Human	7.9	pEC50	=	7.9	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	10385056	111731	0	None	-354	2	Human	6.9	pEC50	=	6.9	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	111731	0	None	-354	2	Human	6.9	pEC50	=	6.9	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	164946945	189625	1	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189625	1	None	-3	2	Human	6.8	pEC50	=	6.8	Functional	Agonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assayAgonist activity at human melatonin MT1 receptor stably expressing in human HEK293 cells assessed as inhibition of forskolin-stimulated cAMP accumulation after 30 mins under dark condition by cAMP assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	145986330	166493	0	None	-3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	166493	0	None	-3	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	52918080	60425	0	None	-12	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	60425	0	None	-12	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	9937825	8765	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	8765	0	None	2	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	71508233	86632	0	None	-676	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	86632	0	None	-676	2	Human	7.8	pEC50	=	7.8	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	122188230	122618	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612461	122618	0	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	137639112	156298	0	None	-8128	2	Human	5.8	pEC50	=	5.8	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	156298	0	None	-8128	2	Human	5.8	pEC50	=	5.8	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	4018512	42959	37	None	-2	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	CHEMBL15060	42959	37	None	-2	2	Human	4.8	pEC50	=	4.8	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	308	5	2	2	3.5	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1039/d2md00156j
	121231413	3834	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	9226	3834	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	CHEMBL3612464	3834	1	None	-	1	Human	6.8	pEC50	=	6.8	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	52953165	62064	0	None	-87	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	62064	0	None	-87	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	137647756	157389	0	None	-213	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	157389	0	None	-213	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	23658146	156564	1	None	-15	2	Human	7.7	pEC50	=	7.7	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	156564	1	None	-15	2	Human	7.7	pEC50	=	7.7	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	122188237	122625	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612469	122625	0	None	-	1	Human	6.7	pEC50	=	6.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145981162	165933	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	165933	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	122188349	122636	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	CHEMBL3612606	122636	0	None	-	1	Human	8.7	pEC50	=	8.7	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	52918079	60416	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	60416	0	None	-2	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	139451766	183855	0	None	-4	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	183855	0	None	-4	2	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1672	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	224	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	896	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	CHEMBL45	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	DB01065	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.04.008
	1357	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	2440	133	None	1	3	Human	8.7	pEC50	=	8.7	Functional	Agonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1AAgonist potency determined by [35S]GTP gamma-S binding assay using CHO cell lines for Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	10163052	8421	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	8421	0	None	10	2	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	46888491	8568	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095522	8568	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	9870683	8786	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097496	8786	0	None	-	1	Human	8.6	pEC50	=	8.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	46888521	8542	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095196	8542	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	71508235	86633	0	None	-14	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	86633	0	None	-14	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	145990308	166468	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4288690	166468	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	166556	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	166556	0	None	-6	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137637884	155693	0	None	-19	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	155693	0	None	-19	2	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	53231366	62057	0	None	-309	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	62057	0	None	-309	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	86273228	120793	0	None	-18	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	120793	0	None	-18	2	Human	6.7	pEC50	=	6.7	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	9927219	111817	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329263	111817	0	None	-	1	Human	7.7	pEC50	=	7.7	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	46888522	8543	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	8543	0	None	3	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	168283863	190366	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	274	3	0	4	2.5	COc1cc2c(CN3CCN(C)CC3)coc2cc1C	10.1039/d2md00156j
	CHEMBL5186032	190366	0	None	-	1	Human	4.7	pEC50	=	4.7	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	274	3	0	4	2.5	COc1cc2c(CN3CCN(C)CC3)coc2cc1C	10.1039/d2md00156j
	46845151	8563	0	None	7	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	8563	0	None	7	2	Human	7.7	pEC50	=	7.7	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	53231465	62056	0	None	-35	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	62056	0	None	-35	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	122188225	122614	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612456	122614	0	None	-	1	Human	6.6	pEC50	=	6.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	122188227	122616	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612458	122616	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	10926138	206228	0	None	-147	2	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	206228	0	None	-147	2	Human	7.6	pEC50	=	7.6	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	23642307	158337	1	None	-39	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	158337	1	None	-39	2	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145	140	48	None	-144	12	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	140	48	None	-144	12	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	140	48	None	-144	12	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	140	48	None	-144	12	Human	6.6	pEC50	=	6.6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	9064	104727	90	None	1	3	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	CHEMBL311498	104727	90	None	1	3	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate ReaderAgonist activity at human MT1R stably expressed in HEK293 cells by FlexStation3 Bench-top MultiMode Microplate Reader	ChEMBL	290	1	5	6	1.5	Oc1cc(O)c2c(c1)O[C@H](c1ccc(O)c(O)c1)[C@@H](O)C2	10.1016/j.ejmech.2020.112960
	7778	799	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	9957516	799	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL1094546	799	0	None	-	1	Human	7.6	pEC50	=	7.6	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	86079062	180140	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	180140	0	None	-3	2	Human	5.6	pEC50	=	5.6	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	198	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	82148	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	99	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	CHEMBL10878	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	DB06594	310	120	None	-3	2	Human	4.6	pEC50	=	4.6	Functional	Agonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysisAgonist activity at human MT1 receptor transfected in HEK293T cells co-transfected with tet-inducible luciferase reporter plasmid, pCDNA3.1(+)-CMV-betaArrestin2-tev plasmid and TANGO plasmid assessed as tango arrestin recruitment incubated for 24 hrs by TANGO-GPCR assay based luminescence plate reader analysis	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/d2md00156j
	122188229	122617	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612460	122617	0	None	-	1	Human	5.6	pEC50	=	5.6	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	86273227	120790	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	120790	0	None	-3	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	127025783	137200	0	None	-8	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	137200	0	None	-8	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	145982333	165993	0	None	-2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	165993	0	None	-2	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	53238410	61684	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774529	61684	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	18007928	8562	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095504	8562	0	None	-	1	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	139451784	184803	0	None	-1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	184803	0	None	-1	2	Human	8.5	pEC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysisAgonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	145993566	166806	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	166806	0	None	-1	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137650826	156951	0	None	-28	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	156951	0	None	-28	2	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	122188236	122624	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612468	122624	0	None	-	1	Human	7.5	pEC50	=	7.5	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	54581170	60424	0	None	-2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	60424	0	None	-2	2	Human	7.5	pEC50	=	7.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	162649247	179485	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	179485	0	None	1	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	122178509	120801	0	None	-9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	120801	0	None	-9	2	Human	6.5	pEC50	=	6.5	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	122188235	122623	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612467	122623	0	None	-	1	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	1353	3368	3	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	3368	3	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	3368	3	None	-51	2	Human	7.4	pEC50	=	7.4	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	86273226	120791	0	None	-12	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	120791	0	None	-12	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	23658145	156909	1	None	-52	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	156909	1	None	-52	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	122188232	122620	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612463	122620	0	None	-	1	Human	6.4	pEC50	=	6.4	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145982167	166047	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	166047	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	52918077	60414	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	60414	2	None	-1	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	53238181	919	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	919	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	919	0	None	-3	2	Human	8.4	pEC50	=	8.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate ReadersAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 30 mins by EnVision Multilabel Plate Readers	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	127026423	137281	0	None	-6	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	137281	0	None	-6	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	127029516	137096	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	137096	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	71508234	696	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	696	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	696	0	None	-173	2	Human	7.4	pEC50	=	7.4	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	162668689	182166	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	182166	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	162656758	180330	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	180330	0	None	-1	2	Human	6.4	pEC50	=	6.4	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	10301190	8465	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	CHEMBL1094545	8465	0	None	-	1	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	23642306	158515	1	None	-17	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	158515	1	None	-17	2	Human	7.3	pEC50	=	7.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	10925526	111829	0	None	-47	2	Human	6.3	pEC50	=	6.3	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	111829	0	None	-47	2	Human	6.3	pEC50	=	6.3	Functional	Intrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1AIntrinsic activity evaluated on [35S]GTP -gamma-S binding in Chinese hamster ovarian (CHO) cells, stably expressing human Melatonin receptor type 1A	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145982333	165993	0	None	-2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	165993	0	None	-2	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145990662	166365	0	None	-16	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	166365	0	None	-16	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988741	166672	0	None	-12	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	166672	0	None	-12	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	52918078	60415	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	60415	0	None	-3	2	Human	8.3	pEC50	=	8.3	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	127026426	137262	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	137262	0	None	-1	2	Human	8.3	pEC50	=	8.3	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	86273229	120792	1	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	120792	1	None	-3	2	Human	6.3	pEC50	=	6.3	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	145979689	166059	0	None	-1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	166059	0	None	-1	2	Human	8.2	pEC50	=	8.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	122188351	122637	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612608	122637	0	None	-	1	Human	8.2	pEC50	=	8.2	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	137650611	156958	0	None	-91	2	Human	7.2	pEC50	=	7.2	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	156958	0	None	-91	2	Human	7.2	pEC50	=	7.2	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	162649850	179548	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	179548	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 expressed in CHO cell membrane incubated for 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	127026062	137151	0	None	-7	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	137151	0	None	-7	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	18360631	8612	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095831	8612	0	None	-	1	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	145983175	165867	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	165867	0	None	-1	2	Human	7.2	pEC50	=	7.2	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	86273222	120796	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	120796	0	None	-2	2	Human	6.2	pEC50	=	6.2	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	44359437	29671	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	29671	0	None	3	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	1355	3371	3	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	3371	3	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	3371	3	None	5	2	Human	7.1	pEC50	=	7.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	127025786	137311	0	None	-12	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	137311	0	None	-12	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	23658144	157622	1	None	-100	2	Human	7.1	pEC50	=	7.1	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	157622	1	None	-100	2	Human	7.1	pEC50	=	7.1	Functional	Partial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assayPartial agonist activity at human MT1 receptor expressed in CHO cells after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145979282	166111	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166111	0	None	-1	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	127025782	137193	0	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	137193	0	None	1	2	Human	8.1	pEC50	=	8.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	71508232	86631	0	None	-75	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	86631	0	None	-75	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	122188352	122638	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612609	122638	0	None	-	1	Human	6.1	pEC50	=	6.1	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	145988269	166626	0	None	-12	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	166626	0	None	-12	2	Human	8.1	pEC50	=	8.1	Functional	Agonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayAgonist activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	46865422	86629	0	None	-181	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	86629	0	None	-181	2	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assayAgonist activity at human MT1 receptor expressed in CHO cells coexpressing Galpha protein 16z25 assessed as increase in calcium mobilization measured for 3 mins by FLIPR assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	18007985	8613	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095832	8613	0	None	-	1	Human	8.0	pEC50	=	8.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	127025784	137195	0	None	-8	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	137195	0	None	-8	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	137636213	155533	0	None	-47	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	155533	0	None	-47	2	Human	8.0	pEC50	=	8.0	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	137655238	158327	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	158327	0	None	-891	2	Human	7.1	pEC50	=	7.1	Functional	Intrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor expressed in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	122188224	122613	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612455	122613	0	None	-	1	Human	6.0	pEC50	=	6.0	Functional	Intrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assayIntrinsic activity at human MT1 receptor transfected in CHO cell membranes after 1 hr by [35S]GTPgammaS binding assay	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	3525815	73783	3	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at MT1Agonist activity at MT1	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	CHEMBL2022867	73783	3	None	-4	3	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at MT1Agonist activity at MT1	ChEMBL	271	2	0	3	4.1	c1ccc(-n2cc(-c3ccnc4ccccc34)cn2)cc1	10.1016/j.bmcl.2012.03.032
	54582195	60423	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	60423	0	None	-9	2	Human	7.0	pEC50	=	7.0	Functional	Agonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assayAgonist activity at human MT1 receptor expressed in CHO cells by [35S]GTPgamma binding assay	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	81689735	120798	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	120798	0	None	1	2	Human	6.0	pEC50	=	6.0	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	86273223	120794	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580911	120794	0	None	-	1	Human	6.0	pEC50	=	6	Functional	Agonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assayAgonist activity at human melatonin receptor-1 transfected in CHO cell membranes after 1 hr by GTPgammaS binding assay	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	44241665	194017	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL556908	194017	0	None	-	1	Human	8.5	pIC50	=	8.5	Functional	Agonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at human MT1 receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	90655902	110365	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	CHEMBL3260982	110365	0	None	-	0	Human	9.7	pKi	=	9.7	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	330	5	2	4	2.5	CCOC(=O)c1[nH]c2ccc(OC)c3c2c1[C@@H](CNC(C)=O)CC3	10.1021/jm401343c
	24763223	214	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	8289	214	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	CHEMBL3260987	214	0	None	-	0	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulationAgonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells assessed as inhibition of forskolin-induced cAMP accumulation	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1021/jm401343c
	52918077	60414	2	None	-1	2	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	CHEMBL1760945	60414	2	None	-1	2	Human	8.9	pKi	=	8.9	Functional	Agonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assayAgonist activity at MT1 receptor (unknown origin) expressed in HEK293 cells by [35S]GTPgamma binding assay	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1021/jm401343c
	11185529	3839	3	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	7772	3839	3	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	CHEMBL189449	3839	3	None	-	0	Human	7.6	pKi	=	7.6	Functional	Antagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assayAntagonist activity at MT1 receptor (unknown origin) expressed in mouse NIH3T3 cells by [35S]GTPgammaS binding assay	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm401343c
	1357	2440	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	None	1	3	Human	8.0	pEC50	=	8.0	Functional	NoneNone	Drug Central	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	103828029	3844	0	None	-20	2	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10667	3844	0	None	-20	2	Human	6.8	pEC50	=	6.8	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	4	1	3	3.5	COc1ccc(c(c1)CNc1cccnc1)Br	32040955
	10666	3845	0	None	21	2	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	138993662	3845	0	None	21	2	Human	7.3	pEC50	=	7.3	Functional	UnclassifiedUnclassified	Guide to Pharmacology	362	4	2	3	4.5	Clc1ccc(c(c1)Br)CNc1cccc(c1)c1nnc[nH]1	32040955
	10665	3843	0	None	50	2	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	137977202	3843	0	None	50	2	Human	7.9	pEC50	=	7.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	3	4.2	CC(c1ccc(cc1)CNc1cccc(c1)c1[nH]cnn1)C	32040955
	23581869	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	7712	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	CHEMBL1783282	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None
	DB13994	548	0	None	-	1	Human	6.9	pIC50	=	6.9	Functional	UnclassifiedUnclassified	Guide to Pharmacology	354	5	2	5	3.2	CCCNC(=O)c1nnc2c(c1N)cccc2c1c(F)cccc1OC	None

Get vendors

Ligands					Receptor			Assay information							Chemical information
Sel. page	Common name	GPCRdb ID	#Vendors	Reference ligand	Fold selectivity (Affinity)	# tested GPCRs (Affinity)	Species	p-value (-log)	Type	Activity Relation	Activity Value	Assay Type	Assay Description	Source	Mol weight	Rot Bonds	H don	H acc	LogP	Smiles	DOI
	10440	2632	15	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2632	15	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2632	15	None	-21	3	Human	6.5	pEC50	=	6.5	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	122178509	120801	0	None	-8	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopyAgonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	120801	0	None	-8	2	Human	7.3	pEC50	=	7.3	Binding	Agonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopyAgonist activity at human recombinant melatonin receptor-1 expressed in CHO cells assessed as effect on impedance by cellular dielectric spectroscopy	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	19703003	30735	0	None	-	0	Human	10.9	pIC50	=	10.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	309	5	2	3	2.9	COc1c[nH]c2nc(-c3ccccc3)c(CCNC(C)=O)c-2c1	10.1021/jm980026p
	CHEMBL139855	30735	0	None	-	0	Human	10.9	pIC50	=	10.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	309	5	2	3	2.9	COc1c[nH]c2nc(-c3ccccc3)c(CCNC(C)=O)c-2c1	10.1021/jm980026p
	9927219	111817	0	None	-25	2	Human	10.8	pIC50	=	10.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL329263	111817	0	None	-25	2	Human	10.8	pIC50	=	10.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm980026p
	57781211	125318	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	CHEMBL3648361	125318	0	None	-	0	Human	10.7	pIC50	=	10.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	376	8	1	3	4.9	CC(=O)NCCC1CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	23634404	125316	0	None	-	0	Human	10.5	pIC50	=	10.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648359	125316	0	None	-	0	Human	10.5	pIC50	=	10.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	23725569	125320	0	None	-	0	Human	10.4	pIC50	=	10.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648363	125320	0	None	-	0	Human	10.4	pIC50	=	10.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)sc3c21	nan
	57781216	125313	0	None	2	2	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648356	125313	0	None	2	2	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	nan
	23725512	125310	0	None	-	0	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648350	125310	0	None	-	0	Human	10.2	pIC50	=	10.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	3	1	3	2.6	CC(=O)NCCC1=CCc2ccc3nc(C)oc3c21	nan
	57781262	160277	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	CHEMBL4114715	160277	0	None	-	0	Human	10.1	pIC50	=	10.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	374	7	1	3	4.9	CC(=O)NC/C=C1\CCc2ccc3nc(CCCCc4ccccc4)oc3c21	nan
	57781258	125326	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
	CHEMBL3648369	125326	0	None	-	0	Human	10.0	pIC50	=	10.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	312	3	1	3	3.2	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C(F)(F)F)CC3	nan
	1357	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	1672	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	224	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	896	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	CHEMBL45	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	DB01065	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human recombinant ML1A receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.03.006
	1357	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	1672	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	224	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	896	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	CHEMBL45	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	DB01065	2440	133	None	-1	9	Human	10.0	pIC50	=	10.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting methodDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in CHO cells measured after 60 mins by scintillation counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2016.11.014
	23725514	125315	0	None	1	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648358	125315	0	None	1	2	Human	9.9	pIC50	=	9.9	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	23725565	125312	0	None	1	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648355	125312	0	None	1	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	nan
	23725567	125319	0	None	2	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648362	125319	0	None	2	2	Human	9.8	pIC50	=	9.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	nan
	15340632	9667	1	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	3	1	2	2.9	CC(=O)NCCc1cccc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	CHEMBL11356	9667	1	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	3	1	2	2.9	CC(=O)NCCc1cccc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	72548703	161007	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisDisplacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	CHEMBL4128926	161007	0	None	-	0	Human	9.8	pIC50	=	9.8	Binding	Displacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysisDisplacement of [125I]NDP-alpha -MSH from human recombinant MT1 receptor after 240 mins by scintillation counting analysis	ChEMBL	583	8	3	6	5.8	CC(C)(C)NS(=O)(=O)c1ccc(-c2sc(C(=O)N[C@H]3C[C@H](C(=O)O)C3)nc2CC2CCCCC2)c2ccccc12	10.1016/j.bmcl.2018.03.093
	1357	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	1672	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	224	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	896	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	DB01065	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	57781280	160405	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
	CHEMBL4115681	160405	0	None	-	0	Human	9.7	pIC50	=	9.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	2	1	3	3.1	CC(=O)NC/C=C1\CCc2ccc3nc(C)sc3c21	nan
	1357	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	1672	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	224	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	896	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	DB01065	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.010
	1357	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	1672	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	224	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	896	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	DB01065	2440	133	None	-1	9	Human	9.7	pIC50	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.03.036
	57781261	125325	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
	CHEMBL3648368	125325	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.1	Cc1nc2ccc3c(c2o1)C(CCNC(=O)C1CC1)CC3	nan
	57781244	160274	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	CHEMBL4114700	160274	0	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	270	3	1	3	3.0	CCC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	15340633	97764	1	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	2	2.8	CC(=O)NCCc1cccc2ccc3c(c12)CCCO3	10.1021/jm980026p
	CHEMBL274358	97764	1	None	-	0	Human	9.6	pIC50	=	9.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	2	2.8	CC(=O)NCCc1cccc2ccc3c(c12)CCCO3	10.1021/jm980026p
	15289276	116274	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	347	6	1	3	3.8	COc1ccc2cc(C(=O)c3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL337764	116274	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	347	6	1	3	3.8	COc1ccc2cc(C(=O)c3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	57781268	160271	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	CHEMBL4114658	160271	0	None	-	0	Human	9.5	pIC50	=	9.5	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	256	2	1	3	2.6	CC(=O)NC/C=C1\CCc2ccc3nc(C)oc3c21	nan
	23725515	125322	0	None	-1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	CHEMBL3648365	125322	0	None	-1	2	Human	9.4	pIC50	=	9.4	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	1357	2440	133	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1672	2440	133	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	224	2440	133	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	896	2440	133	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	DB01065	2440	133	None	-1	9	Human	9.4	pIC50	=	9.4	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1357	2440	133	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	1672	2440	133	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	224	2440	133	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	896	2440	133	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	DB01065	2440	133	None	-1	9	Human	9.3	pIC50	=	9.3	Binding	Binding affinity to human ML1A receptor by radioligand displacement assayBinding affinity to human ML1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2013.03.016
	23725612	125324	0	None	-2	2	Human	9.3	pIC50	=	9.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	CHEMBL3648367	125324	0	None	-2	2	Human	9.3	pIC50	=	9.3	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	nan
	10059864	109322	4	None	2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL323332	109322	4	None	2	2	Human	9.2	pIC50	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	1357	2440	133	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	1672	2440	133	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	224	2440	133	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	896	2440	133	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	CHEMBL45	2440	133	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	DB01065	2440	133	None	-1	9	Human	9.2	pIC50	=	9.2	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/s0960-894x(03)00090-8
	57781246	125323	0	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
	CHEMBL3648366	125323	0	None	-2	2	Human	9.2	pIC50	=	9.2	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	nan
	44359126	28575	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	6	1	2	3.3	CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL137878	28575	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	6	1	2	3.3	CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	44359127	28714	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL137998	28714	1	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	594980	109190	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	4	2	2	2.4	COc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1	10.1021/jm980026p
	CHEMBL322762	109190	13	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	4	2	2	2.4	COc1ccc2[nH]cc(CCNC(=O)C(F)(F)F)c2c1	10.1021/jm980026p
	9859969	174441	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL456727	174441	0	None	-	0	Human	9.1	pIC50	=	9.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	259	4	1	2	3.2	CSc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	57781227	125311	0	None	-6	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
	CHEMBL3648354	125311	0	None	-6	2	Human	9.1	pIC50	=	9.1	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	nan
	1357	2440	133	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	1672	2440	133	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	224	2440	133	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	896	2440	133	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	CHEMBL45	2440	133	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	DB01065	2440	133	None	-1	9	Human	9.0	pIC50	=	9	Binding	Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Binding affinity for melatonin 1A receptor was measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980026p
	115348	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	1343	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	CHEMBL289233	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	DB08190	70	42	None	4	2	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm980026p
	9834952	29092	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	3	1	3	2.4	CC(=O)NCCc1coc2ccc3c(c12)CCCO3	10.1021/jm980026p
	CHEMBL138321	29092	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	3	1	3	2.4	CC(=O)NCCc1coc2ccc3c(c12)CCCO3	10.1021/jm980026p
	10265261	141418	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	2	1	3	2.7	COc1ccc2c(c1)c1c(n2C)CCCC1NC(C)=O	10.1021/jm980026p
	CHEMBL38728	141418	0	None	-	0	Human	9.0	pIC50	=	9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	2	1	3	2.7	COc1ccc2c(c1)c1c(n2C)CCCC1NC(C)=O	10.1021/jm980026p
	34247	8151	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	2.6	COc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL109235	8151	4	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	2.6	COc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	9975634	9640	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	5	2	2	2.3	COc1ccc2[nH]cc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL113441	9640	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	358	5	2	2	2.3	COc1ccc2[nH]cc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	15340631	9734	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	253	3	1	2	3.3	CC(=O)NCCc1cccc2ccc3occc3c12	10.1021/jm980026p
	CHEMBL11404	9734	1	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	253	3	1	2	3.3	CC(=O)NCCc1cccc2ccc3occc3c12	10.1021/jm980026p
	164405	162189	9	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	2	2.9	COc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL417151	162189	9	None	-	0	Human	8.9	pIC50	=	8.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	2	2.9	COc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	10059864	109322	4	None	2	2	Human	8.8	pIC50	=	8.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL323332	109322	4	None	2	2	Human	8.8	pIC50	=	8.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	10061999	7940	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	5	2	2	2.4	COc1cc2c(CCNC(=O)C3CC3)c[nH]c2cc1F	10.1021/jm980026p
	CHEMBL109086	7940	0	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	5	2	2	2.4	COc1cc2c(CCNC(=O)C3CC3)c[nH]c2cc1F	10.1021/jm980026p
	44358991	29622	1	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL138766	29622	1	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	3071631	138118	6	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL37771	138118	6	None	-	0	Human	8.7	pIC50	=	8.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	2	2.9	CCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	10038961	9617	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	3	1	2	3.0	CC(=O)NCCC1CCCc2ccc3c(c21)CCCO3	10.1021/jm980026p
	CHEMBL11328	9617	0	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	3	1	2	3.0	CC(=O)NCCC1CCCc2ccc3c(c21)CCCO3	10.1021/jm980026p
	9993398	29059	2	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	5	2	2	2.7	CCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138288	29059	2	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	272	5	2	2	2.7	CCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	10131203	118222	1	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL341761	118222	1	None	-	0	Human	8.0	pIC50	=	8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm980026p
	4284525	188118	38	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL504585	188118	38	None	-	0	Human	7.0	pIC50	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	3071635	9298	3	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	4	0	2	3.0	COc1ccc2cccc(CCN3CCCC3=O)c2c1	10.1021/jm980026p
	CHEMBL111558	9298	3	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	4	0	2	3.0	COc1ccc2cccc(CCN3CCCC3=O)c2c1	10.1021/jm980026p
	21469690	28521	1	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	4	2	2	2.9	CCc1ccc2scc(CCNC(=O)NC)c2c1	10.1021/jm980026p
	CHEMBL137823	28521	1	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	4	2	2	2.9	CCc1ccc2scc(CCNC(=O)NC)c2c1	10.1021/jm980026p
	44359466	118638	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	1	4	1.9	CCS(=O)(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL342949	118638	0	None	-	0	Human	7.0	pIC50	=	7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	1	4	1.9	CCS(=O)(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	4284525	188118	38	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL504585	188118	38	None	-	0	Human	6.0	pIC50	=	6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	3	3	2.0	COC(=O)Nc1ccc2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	18177433	29167	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	1.8	COc1ccc2c(c1)CC(CCNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138387	29167	0	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	4	1	3	1.8	COc1ccc2c(c1)CC(CCNC(C)=O)CO2	10.1021/jm980026p
	44358869	118352	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	229	4	1	2	2.3	COc1ccc2cccc(CCC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL342207	118352	1	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	229	4	1	2	2.3	COc1ccc2cccc(CCC(N)=O)c2c1	10.1021/jm980026p
	18357874	164485	2	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	3	1.8	CC(=O)NCCC1=COc2ccccc2O1	10.1021/jm980026p
	CHEMBL422636	164485	2	None	-	0	Human	6.0	pIC50	=	6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	3	1.8	CC(=O)NCCC1=COc2ccccc2O1	10.1021/jm980026p
	19703067	28689	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	1	3	1.2	CC(=O)NCCn1ccc2cccnc21	10.1021/jm980026p
	CHEMBL137970	28689	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	1	3	1.2	CC(=O)NCCn1ccc2cccnc21	10.1021/jm980026p
	12288745	29075	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	2	1	3	1.1	COc1ccc2c(c1)CC(NC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138301	29075	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	2	1	3	1.1	COc1ccc2c(c1)CC(NC(C)=O)CO2	10.1021/jm980026p
	19703053	29264	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	234	4	1	4	1.5	COc1nccc2c(CCNC(C)=O)coc12	10.1021/jm980026p
	CHEMBL138468	29264	2	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	234	4	1	4	1.5	COc1nccc2c(CCNC(C)=O)coc12	10.1021/jm980026p
	18175018	29309	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	260	4	2	2	2.2	CC(=O)NCCC1CCc2ccc(NC(C)=O)cc21	10.1021/jm980026p
	CHEMBL138508	29309	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	260	4	2	2	2.2	CC(=O)NCCC1CCc2ccc(NC(C)=O)cc21	10.1021/jm980026p
	15838838	30021	3	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.1	CC(=O)NCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139091	30021	3	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.1	CC(=O)NCc1cccc2c1OCCO2	10.1021/jm980026p
	15372705	30404	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	4	1	4	3.0	COc1ccc2c(c1)OC(CNC(C)=O)=C(c1ccccc1)O2	10.1021/jm980026p
	CHEMBL139418	30404	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	4	1	4	3.0	COc1ccc2c(c1)OC(CNC(C)=O)=C(c1ccccc1)O2	10.1021/jm980026p
	15391788	31475	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	1	1	4	0.9	CC(=O)NC1COc2cc3c(cc2C1)OCCO3	10.1021/jm980026p
	CHEMBL140548	31475	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	1	1	4	0.9	CC(=O)NC1COc2cc3c(cc2C1)OCCO3	10.1021/jm980026p
	44359047	118733	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	4	0.5	CNC(=O)CCc1cccc2c1S(=O)(=O)CCO2	10.1021/jm980026p
	CHEMBL343575	118733	0	None	-	0	Human	5.0	pIC50	=	5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	4	0.5	CNC(=O)CCc1cccc2c1S(=O)(=O)CCO2	10.1021/jm980026p
	15149134	99726	1	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL288300	99726	1	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359375	118703	3	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	211	1	1	1	2.4	O=C1CC(c2cccc3ccccc23)CN1	10.1021/jm980026p
	CHEMBL343381	118703	3	None	-	0	Human	4.0	pIC50	=	4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	211	1	1	1	2.4	O=C1CC(c2cccc3ccccc23)CN1	10.1021/jm980026p
	23725566	125317	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648360	125317	0	None	-	0	Human	8.0	pIC50	=	8.0	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	272	4	1	3	3.1	CCC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	44272486	69470	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19374	69470	0	None	-	0	Human	6.9	pIC50	=	6.9	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	44358830	30179	2	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	4	1.5	COc1ccc2occ(CCNS(C)(=O)=O)c2c1	10.1021/jm980026p
	CHEMBL139228	30179	2	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	5	1	4	1.5	COc1ccc2occ(CCNS(C)(=O)=O)c2c1	10.1021/jm980026p
	44359427	30484	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	373	5	1	2	3.1	COc1ccc2c(c1)C(CCNC(=O)CI)CCC2	10.1021/jm980026p
	CHEMBL139516	30484	0	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	373	5	1	2	3.1	COc1ccc2c(c1)C(CCNC(=O)CI)CCC2	10.1021/jm980026p
	19696845	116020	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	4	1	2	2.5	CNC(=O)CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL336225	116020	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	4	1	2	2.5	CNC(=O)CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359390	118488	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	295	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL342592	118488	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	295	7	1	2	3.5	C=CCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	19385775	118911	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	274	4	2	2	2.9	CN/C(S)=N/CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344880	118911	1	None	-	0	Human	7.9	pIC50	=	7.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	274	4	2	2	2.9	CN/C(S)=N/CCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	44576404	192495	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	286	5	2	3	1.9	CNC(=O)c1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL522674	192495	0	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	286	5	2	3	1.9	CNC(=O)c1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	10399169	28663	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CC(=O)NCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL137948	28663	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CC(=O)NCCCc1cccc2c1OCCO2	10.1021/jm980026p
	19703063	28687	1	None	2	2	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1021/jm980026p
	CHEMBL137969	28687	1	None	2	2	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1021/jm980026p
	23360853	31818	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(C)=O)cc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL140826	31818	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(C)=O)cc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	44359206	118860	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	5	1	3	2.6	CC(=O)NCCCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL344488	118860	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	5	1	3	2.6	CC(=O)NCCCCc1cccc2c1SCCO2	10.1021/jm980026p
	44359079	164693	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	5	1	3	2.5	CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL423011	164693	1	None	-	0	Human	6.9	pIC50	=	6.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	5	1	3	2.5	CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	44358887	26641	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	215	2	1	2	2.2	CNC(=O)c1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL136346	26641	1	None	-	0	Human	5.9	pIC50	=	5.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	215	2	1	2	2.2	CNC(=O)c1cccc2ccc(OC)cc12	10.1021/jm980026p
	44359058	29451	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	2	2	1.2	CC(=O)NCCc1c[nH]c2ncccc12	10.1021/jm980026p
	CHEMBL138631	29451	3	None	-	0	Human	4.9	pIC50	=	4.9	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	203	3	2	2	1.2	CC(=O)NCCc1c[nH]c2ncccc12	10.1021/jm980026p
	23725513	125314	0	None	-3	2	Human	7.8	pIC50	=	7.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	CHEMBL3648357	125314	0	None	-3	2	Human	7.8	pIC50	=	7.8	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	nan
	15340629	9758	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	3	2.1	CC(=O)NCCc1cccc2ccc3c(c12)C(=O)CO3	10.1021/jm980026p
	CHEMBL11416	9758	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	269	3	1	3	2.1	CC(=O)NCCc1cccc2ccc3c(c12)C(=O)CO3	10.1021/jm980026p
	44359205	28703	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL137983	28703	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	44358971	28761	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	3	2.1	C#CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138037	28761	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	5	1	3	2.1	C#CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	10059969	28783	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CNC(=O)CCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL138053	28783	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	4	1	3	1.5	CNC(=O)CCCc1cccc2c1OCCO2	10.1021/jm980026p
	15289277	28962	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	6	1	2	4.1	COc1ccc2cc(Cc3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138201	28962	0	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	6	1	2	4.1	COc1ccc2cc(Cc3ccccc3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	23360848	161110	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	CCc1cc(CCNC(=O)C2CC2)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL413121	161110	1	None	-	0	Human	7.8	pIC50	=	7.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	CCc1cc(CCNC(=O)C2CC2)c2cc(OC)ccc2c1	10.1021/jm980026p
	22375366	69135	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19339	69135	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)C(N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	44358744	26488	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CC(=O)NCCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL136214	26488	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CC(=O)NCCCCc1cccc2c1OCCO2	10.1021/jm980026p
	15340628	27195	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	287	6	2	3	2.0	CC(=O)NCCc1cccc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	CHEMBL136815	27195	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	287	6	2	3	2.0	CC(=O)NCCc1cccc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	10060719	169857	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CC(=O)NCCCc1cccc2c1SCCO2	10.1021/jm980026p
	CHEMBL444857	169857	1	None	-	0	Human	6.8	pIC50	=	6.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	3	2.2	CC(=O)NCCCc1cccc2c1SCCO2	10.1021/jm980026p
	44359046	29633	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	6	1	4	1.8	CC(=O)NCCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL138774	29633	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	265	6	1	4	1.8	CC(=O)NCCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	18782997	32967	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	2	4	1.6	CC(=O)NCCc1coc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	CHEMBL141785	32967	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	2	4	1.6	CC(=O)NCCc1coc2ccc(OCC(=O)O)cc12	10.1021/jm980026p
	19703028	118625	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	204	3	1	3	1.5	CC(=O)NCCc1coc2cnccc12	10.1021/jm980026p
	CHEMBL342836	118625	2	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	204	3	1	3	1.5	CC(=O)NCCc1coc2cnccc12	10.1021/jm980026p
	44359374	118882	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	241	2	1	2	2.5	COc1ccc2cccc(C3CNC(=O)C3)c2c1	10.1021/jm980026p
	CHEMBL344632	118882	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	241	2	1	2	2.5	COc1ccc2cccc(C3CNC(=O)C3)c2c1	10.1021/jm980026p
	21460931	167879	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	5	1	2	3.1	CCCc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL435032	167879	1	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	5	1	2	3.1	CCCc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	15391785	28936	1	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	3	1	3	1.6	COc1ccc2c(c1)C=C(CNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138180	28936	1	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	3	1	3	1.6	COc1ccc2c(c1)C=C(CNC(C)=O)CO2	10.1021/jm980026p
	44358928	29939	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	7	1	2	4.1	COc1ccc2cccc(CC(=O)NCCCc3ccccc3)c2c1	10.1021/jm980026p
	CHEMBL139016	29939	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	333	7	1	2	4.1	COc1ccc2cccc(CC(=O)NCCCc3ccccc3)c2c1	10.1021/jm980026p
	44359070	32564	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	205	3	1	3	0.6	CC(=O)NCCN1CCc2cccnc21	10.1021/jm980026p
	CHEMBL141430	32564	0	None	-	0	Human	4.8	pIC50	=	4.8	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	205	3	1	3	0.6	CC(=O)NCCN1CCc2cccnc21	10.1021/jm980026p
	22375372	66907	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL18808	66907	0	None	-	0	Human	6.8	pIC50	=	6.8	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	302	3	0	3	2.5	COc1ccc2c(c1)C(N1CCN(C(=O)C(C)C)CC1)CC2	10.1016/s0960-894x(03)00090-8
	11059058	9981	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against melatonin receptor type 1ABinding affinity against melatonin receptor type 1A	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	CHEMBL115444	9981	0	None	-	0	Human	5.8	pIC50	=	5.8	Binding	Binding affinity against melatonin receptor type 1ABinding affinity against melatonin receptor type 1A	ChEMBL	429	3	1	7	4.1	O=C(OCc1cc2c(cc1Cl)OCO2)N1CCC(n2c(O)nc3ccccc32)CC1	10.1021/jm010878g
	44576399	188190	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	260	4	2	3	1.5	CNC(=O)c1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL505744	188190	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	260	4	2	3	1.5	CNC(=O)c1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.03.036
	23725568	125321	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
	CHEMBL3648364	125321	0	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Binding Assay: Binding assay using melatonin receptors 1 or 2.Binding Assay: Binding assay using melatonin receptors 1 or 2.	ChEMBL	274	3	1	3	3.2	CC(=O)NCC[C@H]1CCc2ccc3nc(C)sc3c21	nan
	10039072	28664	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	6	3	2	2.4	CCCNC(=O)NCCc1c[nH]c2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL137949	28664	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	6	3	2	2.4	CCCNC(=O)NCCc1c[nH]c2ccc(OC)cc12	10.1021/jm980026p
	10377971	29297	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.4	CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1	10.1021/jm980026p
	CHEMBL138496	29297	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.4	CCCC(=O)NCC1=Cc2cc(OC)ccc2OC1	10.1021/jm980026p
	44359437	29671	0	None	1	3	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138807	29671	0	None	1	3	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1021/jm980026p
	19752678	29673	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	5	1	2	2.7	COc1ccc2cccc(CCCC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL138808	29673	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	243	5	1	2	2.7	COc1ccc2cccc(CCCC(N)=O)c2c1	10.1021/jm980026p
	10448305	29830	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138924	29830	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359018	118926	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CBr)c2c1	10.1021/jm980026p
	CHEMBL345029	118926	1	None	-	0	Human	7.7	pIC50	=	7.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CBr)c2c1	10.1021/jm980026p
	44358910	27196	1	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL136816	27196	1	None	-	0	Human	6.7	pIC50	=	6.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	2821758	29129	15	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.0	CC(=O)NCC1COc2ccccc2O1	10.1021/jm980026p
	CHEMBL138355	29129	15	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	207	2	1	3	1.0	CC(=O)NCC1COc2ccccc2O1	10.1021/jm980026p
	44358944	32668	3	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	9	2	1	4.2	CCCCCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	CHEMBL141522	32668	3	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	9	2	1	4.2	CCCCCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	15149133	119497	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL35017	119497	1	None	-	0	Human	5.7	pIC50	=	5.7	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	8	1	2	4.1	CCCCCC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	53827707	110364	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
	CHEMBL3260981	110364	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK293 cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	279	6	1	3	3.0	CCCNC(=O)CCCc1cccc2c1SCCO2	10.1021/jm401343c
	18360745	29685	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	258	4	2	2	2.3	CNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138817	29685	1	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	258	4	2	2	2.3	CNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	3071630	137698	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	5	1	2	3.2	COc1ccc2cccc(CCNC(=O)C(C)C)c2c1	10.1021/jm980026p
	CHEMBL37703	137698	3	None	-	0	Human	8.6	pIC50	=	8.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	5	1	2	3.2	COc1ccc2cccc(CCNC(=O)C(C)C)c2c1	10.1021/jm980026p
	10266979	98549	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	CHEMBL280142	98549	0	None	-	0	Human	6.7	pIC50	=	6.7	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	303	3	1	3	2.0	CCNC(=O)N1CCN([C@@H]2CCc3ccc(OC)cc32)CC1	10.1016/s0960-894x(03)00090-8
	11178762	66656	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	CHEMBL186941	66656	0	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	463	5	0	2	6.1	COc1cc2c(cc1Br)CCN(C(C)=O)C2CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	44340895	9314	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	2	1.9	COc1ccc2c(c1)C(CNC(C)=O)CC2	10.1021/jm980026p
	CHEMBL111667	9314	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	219	3	1	2	1.9	COc1ccc2c(c1)C(CNC(C)=O)CC2	10.1021/jm980026p
	44359479	29944	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	1	3	3.4	CCCOc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL139021	29944	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	277	6	1	3	3.4	CCCOc1ccc2scc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359019	31368	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	6	1	3	2.7	C=CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL140427	31368	0	None	-	0	Human	7.6	pIC50	=	7.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	6	1	3	2.7	C=CCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	19086015	30413	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	300	7	2	2	3.5	CCCNC(=O)NCCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL139428	30413	4	None	-	0	Human	6.6	pIC50	=	6.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	300	7	2	2	3.5	CCCNC(=O)NCCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	19703043	118808	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	1	4	1.7	COc1cnc2c(c1)c(CCNC(=O)C1CC1)cn2C	10.1021/jm980026p
	CHEMBL344179	118808	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	5	1	4	1.7	COc1cnc2c(c1)c(CCNC(=O)C1CC1)cn2C	10.1021/jm980026p
	3071647	135808	2	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	344	5	2	2	4.3	COc1ccc2cccc(CCNC(=O)c3cc4ccccc4[nH]3)c2c1	10.1021/jm980026p
	CHEMBL37341	135808	2	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	344	5	2	2	4.3	COc1ccc2cccc(CCNC(=O)c3cc4ccccc4[nH]3)c2c1	10.1021/jm980026p
	18175032	175013	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL457992	175013	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	358	6	2	4	2.3	CNS(=O)(=O)c1ccc2cccc(CCNC(=O)c3ccco3)c2c1	10.1016/j.ejmech.2011.02.010
	44593610	186779	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
	CHEMBL493424	186779	0	None	-	0	Human	5.6	pIC50	=	5.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	6	2	4	2.8	C=CCC(=O)NCCc1coc2ccc(NC(=O)OC)cc12	10.1016/j.bmc.2008.03.036
	44359035	31477	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL140549	31477	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	7	1	2	3.7	CCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	18947294	32176	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	248	4	2	3	1.9	CNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL141115	32176	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	248	4	2	3	1.9	CNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359270	168030	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	2	2	3.3	C=CCc1c(O)ccc2cccc(CCNC(=O)CC)c12	10.1021/jm980026p
	CHEMBL436006	168030	1	None	-	0	Human	8.5	pIC50	=	8.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	283	6	2	2	3.3	C=CCc1c(O)ccc2cccc(CCNC(=O)CC)c12	10.1021/jm980026p
	10333620	108704	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	5	1	3	3.0	COc1ccc2scc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL321612	108704	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	5	1	3	3.0	COc1ccc2scc(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	44359308	114978	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	4	2	2	2.1	COc1ccc2cccc(CCNC(N)=O)c2c1	10.1021/jm980026p
	CHEMBL335116	114978	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	4	2	2	2.1	COc1ccc2cccc(CCNC(N)=O)c2c1	10.1021/jm980026p
	18783022	116243	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	3	1	3	2.5	CC(=O)NCCc1coc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	CHEMBL337580	116243	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	257	3	1	3	2.5	CC(=O)NCCc1coc2ccc3c(c12)C=CCO3	10.1021/jm980026p
	19967248	168742	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	6	1	3	3.2	CCCC(=O)NOCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL441664	168742	1	None	-	0	Human	8.4	pIC50	=	8.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	273	6	1	3	3.2	CCCC(=O)NOCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	18175008	174912	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL457763	174912	0	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	292	4	2	3	1.2	CC(=O)NCCc1cccc2ccc(S(N)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	44358896	30479	2	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	228	3	2	1	2.3	CNC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	CHEMBL139510	30479	2	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	228	3	2	1	2.3	CNC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	44358943	31166	1	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	2	4.2	CC(=O)NCCc1cccc2ccc(OC3CCCCC3)cc12	10.1021/jm980026p
	CHEMBL140244	31166	1	None	-	0	Human	6.5	pIC50	=	6.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	5	1	2	4.2	CC(=O)NCCc1cccc2ccc(OC3CCCCC3)cc12	10.1021/jm980026p
	10243074	9690	2	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	4	1.2	COc1ccc2ncn(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL113692	9690	2	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	233	4	1	4	1.2	COc1ccc2ncn(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359228	30074	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	237	4	1	4	1.0	CC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139133	30074	0	None	-	0	Human	5.5	pIC50	=	5.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	237	4	1	4	1.0	CC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	15372706	118909	1	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	281	3	1	3	3.0	CC(=O)NCC1=C(c2ccccc2)Oc2ccccc2O1	10.1021/jm980026p
	CHEMBL344866	118909	1	None	-	0	Human	4.5	pIC50	=	4.5	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	281	3	1	3	3.0	CC(=O)NCC1=C(c2ccccc2)Oc2ccccc2O1	10.1021/jm980026p
	9861677	186966	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL494566	186966	0	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	315	5	1	4	3.1	COC(=O)c1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	10379422	8337	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	5	1	3	3.4	COc1ccc2scc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	CHEMBL109361	8337	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	5	1	3	3.4	COc1ccc2scc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	15391789	29385	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	3	1	3	1.4	COc1ccc2c(c1)CC(CNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL138581	29385	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	235	3	1	3	1.4	COc1ccc2c(c1)CC(CNC(C)=O)CO2	10.1021/jm980026p
	23360817	30561	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(=O)C3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL139627	30561	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	311	6	1	3	3.1	COc1ccc2cc(C(=O)C3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359020	31374	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	337	7	1	3	4.1	CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL140433	31374	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	337	7	1	3	4.1	CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm980026p
	44358768	116281	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	6	1	3	2.8	CCCC(=O)NCCCc1cccc2c1OC=CO2	10.1021/jm980026p
	CHEMBL337802	116281	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	6	1	3	2.8	CCCC(=O)NCCCc1cccc2c1OC=CO2	10.1021/jm980026p
	44358840	118229	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	3	2.7	COC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL341802	118229	1	None	-	0	Human	7.4	pIC50	=	7.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	3	2.7	COC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	2368416	99606	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	242	4	2	1	2.6	O=C(NCCc1c[nH]c2ccccc12)C1CCC1	10.1021/jm980026p
	CHEMBL287310	99606	5	None	-	0	Human	5.4	pIC50	=	5.4	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	242	4	2	1	2.6	O=C(NCCc1c[nH]c2ccccc12)C1CCC1	10.1021/jm980026p
	44272591	71346	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	CHEMBL19653	71346	0	None	-	0	Human	7.4	pIC50	=	7.4	Binding	In vitro receptor binding at MT1 (Melatonin) receptor.In vitro receptor binding at MT1 (Melatonin) receptor.	ChEMBL	300	3	0	3	2.2	COc1ccc2c(c1)[C@H](N1CCN(C(=O)C3CC3)CC1)CC2	10.1016/s0960-894x(03)00090-8
	21916760	175116	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL458209	175116	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	291	4	1	3	1.9	CC(=O)NCCc1cccc2ccc(S(C)(=O)=O)cc12	10.1016/j.ejmech.2011.02.010
	10422677	9199	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	5	1	3	2.5	COc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	CHEMBL110980	9199	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	5	1	3	2.5	COc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1021/jm980026p
	18783019	28612	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	5	1	2	2.5	C#CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL137910	28612	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	267	5	1	2	2.5	C#CCOc1ccc2cccc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44359309	29229	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	2	3	2.0	COc1ccc2cccc(C(O)CNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138440	29229	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	2	3	2.0	COc1ccc2cccc(C(O)CNC(C)=O)c2c1	10.1021/jm980026p
	9881916	29607	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	2	1	3	2.3	COc1ccc2ccc3c(c2c1)CC(NC(C)=O)CO3	10.1021/jm980026p
	CHEMBL138752	29607	0	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	271	2	1	3	2.3	COc1ccc2ccc3c(c2c1)CC(NC(C)=O)CO3	10.1021/jm980026p
	10248871	108065	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	375	5	1	3	3.0	COc1ccc2scc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL320253	108065	1	None	-	0	Human	8.3	pIC50	=	8.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	375	5	1	3	3.0	COc1ccc2scc(CCNC(=O)CI)c2c1	10.1021/jm980026p
	44359464	29719	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138841	29719	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCOc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm980026p
	18947318	118280	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	293	6	3	2	2.6	CCCNC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12	10.1021/jm980026p
	CHEMBL342162	118280	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	293	6	3	2	2.6	CCCNC(=O)NCCc1c[nH]c2cc(F)c(OC)cc12	10.1021/jm980026p
	44358743	118524	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CNC(=O)CCCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL342649	118524	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	249	5	1	3	1.9	CNC(=O)CCCCc1cccc2c1OCCO2	10.1021/jm980026p
	23360832	118765	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	6	1	3	3.1	CCC(=O)c1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL343819	118765	1	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	299	6	1	3	3.1	CCC(=O)c1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	22133298	118855	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	6	2	2	3.1	CCCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344454	118855	0	None	-	0	Human	7.3	pIC50	=	7.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	286	6	2	2	3.1	CCCNC(=O)NCCc1cccc2ccc(OC)cc12	10.1021/jm980026p
	18175028	59749	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	306	5	2	3	1.4	CNS(=O)(=O)c1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL1738752	59749	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	306	5	2	3	1.4	CNS(=O)(=O)c1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	10085672	29278	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	291	7	1	3	3.8	CCCCC(=O)NCCc1csc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL138475	29278	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	291	7	1	3	3.8	CCCCC(=O)NCCc1csc2ccc(OC)cc12	10.1021/jm980026p
	21572387	29512	3	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	214	3	2	1	2.1	NC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	CHEMBL138675	29512	3	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	214	3	2	1	2.1	NC(=O)NCCc1cccc2ccccc12	10.1021/jm980026p
	44359120	29847	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	2	3.4	O=C(NCCc1csc2ccccc12)C1CCC1	10.1021/jm980026p
	CHEMBL138938	29847	1	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	259	4	1	2	3.4	O=C(NCCc1csc2ccccc12)C1CCC1	10.1021/jm980026p
	9837777	31906	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	4	1	4	1.3	COc1cnc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm980026p
	CHEMBL140896	31906	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	247	4	1	4	1.3	COc1cnc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm980026p
	15838839	32985	2	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	3	1	3	1.1	CC(=O)NCCc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL141796	32985	2	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	221	3	1	3	1.1	CC(=O)NCCc1cccc2c1OCCO2	10.1021/jm980026p
	11749479	66549	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
	CHEMBL186452	66549	0	None	-	0	Human	6.3	pIC50	=	6.3	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	385	5	0	2	5.4	COc1ccc2c(c1)C(CC(c1ccccc1)c1ccccc1)N(C(C)=O)CC2	10.1016/j.bmcl.2004.09.024
	44576406	186777	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL493414	186777	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	5	2	4	3.5	COC(=O)Nc1ccc2occ(CCNC(=O)C3CCCC3)c2c1	10.1016/j.bmc.2008.03.036
	17957007	192044	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL521826	192044	0	None	-	0	Human	5.3	pIC50	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	304	5	2	4	2.9	COC(=O)Nc1ccc2occ(CCNC(=O)C(C)C)c2c1	10.1016/j.bmc.2008.03.036
	10265421	9327	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL111718	9327	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	275	7	1	3	3.3	CCCCC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359121	29936	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	CHEMBL139014	29936	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	313	9	1	2	4.5	CCCCCOc1ccc2cccc(CCNC(=O)CC)c2c1	10.1021/jm980026p
	23360808	30396	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	6	1	2	3.5	CCCc1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	CHEMBL139410	30396	1	None	-	0	Human	8.2	pIC50	=	8.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	6	1	2	3.5	CCCc1cc(CCNC(C)=O)c2cc(OC)ccc2c1	10.1021/jm980026p
	11361621	125273	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
	CHEMBL364816	125273	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	401	7	0	3	5.0	COc1cc2c(cc1OC)C(CC(c1ccccc1)c1ccccc1)N(C=O)CC2	10.1016/j.bmcl.2004.09.024
	18177435	28939	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	3	1	3	2.5	COc1ccc2ccc3c(c2c1)CC(CNC(C)=O)CO3	10.1021/jm980026p
	CHEMBL138182	28939	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	285	3	1	3	2.5	COc1ccc2ccc3c(c2c1)CC(CNC(C)=O)CO3	10.1021/jm980026p
	21469691	118628	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	2	3.5	CCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL342855	118628	0	None	-	0	Human	7.2	pIC50	=	7.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	2	3.5	CCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	21469682	31544	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	7	1	2	4.3	CCCCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL140611	31544	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	289	7	1	2	4.3	CCCCC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	44359381	32287	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	5	1	4	1.4	CC(=O)NCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL141208	32287	1	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	5	1	4	1.4	CC(=O)NCCCOc1cccc2c1OCCO2	10.1021/jm980026p
	44359294	116275	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	406	8	4	3	3.8	COc1ccc2[nH]cc(CCNC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1021/jm980026p
	CHEMBL337767	116275	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	406	8	4	3	3.8	COc1ccc2[nH]cc(CCNC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1021/jm980026p
	17524911	31828	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	256	4	2	1	3.0	O=C(NCCc1c[nH]c2ccccc12)C1CCCC1	10.1021/jm980026p
	CHEMBL140835	31828	5	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	256	4	2	1	3.0	O=C(NCCc1c[nH]c2ccccc12)C1CCCC1	10.1021/jm980026p
	588712	32862	10	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	6	2	1	3.0	CCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	CHEMBL141694	32862	10	None	-	0	Human	5.2	pIC50	=	5.2	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	244	6	2	1	3.0	CCCCC(=O)NCCc1c[nH]c2ccccc12	10.1021/jm980026p
	11430378	167645	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	CHEMBL433573	167645	0	None	-	0	Human	6.2	pIC50	=	6.2	Binding	Inhibitory concentration against Melatonin receptor type 1AInhibitory concentration against Melatonin receptor type 1A	ChEMBL	431	6	0	4	5.6	COC(=O)N1CCc2cc(OC)c(OC)cc2C1CC(c1ccccc1)c1ccccc1	10.1016/j.bmcl.2004.09.024
	9837740	29354	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	4	1	3	2.4	COc1ccc2cccc(CONC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL138549	29354	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	245	4	1	3	2.4	COc1ccc2cccc(CONC(C)=O)c2c1	10.1021/jm980026p
	44359113	115889	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCc1cccc2ccc(OCC3CC3)cc12	10.1021/jm980026p
	CHEMBL336010	115889	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCc1cccc2ccc(OCC3CC3)cc12	10.1021/jm980026p
	23360842	118459	1	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	COc1ccc2cc(CC3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	CHEMBL342432	118459	1	None	-	1	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.5	COc1ccc2cc(CC3CC3)cc(CCNC(C)=O)c2c1	10.1021/jm980026p
	44358970	118525	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	359	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CI)c2c1	10.1021/jm980026p
	CHEMBL342655	118525	0	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	359	5	1	3	2.5	COc1ccc2occ(CCNC(=O)CI)c2c1	10.1021/jm980026p
	18947325	118825	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	5	2	3	2.3	CCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL344268	118825	1	None	-	0	Human	8.1	pIC50	=	8.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	262	5	2	3	2.3	CCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	9817006	174402	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
	CHEMBL456646	174402	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	275	4	1	2	2.3	CC(=O)NCCc1cccc2ccc([S+](C)[O-])cc12	10.1016/j.ejmech.2011.02.010
	44358879	29837	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.7	CCOc1ccc2cccc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	CHEMBL138929	29837	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	297	6	1	2	3.7	CCOc1ccc2cccc(CCNC(=O)C3CCC3)c2c1	10.1021/jm980026p
	44359266	31478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	316	4	0	5	2.2	COc1ccc2c(c1)c(CCN(C(C)=O)C(C)=O)cn2C(C)=O	10.1021/jm980026p
	CHEMBL140551	31478	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	316	4	0	5	2.2	COc1ccc2c(c1)c(CCN(C(C)=O)C(C)=O)cn2C(C)=O	10.1021/jm980026p
	18947270	32654	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	6	2	3	2.7	CCCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	CHEMBL141507	32654	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	276	6	2	3	2.7	CCCNC(=O)NCCc1coc2ccc(OC)cc12	10.1021/jm980026p
	44359465	118260	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.9	CC(=O)NCCc1coc2ccc(OC(C)C)cc12	10.1021/jm980026p
	CHEMBL341989	118260	1	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	261	5	1	3	2.9	CC(=O)NCCc1coc2ccc(OC(C)C)cc12	10.1021/jm980026p
	21469693	30649	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	290	6	2	2	3.7	CCCNC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	CHEMBL139744	30649	1	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	290	6	2	2	3.7	CCCNC(=O)NCCc1csc2ccc(CC)cc12	10.1021/jm980026p
	18177465	118822	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	4	1.4	COc1ccc2c(c1)OC(CCNC(C)=O)CO2	10.1021/jm980026p
	CHEMBL344242	118822	0	None	-	0	Human	6.1	pIC50	=	6.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	251	4	1	4	1.4	COc1ccc2c(c1)OC(CCNC(C)=O)CO2	10.1021/jm980026p
	15838841	30016	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	280	6	2	4	1.5	CCCNC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	CHEMBL139087	30016	1	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.Melatonin receptor type 1A binding affinity measured using 2-[125I]iodomelatonin on ovine pars tuberalis membrane homogenates.	ChEMBL	280	6	2	4	1.5	CCCNC(=O)NCCOc1cccc2c1OCCO2	10.1021/jm980026p
	25014882	187102	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	CHEMBL495232	187102	0	None	-	0	Human	5.1	pIC50	=	5.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	302	5	2	4	2.7	COC(=O)Nc1ccc2occ(CCNC(=O)C3CC3)c2c1	10.1016/j.bmc.2008.03.036
	17957000	61061	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	CHEMBL1770214	61061	0	None	-	0	Human	7.1	pIC50	=	7.1	Binding	Binding affinity to human MT1 receptorBinding affinity to human MT1 receptor	ChEMBL	286	4	2	3	2.7	COC(=O)Nc1ccc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2011.02.010
	1357	2440	133	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1672	2440	133	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	224	2440	133	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	896	2440	133	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	CHEMBL45	2440	133	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	DB01065	2440	133	None	-1	9	Human	9.8	pKd	=	9.8	Binding	Binding affinity to melatonin receptor MT1 (unknown origin)Binding affinity to melatonin receptor MT1 (unknown origin)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	10440	2632	15	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	139030523	2632	15	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	CHEMBL4449712	2632	15	None	-21	3	Human	5.2	pKd	=	5.2	Binding	Agonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assayAgonist activity at human MT1 receptor expressed in HTLA cells assessed as stimulation of beta-arrestin recruitment incubated for 16 to 20 hrs by bright-glo luminescence assay	ChEMBL	417	7	3	7	4.2	OCc1cccc(c1c1nc(NCc2ccc(cc2)Oc2ccccc2)nc(n1)N)F	10.1021/acs.jmedchem.9b00869
	22004862	61678	0	None	-1	2	Human	11.1	pKi	=	11.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	4	1	2	3.6	CC(=O)NCCC1=C(c2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200385u
	CHEMBL1774522	61678	0	None	-1	2	Human	11.1	pKi	=	11.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	4	1	2	3.6	CC(=O)NCCC1=C(c2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200385u
	9903515	22576	0	None	9	2	Human	11.0	pKi	=	11	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
	CHEMBL132802	22576	0	None	9	2	Human	11.0	pKi	=	11	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(C)=O)CC3	10.1021/jm000922c
	9839629	99641	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL287560	99641	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10925712	112075	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL330137	112075	0	None	1	2	Human	11.0	pKi	=	11	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	4.3	C=CCC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	9839629	99641	0	None	1	2	Human	11.0	pKi	=	11	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	CHEMBL287560	99641	0	None	1	2	Human	11.0	pKi	=	11	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	309	5	1	3	3.8	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	9796846	115923	0	None	12	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL336054	115923	0	None	12	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	CCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	53237947	61671	0	None	-1	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774514	61671	0	None	-1	2	Human	10.9	pKi	=	10.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	299	5	1	2	3.5	CCC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	115348	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	1343	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	CHEMBL289233	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	DB08190	70	42	None	4	2	Human	10.9	pKi	=	10.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm011053+
	1356	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	208902	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	2355	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	CHEMBL1218	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	DB00980	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/jm0201159
	1356	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	208902	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	2355	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	CHEMBL1218	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	DB00980	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	Binding affinity to human MT1 expressed in CHO cellsBinding affinity to human MT1 expressed in CHO cells	ChEMBL	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	10.1021/acs.jmedchem.0c01836
	9926304	116062	0	None	9	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	CHEMBL336509	116062	0	None	9	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	299	4	1	3	3.0	COc1ccc2ccc(OC)c3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	9797460	117637	0	None	6	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL340832	117637	0	None	6	2	Human	10.8	pKi	=	10.8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	11723593	106382	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL314512	106382	0	None	-1	2	Human	10.7	pKi	=	10.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	3	4.0	C=CC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	53237946	61670	0	None	-1	2	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774513	61670	0	None	-1	2	Human	10.6	pKi	=	10.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	285	4	1	2	3.1	CC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	9840277	23345	0	None	10	2	Human	10.6	pKi	=	10.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL133416	23345	0	None	10	2	Human	10.6	pKi	=	10.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	325	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	53310841	63451	0	None	5	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802028	63451	0	None	5	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	299	5	1	4	2.2	CCC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	164621472	185303	0	None	2	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4868554	185303	0	None	2	2	Human	10.6	pKi	=	10.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	288	4	1	3	3.6	CCC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	9873402	35596	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14417	35596	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	596	19	2	4	7.9	CC(=O)NCCc1cccc2ccc(OCCCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	18466111	19630	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	19630	0	None	1	2	Human	10.5	pKi	=	10.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	122188346	122633	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612603	122633	0	None	-	1	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	262	4	1	3	2.0	CCC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	71533431	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	7775	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	CHEMBL2314259	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	10.1016/j.bmcl.2012.11.069
	57781216	125313	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648356	125313	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	53237949	61673	0	None	-3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774516	61673	0	None	-3	2	Human	10.5	pKi	=	10.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	4	1	2	3.7	CC(C)C1=C(CCNC(=O)C(F)(F)F)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	23725567	125319	0	None	2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648362	125319	0	None	2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	3	1	3	3.2	CC(=O)NCCC1CCc2ccc3nc(C)sc3c21	10.1021/acs.jmedchem.0c01836
	24954990	63449	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802026	63449	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	287	5	1	4	1.9	CCC(=O)NCCc1c(CC)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	10925379	205821	0	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL94838	205821	0	None	1	2	Human	10.4	pKi	=	10.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	5	2	3	3.6	CNC(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	56659223	64643	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	CHEMBL1823015	64643	0	None	5	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	2	3	2.9	COc1ccc2[nH]c(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	127042142	137534	0	None	3	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765540	137534	0	None	3	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	310	5	1	4	3.2	COc1ccc2oc(-c3ccccc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	71533430	85973	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314255	85973	0	None	-1	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2cccc(/C=C/NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	53310840	63450	0	None	6	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802027	63450	0	None	6	2	Human	10.4	pKi	=	10.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	285	4	1	4	1.8	CC(=O)NCCc1c(C2CC2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	22004791	61669	0	None	-2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774512	61669	0	None	-2	2	Human	10.4	pKi	=	10.4	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	243	3	1	2	2.1	CC(=O)NCCC1=CCc2ccc3c(c21)CCO3	10.1021/jm200221q
	9916005	32478	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14136	32478	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	568	17	2	4	7.1	CC(=O)NCCc1cccc2ccc(OCCCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	9914839	97691	0	None	34	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL273787	97691	0	None	34	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	526	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	44264903	203896	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL8168	203896	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	4	1	3	3.4	COc1cccc(N(C)c2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	44272316	67243	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19026	67243	0	None	4	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	10	2	3	5.3	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	10452167	78364	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112690	78364	0	None	1	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	9	1	3	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	9998754	78369	0	None	7	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112700	78369	0	None	7	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	362	8	1	3	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2003.12.052
	10446712	78373	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112722	78373	0	None	6	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	286	6	1	3	3.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	10016733	78374	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
	CHEMBL2112724	78374	0	None	3	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	284	5	1	3	3.0	CCc1nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2003.12.052
	10423378	78375	0	None	8	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	CHEMBL2112727	78375	0	None	8	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	272	5	1	3	3.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2nc(CC)oc12	10.1016/j.bmcl.2003.12.052
	11741001	78379	0	None	9	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
	CHEMBL2112734	78379	0	None	9	2	Human	10.3	pKi	=	10.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	388	9	1	3	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2003.12.052
	57381112	1383	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	7776	1383	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	CHEMBL1946221	1383	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	57381112	1383	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	7776	1383	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	CHEMBL1946221	1383	0	None	20	2	Human	10.3	pKi	=	10.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	10.1039/C5MD00190K
	9798080	19270	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL129890	19270	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	341	7	1	3	4.2	CCCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	53238407	61681	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1cccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)c1	10.1021/jm200221q
	CHEMBL1774526	61681	0	None	-	1	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1cccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)c1	10.1021/jm200221q
	198	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	82148	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	99	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	CHEMBL10878	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	DB06594	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm0255872
	198	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	82148	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	99	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	CHEMBL10878	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	DB06594	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmc.2008.08.052
	15453090	85971	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314253	85971	0	None	3	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	285	4	1	3	2.8	COc1ccc2ccc(OC)c([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	24954989	1497	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	7774	1497	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	CHEMBL1802025	1497	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	10.1021/jm200385u
	23725565	125312	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648355	125312	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	23725514	125315	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648358	125315	0	None	1	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	3.1	CCC(=O)NCCC1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	115348	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	1343	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	CHEMBL289233	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	DB08190	70	42	None	4	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1021/jm401343c
	53238185	61679	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774524	61679	0	None	-2	2	Human	10.2	pKi	=	10.2	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	320	4	1	3	3.0	CC(=O)NCCC1=C(c2cccnc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	9883864	116141	0	None	7	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL337024	116141	0	None	7	2	Human	10.2	pKi	=	10.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	327	6	1	3	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3ccc(OC)c1c23	10.1021/jm000922c
	46888521	8542	0	None	26	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095196	8542	0	None	26	2	Human	10.2	pKi	=	10.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	1	5	5.6	COC(=O)Cc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	1351	2353	15	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	219018	2353	15	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	CHEMBL4079759	2353	15	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	10.1039/C4MD00149D
	9893513	30730	0	None	29	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL13985	30730	0	None	29	2	Human	10.1	pKi	=	10.1	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	540	15	2	4	6.4	CC(=O)NCCc1cccc2ccc(OCCCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	115348	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	1343	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	CHEMBL289233	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	DB08190	70	42	None	4	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	10.1016/S0960-894X(97)00444-7
	11100761	101308	4	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
	CHEMBL300056	101308	4	None	-1	2	Human	10.1	pKi	=	10.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	372	4	1	3	2.5	COc1ccc2c(c1)c(CCNC(C)=O)c(I)n2C	10.1021/jm011053+
	1357	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	1672	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	224	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	896	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	CHEMBL45	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	DB01065	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970437q
	24955343	63446	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802022	63446	0	None	1	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.6	CC(=O)NCCc1c(-c2ccccc2)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	1672	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	224	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	896	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	CHEMBL45	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	DB01065	2440	133	None	-1	9	Human	10.1	pKi	=	10.1	Binding	Binding affinity against human Melatonin receptor type 1A (MT1)Binding affinity against human Melatonin receptor type 1A (MT1)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0201159
	53310839	63448	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802024	63448	0	None	2	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	273	4	1	4	1.6	CCC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	10163052	8421	0	None	72	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1094212	8421	0	None	72	2	Human	10.1	pKi	=	10.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	483	12	2	4	5.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc(-c4ccc(CO)cc4)cc3)cc12	10.1016/j.bmc.2010.04.008
	1357	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1672	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	224	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	896	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL45	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB01065	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1357	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	1672	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	224	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	896	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	CHEMBL45	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	DB01065	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.09.003
	10016919	100131	1	None	3	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL291857	100131	1	None	3	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	10016919	100131	1	None	3	2	Human	10.0	pKi	=	10	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL291857	100131	1	None	3	2	Human	10.0	pKi	=	10	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	287	6	1	3	2.9	CCC(=O)NCCc1c(OC)ccc2ccc(OC)cc12	10.1021/jm970437q
	10659603	20041	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130542	20041	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	CCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	9925797	22037	0	None	3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
	CHEMBL132340	22037	0	None	3	2	Human	10.0	pKi	=	10	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(C)=O)CC3	10.1021/jm000922c
	198	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	82148	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	99	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	CHEMBL10878	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	DB06594	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2017.10.025
	145982070	165911	0	None	1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278248	165911	0	None	1	2	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	3	1	2	3.2	COc1ccc2ccc3c(c2c1)C(C)(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	198	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	82148	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	99	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	CHEMBL10878	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	DB06594	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2016.12.013
	198	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	82148	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	99	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	CHEMBL10878	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	DB06594	310	120	None	-1	6	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.bmcl.2012.11.069
	71540389	85974	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
	CHEMBL2314257	85974	0	None	-1	2	Human	10.0	pKi	=	10	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	241	3	1	2	3.0	COc1ccc2ccccc2c1/C=C/NC(C)=O	10.1016/j.bmcl.2012.11.069
	9839199	21148	0	None	-1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	21148	0	None	-1	2	Human	10.0	pKi	=	10.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	53237948	61672	0	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774515	61672	0	None	-3	2	Human	10.0	pKi	=	10.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	311	5	1	2	3.5	CC(C)C1=C(CCNC(=O)C2CC2)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	1357	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	1672	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	224	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	896	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	CHEMBL45	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	DB01065	2440	133	None	-1	9	Human	10.0	pKi	=	10.0	Binding	Displacement of radiolabeled melatonin from human MT1 receptorDisplacement of radiolabeled melatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm8007618
	10562968	19980	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
	CHEMBL130490	19980	0	None	1	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	255	3	1	2	2.6	COc1ccc2cccc3c2c1C(CNC(C)=O)C3	10.1021/jm000922c
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0005252
	198	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	82148	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	99	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	CHEMBL10878	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	DB06594	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2015.12.047
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.12.013
	198	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	82148	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	99	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	CHEMBL10878	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	DB06594	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1016/j.ejmech.2020.112078
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm011053+
	198	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	82148	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	99	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	CHEMBL10878	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	DB06594	310	120	None	-1	6	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1039/C4MD00149D
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00392-2
	44272305	66971	0	None	14	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL18845	66971	0	None	14	2	Human	9.9	pKi	=	9.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	392	9	2	3	5.1	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCCCc1ccccc1)N2	10.1016/j.bmcl.2003.12.052
	44358146	26855	0	None	2	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136531	26855	0	None	2	2	Human	9.9	pKi	=	9.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0255872
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.08.052
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2014.09.038
	1357	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	1672	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	224	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	896	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	CHEMBL45	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	DB01065	2440	133	None	-1	9	Human	9.9	pKi	=	9.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm700957j
	10059864	109322	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL323332	109322	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1021/jm0005252
	56653119	171216	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
	CHEMBL4467954	171216	0	None	1	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	322	7	2	2	3.5	CC(=O)NCCc1c[nH]c2ccc(OCCc3ccccc3)cc12	10.1016/j.ejmech.2019.111847
	10059864	109322	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL323332	109322	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.12.047
	10059864	109322	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
	CHEMBL323332	109322	4	None	2	2	Human	9.8	pKi	=	9.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	1	3	2.1	COc1ccc2occ(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.01.008
	24954991	63447	0	None	3	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802023	63447	0	None	3	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	259	3	1	4	1.3	CC(=O)NCCc1c(C)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	2440	133	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	1672	2440	133	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	224	2440	133	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	896	2440	133	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	CHEMBL45	2440	133	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	DB01065	2440	133	None	-1	9	Human	9.8	pKi	=	9.8	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm020982d
	25025104	185723	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4874630	185723	0	None	5	2	Human	9.8	pKi	=	9.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.6	CCC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	44358196	118768	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL343825	118768	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	198	310	120	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	82148	310	120	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	99	310	120	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	CHEMBL10878	310	120	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	DB06594	310	120	None	-1	6	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	10.1021/jm000922c
	44272317	98443	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL279343	98443	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c00627
	9817262	19269	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL129889	19269	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	CCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm000922c
	9948714	20489	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	CHEMBL130898	20489	0	None	2	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	313	5	1	3	3.4	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	44272422	167305	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL431103	167305	0	None	3	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	21581654	60413	1	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760944	60413	1	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/S0960-894X(97)00444-7
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.03.080
	59145922	185680	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4874010	185680	0	None	7	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.2	CC(=O)NCCC1CCc2ccn3nc(C)cc3c21	10.1021/acs.jmedchem.0c01836
	127042442	137372	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763503	137372	0	None	-6	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	328	5	1	4	3.3	COc1ccc2oc(-c3ccc(F)cc3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	127042791	137519	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765401	137519	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	4	1	4	2.1	COc1ccc2oc(I)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2012.11.069
	71540396	85976	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314260	85976	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	286	4	2	3	2.8	CNC(=O)N/C=C/c1c(OC)ccc2ccc(OC)cc12	10.1016/j.bmcl.2012.11.069
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.8b00893
	10540964	116115	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL336858	116115	0	None	1	2	Human	9.7	pKi	=	9.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	44272320	98137	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL276921	98137	0	None	-2	2	Human	9.7	pKi	=	9.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	6	2	3	3.2	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)CC)c2O1	10.1016/j.bmcl.2003.12.052
	1357	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	1672	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	224	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	896	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	DB01065	2440	133	None	-1	9	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.02.044
	23725515	125322	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	CHEMBL3648365	125322	0	None	-1	2	Human	9.7	pKi	=	9.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	272	4	1	3	2.9	CCc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2015.12.047
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200385u
	21581654	60413	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	CHEMBL1760944	60413	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2011.06.030
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.0c01836
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm200221q
	21581654	60413	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL1760944	60413	1	None	1	2	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1ccc2[nH]cc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2011.02.097
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2011.06.030
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2016.01.008
	18360631	8612	0	None	26	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095831	8612	0	None	26	2	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	516	13	2	4	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4c(c3)C(CCNC(C)=O)CCC4)cc12	10.1016/j.bmc.2010.04.008
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2011.06.063
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2007.04.013
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2020.112090
	1357	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1672	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	224	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	896	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	CHEMBL45	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	DB01065	2440	133	None	-1	9	Human	9.6	pKi	=	9.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jmedchem.2c00717
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm040768k
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm001125h
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm048956y
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm970721h
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2012.10.060
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2010.02.084
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2005.01.015
	145981162	165933	0	None	-3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4278575	165933	0	None	-3	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	2	2	2.5	COc1ccc2ccc3c(c2c1)C(CNC(N)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986532	166717	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4293386	166717	0	None	-1	3	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	269	3	1	2	3.0	COc1ccc2ccc3c(c2c1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	137660333	158961	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4102177	158961	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2cccc(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.12.013
	25024912	185327	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4869029	185327	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	4	1	3	2.5	CCC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	15453084	85969	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314251	85969	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2cccc([C@@H]3C[C@H]3NC(C)=O)c2c1	10.1016/j.bmcl.2012.11.069
	11079938	192890	4	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL52755	192890	4	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1cc2c(CCNC(C)=O)c(I)[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.07.055
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/acs.jnatprod.7b00853
	53310987	63453	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802030	63453	0	None	1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	327	4	1	4	2.4	CCC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm060850a
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2010.06.100
	139451781	184265	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4852440	184265	0	None	-1	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	289	5	1	5	1.5	CCOc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	1357	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	1672	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	224	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	896	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	CHEMBL45	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	DB01065	2440	133	None	-1	9	Human	9.5	pKi	=	9.5	Binding	Binding affinity to human MT1A receptor by radioligand displacement assayBinding affinity to human MT1A receptor by radioligand displacement assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2013.01.044
	44272440	67171	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL18960	67171	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	260	4	2	3	2.5	CCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	59145872	185584	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4872592	185584	0	None	2	2	Human	9.5	pKi	=	9.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	257	3	1	3	2.1	CC(=O)NCCC1CCc2ccc3nn(C)cc3c21	10.1021/acs.jmedchem.0c01836
	18466111	19630	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	19630	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	10661735	167750	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL434226	167750	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	6	1	2	3.8	CCCC(=O)NCCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	46888522	8543	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	CHEMBL1095197	8543	0	None	11	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	513	12	1	5	6.2	COC(=O)C(C)c1ccc2cc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)ccc2c1	10.1016/j.bmc.2010.04.008
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptorDisplacement of [125I]2-iodomelatonin from human MT1 receptor	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm2006782
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2007.01.005
	139451763	185741	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	CHEMBL4874954	185741	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	305	8	1	5	2.4	CCCC(=O)NCCn1c(OCC)nc2ccc(OC)cc21	10.1021/acs.jmedchem.0c00627
	44317845	203785	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL80736	203785	0	None	3	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	301	7	1	3	3.3	CCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm0512544
	57781246	125323	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648366	125323	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	284	4	1	3	3.3	CC(=O)NCCC1CCc2ccc3nc(C4CC4)oc3c21	10.1021/acs.jmedchem.0c01836
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.09.030
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2004.04.082
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.12.052
	145982333	165993	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	165993	0	None	1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145981769	166103	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4281712	166103	0	None	-1	3	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	270	3	1	3	2.4	COc1ccc2ccc3c(c2n1)C(CNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	10778397	19620	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
	CHEMBL130203	19620	0	None	1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	4	1	2	3.0	COc1ccc2cccc3c2c1C(CCNC(C)=O)C3	10.1021/jm000922c
	139451795	184737	0	None	2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859677	184737	0	None	2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	CCOc1nc2ccc(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	9839199	21148	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	21148	0	None	-1	2	Human	9.4	pKi	=	9.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	57781227	125311	0	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648354	125311	0	None	-6	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	244	3	1	3	2.4	CC(=O)NCCC1CCc2ccc3ncoc3c21	10.1021/acs.jmedchem.0c01836
	23725612	125324	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	CHEMBL3648367	125324	0	None	-2	2	Human	9.4	pKi	=	9.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	1	4	2.4	COc1nc2ccc3c(c2o1)C(CCNC(C)=O)CC3	10.1021/acs.jmedchem.0c01836
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C1MD00149C
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1039/C5MD00190K
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm800974d
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2009.04.068
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 1 hr by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	24954992	63452	0	None	1	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	CHEMBL1802029	63452	0	None	1	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	313	3	1	4	2.0	CC(=O)NCCc1c(C(F)(F)F)nn2ccc3c(c12)CCO3	10.1021/jm200385u
	1362	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	9870523	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	CHEMBL429392	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	1362	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9870523	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL429392	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	1362	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	3370	18	None	39	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmc.2008.07.012
	1357	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	1672	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	224	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	896	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	CHEMBL45	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	DB01065	2440	133	None	-1	9	Human	9.3	pKi	=	9.3	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.bmcl.2003.11.030
	7778	799	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	9957516	799	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL1094546	799	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	10.1016/j.bmc.2010.04.008
	1355	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	9806449	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	CHEMBL14453	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm0255872
	1355	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9806449	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL14453	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	44272425	66975	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL18846	66975	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	300	5	2	3	3.1	CC(C)C1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C3CC3)c2O1	10.1016/j.bmcl.2003.12.052
	1355	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9806449	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL14453	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in HEK293 cells after 120 mins	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	145982333	165993	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	165993	0	None	1	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145993188	166458	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4288497	166458	0	None	-3	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	4	1	3	2.6	COc1ccc2ccc3c(c2c1)C(C)(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	145988741	166672	0	None	-6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292336	166672	0	None	-6	3	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	299	5	1	3	2.6	COCC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	1355	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	9806449	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	CHEMBL14453	3371	3	None	70	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1016/j.bmc.2010.04.008
	137647756	157389	0	None	-6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4084612	157389	0	None	-6	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	259	4	2	3	1.7	CNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	139451764	185675	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	CHEMBL4873903	185675	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	275	4	1	5	1.1	COc1nc2ccc3c(c2n1CCNC(C)=O)CCO3	10.1021/acs.jmedchem.0c00627
	44349100	114300	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	CHEMBL334079	114300	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	44349100	114300	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
	CHEMBL334079	114300	0	None	34	2	Human	9.2	pKi	=	9.2	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	10	1	3	4.9	O=C(NCCCc1cccc2nc(CCCCc3ccccc3)oc12)C1CC1	10.1021/jm401343c
	46888492	8740	0	None	18	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1096991	8740	0	None	18	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	14	2	5	6.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)c5ccco5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10468642	26896	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136564	26896	0	None	-1	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10640828	21267	0	None	2	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL131575	21267	0	None	2	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	339	6	1	3	3.8	COc1ccc2ccc(OC)c3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	1357	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	1672	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	224	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	896	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	CHEMBL45	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	DB01065	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1021/jm980684+
	1357	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2440	133	None	-1	9	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	10400294	18348	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127570	18348	0	None	3	2	Human	9.2	pKi	=	9.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	258	5	1	3	2.6	Cc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	122188347	122634	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612604	122634	0	None	-	1	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	232	3	1	2	2.0	CCC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	139451780	185352	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4869463	185352	0	None	5	2	Human	9.2	pKi	=	9.2	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	303	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CC1	10.1021/acs.jmedchem.0c00627
	46935150	15688	0	None	6	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223130	15688	0	None	6	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	9884406	205882	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL95166	205882	0	None	-3	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	341	6	1	3	3.9	COc1ccc2oc(Cc3cccc(F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10361427	112360	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL330969	112360	0	None	18	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	364	10	1	3	4.9	CCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	12324	3836	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	145966622	3836	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	CHEMBL4210086	3836	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	10.1021/acs.jmedchem.8b00893
	10515048	116298	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL337882	116298	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	46888520	8541	0	None	10	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095195	8541	0	None	10	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	15	2	4	6.1	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10199282	116080	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	CHEMBL336647	116080	0	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	269	3	1	2	3.0	COc1ccc2cccc3c2c1CCC3CNC(C)=O	10.1021/jm000922c
	145982167	166047	0	None	-7	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4280601	166047	0	None	-7	3	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	305	4	1	3	2.4	COc1ccc2ccc3c(c2c1)C(CNS(C)(=O)=O)CC3	10.1016/j.ejmech.2017.10.025
	145990662	166365	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286896	166365	0	None	-2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	4	2	2	3.4	CCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137636213	155533	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4062947	155533	0	None	-8	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	24750192	3842	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	7777	3842	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	CHEMBL237236	3842	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	10.1021/jm700957j
	24750193	88111	1	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL235329	88111	1	None	2	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	236	6	1	3	1.7	COc1cccc(N(C)CCCNC(C)=O)c1	10.1021/jm700957j
	1357	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	139451757	184238	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4852096	184238	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	311	6	1	5	2.2	CCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	1357	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1672	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	224	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	896	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL45	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	DB01065	2440	133	None	-1	9	Human	9.1	pKi	=	9.1	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	53238182	61676	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	3	3.8	CC(=O)NCCC1=C(Cc2ccsc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774520	61676	0	None	-	1	Human	9.1	pKi	=	9.1	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	3	3.8	CC(=O)NCCC1=C(Cc2ccsc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	44358274	28725	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138012	28725	0	None	1	2	Human	9.1	pKi	=	9.1	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	9937825	8765	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097315	8765	0	None	12	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	17	2	4	6.7	C=CCC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)CC=C)c4c3)cc12	10.1016/j.bmc.2010.04.008
	49865268	15686	0	None	13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223128	15686	0	None	13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(OC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	44272335	68319	0	None	-23	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19211	68319	0	None	-23	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	7	2	3	3.6	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CCC)N2	10.1016/j.bmcl.2003.12.052
	9817636	20460	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL130876	20460	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CNC(=O)C1CC1	10.1021/jm000922c
	44272410	67659	0	None	-7	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19128	67659	0	None	-7	2	Human	9.0	pKi	=	9.0	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	5	2	3	2.9	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(C)=O)c2O1	10.1016/j.bmcl.2003.12.052
	44389812	62658	0	None	19	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL178678	62658	0	None	19	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	365	10	1	2	4.9	CCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	11581340	121814	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL359921	121814	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	363	8	1	2	4.6	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	20590653	122746	0	None	5	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	CHEMBL361410	122746	0	None	5	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	389	9	1	2	5.0	O=C(NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	20590654	129635	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL367797	129635	0	None	1	2	Human	9.0	pKi	=	9	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	9	1	2	5.0	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44264892	203459	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7832	203459	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	5	1	3	3.8	CCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	139451799	185247	0	None	3	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4867553	185247	0	None	3	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	279	5	1	5	1.9	COc1ccc2nc(SC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	145979689	166059	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4280791	166059	0	None	-5	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	3	2	2	3.1	CNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145993214	166187	0	None	-5	3	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4283539	166187	0	None	-5	3	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	2	3	2.2	CNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	11110447	206044	0	None	-4	2	Human	9.0	pKi	=	9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96104	206044	0	None	-4	2	Human	9.0	pKi	=	9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	6	1	3	4.3	C/C=C/C(=O)NCCc1c(-c2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	9850873	8764	0	None	13	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	CHEMBL1097314	8764	0	None	13	2	Human	9.0	pKi	=	9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	564	15	2	4	6.4	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12)C1CC1	10.1016/j.bmc.2010.04.008
	10753255	117974	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	CHEMBL341439	117974	0	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	251	3	1	1	3.0	O=C(NCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	18007985	8613	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095832	8613	0	None	10	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	538	14	2	4	6.0	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C5CC5)c4c3)cc12	10.1016/j.bmc.2010.04.008
	44264769	96536	0	None	-10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL266549	96536	0	None	-10	2	Human	9.0	pKi	=	9.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	6	1	3	4.2	CCCC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	139451761	184004	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4848885	184004	0	None	4	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	139451769	185550	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	CHEMBL4872217	185550	0	None	1	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	291	7	1	5	2.0	CCOc1nc2ccc(OC)cc2n1CCNC(=O)CC	10.1021/acs.jmedchem.0c00627
	53237950	61674	0	None	-13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774517	61674	0	None	-13	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	314	5	2	2	3.3	CCNC(=O)NCCC1=C(C(C)C)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	53238186	61680	0	None	-54	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	CHEMBL1774525	61680	0	None	-54	2	Human	9.0	pKi	=	9.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccccc1C1=C(CCNC(C)=O)c2c(ccc3c2CCO3)C1	10.1021/jm200221q
	10873443	193544	4	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL55084	193544	4	None	-1	2	Human	9.0	pKi	=	9.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1cc2c(CCNC(C)=O)c(I)n(C)c2cc1[N+](=O)[O-]	10.1021/jm011053+
	11536239	76334	1	None	2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
	CHEMBL206472	76334	1	None	2	2	Human	9.0	pKi	=	9.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	2	2	2.6	COc1ccc2[nH]cc(C(C)(C)CNC(C)=O)c2c1	10.1021/jm0512544
	24763223	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	8289	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	CHEMBL3260987	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in rat NIH3T3 cells after 90 mins	ChEMBL	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	10.1039/C5MD00190K
	20642483	30422	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	CHEMBL139439	30422	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	10752506	19771	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL130319	19771	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	2	1	1	3.0	CC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	85880795	110366	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	CHEMBL3260984	110366	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity to MT1 receptor (unknown origin) expressed in HEK cellsBinding affinity to MT1 receptor (unknown origin) expressed in HEK cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	139451767	184411	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854625	184411	0	None	2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	263	5	1	5	1.2	COc1ccc2nc(OC)n(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	127041169	136312	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3741890	136312	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	57781248	183970	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4848381	183970	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	274	4	2	4	1.9	CC(=O)NCCC1CCc2ccc3nc(CO)oc3c21	10.1021/acs.jmedchem.0c01836
	11644612	77880	0	None	-9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	77880	0	None	-9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	127041169	136312	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3741890	136312	0	None	6	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	570	14	2	4	5.7	O=C(NCCc1cccc2ccc(OCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	164946945	189625	1	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189625	1	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	9927219	111817	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329263	111817	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	9927219	111817	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	CHEMBL329263	111817	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 melatonin receptor expressed in HEK cells after 120 mins	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/acs.jmedchem.5b00982
	9927219	111817	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
	CHEMBL329263	111817	0	None	-25	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	323	6	1	3	3.7	COc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm401343c
	10019103	67138	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL189395	67138	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	323	5	1	2	3.8	CCCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	10089253	116571	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL339265	116571	0	None	12	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	350	9	1	3	4.5	CC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	10022570	167971	0	None	13	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL435586	167971	0	None	13	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	10	1	3	5.1	CC(C)C(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	44353165	116401	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL338425	116401	0	None	-7	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	4	1	1	3.8	CCCC(=O)NCC1CCc2cccc3cccc1c23	10.1021/jm000922c
	44272438	69951	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19441	69951	0	None	1	2	Human	8.9	pKi	=	8.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	5	2	3	3.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	52918079	60416	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760947	60416	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	261	6	1	4	2.0	CCCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	57781208	185029	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4864102	185029	0	None	-5	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	320	4	1	3	4.1	CC(=O)NCCC1CCc2ccc3nc(-c4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	53238412	61686	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	3	4.8	CC(=O)NCCC1=C(c2csc3ccccc23)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774531	61686	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	3	4.8	CC(=O)NCCC1=C(c2csc3ccccc23)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	10763177	24518	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	393	7	1	4	3.2	CCC(=O)NCCc1c(OC(=O)CBr)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL134416	24518	0	None	-	1	Human	8.9	pKi	=	8.9	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	393	7	1	4	3.2	CCC(=O)NCCc1c(OC(=O)CBr)ccc2ccc(OC)cc12	10.1021/jm970437q
	10850411	114845	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
	CHEMBL334962	114845	0	None	-4	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	281	4	1	2	3.0	COc1ccc2cccc3c2c1C(CNC(=O)C1CC1)C3	10.1021/jm000922c
	20355585	110363	5	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
	CHEMBL3260979	110363	5	None	1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	280	4	2	2	2.8	COc1cc2c(CCNC(C)=O)c(C)[nH]c2cc1Cl	10.1021/jm401343c
	10244841	67140	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL189414	67140	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm040768k
	23642306	158515	1	None	2	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4097233	158515	1	None	2	3	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NCC(CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	9870683	8786	0	None	9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097496	8786	0	None	9	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	502	13	2	5	5.2	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4occ(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	52918077	60414	2	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760945	60414	2	None	-2	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	1	4	1.2	COc1ccc2ccn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	10244841	67140	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
	CHEMBL189414	67140	1	None	-8	2	Human	8.9	pKi	=	8.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	309	4	1	2	3.5	CCC(=O)NCC1Cc2ccccc2Cc2ccc(OC)cc21	10.1021/jm800974d
	53238411	61685	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774530	61685	0	None	-1	2	Human	8.9	pKi	=	8.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	375	4	1	2	4.9	CC(=O)NCCC1=C(c2ccc(C(C)(C)C)cc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	12004056	173640	0	None	13	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
	CHEMBL4548591	173640	0	None	13	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	340	6	3	3	2.0	CC(=O)NCCc1c(Br)[nH]c2ccc(OCCO)cc12	10.1016/j.ejmech.2019.111847
	44358184	116027	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL336268	116027	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	46845151	8563	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095505	8563	0	None	38	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	499	12	2	4	6.1	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cc(C(C)C(=O)O)ccc4c3)cc12	10.1016/j.bmc.2010.04.008
	137641357	156525	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	156525	0	None	-3	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	122188351	122637	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612608	122637	0	None	-	1	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.7	CCC(=O)NCC1CCc2ccccc2N1c1ccccc1	10.1021/acs.jmedchem.5b01066
	19703015	137359	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763281	137359	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1ccc2occ(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	11630146	77716	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
	CHEMBL210147	77716	0	None	1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.4	COc1ccc2[nH]cc(C(C)CNC(C)=O)c2c1	10.1021/jm0512544
	49865204	15659	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223050	15659	0	None	2	2	Human	8.8	pKi	=	8.8	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44429442	149678	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL395221	149678	0	None	-1	2	Human	8.8	pKi	=	8.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	5	2	2	2.6	CCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	44272443	193805	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL553105	193805	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	9858255	206327	0	None	-30	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9772	206327	0	None	-30	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	320	4	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	168296374	191910	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191910	0	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	10542922	116079	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	CHEMBL336633	116079	0	None	6	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	309	5	1	2	3.8	COc1ccc2cccc3c2c1CCC3CCNC(=O)C1CC1	10.1021/jm000922c
	127026427	137146	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758679	137146	0	None	-3	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3oc(CNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	122220128	159116	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	CHEMBL4104020	159116	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	6	2	3	2.3	COc1ccc2cccc(C(CO)CNC(=O)C(F)F)c2c1	10.1039/C4MD00149D
	10637638	20386	0	None	4	2	Human	8.0	pKi	=	8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
	CHEMBL130813	20386	0	None	4	2	Human	8.0	pKi	=	8	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	295	5	1	2	3.4	COc1ccc2cccc3c2c1C(CCNC(=O)C1CC1)C3	10.1021/jm000922c
	127026424	137154	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758720	137154	0	None	-5	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3oc(CCNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	44394415	123875	0	None	1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL363947	123875	0	None	1	2	Human	8.0	pKi	=	8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	10	1	2	6.0	CCCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44429449	86921	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL233309	86921	0	None	-7	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	4	1	3	2.6	COc1cc(Br)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	11536939	76746	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207625	76746	0	None	-12	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	6	1	3	3.5	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	44264818	203504	0	None	-91	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7867	203504	0	None	-91	2	Human	8.0	pKi	=	8.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	6	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44359437	29671	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	CHEMBL138807	29671	0	None	1	3	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	COc1ccc2cccc(C(CO)CNC(C)=O)c2c1	10.1039/C4MD00149D
	10526493	203573	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL79224	203573	0	None	-1	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	427	8	1	3	3.7	CCC(=O)NCCc1c(OCCI)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	24750188	148700	0	None	-114	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
	CHEMBL394430	148700	0	None	-114	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1ccc(N(CCNC(C)=O)c2cccc(OC)c2)cc1	10.1021/jm700957j
	16105169	174095	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
	CHEMBL455909	174095	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2009.04.068
	45268309	194587	0	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
	CHEMBL561928	194587	0	None	-4	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	303	7	2	3	2.3	CCN(C)Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2009.04.068
	16105169	174095	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
	CHEMBL455909	174095	0	None	1	2	Human	6.0	pKi	=	6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	345	3	1	3	3.3	CC(=O)NCCc1c2n(c3ccccc13)CC1Cc3ccccc3N1C2	10.1016/j.bmc.2008.07.012
	25210130	69	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	7782	69	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	CHEMBL514415	69	0	None	-91	2	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	1358	124	35	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	3976006	124	35	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	CHEMBL285718	124	35	None	-870	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm048956y
	54584155	60417	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760949	60417	0	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	366	8	1	5	2.8	COc1ccc2c(CN(C)Cc3ccccc3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	49865148	15640	2	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1222984	15640	2	None	-2	2	Human	5.0	pKi	=	5.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccccc1OC(C)CNC(C)=O	10.1016/j.bmc.2010.06.100
	44394478	65942	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL184762	65942	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	8	1	3	5.3	CC(C)C(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	44264849	203651	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7990	203651	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	298	5	1	3	4.1	COc1cccc(N(C)c2ccc(NC(=O)C(C)C)cc2)c1	10.1016/j.bmcl.2003.11.030
	10956792	101328	7	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL300195	101328	7	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1ccc2[nH]cc(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	25210135	174342	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL456505	174342	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25210135	174342	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL456505	174342	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	378	6	3	4	3.0	COc1ccc2[nH]c(CN3CCc4ccc(N)cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	45268310	194878	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL563847	194878	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	46935149	15660	2	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223051	15660	2	None	2	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44394508	65799	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL184144	65799	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	404	9	1	3	5.5	CCCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	10831675	21565	0	None	-6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
	CHEMBL131919	21565	0	None	-6	2	Human	8.0	pKi	=	8.0	Binding	Inhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cellsInhibition of the 2-[125I]- iodomelatonin binding to Melatonin receptor type 1A expressed in CHO cells	ChEMBL	349	7	1	4	3.1	CCC(=O)NCCc1c(OC(=O)CCl)ccc2ccc(OC)cc12	10.1021/jm970437q
	1346	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	1858	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	CHEMBL34730	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1016/j.ejmech.2019.111847
	1346	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	1858	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	CHEMBL34730	160	42	None	-25	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	10.1021/jm401343c
	11587169	76949	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL208307	76949	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	4	1	3	2.6	COc1ccc2c(c1)c(C(C)(C)CNC(C)=O)cn2C	10.1021/jm0512544
	127041170	136153	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3740377	136153	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	45268303	195060	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
	CHEMBL565176	195060	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	301	4	1	4	1.8	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCN(C)C1	10.1016/j.bmc.2009.04.068
	44272424	68718	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19237	68718	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	4	3	3	2.5	CNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	11666721	64644	0	None	-18	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
	CHEMBL1823016	64644	0	None	-18	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	CNC(=O)CCc1c(-c2ccccc2)nc2ccc(OC)cn12	10.1016/j.ejmech.2011.06.030
	45268310	194878	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL563847	194878	0	None	-1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	419	7	2	3	4.5	COc1ccc2[nH]c(CN(C)c3ccc(C(F)(F)F)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	1362	3370	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	3370	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	3370	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	11403195	123149	1	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	CHEMBL362133	123149	1	None	1	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	278	3	1	2	3.4	CC(=O)NCCN1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	90666309	108885	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219330	108885	0	None	1	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	1362	3370	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	9870523	3370	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	CHEMBL429392	3370	18	None	39	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1039/C5MD00190K
	25210130	69	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	7782	69	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	CHEMBL514415	69	0	None	-91	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)CN1CCc2c1cccc2	10.1021/jm800974d
	16743124	91763	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
	CHEMBL242573	91763	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	282	5	1	2	3.0	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CC1	10.1016/j.ejmech.2007.01.005
	162661094	180851	2	None	-10	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4764211	180851	2	None	-10	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	12436516	15665	6	None	-2	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223056	15665	6	None	-2	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	179	4	1	2	1.2	CC(=O)NCCOc1ccccc1	10.1016/j.bmc.2010.06.100
	49865377	15743	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223280	15743	0	None	1	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	10664333	206432	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9838	206432	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	4	1	2	4.3	CCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	122188227	122616	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612458	122616	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	233	3	3	2	1.7	CCNC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	22718579	16330	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123690	16330	0	None	-3	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	3.0	CC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	11543959	76756	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207676	76756	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	2	2	3.5	CCCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	11791741	206360	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
	CHEMBL9791	206360	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CC1	10.1021/jm980684+
	46885228	7609	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	4.1	CCCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1088825	7609	0	None	-	1	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	341	10	1	3	4.1	CCCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	22718619	16580	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124445	16580	0	None	-7	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.8	CCCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	44264844	203144	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7567	203144	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	296	5	1	3	3.8	COc1cccc(N(C)c2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	127041170	136153	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3740377	136153	0	None	1	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	584	15	2	4	6.1	O=C(NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CCNC(=O)C(F)F)c4c3)cc12)C(F)F	10.1039/C5MD00190K
	145964105	163655	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4211018	163655	0	None	3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	475	12	2	5	4.9	CC(=O)NCCN(C)c1cccc(OCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	11068422	206099	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	CHEMBL96420	206099	0	None	-7	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	361	6	1	4	4.7	COc1ccc2oc(-c3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	127038225	137448	0	None	-13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764421	137448	0	None	-13	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	338	5	1	4	3.8	COc1ccc2oc(-c3c(C)cccc3C)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	25210134	189022	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514904	189022	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	49865317	15703	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223191	15703	0	None	-2	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	10544425	206586	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL9934	206586	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	330	4	1	2	4.1	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CCC1	10.1021/jm980684+
	16094578	82845	1	None	-8	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL218808	82845	1	None	-8	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C\c1ccccc1)c1ccccc1	10.1021/jm060850a
	12436514	15736	6	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223273	15736	6	None	-3	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NC(C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	49865376	15742	2	None	-9	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223279	15742	2	None	-9	2	Human	4.9	pKi	=	4.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	25210134	189022	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514904	189022	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	315	6	2	3	2.5	COc1ccc2[nH]c(CN3CCCC3)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	46865422	86629	0	None	-575	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326199	86629	0	None	-575	2	Human	6.9	pKi	=	6.9	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	54586061	60420	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760952	60420	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	441	7	1	6	3.2	COc1ccc2c(CN3CCN(c4cccc(Cl)c4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	122188238	122626	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612470	122626	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	10656443	206624	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
	CHEMBL99534	206624	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm001125h
	10656443	206624	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm970721h
	CHEMBL99534	206624	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	218	3	2	2	1.8	COc1cccc2[nH]c(CNC(C)=O)cc12	10.1021/jm970721h
	137660180	158564	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4097817	158564	0	None	-4	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.3	COc1cnc2cccc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2016.12.013
	44579164	181538	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL478218	181538	0	None	-14	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	406	7	2	4	4.8	CCOC(=O)Nc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	12985494	190025	0	None	-239	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL518113	190025	0	None	-239	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	2	3	4.1	CCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	24750190	89441	2	None	-32	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
	CHEMBL237840	89441	2	None	-32	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	254	5	1	2	3.0	CC(=O)NCCN(c1ccccc1)c1ccccc1	10.1021/jm700957j
	44429455	87306	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL233740	87306	0	None	-2	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.5	COc1cc(-c2ccccc2)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	12985492	181239	0	None	-177	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL477833	181239	0	None	-177	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	459	6	1	2	5.1	COc1ccc2cc(-c3cccc(CI)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	46885283	8156	0	None	-48	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092400	8156	0	None	-48	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	237	6	1	3	1.8	COc1ccc(OC)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	10428383	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	7783	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	CHEMBL33185	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm001125h
	10903368	206354	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL97885	206354	0	None	-4	2	Human	5.9	pKi	=	5.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2ccc(OC)cc2n1Cc1ccccc1	10.1021/jm001125h
	45267465	193089	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL538129	193089	0	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	365	8	2	3	3.5	COc1ccc2[nH]c(CN(C)Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	24750195	88112	0	None	-24	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL235334	88112	0	None	-24	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	6	0	3	3.3	COc1cccc(N(CCN(C)C(C)=O)c2ccccc2)c1	10.1021/jm700957j
	10428383	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	7783	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	CHEMBL33185	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm048956y
	44429452	86923	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL233311	86923	0	None	-4	2	Human	4.9	pKi	=	4.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	308	5	2	2	3.5	COc1cc(-c2ccccc2)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	44358087	115900	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL336024	115900	0	None	-1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10428383	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	7783	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	CHEMBL33185	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Antagonist activity at human MT1 receptorAntagonist activity at human MT1 receptor	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm401343c
	10428383	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	7783	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	CHEMBL33185	3838	3	None	-151	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	356	6	1	3	4.4	CCC(=O)NCc1cc2c(n1Cc1ccc(cc1)Cl)cccc2OC	10.1021/jm800974d
	139451766	183855	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4846505	183855	0	None	-8	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	325	7	1	5	2.6	CCOc1nc2cc(Cl)c(OC)cc2n1CCCNC(C)=O	10.1021/acs.jmedchem.0c00627
	122188225	122614	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612456	122614	0	None	-	1	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	218	3	2	2	1.9	CCC(=O)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	122193492	123411	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
	CHEMBL3628489	123411	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometryDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 expressed in CHO cell membranes incubated for 60 mins by liquid scintillation spectrometry	ChEMBL	261	4	1	4	1.5	COc1ccc2oc(=O)cc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2015.09.003
	53238410	61684	0	None	-1174	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774529	61684	0	None	-1174	2	Human	7.9	pKi	=	7.9	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	361	5	1	2	4.7	CC(=O)NCCC1=C(c2cccc(C(C)C)c2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	22718610	16693	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125033	16693	0	None	-1	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	308	6	1	3	4.0	CCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	22718602	96084	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL262890	96084	0	None	-2	2	Human	7.9	pKi	=	7.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.1	CCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	24750189	89036	0	None	-1174	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
	CHEMBL237234	89036	0	None	-1174	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	334	6	1	3	4.1	COc1cccc(N(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm700957j
	122188232	122620	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612463	122620	0	None	-	1	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	353	6	2	3	3.3	CCNC(=O)NCC1CCc2c(OC)cccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	44581851	174629	0	None	-1202	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
	CHEMBL457128	174629	0	None	-1202	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	333	6	1	2	4.5	COc1cccc(C(CCNC(C)=O)c2ccc3ccccc3c2)c1	10.1021/jm800974d
	10610443	206556	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	CHEMBL99084	206556	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	10610443	206556	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	CHEMBL99084	206556	0	None	1	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	CCC(=O)NCCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	46865422	86629	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
	CHEMBL2326199	86629	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1039/C1MD00149C
	46865422	86629	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
	CHEMBL2326199	86629	0	None	-575	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	357	10	1	4	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1cccc(OC)c1	10.1016/j.ejmech.2016.01.008
	44579259	186521	0	None	-331	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL491604	186521	0	None	-331	2	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	347	6	1	3	4.0	COc1ccc2cc(-c3cccc(C=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	12436515	15641	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1222985	15641	2	None	-1	2	Human	5.9	pKi	=	5.9	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)NCC(C)Oc1ccccc1	10.1016/j.bmc.2010.06.100
	10427851	181241	0	None	-407	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL477834	181241	0	None	-407	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	3.7	COc1ccc2cc(-c3cccc(CN)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	86273227	120790	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580907	120790	0	None	-3	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	4	2	2	1.5	C#CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	44429450	86922	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233310	86922	0	None	-6	2	Human	7.9	pKi	=	7.9	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	5	1	3	3.0	CCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	11824364	112047	0	None	-42	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329960	112047	0	None	-42	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc2oc(Cc3ccccc3OC)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	56671857	64107	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813324	64107	0	None	10	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	384	13	1	4	4.3	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2ccccc2)c1	10.1016/j.bmc.2011.06.063
	10617720	206074	0	None	-56	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9630	206074	0	None	-56	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2Cc2ccccc2-1	10.1021/jm980684+
	3956219	101064	11	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL298335	101064	11	None	-2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc2c(CCNC(C)=O)c[nH]c2cc1[N+](=O)[O-]	10.1021/jm011053+
	127027022	137271	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759677	137271	0	None	-19	3	Human	6.9	pKi	=	6.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	314	4	2	3	3.6	CCNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	25210132	170300	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	CHEMBL445427	170300	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	10829695	118687	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards Melatonin receptor type 1ABinding Affinity (pKi) towards Melatonin receptor type 1A	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
	CHEMBL34327	118687	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Binding Affinity (pKi) towards Melatonin receptor type 1ABinding Affinity (pKi) towards Melatonin receptor type 1A	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm020982d
	10829695	118687	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
	CHEMBL34327	118687	0	None	-21	2	Human	6.9	pKi	=	6.9	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	322	6	1	3	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1ccccc1	10.1021/jm048956y
	25210132	170300	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	CHEMBL445427	170300	0	None	-9	2	Human	5.9	pKi	=	5.9	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	7	2	3	4.2	COc1ccc2[nH]c(CN3CCc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1021/jm800974d
	22718585	16314	0	None	-9	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123634	16314	0	None	-9	2	Human	6.9	pKi	=	6.9	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	6	1	3	3.4	CCC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	46884599	8319	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1093457	8319	0	None	-13	2	Human	5.8	pKi	=	5.8	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(CCCNC(C)=O)cc2OC)c1	10.1016/j.bmcl.2010.02.084
	25209860	188386	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL508552	188386	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	168274836	189544	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189544	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	162647716	179297	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4745789	179297	0	None	-3	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1nncc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	10853020	97701	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL273897	97701	0	None	-15	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	4	1	2	3.9	CCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	25209860	188386	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL508552	188386	0	None	-10	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.8	COc1ccc2[nH]c(CN3c4ccccc4CC3C)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	11536746	138908	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL379403	138908	0	None	-2	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	4	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(C)=O)CCCC1)cn2C	10.1021/jm0512544
	44241666	194412	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL560865	194412	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	351	7	2	3	3.5	COc1ccc2[nH]c(CN(C)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	44429445	87090	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233516	87090	0	None	-6	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.6	CCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	12985496	181739	0	None	-31	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478438	181739	0	None	-31	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	389	7	2	3	4.5	COc1ccc2cc(-c3cccc(CO)c3)cc(CCNC(=O)C3CCC3)c2c1	10.1016/j.bmc.2008.08.052
	44412079	165693	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL426861	165693	0	None	-1	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	2	3	2.8	CCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	11098363	168539	1	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
	CHEMBL440144	168539	1	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	293	5	1	2	3.7	CC(=O)NCCc1c(Cc2ccccc2)oc2ccccc12	10.1021/jm0005252
	127025786	137311	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	CHEMBL3760044	137311	0	None	1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1coc2ccc3ccc(OC)cc3c12	10.1016/j.ejmech.2015.12.047
	127025782	137193	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759054	137193	0	None	-6	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	297	4	1	3	3.9	COc1ccc2ccc3occ(CNC(=O)C(C)C)c3c2c1	10.1016/j.ejmech.2015.12.047
	122162	2345	67	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	1363	2345	67	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	CHEMBL286615	2345	67	None	-18	2	Human	6.8	pKi	=	6.8	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm401343c
	54581170	60424	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760956	60424	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	359	4	1	4	1.8	COc1ccc2c(I)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	137660726	158773	0	None	-15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4100108	158773	0	None	-15	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	322	6	1	5	1.6	CCS(=O)(=O)NC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	18522267	65978	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL184990	65978	0	None	5	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	11	1	2	5.8	CCCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44394394	122182	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL360428	122182	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	387	9	1	2	5.6	O=C(NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	145971624	164050	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4215980	164050	0	None	1	2	Human	7.8	pKi	=	7.8	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	517	15	2	5	6.0	CCC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	10849065	137	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	1345	137	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	CHEMBL126809	137	8	None	4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10.1016/j.ejmech.2019.111847
	24750191	88110	0	None	-85	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
	CHEMBL235328	88110	0	None	-85	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	332	5	1	2	3.7	CC(=O)NCCN(c1ccccc1)c1cccc(Br)c1	10.1021/jm700957j
	11392720	66701	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
	CHEMBL187160	66701	0	None	-4	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	4	1	2	3.5	COc1ccc2c(c1)C(CCNC(C)=O)Cc1ccccc1C2	10.1021/jm040768k
	10513752	108001	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
	CHEMBL319970	108001	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm001125h
	10513752	108001	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm970721h
	CHEMBL319970	108001	3	None	-1	2	Human	4.8	pKi	=	4.8	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2[nH]c(CCNC(C)=O)cc2c1	10.1021/jm970721h
	22718571	16644	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124782	16644	0	None	-7	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	8	1	3	3.6	CCCC(=O)NCCCc1cccc2nc(CCC)oc12	10.1016/j.bmcl.2004.04.082
	121231413	3834	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	9226	3834	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	CHEMBL3612464	3834	1	None	-16982	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2c(N1Cc1ccccc1)cccc2OC	10.1021/acs.jmedchem.5b01066
	86273229	120792	1	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580909	120792	1	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	244	5	2	2	2.0	C=CCNC(=O)Cc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	127025787	137194	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759080	137194	0	None	-4	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	298	4	2	3	3.4	CCNC(=O)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	44587357	187557	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	CHEMBL498494	187557	0	None	2	2	Human	7.8	pKi	=	7.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4CC3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	44358218	27294	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136895	27294	0	None	-3	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	86273222	120796	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580913	120796	0	None	-3	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nc(C)no3)c2c1	10.1021/acs.jmedchem.5b00245
	11515177	140516	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
	CHEMBL382439	140516	0	None	-5	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.4	COc1ccc2c(c1)c(C(C)(C)CNC(=O)C1CCC1)cn2C	10.1021/jm0512544
	122188348	122635	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.2	CC(=O)NCC1CCc2ccccc2N1CCc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612605	122635	0	None	-	1	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.2	CC(=O)NCC1CCc2ccccc2N1CCc1ccccc1	10.1021/acs.jmedchem.5b01066
	10591657	4593	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL10328	4593	0	None	-14	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	5	1	2	4.1	CCCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	11616029	77625	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
	CHEMBL209711	77625	0	None	-1	2	Human	6.8	pKi	=	6.8	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	1	3	2.4	COc1ccc2c(c1)c(C1(CNC(C)=O)CC1)cn2C	10.1021/jm0512544
	16105170	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	CHEMBL515696	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	44264871	203311	0	None	-26	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7700	203311	0	None	-26	2	Human	7.8	pKi	=	7.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	297	5	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	10854190	97848	0	None	-87	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL274896	97848	0	None	-87	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2Cc2ccccc2-1	10.1021/jm980684+
	15453819	203265	0	None	-30	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7659	203265	0	None	-30	2	Human	6.8	pKi	=	6.8	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	287	6	1	4	3.1	COCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	16105170	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
	CHEMBL515696	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Binding affinity to MT1 receptor (unknown origin)Binding affinity to MT1 receptor (unknown origin)	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm401343c
	16105170	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	CHEMBL515696	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1021/jm800974d
	16105170	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
	CHEMBL515696	189125	0	None	-4	2	Human	5.8	pKi	=	5.8	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2008.07.012
	10447987	116455	1	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
	CHEMBL33869	116455	1	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	308	5	1	3	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2-c1ccccc1	10.1021/jm020982d
	90666303	108879	0	None	-31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219324	108879	0	None	-31	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	361	6	2	3	3.9	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	23658145	156909	1	None	-33	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4079214	156909	1	None	-33	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	10705590	206456	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
	CHEMBL98484	206456	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm001125h
	10705590	206456	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm970721h
	CHEMBL98484	206456	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2cc(CCNC(C)=O)n(C)c2c1	10.1021/jm970721h
	16105170	189125	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
	CHEMBL515696	189125	0	None	-4	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	405	5	1	5	3.3	COc1ccc2c(c1)CC1Cn3c(c(CCNC(C)=O)c4cc(OC)ccc43)CN21	10.1016/j.bmc.2009.04.068
	22718521	16459	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL124216	16459	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	46885284	8006	0	None	-114	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	CHEMBL1091561	8006	0	None	-114	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	251	7	1	3	2.2	CCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	46884552	8028	0	None	-1122	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091716	8028	0	None	-1122	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	314	8	1	4	2.7	COc1ccc(OCc2ccccn2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	122188233	122621	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2cc(OC)ccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612465	122621	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2cc(OC)ccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145977894	163286	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206516	163286	0	None	3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	372	11	2	5	3.2	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	10454621	101397	4	None	-47	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL300728	101397	4	None	-47	2	Human	5.7	pKi	=	5.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	417	5	1	5	2.4	COc1ccc2c(c(CCNC(C)=O)c(I)n2C)c1[N+](=O)[O-]	10.1021/jm011053+
	137636173	155448	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4061905	155448	0	None	-63	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	276	6	1	3	2.3	COc1ccc2cccc(CCC(=O)NCCF)c2n1	10.1016/j.ejmech.2016.12.013
	71540275	85968	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314250	85968	0	None	-2	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	225	2	1	1	2.8	CC(=O)N[C@@H]1C[C@H]1c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	18522208	126751	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL365852	126751	0	None	6	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	349	9	1	2	5.1	CC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	24750077	148500	0	None	-691	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
	CHEMBL394273	148500	0	None	-691	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	314	7	1	4	3.0	COc1cccc(N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm700957j
	10069719	192785	4	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL52559	192785	4	None	1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	403	5	2	4	2.4	COc1ccc2[nH]c(I)c(CCNC(C)=O)c2c1[N+](=O)[O-]	10.1021/jm011053+
	44429446	146187	0	None	-14	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL392422	146187	0	None	-14	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.0	CCCC(=O)NCCc1cn(C)c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	56671856	64105	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813322	64105	0	None	4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	19	2	6	4.6	CC(=O)NCCN(C)c1cccc(OCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	16743294	91635	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL241928	91635	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	256	4	1	2	2.7	CC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	1550607	102581	64	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	298	6	0	3	4.9	CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL307341	102581	64	None	-	1	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	298	6	0	3	4.9	CC(C)=CCC/C(C)=C/COc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	44349269	16396	1	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123972	16396	1	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	6	2	3	3.2	CCNC(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	10517621	206314	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL9765	206314	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	290	3	1	2	3.3	CC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	127039212	137487	0	None	-154	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764879	137487	0	None	-154	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3cccc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	10245336	38968	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	318	5	2	1	4.3	O=C(NCCc1c(-c2ccccc2)[nH]c2ccccc12)C1CCC1	10.1021/jm970721h
	CHEMBL14701	38968	2	None	-	1	Human	6.7	pKi	=	6.7	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	318	5	2	1	4.3	O=C(NCCc1c(-c2ccccc2)[nH]c2ccccc12)C1CCC1	10.1021/jm970721h
	44389845	64486	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	CHEMBL181974	64486	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	377	10	1	2	4.9	O=C(NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2)C1CC1	10.1016/j.bmcl.2005.01.015
	20590652	129443	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL367604	129443	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	10	1	2	5.4	CCCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44389813	130839	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL368886	130839	0	None	15	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	11	1	2	5.3	CCCC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	145991966	166272	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4285145	166272	0	None	-5	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	285	3	1	3	3.2	COC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145987794	166556	0	None	-19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4290302	166556	0	None	-19	3	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	298	4	2	2	3.2	CCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988269	166626	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4291381	166626	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	326	5	2	2	3.8	CCCNC(=O)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137639112	156298	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4071572	156298	0	None	-10	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1ccc2cccc(CCNC(N)=O)c2n1	10.1016/j.ejmech.2016.12.013
	137655238	158327	0	None	-19	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4095210	158327	0	None	-19	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	275	4	2	3	1.9	CNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9805364	36717	0	None	89	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	CHEMBL14514	36717	0	None	89	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	ChEMBL	484	11	2	4	4.8	CC(=O)NCCc1cccc2ccc(OCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm0255872
	9796251	117594	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL340745	117594	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCC(=O)NCCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	139451790	184704	13	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	CHEMBL4859295	184704	13	None	-2	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	297	5	1	5	1.8	COc1cc2c(cc1Cl)nc(OC)n2CCNC(C)=O	10.1021/acs.jmedchem.0c00627
	127026062	137151	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758717	137151	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3oc(CNC(C)=O)cc3c2c1	10.1016/j.ejmech.2015.12.047
	44394438	66615	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186736	66615	0	None	1	2	Human	8.7	pKi	=	8.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	9	1	2	5.6	CCC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44358238	118854	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL344449	118854	0	None	2	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	261	2	2	3	1.1	CNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10333442	202179	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	CHEMBL68864	202179	0	None	-5	2	Human	8.7	pKi	=	8.7	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	272	6	1	3	2.7	CCCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	139451776	184418	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	CHEMBL4854836	184418	0	None	5	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	277	6	1	5	1.6	COc1ccc2nc(OC)n(CCCNC(C)=O)c2c1	10.1021/acs.jmedchem.0c00627
	10754723	168621	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL440692	168621	0	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	273	5	2	3	2.6	CCC(=O)NCCc1c(O)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	127040021	137479	0	None	-24	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764765	137479	0	None	-24	2	Human	8.7	pKi	=	8.7	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	360	5	1	4	4.3	COc1ccc2oc(-c3ccc4ccccc4c3)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	11776674	116136	1	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
	CHEMBL33700	116136	1	None	-1	2	Human	8.7	pKi	=	8.7	Binding	Binding Affinity (pKi) towards human Melatonin receptor type 1ABinding Affinity (pKi) towards human Melatonin receptor type 1A	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm020982d
	10038243	116448	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL338659	116448	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	3.0	CCCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	168274836	189544	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5173623	189544	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	411	7	1	7	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1ccccc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	10301190	8465	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	CHEMBL1094545	8465	0	None	7	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	511	12	1	5	6.2	COC(=O)c1ccc(-c2ccc(OCCCCOc3ccc4cccc(CCNC(C)=O)c4c3)cc2)cc1	10.1016/j.bmc.2010.04.008
	137641357	156525	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	156525	0	None	-3	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	44394535	66663	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL186977	66663	0	None	2	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	8	1	3	5.1	CCC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	86273228	120793	0	None	-5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580910	120793	0	None	-5	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	258	6	2	2	2.4	C=CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	11776674	116136	1	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
	CHEMBL33700	116136	1	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	246	4	1	3	1.9	COc1ccc2c(c1)c(CCNC(C)=O)cn2C	10.1021/jm011053+
	44394435	66578	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL186586	66578	0	None	3	2	Human	8.6	pKi	=	8.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	361	8	1	2	5.2	CC(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	10561982	22805	0	None	-12	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL133001	22805	0	None	-12	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CCC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	16094584	82818	0	None	-33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218708	82818	0	None	-33	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44429441	86285	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL231872	86285	0	None	-1	2	Human	8.6	pKi	=	8.6	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	246	4	2	2	2.2	COc1cc(C)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	53237951	61675	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	CHEMBL1774518	61675	0	None	-	1	Human	8.6	pKi	=	8.6	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	333	5	1	2	3.7	CC(=O)NCCC1=C(Cc2ccccc2)Cc2ccc3c(c21)CCO3	10.1021/jm200221q
	10332159	16600	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124577	16600	0	None	1	2	Human	8.6	pKi	=	8.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.6	CCC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	127026423	137281	0	None	-31	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759802	137281	0	None	-31	3	Human	8.6	pKi	=	8.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	283	4	1	3	3.3	COc1ccc2ccc3occ(CCNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	44429443	144800	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL391350	144800	0	None	-4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	6	2	2	2.9	CCCC(=O)NCCc1c[nH]c2c(C)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	9839199	21148	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	CHEMBL131424	21148	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	297	5	1	2	3.8	CCCC(=O)NCC1CCc2c(OC)ccc3cccc1c23	10.1021/jm000922c
	137636079	155674	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	CHEMBL4064626	155674	0	None	-19	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	232	3	1	2	1.8	CCN1CC(CNC(C)=O)Cc2ccccc21	10.1021/acs.jmedchem.8b00359
	127026425	137282	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759816	137282	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	295	4	1	3	3.6	COc1ccc2ccc3occ(CNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	53310838	63445	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
	CHEMBL1802021	63445	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	321	4	1	4	2.8	CC(=O)NCCn1c(-c2ccccc2)nc2ccc3c(c21)CCO3	10.1021/jm200385u
	44424018	84920	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226162	84920	0	None	3	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	620	16	4	8	4.2	COc1ccc2[nH]c(C(=O)OCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	56661499	64078	0	None	102	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813174	64078	0	None	102	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	456	14	2	6	2.7	CC(=O)NCCN(C)c1cccc(OCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	46884555	8243	0	None	-16	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092911	8243	0	None	-16	2	Human	5.7	pKi	=	5.7	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1ccc(OCc2ccccc2)c(OC)c1	10.1016/j.bmcl.2010.02.084
	44358088	26561	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136273	26561	0	None	-1	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	246	2	1	3	1.3	CC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	10518621	96853	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL269175	96853	0	None	-11	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	4	1	2	3.7	CCC(=O)NCCc1c2n(c3ccccc13)Cc1ccccc1-2	10.1021/jm980684+
	12985493	186499	0	None	-213	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL491403	186499	0	None	-213	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	7	1	3	4.3	COCc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	10736247	206612	0	None	-5	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL9950	206612	0	None	-5	2	Human	5.7	pKi	=	5.7	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	344	4	1	2	4.3	O=C(NCCc1c2n(c3ccccc13)CCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	11208578	125355	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	CHEMBL364845	125355	0	None	-1	2	Human	4.7	pKi	=	4.7	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	292	2	1	2	3.0	CC(=O)NCC(=O)N1c2ccccc2C=Cc2ccccc21	10.1021/jm040768k
	189748	16622	6	None	-60	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
	CHEMBL124699	16622	6	None	-60	2	Human	6.7	pKi	=	6.7	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	262	5	2	3	1.9	COc1cc2[nH]cc(CCNC(C)=O)c2cc1OC	10.1021/jm401343c
	11287002	15738	2	None	-4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223275	15738	2	None	-4	2	Human	4.7	pKi	=	4.7	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	44358217	27290	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136894	27290	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	44394456	65770	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL183962	65770	0	None	2	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	378	10	2	2	5.3	CCNC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	145963877	163693	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4211530	163693	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	503	14	2	5	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	10385056	111731	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL329086	111731	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	10385056	111731	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
	CHEMBL329086	111731	0	None	-194	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	379	9	1	4	4.3	C=CCC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm401343c
	145	140	48	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	1832	140	48	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	CHEMBL7257	140	48	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	DB14010	140	48	None	-40	30	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	218	4	1	2	2.3	COc1ccc2c(c1)c(CCN(C)C)c[nH]2	10.1021/acs.jmedchem.5b00245
	122178507	120797	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580915	120797	0	None	-13	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	3	1	4	2.5	COc1ccc2[nH]cc(Cc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	127025170	137204	0	None	-4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759180	137204	0	None	-4	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	312	5	2	3	3.5	CCNC(=O)NCCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	162656758	180330	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4757920	180330	0	None	-5	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	259	5	1	4	1.7	CCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	162658247	180426	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4759137	180426	0	None	-2	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2cnnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	11688043	77626	0	None	-28	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	CHEMBL209712	77626	0	None	-28	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	6	1	3	3.1	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	122188234	122622	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2ccc(OC)cc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612466	122622	0	None	-	1	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	338	6	1	3	3.5	CCC(=O)NCC1CCc2ccc(OC)cc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	44424019	84921	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226163	84921	0	None	-3	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	648	18	4	8	5.0	COc1ccc2[nH]c(C(=O)OCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	16094595	82834	4	None	-407	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218773	82834	4	None	-407	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.4	COc1cccc(C(CCNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44412078	138974	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL379504	138974	0	None	-1	2	Human	5.7	pKi	=	5.7	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	3	2	3	2.4	CC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	137637884	155693	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4064813	155693	0	None	-10	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.3	CCC(=O)NC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	122188352	122638	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612609	122638	0	None	-	1	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	3	2	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	44394532	66895	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL188016	66895	0	None	-1	2	Human	7.7	pKi	=	7.7	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	376	7	1	3	4.7	CC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	11351216	62060	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779807	62060	0	None	-4	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	1	3	5.4	O=C(CBr)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	162668689	182166	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4790145	182166	0	None	1	2	Human	7.7	pKi	=	7.7	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	285	5	1	4	2.2	COc1ccc2nc(C3CC3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	71508233	86632	0	None	-40	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326201	86632	0	None	-40	2	Human	7.7	pKi	=	7.7	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	355	10	1	3	3.9	CCC(=O)NCCCc1cc(OC)ccc1CCc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	11066802	99612	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL287343	99612	0	None	-21	2	Human	6.7	pKi	=	6.7	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	11463056	62058	0	None	-51	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779805	62058	0	None	-51	2	Human	6.7	pKi	=	6.7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	1	3	5.4	CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11131123	170056	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
	CHEMBL445117	170056	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	323	6	1	3	3.7	COc1cccc(Cc2oc3ccccc3c2CCNC(C)=O)c1	10.1021/jm0005252
	16094593	165480	0	None	-91	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL425644	165480	0	None	-91	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C\CNC(C)=O)c2ccccc2)c1	10.1021/jm060850a
	44349305	170560	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	CHEMBL445840	170560	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	320	6	1	3	4.0	O=C(NCCCc1cccc2nc(-c3ccccc3)oc12)C1CC1	10.1016/j.bmcl.2004.04.082
	23725513	125314	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL3648357	125314	0	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	258	3	1	3	2.7	CC(=O)NCC[C@H]1CCc2ccc3nc(C)oc3c21	10.1021/acs.jmedchem.0c01836
	44394416	65891	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL184562	65891	0	None	2	2	Human	7.6	pKi	=	7.6	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	389	9	1	2	5.9	CC(C)C(=O)NC[C@@H]1CC1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	10750842	188087	3	None	-30	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL50398	188087	3	None	-30	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	207	5	1	2	1.8	COc1cccc(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	127026426	137262	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759606	137262	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3occ(CCNC(=O)C4CC4)c3c2c1	10.1016/j.ejmech.2015.12.047
	90666307	108883	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	CHEMBL3219328	108883	0	None	-2	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	8	2	3	3.9	C=CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	16094584	82818	0	None	-33	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
	CHEMBL218708	82818	0	None	-33	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	281	5	1	2	3.3	COc1cccc(/C(=C/CNC(C)=O)c2ccccc2)c1	10.1021/jm800974d
	86079062	180140	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4755860	180140	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	245	4	1	4	1.3	COc1ccc2ncnc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	10808489	206030	0	None	-42	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL9600	206030	0	None	-42	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	360	6	1	3	4.1	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	53231464	62062	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779809	62062	0	None	-21	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	6	1	3	5.2	C=CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11173131	123566	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL363321	123566	0	None	-7	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	265	2	1	1	3.1	CC(=O)NCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	11014883	206377	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
	CHEMBL98028	206377	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	400	6	1	3	4.1	COc1ccc2c(Br)c(CCNC(C)=O)n(Cc3ccccc3)c2c1	10.1021/jm001125h
	22718576	114094	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL333810	114094	0	None	-4	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	4	1	3	2.2	CC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	11824365	106870	0	None	-47	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
	CHEMBL317742	106870	0	None	-47	2	Human	7.6	pKi	=	7.6	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1ccc(Cc2oc3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1021/jm0005252
	44424021	141547	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL388141	141547	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	690	21	4	8	6.2	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	53231465	62056	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779803	62056	0	None	-5	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	237	3	1	2	2.7	CC(=O)NCCc1csc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	44579260	186522	0	None	-38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL491605	186522	0	None	-38	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	6	1	4	4.0	COC(=O)c1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	10853021	97672	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL273623	97672	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	318	3	1	2	3.9	CC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	10465460	206555	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
	CHEMBL99083	206555	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm001125h
	10465460	206555	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm970721h
	CHEMBL99083	206555	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	202	3	2	1	1.8	CC(=O)NCCc1cc2ccccc2[nH]1	10.1021/jm970721h
	137656715	158988	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4102517	158988	0	None	-5	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	5	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(CCc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	71540393	85972	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314254	85972	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	226	2	2	1	2.7	CNC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	127038130	136087	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3739824	136087	0	None	-1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	44424022	83045	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL220091	83045	0	None	1	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	718	23	4	8	6.9	COc1ccc2[nH]c(C(=O)OCCCCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	10737123	96918	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	CHEMBL269670	96918	0	None	1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	358	4	1	2	4.7	O=C(NCCc1c2n(c3ccccc13)CCCc1ccccc1-2)C1CCC1	10.1021/jm980684+
	90666302	108878	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219323	108878	0	None	-11	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.4	COc1ccc2[nH]c(CN3CCc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3109562	209334	0	None	-2	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		CCC1=C(C)C2=Cc3c(CCNC(C)=O)c4cc(OC)ccc4n3[B-](F)(F)[N+]2=C1C	10.1021/ml4004155
	10596576	4094	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10007	4094	0	None	-39	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	390	7	1	3	5.1	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	46884598	8091	0	None	-20	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
	CHEMBL1092047	8091	0	None	-20	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1cc(CCCNC(C)=O)ccc1O	10.1016/j.bmcl.2010.02.084
	45269177	193186	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL540182	193186	0	None	-3	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	299	5	1	3	2.5	CCCC(=O)NCCc1c2n(c3ccccc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	45269183	194341	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	CHEMBL560186	194341	0	None	-6	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	385	7	2	3	4.1	COc1ccc2[nH]c(CN(C)c3ccc(Cl)cc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2009.04.068
	16094594	82819	0	None	-165	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218709	82819	0	None	-165	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C\CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	162674581	182720	0	None	-51	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4797226	182720	0	None	-51	2	Human	6.6	pKi	=	6.6	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	268	3	1	4	2.7	COc1ccc2cccc(/C=C/c3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	46885227	7975	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091161	7975	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.7	CCC(=O)NCCCc1cc(OC)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	16743464	91880	0	None	-11	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL243002	91880	0	None	-11	2	Human	5.6	pKi	=	5.6	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	310	3	1	2	3.9	CC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	10714573	98028	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL276005	98028	0	None	-12	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)CC)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	1353	3368	3	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	9998187	3368	3	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	CHEMBL33549	3368	3	None	-112	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm800974d
	145976375	163234	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206000	163234	0	None	10	2	Human	7.6	pKi	=	7.6	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	525	15	2	6	5.7	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	46885288	8230	0	None	-95	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092839	8230	0	None	-95	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1ccc(COc2ccc(OC)cc2CCCNC(C)=O)cc1	10.1016/j.bmcl.2010.02.084
	10760155	97954	0	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL275529	97954	0	None	-43	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	4	1	3	3.9	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	7922	1917	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	9798456	1917	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	CHEMBL476131	1917	0	None	-741	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)CO	10.1016/j.bmc.2008.08.052
	11045144	206531	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
	CHEMBL98956	206531	0	None	-1	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	3.0	CCC(=O)NCc1[nH]c2cc(OC)ccc2c1Br	10.1021/jm001125h
	49865205	15661	0	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223052	15661	0	None	-4	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	137644121	157592	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
	CHEMBL4087265	157592	0	None	-7	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	291	4	1	1	4.0	CCC(=O)NCC1=C(c2ccccc2)c2ccccc2CC1	10.1021/acs.jmedchem.8b00359
	11702296	64645	4	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
	CHEMBL1823017	64645	4	None	-3	2	Human	7.6	pKi	=	7.6	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assayDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in human HEK293 cells by radioligand binding assay	ChEMBL	309	5	1	4	2.7	COc1ccc2nc(-c3ccccc3)c(CCNC(C)=O)n2c1	10.1016/j.ejmech.2011.06.030
	86273223	120794	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580911	120794	0	None	-	1	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	242	3	1	3	3.1	COc1ccc2[nH]cc(Cc3ncc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	90666305	108881	0	None	-125	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	CHEMBL3219326	108881	0	None	-125	2	Human	6.6	pKi	=	6.6	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	2	3	3.4	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(C)=O)c2c1	10.1039/C1MD00149C
	49865266	15684	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223126	15684	2	None	-1	2	Human	5.6	pKi	=	5.6	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccc(SCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	10520058	97673	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL273624	97673	0	None	-8	2	Human	6.6	pKi	=	6.6	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	324	3	1	2	4.0	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)Cc1ccccc1-2	10.1021/jm980684+
	53231367	62061	0	None	-117	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779808	62061	0	None	-117	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	425	8	1	3	6.0	O=C(CCCCl)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11078652	206171	0	None	-16	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96778	206171	0	None	-16	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	7	1	3	4.3	CCc1ccc2oc(Cc3cccc(OC)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10641756	97813	0	None	-57	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL274630	97813	0	None	-57	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	352	3	1	2	4.6	CC(=O)NCCc1c2n(c3ccc(Cl)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	56662799	64110	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813327	64110	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	526	15	2	6	2.9	COc1cccc(N(CCNC(C)=O)C(=O)CCCCC(=O)N(CCNC(C)=O)c2cccc(OC)c2)c1	10.1016/j.bmc.2011.06.063
	11088627	205801	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94745	205801	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	324	6	1	4	3.1	COc1ccc2oc(Cc3cccnc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	15453821	203385	0	None	-151	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7771	203385	0	None	-151	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	301	6	1	3	4.6	CCCC(=O)Nc1ccc(Sc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	145983175	165867	0	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4277390	165867	0	None	-14	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	314	4	2	2	3.4	CCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137661786	158557	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4097693	158557	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	262	5	1	3	1.9	COc1cnc2cccc(CCNC(=O)CF)c2c1	10.1016/j.ejmech.2016.12.013
	145975938	163336	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4207166	163336	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	519	14	3	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	122188239	122627	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	320	5	1	2	3.5	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CC1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612471	122627	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	320	5	1	2	3.5	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CC1	10.1021/acs.jmedchem.5b01066
	46885286	8069	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091895	8069	0	None	-218	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	327	9	1	3	3.4	COc1ccc(OCCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	10620323	206589	0	None	-34	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL9935	206589	0	None	-34	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	6	1	3	4.7	CCOc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10658090	206543	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm001125h
	CHEMBL99000	206543	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm001125h
	10658090	206543	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm970721h
	CHEMBL99000	206543	0	None	-	1	Human	5.5	pKi	=	5.5	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	246	5	2	2	2.2	COc1ccc2[nH]c(CCCNC(C)=O)cc2c1	10.1021/jm970721h
	12985490	180628	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL476132	180628	0	None	-12	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccc(CO)cc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	10015474	18358	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127596	18358	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	5	1	3	2.8	Cc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	145979282	166111	0	None	-16	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166111	0	None	-16	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	53238408	61682	0	None	-81	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
	CHEMBL1774527	61682	0	None	-81	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	349	5	1	3	3.6	COc1ccc(C2=C(CCNC(C)=O)c3c(ccc4c3CCO4)C2)cc1	10.1021/jm200221q
	11426853	165804	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
	CHEMBL427516	165804	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	309	3	1	3	2.7	COc1ccc2c(c1)C(CNC(C)=O)Cc1ccccc1C2=O	10.1021/jm040768k
	137641357	156525	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4074273	156525	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	280	3	1	2	3.1	CC(=O)NCC1Cc2ccccc2N(c2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	49865321	15707	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223195	15707	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	44272406	68825	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL19260	68825	0	None	-1	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	289	5	3	3	2.7	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(CC)N2	10.1016/j.bmcl.2003.12.052
	1355	3371	3	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9806449	3371	3	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL14453	3371	3	None	70	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	71540395	85975	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL2314258	85975	0	None	2	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	256	3	2	2	2.7	CNC(=O)N/C=C/c1c(OC)ccc2ccccc12	10.1016/j.bmcl.2012.11.069
	11810280	206183	0	None	-16	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96859	206183	0	None	-16	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.5	CCCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	10091075	17084	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125705	17084	0	None	8	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	378	11	1	3	5.2	CCCC(=O)NCCCc1cccc2nc(CCCCc3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	52918078	60415	0	None	-11	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	CHEMBL1760946	60415	0	None	-11	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	247	5	1	4	1.6	CCC(=O)NCCn1ccc2ccc(OC)nc21	10.1016/j.bmcl.2011.02.097
	23658146	156564	1	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	CHEMBL4074895	156564	1	None	-10	3	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	6	2	3	2.5	CCC(=O)NC[C@H](CO)c1cccc2ccc(OC)cc12	10.1039/C4MD00149D
	56664925	64104	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813321	64104	0	None	53	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	137631636	156055	0	None	-7	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4068887	156055	0	None	-7	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	308	4	1	2	3.4	CCC(=O)NC[C@@H]1CN(C)c2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	85880795	110366	0	None	12	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	CHEMBL3260984	110366	0	None	12	2	Human	8.5	pKi	=	8.5	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	319	9	1	3	4.0	CCCCCCOc1ccc2c(c1)C(CCNC(C)=O)CCO2	10.1021/jm401343c
	18360658	8787	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1097497	8787	0	None	4	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	518	13	2	5	5.7	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4scc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10015475	16569	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124362	16569	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	260	6	1	3	2.8	CCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	44272444	67589	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19109	67589	0	None	-3	2	Human	8.5	pKi	=	8.5	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	303	6	3	3	3.0	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)NCC)c2O1	10.1016/j.bmcl.2003.12.052
	137648419	157285	0	None	-15	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4083618	157285	0	None	-15	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	10926138	206228	0	None	-57	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL97186	206228	0	None	-57	2	Human	8.5	pKi	=	8.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	349	8	1	3	4.3	C=CCC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	44429447	87304	0	None	-5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	CHEMBL233728	87304	0	None	-5	2	Human	8.5	pKi	=	8.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1cc(Br)c2[nH]cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.04.013
	139451784	184803	0	None	6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	CHEMBL4860729	184803	0	None	6	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysisDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis	ChEMBL	317	7	1	5	2.4	CCOc1nc2ccc(OC)cc2n1CCNC(=O)C1CCC1	10.1021/acs.jmedchem.0c00627
	49865149	15642	2	None	2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1222986	15642	2	None	2	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC(C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	25270146	30463	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL139497	30463	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	262	5	1	3	2.2	CCCC(=O)N[C@H]1CCN(c2cccc(OC)c2)C1	10.1016/j.bmcl.2003.09.030
	15453093	85970	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
	CHEMBL2314252	85970	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	255	3	1	2	2.8	COc1ccc2ccccc2c1[C@@H]1C[C@H]1NC(C)=O	10.1016/j.bmcl.2012.11.069
	10022490	66707	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL187186	66707	0	None	22	2	Human	8.4	pKi	=	8.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	377	10	1	2	5.7	CC(C)C(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	49865324	15710	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223198	15710	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	9860296	28989	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	CHEMBL138228	28989	0	None	8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	272	3	1	3	1.7	O=C(N[C@@H]1CCN(c2cccc3c2CCO3)C1)C1CC1	10.1016/j.bmcl.2003.09.030
	18466111	19630	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	CHEMBL130214	19630	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	5	1	2	3.4	CCCC(=O)NCC1Cc2cccc3ccc(OC)c1c23	10.1021/jm000922c
	1362	3370	18	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	9870523	3370	18	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	CHEMBL429392	3370	18	None	39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	10.1021/jm401343c
	56653120	110367	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
	CHEMBL3260985	110367	0	None	12	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	336	8	2	2	3.9	CC(=O)NCCc1c[nH]c2ccc(OCCCc3ccccc3)cc12	10.1021/jm401343c
	56681902	64106	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813323	64106	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	22718532	16589	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124488	16589	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	218	4	1	3	1.9	CC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	9881917	96581	0	None	-44	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL266970	96581	0	None	-44	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	271	5	1	3	3.8	CCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	25210000	188894	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL513933	188894	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25022442	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	CHEMBL514413	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	11681201	140532	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	CHEMBL382555	140532	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	314	5	1	3	3.5	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	162663385	181406	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4780509	181406	0	None	-2	2	Human	5.5	pKi	=	5.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2cnnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	122188229	122617	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612460	122617	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	249	3	3	2	1.9	CCNC(=S)NCC1CCc2ccccc2N1	10.1021/acs.jmedchem.5b01066
	11573203	140534	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
	CHEMBL382579	140534	0	None	-2	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	1	3	3.1	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCC1)cn2C	10.1021/jm0512544
	10991315	206544	0	None	-23	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL99001	206544	0	None	-23	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	4.1	CCC(=O)NCCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	25210000	188894	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL513933	188894	0	None	-11	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	408	7	2	5	3.3	COc1ccc2[nH]c(CN3CCc4ccc([N+](=O)[O-])cc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	145974583	163927	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4214348	163927	0	None	4	2	Human	5.5	pKi	=	5.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	279	9	2	4	1.4	CC(=O)NCCN(C)c1cccc(OCCCCN)c1	10.1021/acs.jmedchem.8b00893
	44264705	202746	1	None	-79	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7229	202746	1	None	-79	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	284	6	2	3	4.2	CCCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	127040022	137411	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3764063	137411	0	None	-6	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3c4ccccc4cc4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	9819843	206387	0	None	-20	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL98074	206387	0	None	-20	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	351	8	1	3	4.3	COc1ccc2oc(CCCc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	145978811	163297	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4206642	163297	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	531	16	2	5	6.4	CC(=O)NCCN(C)c1cccc(OCCCCCCCCNC(=O)Oc2cccc(-c3ccccc3)c2)c1	10.1021/acs.jmedchem.8b00893
	137655489	158417	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4096197	158417	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	245	4	2	3	1.5	COc1cnc2cccc(CCNC(N)=O)c2c1	10.1016/j.ejmech.2016.12.013
	25022442	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
	CHEMBL514413	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2009.04.068
	11058163	206463	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
	CHEMBL98520	206463	0	None	-22	2	Human	5.5	pKi	=	5.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	386	5	1	3	4.1	COc1cccc2c1c(Br)c(CNC(C)=O)n2Cc1ccccc1	10.1021/jm001125h
	49865423	15767	2	None	-4	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223345	15767	2	None	-4	2	Human	4.5	pKi	=	4.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)NC(C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	25022442	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
	CHEMBL514413	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1016/j.bmc.2008.07.012
	145982333	165993	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4279639	165993	0	None	1	3	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	3	2	2	2.8	CNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL3109563	209335	0	None	-3	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc2c(c1)c(CCNC(C)=O)c1n2[B-](F)(F)[N+]2=C(C)C=C(C)C2=C1	10.1021/ml4004155
	129776	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	1364	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	CHEMBL339105	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting methodDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in COS7 cells incubated for 1.5 hrs by gamma counting method	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1016/j.ejmech.2019.111847
	129776	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	1364	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	CHEMBL339105	142	5	None	-128	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	322	6	2	2	3.4	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)Cc1ccccc1	10.1021/jm401343c
	71508235	86633	0	None	-95	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326203	86633	0	None	-95	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	327	8	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1-c1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	25022442	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	CHEMBL514413	188958	0	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	375	4	1	4	3.3	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CC2Cc3ccccc3N2C1	10.1021/jm800974d
	162649850	179548	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	CHEMBL4748822	179548	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	273	6	1	4	2.1	CCCC(=O)NCCc1ncnc2ccc(OC)cc12	10.1016/j.ejmech.2020.112078
	24750194	89504	0	None	-87	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL238049	89504	0	None	-87	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	324	7	1	3	3.8	COc1cccc(N(CCNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm700957j
	122188353	122639	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	322	6	1	2	3.9	CCC(=O)NCCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612610	122639	0	None	-	1	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	322	6	1	2	3.9	CCC(=O)NCCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	20590664	123142	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL362097	123142	0	None	2	2	Human	7.5	pKi	=	7.5	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	390	9	2	2	5.4	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44429451	148668	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL394406	148668	0	None	-15	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	352	6	1	3	3.4	CCCC(=O)NCCc1cn(C)c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	11002150	107054	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL318871	107054	0	None	-7	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	334	6	1	3	3.7	COc1cccc2c1cc(CCNC(=O)C1CC1)n2-c1ccccc1	10.1021/jm001125h
	44349270	112580	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL331317	112580	0	None	3	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	6	1	3	3.4	CC(C)c1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	44264843	203129	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7556	203129	0	None	-4	2	Human	7.5	pKi	=	7.5	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	300	5	1	4	4.0	CCOC(=O)Nc1ccc(N(C)c2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	137640407	156190	0	None	-67	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4070527	156190	0	None	-67	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	270	5	1	3	2.5	COc1ccc2cccc(CCC(=O)NC3CC3)c2n1	10.1016/j.ejmech.2016.12.013
	11638009	165199	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL424693	165199	0	None	-7	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	1	3	3.1	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	44587356	192771	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
	CHEMBL525374	192771	0	None	-1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	423	8	3	5	2.8	COc1ccc2c(c1)CC(CO)N2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2008.07.012
	168296374	191910	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	CHEMBL5209359	191910	0	None	-2	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	505	9	1	8	4.5	CCN(CC)c1ccc2c(COC(=O)n3cc(CCNC(C)=O)c4cc(OC)ccc43)cc(=O)oc2c1	10.1021/acs.jmedchem.2c00717
	145966403	163645	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4210884	163645	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	497	13	2	6	4.9	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(OC(=O)NC3CCCCC3)c2)c1	10.1021/acs.jmedchem.8b00893
	44349294	18352	1	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL127576	18352	1	None	-5	2	Human	6.5	pKi	=	6.5	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	323	6	2	3	3.7	CCNC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	23658143	155824	1	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4066279	155824	1	None	-6	2	Human	6.5	pKi	=	6.5	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	49865375	15741	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223278	15741	0	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	127038131	136115	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3740052	136115	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	122178509	120801	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580919	120801	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1021/acs.jmedchem.5b00245
	122178509	120801	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL3580919	120801	0	None	-8	2	Human	7.5	pKi	=	7.5	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	259	4	2	4	1.6	COc1ccc2[nH]cc(CCc3n[nH]c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	127038131	136115	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3740052	136115	0	None	1	2	Human	7.5	pKi	=	7.5	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	363	9	1	3	4.4	CC(=O)NCCc1cccc2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	49865373	15739	2	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223276	15739	2	None	-1	2	Human	6.5	pKi	=	6.5	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OCC(C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	44264861	203424	0	None	-74	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7807	203424	0	None	-74	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	310	5	1	3	4.1	CCCC(=O)Nc1ccc(N(C)c2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	16094587	82835	3	None	-72	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL218774	82835	3	None	-72	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.7	CCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	16094592	82858	1	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL218926	82858	1	None	-6	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.4	CC(=O)NC/C(=C/c1ccccc1)c1ccccc1	10.1021/jm060850a
	49865267	15685	2	None	-7	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1223127	15685	2	None	-7	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1ccccc1SCCNC(C)=O	10.1016/j.bmc.2010.06.100
	49865374	15740	0	None	-7	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223277	15740	0	None	-7	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(OC[C@@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188235	122623	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612467	122623	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	308	5	1	2	3.5	CCC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	145971692	162458	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	264	3	0	3	3.8	O=c1ccc2ccc(O/C=C/c3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	CHEMBL4175759	162458	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	264	3	0	3	3.8	O=c1ccc2ccc(O/C=C/c3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	16743125	91857	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL242786	91857	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	296	5	1	2	3.4	O=C(NCCCc1cn2c3c(cccc13)CCC2)C1CCC1	10.1016/j.ejmech.2007.01.005
	49865425	15769	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223347	15769	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	4207624	15664	35	None	-5	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
	CHEMBL1223055	15664	35	None	-5	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccccc1OCCNC(C)=O	10.1016/j.bmc.2010.06.100
	46885230	8094	0	None	-8	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092062	8094	0	None	-8	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	223	5	2	3	1.5	COc1ccc(O)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	25210131	174733	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457352	174733	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210131	174733	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457352	174733	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2CCc3ccccc32)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	71508232	86631	0	None	-524	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	CHEMBL2326200	86631	0	None	-524	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	351	7	1	3	3.6	CCC(=O)NCCCc1cc(OC)ccc1C#Cc1cccc(OC)c1	10.1016/j.bmc.2012.10.060
	44579296	186202	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL489170	186202	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	376	6	2	3	4.2	COc1ccc2cc(-c3cccc(NC(C)=O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	145969866	164278	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4218897	164278	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	546	15	3	6	4.8	CC(=O)NCCN(C)c1cccc(OCCCCCCNC(=O)Oc2cccc(-c3cccc(C(N)=O)c3)c2)c1	10.1021/acs.jmedchem.8b00893
	56662798	64109	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813326	64109	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	554	21	2	6	5.4	COc1cccc(N(CCCCCCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	10704742	106764	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
	CHEMBL316952	106764	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm001125h
	10704742	106764	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm970721h
	CHEMBL316952	106764	0	None	1	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2cc(CCNC(C)=O)[nH]c12	10.1021/jm970721h
	13250272	15683	14	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223125	15683	14	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	195	4	1	2	1.9	CC(=O)NCCSc1ccccc1	10.1016/j.bmc.2010.06.100
	44579261	186386	0	None	-87	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490594	186386	0	None	-87	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	363	6	2	3	3.9	COc1ccc2cc(-c3cccc(C(=O)O)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44424026	141792	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL388591	141792	0	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	546	17	4	4	5.8	COc1ccc2[nH]cc(CCNC(=O)CCCCCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	10709646	206088	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9634	206088	0	None	-10	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	304	3	1	2	3.5	CC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	11219713	125309	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL364835	125309	0	None	-4	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	279	3	1	1	3.4	CC(=O)NCCC1Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	16094579	80415	5	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
	CHEMBL215252	80415	5	None	1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	267	6	1	1	3.3	CCC(=O)NCCc1cccc(Cc2ccccc2)c1	10.1021/jm060850a
	44394338	121516	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	CHEMBL359561	121516	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	405	8	2	3	4.9	CCNC(=O)N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1	10.1016/j.bmcl.2004.07.055
	71508234	696	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	7924	696	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	CHEMBL2326202	696	0	None	-38	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation methodDisplacement of [3H]melatonin from human MT1 receptor expressed in CHO cells after 60 mins by microbeta scintillation method	ChEMBL	341	9	1	3	3.8	CCC(=O)NCCCc1cc(OC)ccc1Cc1cccc(c1)OC	10.1016/j.bmc.2012.10.060
	10638747	206616	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	CHEMBL99512	206616	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	10638747	206616	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	CHEMBL99512	206616	0	None	-11	2	Human	5.4	pKi	=	5.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	310	4	2	2	2.6	COc1ccc2c(Br)c(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	44389839	64255	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181687	64255	0	None	10	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	379	10	1	2	5.1	CC(C)C(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	12071674	123412	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL362849	123412	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	351	9	1	2	4.5	CC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	145979282	166111	0	None	-16	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166111	0	None	-16	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	145988801	166482	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4288925	166482	0	None	-1	3	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	283	4	1	2	3.4	COc1ccc2ccc3c(c2c1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145986700	166655	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4292109	166655	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	4	2	2	3.5	CCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137650826	156951	0	None	-10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079699	156951	0	None	-10	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	46888491	8568	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095522	8568	0	None	20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	501	13	3	4	4.9	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4[nH]cc(CCNC(C)=O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	10522675	4257	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10099	4257	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	10522675	4257	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
	CHEMBL10099	4257	0	None	-20	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assayDisplacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in NIH3T3 cells membranes by radioligand binding assay	ChEMBL	362	6	1	3	4.3	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1016/j.ejmech.2019.111847
	16656789	88109	0	None	-63	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
	CHEMBL235327	88109	0	None	-63	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1cccc(N(CCNC(C)=O)c2ccccc2)c1	10.1021/jm700957j
	24750071	98450	0	None	-39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
	CHEMBL279401	98450	0	None	-39	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	312	8	1	3	3.8	CCCC(=O)NCCN(c1ccccc1)c1cccc(OC)c1	10.1021/jm700957j
	44429448	87305	0	None	-7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233729	87305	0	None	-7	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	49865319	15705	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223193	15705	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NCC(C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	10704399	21292	0	None	-8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL131602	21292	0	None	-8	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	225	2	1	1	2.6	CC(=O)NCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	11652196	137772	0	None	-9	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL377101	137772	0	None	-9	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	6	1	3	3.2	CCCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	10495702	203514	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL78751	203514	0	None	-3	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	317	8	2	4	2.3	CCC(=O)NCCc1c(OCCO)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	10729569	116043	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL336333	116043	0	None	-2	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	253	4	1	1	3.4	CCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	9840647	97756	0	None	-25	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL274317	97756	0	None	-25	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	5	1	3	3.7	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	44358276	118454	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL342393	118454	0	None	-1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	289	4	2	3	1.9	CCCNC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	57781240	185396	0	None	-36	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4870108	185396	0	None	-36	2	Human	8.4	pKi	=	8.4	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	334	5	1	3	4.0	CC(=O)NCCC1CCc2ccc3nc(Cc4ccccc4)oc3c21	10.1021/acs.jmedchem.0c01836
	1350	1951	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	4172142	1951	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	CHEMBL10009	1951	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm980684+
	1350	1951	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	4172142	1951	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	CHEMBL10009	1951	0	None	-95	3	Human	8.4	pKi	=	8.4	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10.1021/jm401343c
	44348996	17010	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL125642	17010	0	None	1	2	Human	8.4	pKi	=	8.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	272	6	1	3	2.8	CCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	127029516	137096	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3758225	137096	0	None	-6	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	269	3	1	3	3.2	COc1ccc2ccc3occ(CNC(C)=O)c3c2c1	10.1016/j.ejmech.2015.12.047
	23642307	158337	1	None	-8	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4095334	158337	1	None	-8	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc(C(CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	145976009	162968	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	CHEMBL4202816	162968	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	541	15	3	4	7.0	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	44272334	67278	0	None	-17	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	CHEMBL19050	67278	0	None	-17	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	302	6	2	3	3.5	CCCC1Nc2cccc([C@@H]3C[C@H]3CNC(=O)C(C)C)c2O1	10.1016/j.bmcl.2003.12.052
	44272430	166368	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL428692	166368	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	288	5	2	3	3.1	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	11550834	139001	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL379616	139001	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	274	5	1	3	2.8	CCC(=O)NCC(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	22718555	16397	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123973	16397	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	6	1	3	3.7	CC(C)C(=O)NCCCc1cccc2nc(C(C)C)oc12	10.1016/j.bmcl.2004.04.082
	22718530	17750	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL126005	17750	0	None	2	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	294	5	1	3	3.6	CC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	19703063	28687	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	CHEMBL137969	28687	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.bmcl.2011.02.097
	19703063	28687	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
	CHEMBL137969	28687	1	None	2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.2	COc1c[nH]c2ncc(CCNC(C)=O)c-2c1	10.1016/j.ejmech.2016.01.008
	1347	162	51	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	1864	162	51	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	CHEMBL127421	162	51	None	-1	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity to MT1 receptor (unknown origin) assessed as inhibition constantBinding affinity to MT1 receptor (unknown origin) assessed as inhibition constant	ChEMBL	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10.1016/j.ejmech.2019.111847
	1353	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	9998187	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	CHEMBL33549	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm0005252
	1353	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	9998187	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	CHEMBL33549	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cellsDisplacement of [125I]2-iodomelatonin from MT1 receptor (unknown origin) expressed in HEK293 cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm401343c
	25209861	174637	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457138	174637	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210133	188960	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514427	188960	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	44436051	150819	6	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL396132	150819	6	None	1	2	Human	7.4	pKi	=	7.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	1353	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	9998187	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	CHEMBL33549	3368	3	None	-112	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	10.1021/jm048956y
	46885285	8068	0	None	-186	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	CHEMBL1091894	8068	0	None	-186	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	265	8	1	3	2.6	CCCOc1ccc(OC)cc1CCCNC(C)=O	10.1016/j.bmcl.2010.02.084
	10657206	119171	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	CHEMBL34728	119171	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm001125h
	10657206	119171	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	CHEMBL34728	119171	2	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	2.2	CCC(=O)NCc1cc2c(OC)cccc2[nH]1	10.1021/jm970721h
	44264904	203899	0	None	-57	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL8169	203899	0	None	-57	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	295	5	1	2	4.0	CCCC(=O)Nc1ccc(Cc2cccc3c2CCO3)cc1	10.1016/j.bmcl.2003.11.030
	25209861	174637	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	CHEMBL457138	174637	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	405	8	2	3	4.6	CCCC(=O)NCCc1c(CN2c3ccccc3CC2C)[nH]c2ccc(OC)cc12	10.1021/jm800974d
	25210133	188960	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL514427	188960	0	None	-2	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	6	2	3	3.7	COc1ccc2[nH]c(CN3CCc4cc(C)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	16743295	92743	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL244472	92743	0	None	-3	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	284	6	1	2	3.4	CCCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	5151463	82906	12	None	-29	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL219177	82906	12	None	-29	2	Human	5.4	pKi	=	5.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.3	CC(=O)NCCC(c1ccccc1)c1ccccc1	10.1021/jm060850a
	10545399	203791	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL80792	203791	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	344	9	1	4	2.9	CCC(=O)NCCc1c(OCCN(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	44394556	123693	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL363441	123693	0	None	3	2	Human	7.4	pKi	=	7.4	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	402	8	1	3	5.1	O=C(N[C@H]1CCN(c2cccc3oc(CCCCc4ccccc4)cc23)C1)C1CC1	10.1016/j.bmcl.2004.07.055
	56661512	64101	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813319	64101	0	None	23	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	470	15	2	6	3.1	CC(=O)NCCN(C)c1cccc(OCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	10959837	205834	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94919	205834	0	None	-4	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	379	10	1	3	5.3	CCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	49865147	15639	2	None	-3	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1222983	15639	2	None	-3	2	Human	4.4	pKi	=	4.4	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1ccc(OC(C)CNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	127025788	137229	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759372	137229	0	None	-53	2	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	300	3	2	3	3.2	CNC(=S)NCc1cc2c(ccc3ccc(OC)cc32)o1	10.1016/j.ejmech.2015.12.047
	130400672	156442	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4073210	156442	0	None	-3	2	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	204	2	2	2	1.4	CC(=O)NCC1CNc2ccccc2C1	10.1021/acs.jmedchem.8b00359
	10595585	98081	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
	CHEMBL276490	98081	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCc2ccccc2-1	10.1021/jm980684+
	44349362	16382	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL123899	16382	0	None	-5	2	Human	7.4	pKi	=	7.4	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	286	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)C3CC3)c2o1	10.1016/j.bmcl.2004.04.082
	46884553	8198	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(OC)cc2CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092646	8198	0	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	343	9	1	4	3.4	COc1cccc(COc2ccc(OC)cc2CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	910172	37481	23	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	252	3	0	3	3.4	O=c1ccc2ccc(OCc3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	CHEMBL145781	37481	23	None	-	1	Human	6.4	pKi	=	6.4	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	252	3	0	3	3.4	O=c1ccc2ccc(OCc3ccccc3)cc2o1	10.1021/acs.jnatprod.7b00853
	145965883	163519	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4209446	163519	0	None	-1	2	Human	6.4	pKi	=	6.4	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	307	11	2	4	2.2	CC(=O)NCCN(C)c1cccc(OCCCCCCN)c1	10.1021/acs.jmedchem.8b00893
	122188236	122624	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612468	122624	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NCC1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	122188237	122625	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612469	122625	0	None	-	1	Human	7.4	pKi	=	7.4	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	294	4	1	2	3.1	CC(=O)NC[C@H]1CCc2ccccc2N1Cc1ccccc1	10.1021/acs.jmedchem.5b01066
	10712600	4277	0	None	-48	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	CHEMBL10110	4277	0	None	-48	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	3	3.7	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2Cc2ccccc2-1	10.1021/jm980684+
	11602301	76333	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL206471	76333	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CC3)CCCC1)cn2C	10.1021/jm0512544
	10950593	111020	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL327864	111020	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	459	6	1	3	5.7	COc1ccc2oc(Cc3cc(C(F)(F)F)cc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	164946945	189625	1	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5174929	189625	1	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	427	9	1	7	3.3	COc1ccc2c(c1)c(CCNC(C)=O)cn2Cc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	49865378	15744	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223281	15744	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(SC[C@H](C)NC(C)=O)c1	10.1016/j.bmc.2010.06.100
	11501012	76874	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
	CHEMBL207959	76874	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	340	5	1	3	3.9	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCCC1)cn2C	10.1021/jm0512544
	49865203	15658	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223049	15658	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	223	5	1	3	1.6	COc1cccc(O[C@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188226	122615	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	4	3	3	1.7	CCNC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612457	122615	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	263	4	3	3	1.7	CCNC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	11616210	138915	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
	CHEMBL379413	138915	0	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	4	1	3	2.7	COc1ccc2c(c1)c(C1(CNC(C)=O)CCC1)cn2C	10.1021/jm0512544
	44347098	16224	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	344	5	1	4	2.7	CCCCC(=O)n1c(OC)cc2c1=C(CN)C1CCCCC(C)C1C=2	10.1021/jm970721h
	CHEMBL123119	16224	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	344	5	1	4	2.7	CCCCC(=O)n1c(OC)cc2c1=C(CN)C1CCCCC(C)C1C=2	10.1021/jm970721h
	CHEMBL3109561	209333	0	None	6	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
	11065731	101398	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
	CHEMBL300729	101398	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	277	5	2	4	1.8	COc1cc([N+](=O)[O-])c2[nH]cc(CCNC(C)=O)c2c1	10.1021/jm011053+
	44358035	29735	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138848	29735	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	260	3	1	3	1.7	CCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	44579163	181537	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL478217	181537	0	None	-53	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	362	6	1	3	4.3	COc1ccc2cc(-c3cccc(N(C)C)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44349329	18347	1	None	-13	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL127565	18347	1	None	-13	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	289	7	2	3	3.0	CCCc1nc2cccc(CCCNC(=O)NCC)c2o1	10.1016/j.bmcl.2004.04.082
	11500596	138137	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
	CHEMBL377809	138137	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	312	5	2	2	3.5	COc1ccc2[nH]cc(C3(CNC(=O)C4CCC4)CCC3)c2c1	10.1021/jm0512544
	122188230	122618	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612461	122618	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	277	4	2	3	1.8	CCNC(=O)NCC1CCc2c(OC)cccc2N1C	10.1021/acs.jmedchem.5b01066
	10424693	109142	1	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	CHEMBL322339	109142	1	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	127038129	136336	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	CHEMBL3742090	136336	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	86273226	120791	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	CHEMBL3580908	120791	0	None	-5	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	256	5	2	2	1.9	C#CCNC(=O)CCc1c[nH]c2ccc(OC)cc12	10.1021/acs.jmedchem.5b00245
	145983929	165857	0	None	-6	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4277185	165857	0	None	-6	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	284	4	1	3	2.8	COc1ccc2ccc3c(c2n1)C(CCNC(C)=O)CC3	10.1016/j.ejmech.2017.10.025
	145993566	166806	0	None	-25	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4294790	166806	0	None	-25	3	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	312	5	2	2	3.6	CCCNC(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137642160	157835	0	None	-165	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4089965	157835	0	None	-165	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	308	5	1	5	1.3	COc1ccc2cccc(CCC(=O)NS(C)(=O)=O)c2n1	10.1016/j.ejmech.2016.12.013
	127038129	136336	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	CHEMBL3742090	136336	0	None	-2	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	311	5	1	2	3.3	COc1ccc2cccc(CCNC(=O)C(Cl)Cl)c2c1	10.1039/C5MD00190K
	44272431	98388	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	CHEMBL278922	98388	0	None	-4	2	Human	8.3	pKi	=	8.3	Binding	Binding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1ABinding of 2-[125I]iodomelatonin to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	274	4	2	3	2.7	CC(=O)NC[C@@H]1C[C@H]1c1cccc2c1OC(C(C)C)N2	10.1016/j.bmcl.2003.12.052
	16750569	86920	0	None	-14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233308	86920	0	None	-14	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	338	6	2	2	3.4	CCCC(=O)NCCc1c[nH]c2c(Br)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	9888609	8789	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
	CHEMBL1097525	8789	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO-K1 cells after 2 hrs	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1039/C5MD00190K
	9888609	8789	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
	CHEMBL1097525	8789	0	None	46	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	424	7	2	2	5.0	CC(=O)NCCc1cccc2ccc(-c3ccc4cccc(CCNC(C)=O)c4c3)cc12	10.1021/jm401343c
	24750070	153007	4	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL398017	153007	4	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	208	5	2	3	1.2	COc1cccc(NCCNC(C)=O)c1	10.1021/jm700957j
	122188231	122619	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	CHEMBL3612462	122619	0	None	-	1	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	247	3	2	2	1.8	CCNC(=O)NCC1CCc2ccccc2N1C	10.1021/acs.jmedchem.5b01066
	10882307	205731	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL94301	205731	0	None	-15	2	Human	8.3	pKi	=	8.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	338	6	2	3	3.5	CNC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	49865318	15704	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223192	15704	0	None	1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(S[C@@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	11644612	77880	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	77880	0	None	-9	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	90666306	108882	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	CHEMBL3219327	108882	0	None	-1	2	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	377	7	2	3	3.8	CCC(=O)NCCc1c(CN2Cc3ccccc3C2)[nH]c2ccc(OC)cc12	10.1039/C1MD00149C
	127025784	137195	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759084	137195	0	None	-8	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3oc(CNC(=O)CF)cc3c2c1	10.1016/j.ejmech.2015.12.047
	10424693	109142	1	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	CHEMBL322339	109142	1	None	-2	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	297	4	1	2	3.1	COc1ccc2cccc(CCNC(=O)C(F)(F)F)c2c1	10.1039/C5MD00190K
	25209998	189140	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	CHEMBL515856	189140	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	49865206	15662	1	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223053	15662	1	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	239	5	1	3	2.3	COc1cccc(S[C@@H](C)CNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	122188349	122636	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	CHEMBL3612606	122636	0	None	-	1	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	246	4	1	2	2.4	CCCN1c2ccccc2CCC1CNC(C)=O	10.1021/acs.jmedchem.5b01066
	25209998	189140	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	CHEMBL515856	189140	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	393	7	2	4	3.4	COc1ccc2c(c1)CCN2Cc1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1021/jm800974d
	23658144	157622	1	None	-6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	CHEMBL4087633	157622	1	None	-6	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	291	6	2	3	2.0	COc1ccc2cccc([C@@H](CO)CNC(=O)CF)c2c1	10.1039/C4MD00149D
	10712733	206690	0	None	-48	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9997	206690	0	None	-48	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	348	5	1	3	3.9	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCc1ccccc1-2	10.1021/jm980684+
	10399579	202276	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
	CHEMBL69521	202276	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	244	4	1	3	1.9	COc1ccc2nccc(CCNC(C)=O)c2c1	10.1016/S0960-894X(97)00392-2
	12985489	189632	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL517502	189632	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	349	6	2	3	3.7	COc1ccc2cc(-c3ccccc3CO)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	44349258	16721	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL125226	16721	1	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	261	5	2	3	2.4	CCNC(=O)NCCCc1cccc2nc(C)oc12	10.1016/j.bmcl.2004.04.082
	10903463	206613	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
	CHEMBL99502	206613	0	None	2	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	324	5	2	2	3.0	CCC(=O)NCCc1[nH]c2cccc(OC)c2c1Br	10.1021/jm001125h
	24750069	149938	0	None	-66	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
	CHEMBL395437	149938	0	None	-66	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	298	7	1	3	2.8	COc1cccc(N(CCNC(C)=O)Cc2ccccc2)c1	10.1021/jm700957j
	12985491	186387	0	None	-91	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL490595	186387	0	None	-91	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	411	6	1	2	5.1	COc1ccc2cc(-c3cccc(CBr)c3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	118712359	113638	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	350	3	1	4	3.4	O=C(CN1CCCC2Cc3cc4c(cc3C21)OCO4)Nc1ccccc1	10.1016/j.ejmech.2014.09.038
	CHEMBL3329376	113638	0	None	-	1	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	350	3	1	4	3.4	O=C(CN1CCCC2Cc3cc4c(cc3C21)OCO4)Nc1ccccc1	10.1016/j.ejmech.2014.09.038
	162649247	179485	0	None	-10	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	CHEMBL4747996	179485	0	None	-10	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	351	6	1	5	3.0	COc1cccc(-c2nc(CCNC(C)=O)c3cc(OC)ccc3n2)c1	10.1016/j.ejmech.2020.112078
	10738183	4296	0	None	-41	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL10124	4296	0	None	-41	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	374	5	1	3	4.3	COc1ccc2c(c1)c(CCNC(=O)C1CC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	1358	124	35	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	3976006	124	35	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	CHEMBL285718	124	35	None	-870	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm401343c
	22718661	16645	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL124783	16645	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCc1nc2cccc(CCCNC(=O)CC)c2o1	10.1016/j.bmcl.2004.04.082
	168288029	191015	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5195595	191015	0	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes under dark condition by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	54582194	60418	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760950	60418	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	330	6	1	5	2.2	COc1ccc2c(CN3CCCCC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	16094582	82887	5	None	-44	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL219076	82887	5	None	-44	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	251	4	1	1	3.3	CC(=O)NCC=C(c1ccccc1)c1ccccc1	10.1021/jm060850a
	10666373	97856	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL274995	97856	0	None	-4	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCOc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10737372	4549	0	None	-37	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL10293	4549	0	None	-37	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	5	1	3	4.3	CCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCCc1ccccc1-2	10.1021/jm980684+
	52953165	62064	0	None	-218	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779810	62064	0	None	-218	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	1	3	5.6	C=CCC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	320362	49444	42	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	230	3	0	3	3.1	CC(C)=CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL156692	49444	42	None	-	1	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	230	3	0	3	3.1	CC(C)=CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	10563168	119174	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
	CHEMBL34729	119174	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm001125h
	10563168	119174	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm970721h
	CHEMBL34729	119174	0	None	1	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	258	4	2	2	2.6	COc1cccc2[nH]c(CNC(=O)C3CCC3)cc12	10.1021/jm970721h
	16094577	83051	4	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL220136	83051	4	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	297	7	1	2	3.5	CCC(=O)NCC(Cc1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	9818487	172951	0	None	-141	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	CHEMBL453138	172951	0	None	-141	2	Human	7.3	pKi	=	7.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	319	5	1	2	4.2	COc1ccc2cc(-c3ccccc3)cc(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.08.052
	9884156	206130	0	None	-77	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96548	206130	0	None	-77	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	335	7	1	3	3.9	C=CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(OC)cc12	10.1021/jm0005252
	44429457	168774	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL441916	168774	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	350	7	1	3	4.3	CCCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	49865265	15682	2	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223124	15682	2	None	-1	2	Human	7.3	pKi	=	7.3	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	225	5	1	3	1.9	COc1cccc(SCCNC(C)=O)c1	10.1016/j.bmc.2010.06.100
	162643514	181095	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4776540	181095	0	None	-1	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	271	5	1	4	1.7	COc1ccc2ncnc(CCNC(=O)C3CC3)c2c1	10.1016/j.ejmech.2020.112078
	11208632	122377	1	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
	CHEMBL360600	122377	1	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	294	4	1	2	3.5	CCC(=O)NCCN1c2ccccc2CCc2ccccc21	10.1021/jm040768k
	11277044	126068	1	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	CHEMBL365249	126068	1	None	-6	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	263	2	1	1	3.3	CC(=O)NCC1=Cc2ccccc2Cc2ccccc21	10.1021/jm040768k
	16094588	136186	4	None	-208	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	CHEMBL374075	136186	4	None	-208	2	Human	6.3	pKi	=	6.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	8	1	2	4.1	CCCC(=O)NCCC(c1ccccc1)c1cccc(OC)c1	10.1021/jm060850a
	11046748	206189	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	CHEMBL96916	206189	0	None	-19	2	Human	7.3	pKi	=	7.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	365	8	1	4	3.9	C=CC(=O)NCCc1c(Cc2cccc(OC)c2)oc2ccc(OC)cc12	10.1021/jm0005252
	162673916	182442	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4793947	182442	0	None	-2	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	327	6	1	5	2.9	COc1ccc2[nH]cc(CCc3nn(CC4CCC4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	162673578	182526	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
	CHEMBL4794879	182526	0	None	-5	2	Human	6.3	pKi	=	6.3	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	272	5	2	5	2.4	CNc1nnc(CCc2c[nH]c3ccc(OC)cc23)o1	10.1016/j.ejmech.2020.112090
	45268318	194642	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
	CHEMBL562328	194642	0	None	-6	2	Human	5.3	pKi	=	5.3	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	315	4	1	4	2.2	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCCN(C)C1	10.1016/j.bmc.2009.04.068
	11109646	205333	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
	CHEMBL91813	205333	0	None	-7	2	Human	6.3	pKi	=	6.3	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	309	5	2	3	3.4	CC(=O)NCCc1c(Cc2ccccc2)oc2ccc(O)cc12	10.1021/jm0005252
	122188224	122613	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612455	122613	0	None	-	1	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	248	4	2	3	1.9	CCC(=O)NCC1CCc2c(cccc2OC)N1	10.1021/acs.jmedchem.5b01066
	53231366	62057	0	None	-66	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	CHEMBL1779804	62057	0	None	-66	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	5	1	3	5.0	CC(=O)NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12	10.1016/j.ejmech.2011.02.044
	11393103	125270	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
	CHEMBL364806	125270	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	322	5	1	3	3.8	CCC(=O)NCCN1c2ccccc2C=Cc2ccc(OC)cc21	10.1021/jm040768k
	90666304	108880	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219325	108880	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	401	7	2	3	4.6	COc1ccc2[nH]c(Cn3ccc4ccccc43)c(CCNC(=O)C3CCC3)c2c1	10.1039/C1MD00149C
	56678563	64103	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813320	64103	0	None	14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	484	16	2	6	3.5	CC(=O)NCCN(C)c1cccc(OCCCCCOc2cccc(N(C)CCNC(C)=O)c2)c1	10.1016/j.bmc.2011.06.063
	11529521	76391	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
	CHEMBL206790	76391	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	5	2	2	3.1	COc1ccc2[nH]cc(C3(CNC(=O)C4CC4)CCC3)c2c1	10.1021/jm0512544
	122178508	120799	0	None	-8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580917	120799	0	None	-8	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	243	4	1	4	2.3	COc1ccc2[nH]cc(CCc3nnco3)c2c1	10.1021/acs.jmedchem.5b00245
	137633839	156057	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4068922	156057	0	None	-7	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	273	5	2	3	2.1	CCNC(=O)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	137640743	156491	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
	CHEMBL4073867	156491	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1ccc2ccc(CCNC(C)=O)cc2n1	10.1016/j.ejmech.2016.12.013
	16094586	82721	4	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
	CHEMBL218225	82721	4	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	311	6	1	3	3.3	COc1cccc(C(=CCNC(C)=O)c2cccc(OC)c2)c1	10.1021/jm060850a
	145968467	164226	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	CHEMBL4218247	164226	0	None	5	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	400	13	2	5	4.0	CC(=O)NCCN(C)c1cccc(OCCCCCCOc2cccc(O)c2)c1	10.1021/acs.jmedchem.8b00893
	44429456	87487	0	None	-8	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233945	87487	0	None	-8	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	6	1	3	3.9	CCC(=O)NCCc1cn(C)c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	16743288	91881	0	None	-14	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	CHEMBL243003	91881	0	None	-14	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	338	5	1	2	4.7	CCCC(=O)NCC1(c2cn3c4c(cccc24)CCC3)CCCCC1	10.1016/j.ejmech.2007.01.005
	11595087	76299	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	CHEMBL206419	76299	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	328	6	1	3	3.9	CCCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CCCC1	10.1021/jm0512544
	137645887	157385	0	None	-58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4084568	157385	0	None	-58	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.0	CC(=O)NCC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	1358	124	35	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	3976006	124	35	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	CHEMBL285718	124	35	None	-870	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	10.1021/jm800974d
	44424020	84924	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226171	84924	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	676	20	4	8	5.8	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	39847023	83967	1	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	330	9	1	3	4.9	COc1cc(/C=C/C(=O)O)ccc1OC/C=C(\C)CCC=C(C)C	10.1021/acs.jnatprod.7b00853
	CHEMBL221960	83967	1	None	-	1	Human	4.2	pKi	=	4.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	330	9	1	3	4.9	COc1cc(/C=C/C(=O)O)ccc1OC/C=C(\C)CCC=C(C)C	10.1021/acs.jnatprod.7b00853
	20590665	123099	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL361854	123099	0	None	14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	391	9	1	2	5.3	CC(C)C(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	44358312	29593	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL138744	29593	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	3	1	3	2.0	CC(C)C(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	145986330	166493	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	CHEMBL4289115	166493	0	None	-15	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	286	3	2	2	2.7	COc1ccc2ccc3c(c2c1)C(CNC(N)=S)CC3	10.1016/j.ejmech.2017.10.025
	18522272	65743	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	CHEMBL183846	65743	0	None	15	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	375	10	1	2	5.5	O=C(NCCCc1cccc2oc(CCCCc3ccccc3)cc12)C1CC1	10.1016/j.bmcl.2004.07.055
	145972981	163932	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	CHEMBL4214478	163932	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysisDisplacement of [125I]iodomelatonin from human MT1 receptor expressed in rat NIH/3T3 cell membranes incubated for 90 mins by Cheng-Prusoff equation analysis	ChEMBL	513	13	3	4	6.2	CC(=O)NCCc1c[nH]c2ccc(OCCCCCCNC(=O)Oc3cccc(-c4ccccc4)c3)cc12	10.1021/acs.jmedchem.8b00893
	11507534	165569	0	None	-5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL426127	165569	0	None	-5	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	288	5	1	3	3.0	CCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	11185529	3839	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	7772	3839	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	CHEMBL189449	3839	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cellsBinding affinity for human recombinant Melatonin receptor type 1 expressed in NIH3T3 cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm040768k
	127041168	136068	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3739674	136068	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	11185529	3839	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	7772	3839	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	CHEMBL189449	3839	3	None	-14	2	Human	8.2	pKi	=	8.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	10.1021/jm048956y
	127041168	136068	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	CHEMBL3739674	136068	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	388	10	2	3	3.9	O=C(NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12)C(F)F	10.1039/C5MD00190K
	10611901	23358	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL133426	23358	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	267	5	1	1	3.8	CCCC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	10801655	21160	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	CHEMBL131431	21160	0	None	2	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	265	4	1	1	3.4	O=C(NCCC1Cc2cccc3cccc1c23)C1CC1	10.1021/jm000922c
	10800029	116197	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	CHEMBL337295	116197	0	None	-1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	239	3	1	1	3.0	CC(=O)NCCC1Cc2cccc3cccc1c23	10.1021/jm000922c
	44358275	167877	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL435023	167877	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	287	3	2	3	1.7	O=C(NC1CC1)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	22718564	16586	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124476	16586	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	232	5	1	3	2.3	CCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	44241665	194017	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	CHEMBL556908	194017	0	None	1	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	329	6	1	4	2.6	CCCC(=O)NCCc1c2n(c3ccc(OC)cc13)CCN(C)C2	10.1016/j.bmc.2009.04.068
	44426096	85295	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	CHEMBL229015	85295	0	None	-4	2	Human	8.2	pKi	=	8.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	211	2	1	1	2.9	CC(=O)N/C=C/c1cccc2ccccc12	10.1016/j.bmcl.2012.11.069
	10061064	102482	0	None	-7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	CHEMBL306468	102482	0	None	-7	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cellsBinding affinity against human Melatonin receptor type 1A by displacement of [125I]iodomelatonin stably expressed in CHO cells	ChEMBL	258	5	1	3	2.3	CCC(=O)NCCc1ccnc2ccc(OC)cc12	10.1016/S0960-894X(97)00392-2
	44389768	64197	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181457	64197	0	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	426	9	2	2	5.5	CCNC(=O)NC[C@@H]1C[C@H]1c1c(Cl)ccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	22718654	112820	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL331636	112820	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	288	7	1	3	3.5	CCCc1nc2cccc(CCCNC(=O)C(C)C)c2o1	10.1016/j.bmcl.2004.04.082
	22718596	116857	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL339784	116857	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	7	1	3	4.3	CCCC(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	137655435	158252	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
	CHEMBL4094436	158252	0	None	-15	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	COc1cnc2cccc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2016.12.013
	12985495	180794	0	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	CHEMBL476341	180794	0	None	-213	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	377	8	2	3	4.5	CCCC(=O)NCCc1cc(-c2cccc(CO)c2)cc2ccc(OC)cc12	10.1016/j.bmc.2008.08.052
	122162	2345	67	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	1363	2345	67	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	CHEMBL286615	2345	67	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1021/jm980684+
	44264706	202715	1	None	-33	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7215	202715	1	None	-33	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	270	5	2	3	3.8	CCC(=O)Nc1ccc(Nc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44264689	203332	1	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7713	203332	1	None	1	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	282	5	2	3	3.8	COc1cccc(Nc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	90666308	108884	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
	CHEMBL3219329	108884	0	None	-1	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	389	7	2	3	3.8	COc1ccc2[nH]c(CN3Cc4ccccc4C3)c(CCNC(=O)C3CC3)c2c1	10.1039/C1MD00149C
	44429453	87099	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL233517	87099	0	None	1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	322	6	2	2	3.9	CCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	3964826	15663	30	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223054	15663	30	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	5	1	3	1.2	COc1ccc(OCCNC(C)=O)cc1	10.1016/j.bmc.2010.06.100
	44412063	77220	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
	CHEMBL208802	77220	0	None	2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	298	4	2	3	2.8	Cn1cc(C2(CNC(=O)C3CC3)CCC2)c2cc(O)ccc21	10.1021/jm0512544
	137637541	155445	0	None	-269	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	CHEMBL4061850	155445	0	None	-269	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	293	4	1	1	3.9	CCC(=O)NC[C@@H]1CCc2ccccc2[C@H]1c1ccccc1	10.1021/acs.jmedchem.8b00359
	9947753	203182	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7599	203182	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	285	6	1	3	4.2	CCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	44264949	203250	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7650	203250	0	None	-83	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	299	7	1	3	4.6	CCCCC(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	145990308	166468	0	None	-20	3	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4288690	166468	0	None	-20	3	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	328	5	2	2	3.8	CCCNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	10567865	4099	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	CHEMBL100104	4099	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm001125h
	10567865	4099	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm970721h
	CHEMBL100104	4099	0	None	-38	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCCc1cc2c(OC)cccc2n1-c1ccccc1	10.1021/jm970721h
	10639585	113952	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL33346	113952	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	10513751	162731	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
	CHEMBL418789	162731	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm001125h
	10639585	113952	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	CHEMBL33346	113952	0	None	-83	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	322	6	1	3	3.7	CCC(=O)NCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	10513751	162731	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm970721h
	CHEMBL418789	162731	1	None	1	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1cccc2[nH]c(CCNC(C)=O)cc12	10.1021/jm970721h
	11310062	15737	2	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223274	15737	2	None	-1	2	Human	4.2	pKi	=	4.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	193	4	1	2	1.6	CC(=O)N[C@H](C)COc1ccccc1	10.1016/j.bmc.2010.06.100
	122188345	122632	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	334	5	1	2	3.9	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CCC1	10.1021/acs.jmedchem.5b01066
	CHEMBL3612602	122632	0	None	-	1	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor transfected in CHO cell membranes after 120 mins	ChEMBL	334	5	1	2	3.9	O=C(NCC1CCc2ccccc2N1Cc1ccccc1)C1CCC1	10.1021/acs.jmedchem.5b01066
	10969292	206087	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96333	206087	0	None	-7	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	321	6	1	2	4.3	CCc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	44424025	84736	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL225302	84736	0	None	1	2	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	504	14	4	4	4.6	COc1ccc2[nH]cc(CCNC(=O)CCCCCC(=O)NCCc3c[nH]c4ccc(OC)cc34)c2c1	10.1016/j.bmc.2007.03.080
	11680808	76711	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	CHEMBL207420	76711	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	2	2	3.1	CCC(=O)NCC1(c2c[nH]c3ccc(OC)cc23)CCC1	10.1021/jm0512544
	1359	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	5311198	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	CHEMBL274438	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm800974d
	1359	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	5311198	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	CHEMBL274438	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Inhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cellsInhibition of 2-[125I]iodomelatonin binding to human melatonin receptor type 1A (MT1) expressed in NIH3T3 rat fibroblast cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm048956y
	1359	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	5311198	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	CHEMBL274438	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm980684+
	1359	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	5311198	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	CHEMBL274438	2130	20	None	-125	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in mouse NIH3T3 cells	ChEMBL	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10.1021/jm401343c
	10925526	111829	0	None	-26	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL329299	111829	0	None	-26	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	329	6	1	3	4.2	COc1ccc2oc(CC3CCCCC3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	44357899	118163	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL341705	118163	0	None	-3	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	274	4	1	3	2.1	CCCC(=O)N[C@@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	118712372	113640	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
	CHEMBL3329390	113640	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor stably transfected in HEK293 cells after 120 mins by scintillation counting	ChEMBL	308	2	1	2	3.4	CCNC(=O)N1CCCC2Cc3cc(Cl)c(OC)cc3C21	10.1016/j.ejmech.2014.09.038
	127040355	137374	0	None	-13	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763537	137374	0	None	-13	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	410	5	1	4	5.5	COc1ccc2oc(-c3cc4ccccc4c4ccccc34)c(CCNC(C)=O)c2n1	10.1016/j.ejmech.2016.01.008
	16094580	81132	4	None	-11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
	CHEMBL216158	81132	4	None	-11	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.0	COc1ccc(Cc2ccccc2)c(CCNC(C)=O)c1	10.1021/jm060850a
	137657824	159238	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4105511	159238	0	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	289	5	2	3	2.3	CCNC(=S)NCCc1cccc2ncc(OC)cc12	10.1016/j.ejmech.2016.12.013
	162668486	181982	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	CHEMBL4787877	181982	0	None	-2	2	Human	6.2	pKi	=	6.2	Binding	Displacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysisDisplacement of [125l]-lodomelatonin from human MT1 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis	ChEMBL	377	8	1	5	3.7	COc1ccc2[nH]cc(CCc3nn(CCCc4ccccc4)c(=O)o3)c2c1	10.1016/j.ejmech.2020.112090
	10893437	206697	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL99987	206697	0	None	-6	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	348	6	1	3	4.1	COc1cccc2c1cc(CCNC(=O)C1CCC1)n2-c1ccccc1	10.1021/jm001125h
	16094591	82896	4	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
	CHEMBL219127	82896	4	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	283	6	1	2	3.2	COc1cccc(C(CNC(C)=O)Cc2ccccc2)c1	10.1021/jm060850a
	10948786	206055	0	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	CHEMBL96173	206055	0	None	-18	2	Human	6.2	pKi	=	6.2	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	375	7	1	4	4.6	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)c3ccco3)c2c1	10.1021/jm0005252
	44358231	26727	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	CHEMBL136431	26727	0	None	-3	2	Human	8.2	pKi	=	8.2	Binding	Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.Binding affinity against human MT1 melatonin receptor expressed in NIH3T3 cells.	ChEMBL	275	3	2	3	1.5	CCNC(=O)N[C@H]1CCN(c2cccc3c2CCO3)C1	10.1016/j.bmcl.2003.09.030
	145979585	165926	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4278446	165926	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	313	5	2	3	3.0	CCCNC(=O)NCC1CCc2ccc3ccc(OC)nc3c21	10.1016/j.ejmech.2017.10.025
	145991111	166348	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4286494	166348	0	None	-17	3	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	319	5	1	3	2.8	CCS(=O)(=O)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	137645530	157169	0	None	-23	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4082097	157169	0	None	-23	2	Human	8.2	pKi	=	8.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	260	4	1	4	2.1	COC(=O)NCCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	11002840	205784	0	None	-33	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL94607	205784	0	None	-33	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	357	6	1	3	4.4	COc1ccc2oc(Cc3cccc(Cl)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	10616723	97840	0	None	-14	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
	CHEMBL274842	97840	0	None	-14	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	334	4	1	3	3.6	COc1ccc2c(c1)c(CCNC(C)=O)c1n2CCc2ccccc2-1	10.1021/jm980684+
	44436051	150819	6	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
	CHEMBL396132	150819	6	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	209	5	1	3	1.2	COc1cccc(OCCNC(C)=O)c1	10.1021/jm700957j
	10384120	123859	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	CHEMBL363936	123859	0	None	7	2	Human	8.1	pKi	=	8.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1AInhibition of 2-[125I]iodomelatonin binding to membrane preparations of NIH3T3 cells stably expressing human Melatonin receptor type 1A	ChEMBL	363	10	1	2	5.5	CCC(=O)NCCCc1cccc2oc(CCCCc3ccccc3)cc12	10.1016/j.bmcl.2004.07.055
	44317725	203948	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL82135	203948	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	329	9	1	3	4.1	CCCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	11644612	77880	0	None	-9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	CHEMBL210791	77880	0	None	-9	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.4	COc1ccc2c(c1)c(C(C)CNC(C)=O)cn2C	10.1021/jm0512544
	168288029	191015	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	CHEMBL5195595	191015	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assayDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor stably expressing in human HEK293 cell membranes in presence of light-activated compounds by radioligand based competition binding assay	ChEMBL	471	9	1	9	3.4	COc1ccc2c(c1)c(CCNC(C)=O)cn2C(=O)OCc1cc(OC)c(OC)cc1[N+](=O)[O-]	10.1021/acs.jmedchem.2c00717
	49865269	15687	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223129	15687	0	None	2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	249	6	1	3	2.0	COc1cccc(O[C@H](C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	56653479	110368	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3260986	110368	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	56653479	110368	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
	CHEMBL3260986	110368	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of [125I]2-iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1021/jm401343c
	16750566	141488	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL387655	141488	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	662	19	4	8	5.4	COc1ccc2[nH]c(C(=O)OCCCCCCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	56653479	110368	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3260986	110368	0	None	10	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	352	9	2	3	3.7	CC(=O)NCCc1c[nH]c2ccc(OCCCOc3ccccc3)cc12	10.1039/C5MD00190K
	44424023	144269	0	None	-14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
	CHEMBL390944	144269	0	None	-14	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	346	9	2	4	3.2	CCCCCOC(=O)c1[nH]c2ccc(OC)cc2c1CCNC(C)=O	10.1016/j.bmc.2007.03.080
	49865323	15709	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223197	15709	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NC[C@@H](C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	10711649	206039	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9605	206039	0	None	-19	2	Human	7.2	pKi	=	7.2	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	332	5	1	2	4.3	CCCC(=O)NCCc1c2n(c3ccccc13)CCc1ccccc1-2	10.1021/jm980684+
	16094576	137591	6	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
	CHEMBL376693	137591	6	None	-1	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	253	5	1	1	3.1	CC(=O)NCC(Cc1ccccc1)c1ccccc1	10.1021/jm060850a
	81689735	120798	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3580916	120798	0	None	-3	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 minsDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor-1 transfected in CHO cell membranes after 120 mins	ChEMBL	257	4	1	4	2.7	COc1ccc2[nH]cc(CCc3nnc(C)o3)c2c1	10.1021/acs.jmedchem.5b00245
	CHEMBL3109560	209332	0	None	-2	2	Human	7.2	pKi	=	7.2	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 minsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells after 120 mins	ChEMBL		None	None	None		COc1ccc(/C=C/C2=[N+]3C(=Cc4c(CCNC(C)=O)c5cc(OC)ccc5n4[B-]3(F)F)C=C2)cc1	10.1021/ml4004155
	681	1432	65	None	-38	39	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	940	1432	65	None	-38	39	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	947	1432	65	None	-38	39	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	CHEMBL59	1432	65	None	-38	39	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	DB00988	1432	65	None	-38	39	Human	5.2	pKi	=	5.2	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	10.1016/S0960-894X(97)00444-7
	11624018	140344	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
	CHEMBL382050	140344	0	None	5	2	Human	6.2	pKi	=	6.2	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	326	5	1	3	3.5	COc1ccc2c(c1)c(C1(CNC(=O)C3CCC3)CCC1)cn2C	10.1021/jm0512544
	44412082	138736	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	CHEMBL379096	138736	0	None	2	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	300	5	2	3	3.2	CCCC(=O)NCC1(c2cn(C)c3ccc(O)cc23)CCC1	10.1021/jm0512544
	127025781	137286	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759859	137286	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	309	5	1	3	3.7	COc1ccc2ccc3oc(CCNC(=O)C4CC4)cc3c2c1	10.1016/j.ejmech.2015.12.047
	127039218	137357	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
	CHEMBL3763247	137357	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	234	4	1	4	1.5	COc1cc2c(CCNC(C)=O)coc2cn1	10.1016/j.ejmech.2016.01.008
	56671858	64108	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	CHEMBL1813325	64108	0	None	-20	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membraneDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in mouse NIH-3T3 cell membrane	ChEMBL	498	17	2	6	3.8	COc1cccc(N(CCCCCCN(CCNC(C)=O)c2cccc(OC)c2)CCNC(C)=O)c1	10.1016/j.bmc.2011.06.063
	49865424	15768	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	CHEMBL1223346	15768	0	None	-1	2	Human	4.1	pKi	=	4.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	209	4	1	2	2.3	CC(=O)N[C@H](C)CSc1ccccc1	10.1016/j.bmc.2010.06.100
	44349171	16461	1	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124217	16461	1	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	275	6	2	3	2.6	CCNC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	16743123	92630	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	CHEMBL244263	92630	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	270	5	1	2	3.0	CCC(=O)NCCCc1cn2c3c(cccc13)CCC2	10.1016/j.ejmech.2007.01.005
	11794657	206570	0	None	-23	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	CHEMBL9917	206570	0	None	-23	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	388	5	1	3	4.7	COc1ccc2c(c1)c(CCNC(=O)C1CCC1)c1n2CCCc2ccccc2-1	10.1021/jm980684+
	10567427	4160	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
	CHEMBL10043	4160	0	None	-3	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	316	4	1	2	3.7	O=C(NCCc1c2n(c3ccccc13)Cc1ccccc1-2)C1CC1	10.1021/jm980684+
	24749950	3841	6	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	7923	3841	6	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	CHEMBL394676	3841	6	None	-588	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	284	6	1	3	3.0	COc1ccc(cc1)N(c1ccccc1)CCNC(=O)C	10.1021/jm700957j
	9859693	73762	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	246	6	0	3	3.3	COc1cc(/C=C/C=O)ccc1OCC=C(C)C	10.1021/acs.jnatprod.7b00853
	CHEMBL2022666	73762	1	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	246	6	0	3	3.3	COc1cc(/C=C/C=O)ccc1OCC=C(C)C	10.1021/acs.jnatprod.7b00853
	10807560	206396	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	CHEMBL9815	206396	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	346	5	1	2	4.7	CCCC(=O)NCCc1c2n(c3ccccc13)CCCc1ccccc1-2	10.1021/jm980684+
	122162	2345	67	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	1363	2345	67	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	CHEMBL286615	2345	67	None	-18	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cellsDisplacement of 2[125I]iodomelatonin from recombinant human MT1 receptor expressed in NIH 3T3 cells	ChEMBL	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10.1016/j.ejmech.2007.01.005
	10044270	188943	0	None	-891	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
	CHEMBL514280	188943	0	None	-891	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	363	6	1	2	4.8	COc1ccc2c(c1)[C@@H](CCNC(=O)C1CCC1)C[C@@H](c1ccccc1)C2	10.1021/jm800974d
	45270052	193712	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	CHEMBL552002	193712	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	137650611	156958	0	None	-26	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	CHEMBL4079784	156958	0	None	-26	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK or CHO cell membranes after 120 mins	ChEMBL	244	4	1	3	1.9	CNC(=O)CCc1cccc2ccc(OC)nc12	10.1016/j.ejmech.2016.12.013
	9970584	16577	0	None	-8	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124422	16577	0	None	-8	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	274	7	1	3	3.2	CCCC(=O)NCCCc1cccc2nc(CC)oc12	10.1016/j.bmcl.2004.04.082
	44317822	104384	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	CHEMBL311106	104384	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	315	8	1	3	3.7	CCCOc1ccc2ccc(OC)cc2c1CCNC(=O)CC	10.1016/S0960-894X(97)00444-7
	45270052	193712	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	CHEMBL552002	193712	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma countingDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells by gamma counting	ChEMBL	381	8	2	4	3.5	COc1ccc(N(C)Cc2[nH]c3ccc(OC)cc3c2CCNC(C)=O)cc1	10.1016/j.bmc.2009.04.068
	10938056	106562	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL315653	106562	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	393	11	1	3	5.7	CCCCCCOc1ccc2oc(Cc3ccccc3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	11637615	76879	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
	CHEMBL207960	76879	0	None	-2	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	272	4	2	2	2.7	COc1ccc2[nH]cc(C3(CNC(C)=O)CCC3)c2c1	10.1021/jm0512544
	11681026	76772	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	CHEMBL207745	76772	0	None	-11	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	302	6	1	3	3.4	CCCC(=O)NCC(C)(C)c1cn(C)c2ccc(OC)cc12	10.1021/jm0512544
	49865270	15689	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223131	15689	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	265	6	1	3	2.7	COc1cccc(SC(C)CNC(=O)C2CC2)c1	10.1016/j.bmc.2010.06.100
	11733059	111150	0	None	-21	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
	CHEMBL328617	111150	0	None	-21	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	449	7	1	3	4.1	COc1ccc2oc(Cc3ccccc3)c(CCNC(=O)CI)c2c1	10.1021/jm0005252
	44429444	146186	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	CHEMBL392421	146186	0	None	-5	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	260	4	1	3	2.2	COc1cc(C)c2c(c1)c(CCNC(C)=O)cn2C	10.1016/j.bmc.2007.04.013
	9860588	19731	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	CHEMBL130286	19731	0	None	1	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)Binding affinity for human melatonin receptor type 1A, expressed in HEK293 cells (2-[125I]iodomelatonin is used as radioligand)	ChEMBL	283	4	1	2	3.4	COc1ccc2cccc3c2c1CCC3CCNC(C)=O	10.1021/jm000922c
	10522674	206016	0	None	-56	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	CHEMBL9590	206016	0	None	-56	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assayBinding affinity towards recombinant human melatonin receptor type 1A expressed in NIH 3T3 cells using 2-[121I]iodomelatonin radioligand binding assay	ChEMBL	362	7	1	3	4.5	CCCC(=O)NCCc1c2n(c3ccc(OCC)cc13)Cc1ccccc1-2	10.1021/jm980684+
	11784134	106453	0	None	-67	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL314947	106453	0	None	-67	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	4.7	COc1ccc2oc(Cc3cccc(C(F)(F)F)c3)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	49865320	15706	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223194	15706	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	251	7	1	3	2.4	CCCC(=O)NC[C@@H](C)Oc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	1354	3369	10	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	22133318	3369	10	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	CHEMBL490188	3369	10	None	-275	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	10.1016/j.bmc.2008.08.052
	44579115	181243	0	None	-162	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	CHEMBL477835	181243	0	None	-162	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	348	6	2	3	4.2	CNc1cccc(-c2cc(CCNC(C)=O)c3cc(OC)ccc3c2)c1	10.1016/j.bmc.2008.08.052
	54583162	60422	0	None	-7	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
	CHEMBL1760954	60422	0	None	-7	2	Human	5.1	pKi	=	5.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	276	6	2	5	0.9	CNCc1cn(CCNC(C)=O)c2nc(OC)ccc12	10.1016/j.bmcl.2011.02.097
	137653199	158065	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4092308	158065	0	None	-5	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	218	2	1	2	1.4	CC(=O)NCC1Cc2ccccc2N(C)C1	10.1021/acs.jmedchem.8b00359
	44424024	84735	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL225301	84735	0	None	-4	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	522	16	2	6	5.6	COc1ccc2[nH]c(C(=O)OCCCCCCCCCOC(=O)c3ccccc3)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	10640625	206545	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	CHEMBL99002	206545	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm001125h
	10640625	206545	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	CHEMBL99002	206545	0	None	-46	2	Human	6.1	pKi	=	6.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	336	7	1	3	3.8	CCC(=O)NCCc1cc2c(OC)cccc2n1Cc1ccccc1	10.1021/jm970721h
	44264707	96710	1	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL268165	96710	1	None	-19	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	256	4	2	3	3.4	COc1cccc(Nc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	9859913	203809	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL8094	203809	0	None	-20	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	257	4	1	3	3.4	COc1cccc(Oc2ccc(NC(C)=O)cc2)c1	10.1016/j.bmcl.2003.11.030
	9930390	206134	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	CHEMBL96562	206134	0	None	-6	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.Binding affinity on human melatonin receptor type 1A stably transfected in human embryonic kidney (HEK 293) using 2-[125I]iodomelatonin as radioligand.	ChEMBL	391	6	1	3	5.0	COc1ccc2oc(Cc3c(Cl)cccc3Cl)c(CCNC(C)=O)c2c1	10.1021/jm0005252
	25209999	174935	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL457807	174935	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	25209999	174935	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	CHEMBL457807	174935	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	441	6	2	3	4.2	COc1ccc2[nH]c(CN3CCc4cc(Br)ccc43)c(CCNC(C)=O)c2c1	10.1021/jm800974d
	10104923	101017	2	None	-12	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL297947	101017	2	None	-12	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	221	6	1	2	2.2	CCC(=O)NCCCc1cccc(OC)c1	10.1016/j.bmcl.2010.02.084
	10609620	206558	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	CHEMBL99091	206558	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm001125h
	10609620	206558	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	CHEMBL99091	206558	1	None	-5	2	Human	5.1	pKi	=	5.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	232	4	2	2	1.9	COc1ccc2cc(CCNC(C)=O)[nH]c2c1	10.1021/jm970721h
	10946222	193063	0	None	-43	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
	CHEMBL53622	193063	0	None	-43	2	Human	5.1	pKi	=	5.1	Binding	Inhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cellsInhibition of 2-[125I]iodomelatonin binding to human Melatonin receptor type 1A expressed in HEK293 cells	ChEMBL	291	5	1	5	1.8	COc1ccc2c(c(CCNC(C)=O)cn2C)c1[N+](=O)[O-]	10.1021/jm011053+
	11623375	138150	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	CHEMBL377871	138150	0	None	-2	2	Human	7.1	pKi	=	7.1	Binding	Displacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	286	5	1	3	2.7	CCC(=O)NCC1(c2cn(C)c3ccc(OC)cc23)CC1	10.1021/jm0512544
	22718548	16309	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	CHEMBL123612	16309	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	322	6	1	3	4.2	CC(C)C(=O)NCCCc1cccc2nc(-c3ccccc3)oc12	10.1016/j.bmcl.2004.04.082
	71540390	85977	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
	CHEMBL2314263	85977	0	None	-1	2	Human	7.1	pKi	=	7.1	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma countingDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in HEK293 cells after 2 hrs by gamma counting	ChEMBL	235	4	1	3	1.7	COc1ccc(OC)c([C@@H]2C[C@H]2NC(C)=O)c1	10.1016/j.bmcl.2012.11.069
	10518884	112049	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
	CHEMBL329979	112049	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligandBinding affinity towards melatonin receptor type 1A stably expressed in NIH3T3 rat fibroblast cells using 2-[125I]iodomelatonin (100 pM) as radioligand	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm001125h
	10518884	112049	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm970721h
	CHEMBL329979	112049	0	None	-11	2	Human	7.1	pKi	=	7.1	Binding	Binding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cellsBinding affinity was measured against cloned human Melatonin receptor type 1A subtype stably expressed in rat fibroblasts NIH3T3 cells	ChEMBL	308	5	1	3	3.3	COc1cccc2c1cc(CCNC(C)=O)n2-c1ccccc1	10.1021/jm970721h
	46885226	7974	0	None	-18620	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	CHEMBL1091160	7974	0	None	-18620	2	Human	6.1	pKi	=	6.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1ccc(OCc2ccccc2)c(CCCNC(C)=O)c1	10.1016/j.bmcl.2010.02.084
	76319554	85044	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	228	2	0	3	2.6	CCC#CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	CHEMBL2268532	85044	0	None	-	1	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysisDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell lysates after 1 hr by gamma counting analysis	ChEMBL	228	2	0	3	2.6	CCC#CCOc1ccc2ccc(=O)oc2c1	10.1021/acs.jnatprod.7b00853
	137656978	159204	0	None	-147	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	CHEMBL4105125	159204	0	None	-147	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]-Iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	294	4	1	2	3.1	CCC(=O)NC1Cc2ccccc2N(Cc2ccccc2)C1	10.1021/acs.jmedchem.8b00359
	162644724	178804	0	None	-57	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	CHEMBL4739898	178804	0	None	-57	2	Human	6.1	pKi	=	6.1	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cells incubated for 120 mins by radioligand binding assay	ChEMBL	321	5	1	4	3.0	COc1ccc2nc(-c3ccccc3)nc(CCNC(C)=O)c2c1	10.1016/j.ejmech.2020.112078
	46884554	8199	0	None	-128	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	CHEMBL1092647	8199	0	None	-128	2	Human	5.1	pKi	=	5.1	Binding	Displacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation countingDisplacement of [3H]melatonin from human melatonin MT1 receptor expressed in CHO cells after 60 mins by scintillation counting	ChEMBL	313	8	1	3	3.3	COc1cc(CCCNC(C)=O)ccc1OCc1ccccc1	10.1016/j.bmcl.2010.02.084
	44389864	63990	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL181192	63990	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	380	10	2	2	4.7	CCNC(=O)NCCCc1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	11165283	122603	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	CHEMBL361206	122603	0	None	4	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatoninBinding affinity against Melatonin receptor type 1A stably expressed in NIH3T3 cells using 2-[125I]iodomelatonin	ChEMBL	392	9	2	2	4.8	CCNC(=O)NC[C@@H]1C[C@H]1c1cccc2c1C[C@@H](CCCCc1ccccc1)O2	10.1016/j.bmcl.2005.01.015
	22718561	17058	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	CHEMBL125665	17058	0	None	-3	2	Human	8.1	pKi	=	8.1	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	5	1	3	2.5	CCc1nc2cccc(CCCNC(C)=O)c2o1	10.1016/j.bmcl.2004.04.082
	52918080	60425	0	None	-13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	CHEMBL1760957	60425	0	None	-13	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	287	4	1	4	2.1	COc1ccc2c3c(n(CCNC(C)=O)c2n1)CCCC3	10.1016/j.bmcl.2011.02.097
	127038130	136087	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3739824	136087	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	347	8	1	2	4.5	CC(=O)NCCc1cccc2ccc(OCCCc3ccccc3)cc12	10.1039/C5MD00190K
	127038132	136278	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3741561	136278	0	None	-1	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	145992795	166227	0	None	-29	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4284223	166227	0	None	-29	2	Human	8.1	pKi	=	8.1	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	342	5	2	2	3.9	CCCNC(=S)NCC1(C)CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	18007928	8562	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	CHEMBL1095504	8562	0	None	5	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	485	12	2	4	5.5	CC(=O)NCCc1cccc2ccc(OCCCCOc3ccc4cccc(CC(=O)O)c4c3)cc12	10.1016/j.bmc.2010.04.008
	49865322	15708	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	CHEMBL1223196	15708	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 minsDisplacement of [125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells after 90 mins	ChEMBL	267	7	1	3	3.1	CCCC(=O)NCC(C)Sc1cccc(OC)c1	10.1016/j.bmc.2010.06.100
	53238181	919	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	7780	919	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	CHEMBL1774519	919	0	None	-741	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation countingDisplacement of [125I]-2-iodomelatonin from human MT1 receptor expressed on CHO cells by microscintillation counting	ChEMBL	339	5	1	2	4.4	CC(=O)NCCC1=C(CC2CCCCC2)Cc2c1c1CCOc1cc2	10.1021/jm200221q
	59145848	185475	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	3	1	3	2.5	CC(=O)NCCC1CCc2ccn3nc(C)c(C)c3c21	10.1021/acs.jmedchem.0c01836
	CHEMBL4871181	185475	0	None	-	1	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assayDisplacement of 2-[125l]-lodomelatonin from human MT1 expressed in CHO cell membrane incubated for 150 mins by radioligand binding assay	ChEMBL	271	3	1	3	2.5	CC(=O)NCCC1CCc2ccn3nc(C)c(C)c3c21	10.1021/acs.jmedchem.0c01836
	127038132	136278	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	CHEMBL3741561	136278	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysisDisplacement of 2-[125I]-iodomelatonin from human melatonin receptor MT1 expressed in CHO cells after 1 hr by gamma counting analysis	ChEMBL	361	9	1	2	4.9	CC(=O)NCCc1cccc2ccc(OCCCCc3ccccc3)cc12	10.1039/C5MD00190K
	44424017	84885	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	CHEMBL226112	84885	0	None	1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human cloned MT1 receptor expressed in rat NIH3T3 cells	ChEMBL	592	14	4	8	3.4	COc1ccc2[nH]c(C(=O)OCCCOC(=O)c3[nH]c4ccc(OC)cc4c3CCNC(C)=O)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2007.03.080
	21581653	137502	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
	CHEMBL3765249	137502	0	None	3	2	Human	8.0	pKi	=	8.0	Binding	Displacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assayDisplacement of [125I]2-Iodomelatonin from human MT1 receptor expressed in HEK293 cells after 120 mins by radioligand competition assay	ChEMBL	233	4	2	3	1.3	COc1cc2c(CCNC(C)=O)c[nH]c2cn1	10.1016/j.ejmech.2016.01.008
	25022429	187556	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	CHEMBL498493	187556	0	None	-1	2	Human	8.0	pKi	=	8.0	Binding	Displacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human melatonin MT1 receptor expressed in CHO cells	ChEMBL	393	7	3	4	2.8	COc1ccc2[nH]c(CN3c4ccccc4C[C@H]3CO)c(CCNC(C)=O)c2c1	10.1016/j.bmc.2008.07.012
	44349108	16670	0	None	-2	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	CHEMBL124914	16670	0	None	-2	2	Human	8.0	pKi	=	8	Binding	Binding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligandBinding affinity against human Melatonin receptor type 1A by using 2-[125I]iodomelatonin as radioligand	ChEMBL	246	6	1	3	2.7	CCCC(=O)NCCCc1cccc2ncoc12	10.1016/j.bmcl.2004.04.082
	127025783	137200	0	None	-4	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	CHEMBL3759160	137200	0	None	-4	2	Human	8.0	pKi	=	8	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 minsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins	ChEMBL	287	4	1	3	3.2	COc1ccc2ccc3occ(CNC(=O)CF)c3c2c1	10.1016/j.ejmech.2015.12.047
	137633385	155860	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	CHEMBL4066660	155860	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	CHEMBL5200484	155860	0	None	-	1	Human	7.1	pKi	=	7.1	Binding	Binding affinity to human melatonin MT1 assessed as inhibition constantBinding affinity to human melatonin MT1 assessed as inhibition constant	ChEMBL	311	4	0	1	4.8	O=C(c1ccc(F)cc1)N(Cc1ccccc1)C1CCCCC1	10.1021/acs.jmedchem.1c01571
	1348	1807	1	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	44208891	1807	1	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	CHEMBL3260983	1807	1	None	-100	2	Human	7.0	pKi	=	7.0	Binding	Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cellsDisplacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells	ChEMBL	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10.1021/jm401343c
	54582195	60423	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760955	60423	0	None	-3	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	329	5	1	5	1.9	COc1ccc2c(C(=O)C(F)(F)F)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	16094583	165576	3	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
	CHEMBL426168	165576	3	None	-69	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	291	5	1	1	4.0	O=C(NCC=C(c1ccccc1)c1ccccc1)C1CCC1	10.1021/jm060850a
	11418246	62059	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
	CHEMBL1779806	62059	0	None	-4	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cells	ChEMBL	403	6	1	3	5.8	O=C(NCCc1c(Sc2ccc(F)cc2)sc2ccc(F)cc12)C1CCC1	10.1016/j.ejmech.2011.02.044
	44264909	203513	0	None	-117	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7875	203513	0	None	-117	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	293	5	1	2	4.8	CCCC(=O)Nc1ccc(Cc2cccc3occc23)cc1	10.1016/j.bmcl.2003.11.030
	44264942	203723	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL8032	203723	0	None	-19	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	313	5	1	4	4.0	CCCC(=O)Nc1ccc(Oc2cccc3c2OCCO3)cc1	10.1016/j.bmcl.2003.11.030
	10390684	11210	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL1179488	11210	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	CHEMBL78338	11210	0	None	-4	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	ChEMBL	359	9	1	3	3.0	CCC(=O)NCCc1c(OCC[N+](C)(C)C)ccc2ccc(OC)cc12	10.1016/S0960-894X(97)00444-7
	16094585	82463	0	None	-204	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	CHEMBL218065	82463	0	None	-204	2	Human	7.0	pKi	=	7.0	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cellsDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in NIH3T3 cells	ChEMBL	321	6	1	2	4.0	COc1cccc(/C(=C/CNC(=O)C2CCC2)c2ccccc2)c1	10.1021/jm060850a
	54583161	60421	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	CHEMBL1760953	60421	0	None	-1	2	Human	5.0	pKi	=	5.0	Binding	Displacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cellsDisplacement of 2-[125I]-iodomelatonin from human MT1 receptor expressed in HEK293 cells	ChEMBL	452	8	1	6	3.4	COc1ccc2c(CN3CCC(C(=O)c4ccc(F)cc4)CC3)cn(CCNC(C)=O)c2n1	10.1016/j.bmcl.2011.02.097
	44429454	148671	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	CHEMBL394408	148671	0	None	-1	2	Human	6.0	pKi	=	6.0	Binding	Displacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cellsDisplacement of 2[125I]iodomelatonin from human recombinant MT1 receptor expressed in NIH3T3 cells	ChEMBL	336	7	2	2	4.3	CCCC(=O)NCCc1c[nH]c2c(-c3ccccc3)cc(OC)cc12	10.1016/j.bmc.2007.04.013
	44264962	203132	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	CHEMBL7559	203132	0	None	-46	2	Human	7.0	pKi	=	7.0	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	4.0	C/C=C/C(=O)Nc1ccc(Oc2cccc(OC)c2)cc1	10.1016/j.bmcl.2003.11.030
	18702059	203278	3	None	-7	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	CHEMBL7673	203278	3	None	-7	2	Human	7.0	pKi	=	7	Binding	Binding affinity towards human melatonin receptor type 1ABinding affinity towards human melatonin receptor type 1A	ChEMBL	283	5	1	3	3.8	COc1cccc(Oc2ccc(NC(=O)C3CC3)cc2)c1	10.1016/j.bmcl.2003.11.030
	145979282	166111	0	None	-16	3	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	CHEMBL4281915	166111	0	None	-16	3	Human	7.0	pKi	=	7	Binding	Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding methodDisplacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in CHO cell membranes after 120 mins by filter binding method	ChEMBL	300	3	2	2	3.0	CNC(=S)NCC1CCc2ccc3ccc(OC)cc3c21	10.1016/j.ejmech.2017.10.025
	1357	2440	133	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	1672	2440	133	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	224	2440	133	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	896	2440	133	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	CHEMBL45	2440	133	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	DB01065	2440	133	None	-1	9	Human	9.7	pKd	=	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	10696085
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	11.0	pKi	=	11	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	10.7	pKi	=	10.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	310	120	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	125I-Iodomelatonin	-1	6	Human	10.4	pKi	=	10.4	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	10.2	pKi	=	10.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Mel	-1	9	Human	10.1	pKi	=	10.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1349	1811	0	125I-Iodomelatonin	-1	2	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	5311134	1811	0	125I-Iodomelatonin	-1	2	Human	9.9	pKi	=	9.9	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.8	pKi	=	9.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Mel	-1	9	Human	9.7	pKi	=	9.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	4004	214319	0	35S-GTPGammaS	-	1	Human	9.5	pKi	=	9.5	Binding	NoneNone	PDSP KiDatabase	330	9	0	8	2.1	CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.3	pKi	=	9.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.2	pKi	=	9.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	310	120	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	125I-Mel	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	198	310	120	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	125I-Iodomelatonin	-1	6	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	9.1	pKi	=	9.1	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	8.9	pKi	=	8.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Mel	-1	9	Human	8.8	pKi	=	8.8	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	8.7	pKi	=	8.7	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	198	310	120	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	82148	310	120	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	99	310	120	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	CHEMBL10878	310	120	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	DB06594	310	120	None	-1	6	Human	8.0	pKi	=	8.0	Binding	Binding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligandBinding affinity for human Melatonin receptor type 1A stably transfected in human embryonic kidney cells (HEK 293) using 2-[125I]iodomelatonin as radioligand	Drug Central	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	None
	1356	3224	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	208902	3224	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	2355	3224	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	CHEMBL1218	3224	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	DB00980	3224	98	None	3	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	None
	5	139	66	125I-Mel	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	5202	139	66	125I-Mel	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	CHEMBL39	139	66	125I-Mel	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	DB08839	139	66	125I-Mel	-23442	55	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	176	2	3	2	1.4	NCCc1c[nH]c2c1cc(O)cc2	None
	107	141	116	125I-Iodomelatonin	-14791	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	1833	141	116	125I-Iodomelatonin	-14791	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	CHEMBL8165	141	116	125I-Iodomelatonin	-14791	31	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	190	3	2	2	1.7	NCCc1c[nH]c2c1cc(OC)cc2	None
	4209	3102	71	125I-Mel	-63095	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	4893	3102	71	125I-Mel	-63095	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	503	3102	71	125I-Mel	-63095	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	5385	3102	71	125I-Mel	-63095	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	CHEMBL2	3102	71	125I-Mel	-63095	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	DB00457	3102	71	125I-Mel	-63095	34	Human	5.0	pKi	=	5	Binding	NoneNone	PDSP KiDatabase	383	4	1	8	1.8	COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)c1ccco1	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	7.9	pKi	=	7.9	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	122162	2345	67	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	2345	67	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	2345	67	125I-Iodomelatonin	-18	2	Human	6.8	pKi	=	6.8	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	70547	112831	72	125I-Iodomelatonin	-10	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	CHEMBL33171	112831	72	125I-Iodomelatonin	-10	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	1349	1811	0	125I-Iodomelatonin	-1	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	5311134	1811	0	125I-Iodomelatonin	-1	2	Human	8.6	pKi	=	8.6	Binding	NoneNone	PDSP KiDatabase	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	None
	164157684	214322	0	125I-Iodomelatonin	-60	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	1094	24	4	18	8.7	CC(C)(C)OC(=O)N(C)CC(CN(C)C(=O)OC(C)(C)C)CSP(=O)(O)O.CNCC(CNC)CSP(=O)(OCOC(=O)C1=CC=CC=C1)OCOC(=O)C2=CC=CC=C2.C1=CC=C(C=C1)C(=O)OCCl	None
	903	112389	83	125I-Iodomelatonin	1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	CHEMBL33103	112389	83	125I-Iodomelatonin	1	2	Human	6.7	pKi	=	6.7	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	122162	2345	67	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	2345	67	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	2345	67	125I-Iodomelatonin	-18	2	Human	6.6	pKi	=	6.6	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	8.3	pKi	=	8.3	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1357	2440	133	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Iodomelatonin	-1	9	Human	7.4	pKi	=	7.4	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1358	124	35	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	3976006	124	35	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	CHEMBL285718	124	35	125I-Iodomelatonin	-870	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	None
	None	214318	0	125I-Iodomelatonin	-1	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	None	214318	0	35S-GTPGammaS	-1	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	681	1432	65	None	-38	39	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	940	1432	65	None	-38	39	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	947	1432	65	None	-38	39	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	CHEMBL59	1432	65	None	-38	39	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	DB00988	1432	65	None	-38	39	Human	8.3	pKi	=	8.3	Binding	Displacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cellsDisplacement of 2-[125I]iodomelatonin from human Melatonin receptor type 1A expressed in CHO cells	Drug Central	153	2	3	3	0.6	NCCc1ccc(c(c1)O)O	None
	12835	214323	0	125I-Iodomelatonin	-6	2	Human	5.3	pKi	=	5.3	Binding	NoneNone	PDSP KiDatabase	191	3	2	2	1.7	COC1=CC2=C(C=C1)NC=C2CCO	None
	122162	2345	67	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1363	2345	67	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	CHEMBL286615	2345	67	125I-Iodomelatonin	-18	2	Human	6.3	pKi	=	6.3	Binding	NoneNone	PDSP KiDatabase	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	None
	1357	2440	133	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	1672	2440	133	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	224	2440	133	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	896	2440	133	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	CHEMBL45	2440	133	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	DB01065	2440	133	125I-Mel	-1	9	Human	8.2	pKi	=	8.2	Binding	NoneNone	PDSP KiDatabase	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	None
	903	112389	83	125I-Iodomelatonin	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	CHEMBL33103	112389	83	125I-Iodomelatonin	1	2	Human	7.1	pKi	=	7.1	Binding	NoneNone	PDSP KiDatabase	218	3	3	2	1.6	CC(=O)NCCc1c[nH]c2ccc(O)cc12	None
	70547	112831	72	125I-Iodomelatonin	-10	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	CHEMBL33171	112831	72	125I-Iodomelatonin	-10	2	Human	6.1	pKi	=	6.1	Binding	NoneNone	PDSP KiDatabase	202	3	2	1	1.8	CC(=O)NCCc1c[nH]c2ccccc12	None
	10220503	3687	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	4820	3687	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	7393	3687	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	CHEMBL2103822	3687	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	DB09071	3687	0	None	-2	2	Human	8.0	pKi	=	8.0	Binding	NoneNone	Drug Central	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	None
	None	214318	0	125I-Mel	-1	2	Human	6.0	pKi	=	6.0	Binding	NoneNone	PDSP KiDatabase	218	2	2	4	1.5	CC(=O)N1C=C(C2=C1C=CC(=C2)O)CCN	None
	198	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	198	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	82148	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	82148	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	99	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	99	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	CHEMBL10878	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	CHEMBL10878	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	DB06594	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	12764576
	DB06594	310	120	None	-1	6	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	243	4	1	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)ccc2	9618428
	24954989	1497	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	7774	1497	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	CHEMBL1802025	1497	1	None	6	2	Human	10.2	pKi	=	10.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	273	4	1	4	1.5	CCc1nn2c(c1CCNC(=O)C)c1CCOc1cc2	21568291
	71533431	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	7775	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	CHEMBL2314259	78	0	None	2	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	271	4	1	3	3.0	COc1ccc2c(c1/C=C/NC(=O)C)cc(cc2)OC	23265885
	57381112	1383	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	7776	1383	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	CHEMBL1946221	1383	0	None	20	2	Human	10.5	pKi	=	10.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	5	1	2	2.8	COc1ccc2c(c1)c(CCNC(=O)C(F)F)ccc2	22301214
	115348	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	115348	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	1343	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	1343	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	CHEMBL289233	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	CHEMBL289233	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	DB08190	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	12764576
	DB08190	70	42	None	4	2	Human	10.6	pKi	=	10.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	358	4	2	2	2.5	COc1ccc2c(c1)c(CCNC(=O)C)c([nH]2)I	2991499
	1356	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	208902	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	2355	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	CHEMBL1218	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	DB00980	3224	98	None	3	2	Human	10.9	pKi	=	10.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	259	4	1	2	2.6	CCC(=O)NCC[C@@H]1CCc2c1c1CCOc1cc2	15695169
	11196	1947	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
	154699456	1947	0	None	-3	2	Human	5.0	pKi	=	5.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	888	18	3	11	5.9	COc1ccc2c(n1)c(CCNC(=O)C)cn2CCNC(=O)CCCCCN1c2ccc(cc2C(/C/1=C\C=C\C1=[N+](CC)c2c(C1(C)C)cc(cc2)S(=O)(=O)O)(C)C)S(=O)(=O)[O-]	28493341
	122162	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	122162	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	122162	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	122162	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	1363	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	1363	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	1363	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	1363	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	CHEMBL286615	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	10696085
	CHEMBL286615	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	12764576
	CHEMBL286615	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	2843633
	CHEMBL286615	2345	67	None	-18	2	Human	6.5	pKi	=	6.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	292	5	2	1	3.4	CC(=O)NCCc1c(Cc2ccccc2)[nH]c2c1cccc2	9089668
	7773	3840	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	17907131
	86277838	3840	0	None	-12	2	Human	6.9	pKi	=	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	296	3	2	2	2.6	COc1ccc2c(c1)C(CNC(=O)N)Cc1c(C2)cccc1	17907131
	11185529	3839	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	11185529	3839	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	7772	3839	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	7772	3839	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	CHEMBL189449	3839	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	15293992
	CHEMBL189449	3839	3	None	-14	2	Human	7.9	pKi	=	7.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	295	3	1	2	3.1	COc1ccc2c(c1)C(CNC(=O)C)Cc1c(C2)cccc1	17907131
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	1346	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	1858	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	12764576
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	2991499
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9089668
	CHEMBL34730	160	42	None	-25	2	Human	8.6	pKi	=	8.6	Binding	UnclassifiedUnclassified	Guide to Pharmacology	266	4	2	2	2.5	COc1cc2c(CCNC(=O)C)c[nH]c2cc1Cl	9618428
	24763223	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	8289	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	CHEMBL3260987	214	0	None	74	2	Human	8.9	pKi	=	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	340	10	1	3	3.7	CC(=O)NCCN(c1cccc(c1)OCCCCc1ccccc1)C	22927210
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	1347	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	1864	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	10696085
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	2991499
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9089668
	CHEMBL127421	162	51	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	248	4	3	3	1.6	COc1cc2c(CCNC(=O)C)c[nH]c2cc1O	9618428
	24750192	3842	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	7777	3842	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	CHEMBL237236	3842	10	None	-1	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	222	5	1	3	1.3	COc1cccc(c1)N(CCNC(=O)C)C	18052314
	12324	3836	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	145966622	3836	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	CHEMBL4210086	3836	0	None	2	2	Human	9.1	pKi	=	9.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	591	13	3	4	7.0	O=C(C)NCCc1c(Br)[nH]c2c1cc(cc2)OCCCCCCNC(=O)Oc1cc(ccc1)c1ccccc1	30126274
	7778	799	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	9957516	799	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	CHEMBL1094546	799	0	None	97	2	Human	9.3	pKi	=	9.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	497	12	2	4	6.1	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc(cc1)c1ccc(cc1)C(=O)O)cc2	20444610
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	1357	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	1672	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	224	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	896	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	CHEMBL45	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	12764576
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	2991499
	DB01065	2440	133	None	-1	9	Human	9.4	pKi	=	9.4	Binding	UnclassifiedUnclassified	Guide to Pharmacology	232	4	2	2	1.9	COc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	9089668
	10220503	3687	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	4820	3687	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	7393	3687	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	CHEMBL2103822	3687	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	DB09071	3687	0	None	-2	2	Human	9.5	pKi	=	9.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	245	4	1	2	2.3	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2c1CCO2	19054552
	4004	214319	0	None	-	1	Human	8.0	pKi	None	8.0	Binding	NoneNone	Drug Central	330	9	0	8	2.1	CCOC(=O)CC(C(=O)OCC)SP(=S)(OC)OC	None
	1351	2353	15	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	219018	2353	15	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	CHEMBL4079759	2353	15	None	-1	2	Human	10.1	pKi	None	10.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	280	4	2	2	3.1	COc1cc2c(cc1Cl)[nH]cc2[C@H](CNC(=O)C)C	15302228
	127856	3366	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	1360	3366	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	CHEMBL12296	3366	0	None	-3	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	253	4	1	1	3.3	O=C(C1CCC1)NCCc1cccc2c1cccc2	12764576
	1358	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	1358	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	1358	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	3976006	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	3976006	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	3976006	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	CHEMBL285718	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	12764576
	CHEMBL285718	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9089668
	CHEMBL285718	124	35	None	-870	2	Human	6.7	pKi	None	6.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	279	3	1	1	3.7	CCC(=O)NC1Cc2ccccc2C(C1)c1ccccc1	9737724
	1348	1807	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	1348	1807	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	44208891	1807	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	44208891	1807	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	CHEMBL3260983	1807	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	10205014
	CHEMBL3260983	1807	1	None	-100	2	Human	6.9	pKi	None	6.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	272	2	1	2	2.9	COc1ccc2c(c1)c(c[nH]2)C1CCCN(C1)C(=O)C	9089668
	1354	3369	10	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	22133318	3369	10	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	CHEMBL490188	3369	10	None	-275	2	Human	7.1	pKi	None	7.1	Binding	UnclassifiedUnclassified	Guide to Pharmacology	334	5	2	3	3.8	COc1ccc2c(c1)c(CCNC(=O)C)cc(c2)c1cccc(c1)N	12764576
	1359	2130	20	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	5311198	2130	20	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	CHEMBL274438	2130	20	None	-125	2	Human	7.2	pKi	None	7.2	Binding	UnclassifiedUnclassified	Guide to Pharmacology	376	6	1	3	4.7	CCCC(=O)NCCc1c2c3ccccc3CCCn2c2c1cc(OC)cc2	10737738
	1353	3368	3	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	9998187	3368	3	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	CHEMBL33549	3368	3	None	-112	2	Human	7.5	pKi	None	7.5	Binding	UnclassifiedUnclassified	Guide to Pharmacology	353	7	1	4	3.7	COc1cccc(c1)Cc1oc2c(c1CCNC(=O)C)cc(cc2)OC	12764576
	10849065	137	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	1345	137	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	CHEMBL126809	137	8	None	4	2	Human	7.8	pKi	None	7.8	Binding	UnclassifiedUnclassified	Guide to Pharmacology	262	6	3	3	1.2	OCCOc1ccc2c(c1)c(CCNC(=O)C)c[nH]2	11068946
	1361	3367	0	None	-1	2	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
	9816339	3367	0	None	-1	2	Human	8.0	pKi	None	8.0	Binding	UnclassifiedUnclassified	Guide to Pharmacology	247	4	1	2	3.1	CCc1ccc2c(c1)c(CCNC(=O)C)cs2	12764576
	1350	1951	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	4172142	1951	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	CHEMBL10009	1951	0	None	-95	3	Human	8.3	pKi	None	8.3	Binding	UnclassifiedUnclassified	Guide to Pharmacology	348	6	1	3	4.1	CCCC(=O)NCCc1c2c3ccccc3Cn2c2c1cc(OC)cc2	10737738
	1362	3370	18	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	9870523	3370	18	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	CHEMBL429392	3370	18	None	39	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	498	12	2	4	5.2	CC(=O)NCCc1cccc2c1cc(OCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	1355	3371	3	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	9806449	3371	3	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	CHEMBL14453	3371	3	None	70	2	Human	8.9	pKi	None	8.9	Binding	UnclassifiedUnclassified	Guide to Pharmacology	512	13	2	4	5.6	CC(=O)NCCc1cccc2c1cc(OCCCCOc1ccc3c(c1)c(CCNC(=O)C)ccc3)cc2	12764576
	1349	1811	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
	1349	1811	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428
	5311134	1811	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	10696085
	5311134	1811	0	None	-1	2	Human	9.7	pKi	None	9.7	Binding	UnclassifiedUnclassified	Guide to Pharmacology	246	3	1	3	1.1	CC(=O)NCCN1CCc2c1c1CCOc1cc2	9618428

Join us

Cite us

Main reference

Ligand source activities (1 row/activity)