Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
casr_human 2.55x55 667 TM2 F => A Unchanged Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 2.56x56 668 TM2 F => A Abolished effect Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 2.56x56 668 TM2 F => L Decreased effect Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 3.32x32 680 TM3 R => A Unchanged Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 3.36x36 684 TM3 F => A Decreased effect Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 3.36x36 684 TM3 F => L Unchanged Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 7.32x33 837 TM7 E => I Inversion of ligand function (e.g. NAM to PAM) Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 7.32x33 837 TM7 E => Q Inversion of ligand function (e.g. NAM to PAM) Single-point (Functional - Ca2+ accumulation) tecalcet Miedlich SU et al (2004)
casr_human 2.56x56 668 TM2 F => A Decreased effect Single-point (Functional - Ca2+ accumulation) NPS 2143 Miedlich SU et al (2004)
casr_human 3.32x32 680 TM3 R => A Abolished effect Single-point (Functional - Ca2+ accumulation) NPS 2143 Miedlich SU et al (2004)
casr_human 3.36x36 684 TM3 F => A Abolished effect Single-point (Functional - Ca2+ accumulation) NPS 2143 Miedlich SU et al (2004)
casr_human 7.32x33 837 TM7 E => I Abolished effect Single-point (Functional - Ca2+ accumulation) NPS 2143 Miedlich SU et al (2004)
casr_human 3.36x36 684 TM3 F => A >250.0↓ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 3.40x40 688 TM3 F => A 8.197↓ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 764 ECL2 T => A 1.393↑ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 45.51x51 766 ECL2 H => A 1.642↓ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 5.43x43 776 TM5 L => A 5.571↑ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 6.50x50 818 TM6 W => A 8.475↓ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 6.53x53 821 TM6 F => A 6.5↑ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 7.32x33 837 TM7 E => A >250.0↓ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 7.36x37 841 TM7 I => A 6.944↓ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2003)
casr_human 3.32x32 680 TM3 R => A 3.25↑ IC50 (Functional - IP accumulation) calhex 231 Petrel C et al (2004)
casr_human 3.36x36 684 TM3 F => A Unchanged Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 3.40x40 688 TM3 F => A Unchanged Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 5.43x43 776 TM5 L => A Unchanged Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 6.50x50 818 TM6 W => A Abolished effect Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 6.53x53 821 TM6 F => A Unchanged Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 7.32x33 837 TM7 E => A Abolished effect Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 7.36x37 841 TM7 I => A Abolished effect Single-point (Functional - IP accumulation) calindol Petrel C et al (2004)
casr_human 3.36x36 684 TM3 F => A Unchanged Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 3.40x40 688 TM3 F => A Unchanged Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 5.43x43 776 TM5 L => A Unchanged Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 6.50x50 818 TM6 W => A Unchanged Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 6.53x53 821 TM6 F => A Abolished effect Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 7.32x33 837 TM7 E => A Decreased effect Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 7.36x37 841 TM7 I => A Abolished effect Single-point (Functional - IP accumulation) tecalcet Petrel C et al (2004)
casr_human 3.32x32 680 TM3 R => A 11.765↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 3.36x36 684 TM3 F => A >333.333↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 3.40x40 688 TM3 F => A >333.333↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 764 ECL2 T => A 1.258↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 45.51x51 766 ECL2 H => A 1.543↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 5.43x43 776 TM5 L => A 1.057↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 6.50x50 818 TM6 W => A 1.859↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 6.53x53 821 TM6 F => A 1.629↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 7.32x33 837 TM7 E => A >333.333↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 7.36x37 841 TM7 I => A 11.905↓ IC50 (Functional - IP accumulation) NPS 2143 Petrel C et al (2004)
casr_human 185 N-term R => Q 2.188↑ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 2.45x45 657 TM2 S => Y 4.464↓ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 670 ECL1 G => E 1.175↑ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 670 ECL1 G => R 6.173↓ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 3.32x32 680 TM3 R => C 1.862↓ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 3.32x32 680 TM3 R => H 1.779↓ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 4.42x42 734 TM4 M => R N/A (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 748 ECL2 P => C 5.012↑ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 5.45x45 778 TM5 G => D N/A (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 6.36x36 804 TM6 A => D 3.02↑ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 6.49x49 817 TM6 V => I 1.38↑ pK(b) (Functional - Other) cinacalcet Leach K et al (2013)
casr_human 1.39x39 612 TM1 F => S 1.66↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 3.33x33 681 TM3 Q => H 1.549↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 4.35x35 727 TM4 L => Q 1.778↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 45.52x52 767 ECL2 E => K 1.23↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 5.40x40 773 TM5 L => R 5.128↓ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 6.52x52 820 TM6 S => F 2.57↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 6.53x53 821 TM6 F => L 1.585↓ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 7.27x28 832 TM7 F => S 2.754↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 7.31x32 836 TM7 V => L 2.089↑ pK(b) (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 7.38x39 843 TM7 A => E N/A (Functional - Other) NPS 2143 Leach K et al (2013)
casr_human 1.39x39 612 TM1 F => A 2.239↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 1.42x42 615 TM1 A => V 1.949↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 1.43x43 616 TM1 L => A 1.35↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 2.56x56 668 TM2 F => A 13.514↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 2.57x57 669 TM2 I => A 1.949↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 670 ECL1 G => A 1.349↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 672 ECL1 P => A 1.289↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 3.31x31 679 TM3 L => A 1.779↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 3.32x32 680 TM3 R => A 1.698↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 3.34x34 682 TM3 P => A 1.175↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 3.36x36 684 TM3 F => A 8.696↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 3.40x40 688 TM3 F => A 4.902↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 3.41x41 689 TM3 V => A No response pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 4.52x52 744 TM4 Y => A 1.38↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 748 ECL2 P => A 1.318↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 45.52x52 767 ECL2 E => A 3.311↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 5.39x39 772 TM5 A => V 2.818↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 5.40x40 773 TM5 L => A 1.318↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 5.42x42 775 TM5 F => A 1.318↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 5.43x43 776 TM5 L => A 1.148↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 5.47x47 780 TM5 T => A 2.041↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 6.49x49 817 TM6 V => A 1.175↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 6.50x50 818 TM6 W => A 3.39↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 6.53x53 821 TM6 F => A 2.884↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 6.57x57 825 TM6 Y => A 5.012↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.26x27 831 TM7 K => A 1.778↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.27x28 832 TM7 F => A 1.047↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.28x29 833 TM7 V => A 3.981↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.29x30 834 TM7 S => A 2.137↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => A Abolished effect pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => D 5.888↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => I Abolished effect pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.33x34 838 TM7 V => A 1.739↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.35x36 840 TM7 A => V 2.882↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.36x37 841 TM7 I => A Abolished effect pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.39x40 844 TM7 A => V 2.042↑ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 7.43x44 848 TM7 L => A 1.318↓ pK(b) (Functional - Ca2+ accumulation) cinacalcet Leach K et al (2016)
casr_human 1.39x39 612 TM1 F => A 4.571↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 1.42x42 615 TM1 A => V 1.202↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 1.43x43 616 TM1 L => A 1.072↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 2.56x56 668 TM2 F => A 7.752↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 2.57x57 669 TM2 I => A 1.122↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 670 ECL1 G => A 5.248↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 672 ECL1 P => A 2.818↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 3.31x31 679 TM3 L => A 1.622↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 3.32x32 680 TM3 R => A 5.376↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 3.34x34 682 TM3 P => A 3.631↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 3.36x36 684 TM3 F => A Abolished effect pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 3.40x40 688 TM3 F => A Abolished effect pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 3.41x41 689 TM3 V => A No response pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 4.52x52 744 TM4 Y => A 1.23↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 748 ECL2 P => A 1.585↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 45.52x52 767 ECL2 E => A 1.096↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 5.39x39 772 TM5 A => V 1.82↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 5.40x40 773 TM5 L => A 1.259↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 5.42x42 775 TM5 F => A 1.349↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 5.43x43 776 TM5 L => A 2.817↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 5.47x47 780 TM5 T => A 2.237↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 6.49x49 817 TM6 V => A 1.95↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 6.50x50 818 TM6 W => A 1.548↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 6.53x53 821 TM6 F => A 4.274↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 6.57x57 825 TM6 Y => A 1.479↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.26x27 831 TM7 K => A 2.399↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.27x28 832 TM7 F => A 2.455↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.28x29 833 TM7 V => A 3.548↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.29x30 834 TM7 S => A 3.02↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => A Abolished effect pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => D Abolished effect pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => I Abolished effect pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.33x34 838 TM7 V => A 3.086↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.35x36 840 TM7 A => V 1.513↓ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.36x37 841 TM7 I => A Abolished effect pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.39x40 844 TM7 A => V 4.898↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 7.43x44 848 TM7 L => A 2.512↑ pK(b) (Functional - Ca2+ accumulation) NPS 2143 Leach K et al (2016)
casr_human 1.39x39 612 TM1 F => A 2.692↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 1.42x42 615 TM1 A => V 7.079↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 1.43x43 616 TM1 L => A 1.513↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 2.56x56 668 TM2 F => A 1.548↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 2.57x57 669 TM2 I => A 1.23↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 670 ECL1 G => A 1.289↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 3.32x32 680 TM3 R => A 1.289↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 3.34x34 682 TM3 P => A 1.259↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 3.36x36 684 TM3 F => A 12.048↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 3.40x40 688 TM3 F => A 4.566↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 3.41x41 689 TM3 V => A No response pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 4.52x52 744 TM4 Y => A 1.381↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 45.52x52 767 ECL2 E => A 8.71↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 5.39x39 772 TM5 A => V 1.66↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 5.40x40 773 TM5 L => A 1.023↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 5.42x42 775 TM5 F => A 2.291↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 5.43x43 776 TM5 L => A 2.455↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 5.47x47 780 TM5 T => A 1.096↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 6.49x49 817 TM6 V => A 1.23↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 6.50x50 818 TM6 W => A 11.494↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 6.53x53 821 TM6 F => A 3.311↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 6.57x57 825 TM6 Y => A 1.35↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.26x27 831 TM7 K => A 2.884↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.27x28 832 TM7 F => A 1.479↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.28x29 833 TM7 V => A 1.072↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.29x30 834 TM7 S => A 1.072↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => A Abolished effect pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => D 2.951↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.32x33 837 TM7 E => I Abolished effect pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.33x34 838 TM7 V => A 2.632↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.35x36 840 TM7 A => V 2.951↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.36x37 841 TM7 I => A 1.698↓ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.39x40 844 TM7 A => V 10.0↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 7.43x44 848 TM7 L => A 2.239↑ pK(b) (Functional - Ca2+ accumulation) AC265347 Leach K et al (2016)
casr_human 1.42x42 615 TM1 A => V 1.0 pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 2.56x56 668 TM2 F => A 16.667↓ pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 3.40x40 688 TM3 F => A 3.162↑ pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 5.43x43 776 TM5 L => A 2.692↑ pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 6.50x50 818 TM6 W => A 3.984↓ pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 7.39x40 844 TM7 A => V 4.467↑ pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 7.43x44 848 TM7 L => A 1.38↑ pK(b) (Functional - ERK activation) cinacalcet Leach K et al (2016)
casr_human 1.42x42 615 TM1 A => V 3.162↑ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 2.56x56 668 TM2 F => A 16.129↓ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 3.40x40 688 TM3 F => A 1.202↓ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 5.43x43 776 TM5 L => A 1.381↓ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 6.50x50 818 TM6 W => A 1.513↓ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 7.39x40 844 TM7 A => V 1.622↑ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 7.43x44 848 TM7 L => A 1.047↑ pK(b) (Functional - ERK activation) NPS 2143 Leach K et al (2016)
casr_human 1.42x42 615 TM1 A => V 7.244↑ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 2.56x56 668 TM2 F => A 1.289↓ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 3.40x40 688 TM3 F => A 1.148↑ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 5.43x43 776 TM5 L => A 7.079↑ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 6.50x50 818 TM6 W => A 2.088↓ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 7.39x40 844 TM7 A => V 8.128↑ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 7.43x44 848 TM7 L => A 6.761↑ pK(b) (Functional - ERK activation) AC265347 Leach K et al (2016)
casr_human 1.39x39 612 TM1 F => S N/A N/A De Luca F et al (1997)
casr_human 5.40x40 773 TM5 L => R N/A N/A De Luca F et al (1997)
casr_human 118 N-term N => K N/A N/A De Luca F et al (1997)
casr_human 6.38x38 806 TM6 F => S N/A N/A De Luca F et al (1997)
casr_human 185 N-term R => Q N/A N/A Bai M et al (1997)
casr_human 55 N-term P => L N/A N/A Pearce SH et al (1996)
casr_human 178 N-term N => D N/A N/A Pearce SH et al (1996)
casr_human 221 N-term P => S N/A N/A Pearce SH et al (1996)
casr_human 227 N-term R => V N/A N/A Pearce SH et al (1996)
casr_human 6.49x49 817 TM6 V => I N/A N/A Pearce SH et al (1996)
casr_human 3.32x32 680 TM3 R => C N/A N/A Pearce SH et al (1996)
casr_human 218 N-term Y => S N/A N/A Pearce SH et al (1996)
casr_human 128 N-term F => L N/A N/A Pearce SH et al (1996)
casr_human 151 N-term T => M N/A N/A Pearce SH et al (1996)
casr_human 191 N-term E => K N/A N/A Pearce SH et al (1996)
casr_human 90 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 130 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 261 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 287 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 446 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 468 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 488 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 541 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 594 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 386 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 400 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 876 C-term T => D N/A N/A Gama L et al (1998)
casr_human 12.53x53 646 ICL1 T => V N/A N/A Bai M et al (1998)
casr_human 5.61x61 794 TM5 S => A N/A N/A Bai M et al (1998)
casr_human 888 C-term T => V N/A N/A Bai M et al (1998)
casr_human 895 C-term S => A N/A N/A Bai M et al (1998)
casr_human 915 C-term S => A N/A N/A Bai M et al (1998)
casr_human 39 N-term P => A N/A N/A Brown EM et al (1999)
casr_human 128 N-term F => L N/A N/A Brown EM et al (1999)
casr_human 151 N-term T => M N/A N/A Brown EM et al (1999)
casr_human 191 N-term E => K N/A N/A Brown EM et al (1999)
casr_human 245 N-term Q => R N/A N/A Brown EM et al (1999)
casr_human 1.39x39 612 TM1 F => S N/A N/A Brown EM et al (1999)
casr_human 3.33x33 681 TM3 Q => H N/A N/A Brown EM et al (1999)
casr_human 6.38x38 806 TM6 F => S N/A N/A Brown EM et al (1999)
casr_human 53 N-term S => P N/A N/A Brown EM et al (1999)
casr_human 55 N-term P => L N/A N/A Brown EM et al (1999)
casr_human 62 N-term R => M N/A N/A Brown EM et al (1999)
casr_human 66 N-term R => C N/A N/A Brown EM et al (1999)
casr_human 138 N-term T => M N/A N/A Brown EM et al (1999)
casr_human 143 N-term G => E N/A N/A Brown EM et al (1999)
casr_human 178 N-term N => D N/A N/A Brown EM et al (1999)
casr_human 185 N-term R => Q N/A N/A Brown EM et al (1999)
casr_human 215 N-term D => G N/A N/A Brown EM et al (1999)
casr_human 218 N-term Y => S N/A N/A Brown EM et al (1999)
casr_human 221 N-term P => S N/A N/A Brown EM et al (1999)
casr_human 227 N-term R => L N/A N/A Brown EM et al (1999)
casr_human 227 N-term R => Q N/A N/A Brown EM et al (1999)
casr_human 297 N-term E => K N/A N/A Brown EM et al (1999)
casr_human 582 N-term C => Y N/A N/A Brown EM et al (1999)
casr_human 2.45x45 657 TM2 S => Y N/A N/A Brown EM et al (1999)
casr_human 670 ECL1 G => R N/A N/A Brown EM et al (1999)
casr_human 3.32x32 680 TM3 R => C N/A N/A Brown EM et al (1999)
casr_human 748 ECL2 P => R N/A N/A Brown EM et al (1999)
casr_human 5.62x62 795 TM5 R => W N/A N/A Brown EM et al (1999)
casr_human 6.49x49 817 TM6 V => I N/A N/A Brown EM et al (1999)
casr_human 116 N-term A => T N/A N/A Brown EM et al (1999)
casr_human 118 N-term N => K N/A N/A Brown EM et al (1999)
casr_human 127 N-term E => A N/A N/A Brown EM et al (1999)
casr_human 60 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 131 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 101 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 236 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 7.38x39 843 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 116 N-term A => T N/A N/A Zhao XM et al (1999)
casr_human 7.35x36 840 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => K N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => V N/A N/A Zhao XM et al (1999)
casr_human 143 N-term G => E N/A N/A Bai M et al (1999)
casr_human 297 N-term E => K N/A N/A Bai M et al (1999)
casr_human 143 N-term G => E N/A N/A Bai M et al (1999)
casr_human 297 N-term E => K N/A N/A Bai M et al (1999)
casr_human 5.62x62 795 TM5 R => W N/A N/A Bai M et al (1999)
casr_human 5.62x62 795 TM5 R => W N/A N/A Bai M et al (1999)
casr_human 185 N-term R => Q N/A N/A Bai M et al (1999)
casr_human 185 N-term R => Q N/A N/A Bai M et al (1999)
casr_human 90 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 130 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 261 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 287 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 446 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 488 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 541 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 594 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 386 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 400 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 468 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 7.38x39 843 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 116 N-term A => T N/A N/A Zhao XM et al (1999)
casr_human 7.35x36 840 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => K N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => V N/A N/A Zhao XM et al (1999)
casr_human 11 N-term L => S N/A N/A Pidasheva S et al (2005)
casr_human 13 N-term L => P N/A N/A Pidasheva S et al (2005)
casr_human 27 N-term Q => R N/A N/A Chikatsu N et al (1999)
casr_human 27 N-term Q => R N/A N/A Fukumoto S et al (2001)
casr_human 39 N-term P => A N/A N/A Chikatsu N et al (1999)
casr_human 39 N-term P => A N/A N/A Reyes-Cruz G et al (2001)
casr_human 39 N-term P => A N/A N/A Okazaki R et al (1999)
casr_human 40 N-term I => F N/A N/A Vargas-Poussou R et al (2002)
casr_human 47 N-term K => N N/A N/A Conley YP et al (2000)
casr_human 47 N-term K => N N/A N/A Watanabe S et al (2002)
casr_human 47 N-term K => N N/A N/A Okazaki R et al (1999)
casr_human 48 N-term D => A N/A N/A Reyes-Cruz G et al (2001)
casr_human 50 N-term D => A N/A N/A Reyes-Cruz G et al (2001)
casr_human 53 N-term S => P N/A N/A Reyes-Cruz G et al (2001)
casr_human 53 N-term S => P N/A N/A Okazaki R et al (1999)
casr_human 55 N-term P => L N/A N/A Reyes-Cruz G et al (2001)
casr_human 55 N-term P => L N/A N/A Fukumoto S et al (2001)
casr_human 55 N-term P => L N/A N/A Cetani F et al (2003)
casr_human 55 N-term P => L N/A N/A Okazaki R et al (1999)
casr_human 59 N-term E => A N/A N/A Reyes-Cruz G et al (2001)
casr_human 60 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 60 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 60 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 62 N-term R => M N/A N/A Bai M et al (1996)
casr_human 62 N-term R => M N/A N/A Okazaki R et al (1999)
casr_human 66 N-term R => C N/A N/A Zhang Z et al (2001)
casr_human 66 N-term R => C N/A N/A Bai M et al (1996)
casr_human 66 N-term R => C N/A N/A Bai M et al (1997)
casr_human 66 N-term R => C N/A N/A Okazaki R et al (1999)
casr_human 90 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 100 N-term T => I N/A N/A Warner J et al (2004)
casr_human 101 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 101 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 101 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 112 N-term L => S N/A N/A Jiang Y et al (2004)
casr_human 116 N-term A => T N/A N/A Conley YP et al (2000)
casr_human 116 N-term A => T N/A N/A Vargas-Poussou R et al (2002)
casr_human 116 N-term A => T N/A N/A Watanabe T et al (1998)
casr_human 116 N-term A => T N/A N/A Okazaki R et al (1999)
casr_human 117 N-term Q => N N/A N/A Reyes-Cruz G et al (2001)
casr_human 118 N-term N => K N/A N/A Conley YP et al (2000)
casr_human 118 N-term N => K N/A N/A Pearce SH et al (1996)
casr_human 118 N-term N => K N/A N/A De Luca F et al (1997)
casr_human 118 N-term N => K N/A N/A Watanabe T et al (1998)
casr_human 118 N-term N => K N/A N/A Okazaki R et al (1999)
casr_human 125 N-term L => P N/A N/A Lienhardt A et al (2001)
casr_human 125 N-term L => P N/A N/A Sato K et al (2002)
casr_human 125 N-term L => P N/A N/A Vargas-Poussou R et al (2002)
casr_human 127 N-term E => A N/A N/A Zhang Z et al (2001)
casr_human 127 N-term E => A N/A N/A Conley YP et al (2000)
casr_human 127 N-term E => A N/A N/A Bai M et al (1996)
casr_human 127 N-term E => A N/A N/A Watanabe T et al (1998)
casr_human 127 N-term E => A N/A N/A Okazaki R et al (1999)
casr_human 127 N-term E => K N/A N/A Lienhardt A et al (2001)
casr_human 128 N-term F => L N/A N/A Zhang Z et al (2001)
casr_human 128 N-term F => L N/A N/A Conley YP et al (2000)
casr_human 128 N-term F => L N/A N/A Vargas-Poussou R et al (2002)
casr_human 128 N-term F => L N/A N/A Pearce SH et al (1996)
casr_human 128 N-term F => L N/A N/A Watanabe T et al (1998)
casr_human 128 N-term F => L N/A N/A Okazaki R et al (1999)
casr_human 129 N-term C => F N/A N/A Lienhardt A et al (2001)
casr_human 129 N-term C => S N/A N/A Jensen AA et al (2000)
casr_human 129 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 129 N-term C => S N/A N/A Hirai H et al (2001)
casr_human 129 N-term C => S N/A N/A Jiang Y et al (2004)
casr_human 129 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 130 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 131 N-term C => F N/A N/A Suzuki M et al (2005)
casr_human 131 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 131 N-term C => S N/A N/A Jensen AA et al (2000)
casr_human 131 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 131 N-term C => S N/A N/A Jiang Y et al (2004)
casr_human 131 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 131 N-term C => W N/A N/A Watanabe S et al (2002)
casr_human 138 N-term T => M N/A N/A D'Souza-Li L et al (2002)
casr_human 138 N-term T => M N/A N/A Bai M et al (1996)
casr_human 143 N-term G => E N/A N/A Bai M et al (1999)
casr_human 143 N-term G => E N/A N/A Zhang Z et al (2002)
casr_human 143 N-term G => E N/A N/A Zhang Z et al (2002)
casr_human 143 N-term G => E N/A N/A Jiang Y et al (2004)
casr_human 143 N-term G => E N/A N/A Bai M et al (1996)
casr_human 143 N-term G => E N/A N/A Bai M et al (1997)
casr_human 147 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 147 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 151 N-term T => M N/A N/A Conley YP et al (2000)
casr_human 151 N-term T => M N/A N/A Poppe K et al (2002)
casr_human 151 N-term T => M N/A N/A Lovlie R et al (1996)
casr_human 151 N-term T => M N/A N/A Pearce SH et al (1996)
casr_human 151 N-term T => M N/A N/A Watanabe T et al (1998)
casr_human 151 N-term T => M N/A N/A Okazaki R et al (1999)
casr_human 156 N-term L => S N/A N/A Jiang Y et al (2004)
casr_human 169 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 169 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 170 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 170 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 171 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 171 N-term S => A N/A N/A Zhang Z et al (2002)
casr_human 173 N-term L => P N/A N/A Felderbauer P et al (2006)
casr_human 178 N-term N => D N/A N/A Pearce SH et al (1996)
casr_human 185 N-term R => Q N/A N/A Bai M et al (1999)
casr_human 185 N-term R => Q N/A N/A Pace AJ et al (1999)
casr_human 185 N-term R => Q N/A N/A Brown EM et al (1999)
casr_human 185 N-term R => Q N/A N/A Lienhardt A et al (2000)
casr_human 185 N-term R => Q N/A N/A Ye C et al (2000)
casr_human 185 N-term R => Q N/A N/A Zhang Z et al (2002)
casr_human 185 N-term R => Q N/A N/A Zhang Z et al (2002)
casr_human 185 N-term R => Q N/A N/A Jiang Y et al (2004)
casr_human 185 N-term R => Q N/A N/A Bai M et al (1996)
casr_human 185 N-term R => Q N/A N/A Bai M et al (1997)
casr_human 190 N-term D => A N/A N/A Zhang Z et al (2002)
casr_human 190 N-term D => A N/A N/A Zhang Z et al (2002)
casr_human 191 N-term E => K N/A N/A Brown EM et al (1999)
casr_human 191 N-term E => K N/A N/A Conley YP et al (2000)
casr_human 191 N-term E => K N/A N/A Pearce SH et al (1996)
casr_human 191 N-term E => K N/A N/A Watanabe T et al (1998)
casr_human 191 N-term E => K N/A N/A Okazaki R et al (1999)
casr_human 212 N-term I => T N/A N/A Marcocci C et al (2003)
casr_human 215 N-term D => E N/A N/A Brown EM et al (1999)
casr_human 215 N-term D => G N/A N/A Brown EM et al (1999)
casr_human 218 N-term Y => A N/A N/A Zhang Z et al (2002)
casr_human 218 N-term Y => A N/A N/A Zhang Z et al (2002)
casr_human 218 N-term Y => C N/A N/A Cetani F et al (2003)
casr_human 218 N-term Y => S N/A N/A Zhang Z et al (2002)
casr_human 218 N-term Y => S N/A N/A Zhang Z et al (2002)
casr_human 220 N-term R => Q N/A N/A D'Souza-Li L et al (2002)
casr_human 220 N-term R => Q N/A N/A Pearce SH et al (1996)
casr_human 220 N-term R => W N/A N/A Fukumoto S et al (2001)
casr_human 220 N-term R => W N/A N/A D'Souza-Li L et al (2002)
casr_human 221 N-term P => L N/A N/A Conley YP et al (2000)
casr_human 221 N-term P => L N/A N/A Lienhardt A et al (2001)
casr_human 221 N-term P => L N/A N/A Poppe K et al (2002)
casr_human 221 N-term P => L N/A N/A Watanabe S et al (2002)
casr_human 221 N-term P => L N/A N/A Chikatsu N et al (2003)
casr_human 221 N-term P => S N/A N/A Pearce SH et al (1996)
casr_human 227 N-term R => L N/A N/A Wystrychowski A et al (2005)
casr_human 227 N-term R => Q N/A N/A Wystrychowski A et al (2005)
casr_human 228 N-term E => Q N/A N/A Conley YP et al (2000)
casr_human 236 N-term C => S N/A N/A Pace AJ et al (1999)
casr_human 245 N-term Q => R N/A N/A Conley YP et al (2000)
casr_human 245 N-term Q => R N/A N/A Watanabe T et al (1998)
casr_human 287 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 297 N-term E => K N/A N/A Bai M et al (1999)
casr_human 297 N-term E => K N/A N/A Zhang Z et al (2001)
casr_human 297 N-term E => K N/A N/A Zhang Z et al (2002)
casr_human 297 N-term E => K N/A N/A Zhang Z et al (2002)
casr_human 297 N-term E => K N/A N/A Bai M et al (1996)
casr_human 297 N-term E => K N/A N/A Bai M et al (1997)
casr_human 297 N-term E => S N/A N/A Zhang Z et al (2002)
casr_human 395 N-term C => R N/A N/A Vigouroux C et al (2000)
casr_human 400 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 437 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 437 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 449 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 449 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 468 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 482 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 482 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 488 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 549 N-term G => R N/A N/A D'Souza-Li L et al (2002)
casr_human 549 N-term G => R N/A N/A Zhang Z et al (2002)
casr_human 549 N-term G => R N/A N/A Zhang Z et al (2002)
casr_human 557 N-term G => E N/A N/A Nakayama T et al (2001)
casr_human 562 N-term C => Y N/A N/A Burski K et al (2002)
casr_human 594 N-term N => Q N/A N/A Ray K et al (1998)
casr_human 598 N-term C => S N/A N/A Zhang Z et al (2001)
casr_human 598 N-term C => S N/A N/A Fan GF et al (1998)
casr_human 604 N-term E => K N/A N/A Tan YM et al (2003)
casr_human 604 N-term E => K N/A N/A Alvarez-Hernandez D et al (2003)
casr_human 604 N-term E => K N/A N/A Pearce SH et al (1996)
casr_human 1.39x39 612 TM1 F => S N/A N/A Conley YP et al (2000)
casr_human 1.39x39 612 TM1 F => S N/A N/A Vargas-Poussou R et al (2002)
casr_human 1.39x39 612 TM1 F => S N/A N/A Pearce SH et al (1996)
casr_human 1.39x39 612 TM1 F => S N/A N/A Watanabe T et al (1998)
casr_human 1.39x39 612 TM1 F => S N/A N/A Mancilla EE et al (1998)
casr_human 1.39x39 612 TM1 F => S N/A N/A Okazaki R et al (1999)
casr_human 12.53x53 646 ICL1 T => V N/A N/A Bai M et al (1998)
casr_human 2.36x36 648 TM2 R => X N/A N/A Jap TS et al (2001)
casr_human 2.38x38 650 TM2 L => P N/A N/A Warner J et al (2004)
casr_human 2.55x55 667 TM2 F => A N/A N/A Miedlich SU et al (2004)
casr_human 2.56x56 668 TM2 F => A N/A N/A Miedlich SU et al (2004)
casr_human 2.56x56 668 TM2 F => L N/A N/A Miedlich SU et al (2004)
casr_human 2.56x56 668 TM2 F => V N/A N/A Miedlich SU et al (2004)
casr_human 670 ECL1 G => R N/A N/A Hebert SC et al (1997)
casr_human 3.32x32 680 TM3 R => A N/A N/A Miedlich SU et al (2004)
casr_human 3.32x32 680 TM3 R => C N/A N/A Zhang Z et al (2001)
casr_human 3.32x32 680 TM3 R => L N/A N/A Miedlich SU et al (2004)
casr_human 3.32x32 680 TM3 R => V N/A N/A Miedlich SU et al (2004)
casr_human 3.33x33 681 TM3 Q => H N/A N/A Zhao XM et al (1999)
casr_human 3.33x33 681 TM3 Q => H N/A N/A Conley YP et al (2000)
casr_human 3.33x33 681 TM3 Q => H N/A N/A Okazaki R et al (1999)
casr_human 3.36x36 684 TM3 F => A N/A N/A Miedlich SU et al (2004)
casr_human 3.36x36 684 TM3 F => L N/A N/A Miedlich SU et al (2004)
casr_human 3.36x36 684 TM3 F => V N/A N/A Miedlich SU et al (2004)
casr_human 3.41x41 689 TM3 V => M N/A N/A Warner J et al (2004)
casr_human 45.52x52 767 ECL2 E => K N/A N/A Uckun-Kitapci A et al (2005)
casr_human 5.40x40 773 TM5 L => R N/A N/A Zhao XM et al (1999)
casr_human 5.40x40 773 TM5 L => R N/A N/A Conley YP et al (2000)
casr_human 5.40x40 773 TM5 L => R N/A N/A De Luca F et al (1997)
casr_human 5.40x40 773 TM5 L => R N/A N/A Watanabe T et al (1998)
casr_human 5.40x40 773 TM5 L => R N/A N/A Okazaki R et al (1999)
casr_human 5.55x55 788 TM5 F => C N/A N/A Zhao XM et al (1999)
casr_human 5.55x55 788 TM5 F => C N/A N/A Conley YP et al (2000)
casr_human 5.55x55 788 TM5 F => C N/A N/A Lienhardt A et al (2001)
casr_human 5.55x55 788 TM5 F => C N/A N/A Watanabe T et al (1998)
casr_human 5.55x55 788 TM5 F => C N/A N/A Okazaki R et al (1999)
casr_human 5.61x61 794 TM5 S => A N/A N/A Bai M et al (1998)
casr_human 5.62x62 795 TM5 R => W N/A N/A Bai M et al (1999)
casr_human 5.62x62 795 TM5 R => W N/A N/A Brown EM et al (1999)
casr_human 5.62x62 795 TM5 R => W N/A N/A Carling T et al (2000)
casr_human 5.62x62 795 TM5 R => W N/A N/A D'Souza-Li L et al (2002)
casr_human 5.62x62 795 TM5 R => W N/A N/A Zhang Z et al (2002)
casr_human 5.62x62 795 TM5 R => W N/A N/A Zhang Z et al (2002)
casr_human 5.62x62 795 TM5 R => W N/A N/A Bai M et al (1996)
casr_human 5.62x62 795 TM5 R => W N/A N/A Bai M et al (1997)
casr_human 799 ICL3 E => K N/A N/A Lienhardt A et al (2001)
casr_human 6.38x38 806 TM6 F => S N/A N/A Conley YP et al (2000)
casr_human 6.38x38 806 TM6 F => S N/A N/A De Luca F et al (1997)
casr_human 6.38x38 806 TM6 F => S N/A N/A Watanabe T et al (1998)
casr_human 6.38x38 806 TM6 F => S N/A N/A Okazaki R et al (1999)
casr_human 6.52x52 820 TM6 S => F N/A N/A Yamamoto M et al (2000)
casr_human 6.52x52 820 TM6 S => F N/A N/A Nagase T et al (2002)
casr_human 6.52x52 820 TM6 S => F N/A N/A Pearce SH et al (1996)
casr_human 6.53x53 821 TM6 F => L N/A N/A Shiohara M et al (2004)
casr_human 6.58x58 826 TM6 A => T N/A N/A Cetani F et al (1999)
casr_human 7.32x33 837 TM7 E => I N/A N/A Miedlich SU et al (2004)
casr_human 7.32x33 837 TM7 E => Q N/A N/A Miedlich SU et al (2004)
casr_human 7.35x36 840 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => E N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => E N/A N/A Jensen AA et al (2000)
casr_human 7.38x39 843 TM7 A => E N/A N/A Lienhardt A et al (2001)
casr_human 7.38x39 843 TM7 A => E N/A N/A Sato K et al (2002)
casr_human 7.38x39 843 TM7 A => E N/A N/A Watanabe S et al (2002)
casr_human 7.38x39 843 TM7 A => K N/A N/A Zhao XM et al (1999)
casr_human 7.38x39 843 TM7 A => V N/A N/A Zhao XM et al (1999)
casr_human 7.46x47 851 TM7 C => S N/A N/A Conley YP et al (2000)
casr_human 8.55x55 873 H8 R => A N/A N/A Miedlich S et al (2002)
casr_human 8.55x55 873 H8 R => A N/A N/A Gama L et al (1998)
casr_human 8.56x56 874 H8 C => A N/A N/A Miedlich S et al (2002)
casr_human 8.56x56 874 H8 C => A N/A N/A Gama L et al (1998)
casr_human 8.57x57 875 H8 S => A N/A N/A Miedlich S et al (2002)
casr_human 8.57x57 875 H8 S => A N/A N/A Gama L et al (1998)
casr_human 876 C-term T => A N/A N/A Miedlich S et al (2002)
casr_human 876 C-term T => D N/A N/A Miedlich S et al (2002)
casr_human 876 C-term T => D N/A N/A Gama L et al (1998)
casr_human 879 C-term H => A N/A N/A Miedlich S et al (2002)
casr_human 881 C-term F => L N/A N/A Carling T et al (2000)
casr_human 888 C-term T => A N/A N/A Young SH et al (2002)
casr_human 888 C-term T => A N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => D N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => E N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => G N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => K N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => N N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => Q N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => V N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => V N/A N/A Bai M et al (1998)
casr_human 888 C-term T => W N/A N/A Jiang YF et al (2002)
casr_human 888 C-term T => Y N/A N/A Jiang YF et al (2002)
casr_human 895 C-term S => A N/A N/A Bai M et al (1998)
casr_human 896 C-term R => H N/A N/A Felderbauer P et al (2006)
casr_human 915 C-term S => A N/A N/A Bai M et al (1998)
casr_human 986 C-term A => S N/A N/A Lerolle N et al (2001)
casr_human 986 C-term A => S N/A N/A Eckstein M et al (2002)
casr_human 986 C-term A => S N/A N/A Warner J et al (2004)
casr_human 990 C-term R => G N/A N/A Warner J et al (2004)
casr_human 988 C-term A => G N/A N/A Kapoor A et al (2008)
casr_human 3.38x38 686 TM3 I => V N/A N/A Kapoor A et al (2008)
casr_human 988 C-term A => V N/A N/A Kapoor A et al (2008)
casr_human 898 C-term R => Q N/A N/A Kapoor A et al (2008)
casr_human 354 N-term E => A N/A N/A Kapoor A et al (2008)
casr_human 990 C-term R => G N/A N/A Kapoor A et al (2008)
casr_human 986 C-term A => S N/A N/A Kapoor A et al (2008)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S F H R K W W ICL2ECL2 P P S S Y R N Q E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M A F Y S C C W V L L A L T W H T S A Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E G A K G P L P V D T F L R G H E E S G D R F S N S S T A F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S S S L G G S T G S T P S S S I S S K S N S E D P F P Q P E R Q K Q Q Q P L A L T Q Q E Q Q Q Q P L T L P Q Q Q R S Q Q Q P R C K Q K V I F G S G T V T F S L S F D E P Q K N A M A H R N S T H Q N S L E A Q K S S D T L T R H E P L L P L Q C G E T D L D L T V Q E T G L Q G P V G G D Q R P E V E D P E E L S P A L V V S S S Q S F V I S G G G S T V T E N V V N S C-term E P F G I A L T L F A V L G I F L T A F V L G V F I K F N R E L S Y L L L F S L L C C F S S S L F F I Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R E V R N T I E C S
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A T L F I G L V A F L T L A I G F P E 1 Y L L L F S L L C C F S S S L F F I 2 V L I C S I C L V F S I G F A P Q R L R 3 Q F L L V F L C T F M Q I V I C V I W L 4 A F F F C I A A L L C T Y G I L F G L A 5 T F S M L I F F I V W I S F I P A Y A S 6 A L L G F S A A L I A I V E V A S V F K 7
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Residue Table


GPCRdb(A)
GPCRdb(C)
CaS receptor
TM1
1x35 1.39x39 F612
1x38 1.42x42 A615
1x39 1.43x43 L616
TM2
2x40 2.36x36 R648
2x42 2.38x38 L650
2x49 2.45x45 S657
2x59 2.55x55 F667
2x60 2.56x56 F668
2x61 2.57x57 I669
TM3
3x27 3.31x31 L679
3x28 3.32x32 R680
3x29 3.33x33 Q681
3x30 3.34x34 P682
3x32 3.36x36 F684
3x34 3.38x38 I686
3x36 3.40x40 F688
3x37 3.41x41 V689
TM4
4x45 4.35x35 L727
4x52 4.42x42 M734
4x62 4.52x52 Y744
TM5
5x39 5.39x39 A772
5x40 5.40x40 L773
5x42 5.42x42 F775
5x43 5.43x43 L776
5x45 5.45x45 G778
5x47 5.47x47 T780
5x55 5.55x55 F788
5x61 5.61x61 S794
5x62 5.62x62 R795
TM6
6x34 6.36x36 A804
6x36 6.38x38 F806
6x47 6.49x49 V817
6x48 6.50x50 W818
6x50 6.52x52 S820
6x51 6.53x53 F821
6x55 6.57x57 Y825
6x56 6.58x58 A826
TM7
7x32 7.26x27 K831
7x33 7.27x28 F832
7x34 7.28x29 V833
7x35 7.29x30 S834
7x37 7.31x32 V836
7x38 7.32x33 E837
7x39 7.33x34 V838
7x41 7.35x36 A840
7x42 7.36x37 I841
7x44 7.38x39 A843
7x45 7.39x40 A844
7x49 7.43x44 L848
7x52 7.46x47 C851
H8
8x55 8.55x55 R873
8x56 8.56x56 C874
8x57 8.57x57 S875