Mutant Browser

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Protein name Generic number Position Segment Mutation FoldChange or Qual Exp Type Ligand Reference Review
hrh4_human 3.32x32 94 TM3 D => A N/A N/A Shin N et al (2002)
hrh4_human 3.32x32 94 TM3 D => E N/A N/A Shin N et al (2002)
hrh4_human 3.32x32 94 TM3 D => N N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => A N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => F N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => Y N/A N/A Shin N et al (2002)
hrh4_human 5.42x43 178 TM5 T => A N/A N/A Shin N et al (2002)
hrh4_human 5.43x44 179 TM5 S => A N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => A N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => D N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => N N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => Q N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => A N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => F N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => A N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => F N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => F N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => F N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => F N/A N/A Shin N et al (2002)
hrh4_human 6.52x52 320 TM6 S => F N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => Q N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => D N/A N/A Shin N et al (2002)
hrh4_human 5.46x461 182 TM5 E => A N/A N/A Shin N et al (2002)
hrh4_human 5.43x44 179 TM5 S => A N/A N/A Shin N et al (2002)
hrh4_human 5.42x43 178 TM5 T => A N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => A N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => Y N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => Y N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => Y N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => Y N/A N/A Shin N et al (2002)
hrh4_human 4.57x57 147 TM4 N => Y N/A N/A Shin N et al (2002)
hrh4_human 3.32x32 94 TM3 D => N N/A N/A Shin N et al (2002)
hrh4_human 3.32x32 94 TM3 D => E N/A N/A Shin N et al (2002)
hrh4_human 3.32x32 94 TM3 D => A N/A N/A Shin N et al (2002)
hrh4_human 6.30x30 298 TM6 A => E N/A N/A Schneider EH et al (2010)
hrh4_human 3.50x50 112 TM3 R => A N/A N/A Schneider EH et al (2010)
hrh4_human 169 ECL2 F => V 8.696↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL1078642 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 2.138↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL1078642 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.479↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL1078642 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 4.51x51 141 TM4 V => I 1.349↑ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => H 5.0↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.60x61 150 TM4 M => V 1.996↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.63x64 153 TM4 V => A 1.0 pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 155 ECL2 E => D 1.122↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 156 ECL2 S => A 1.0 pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 2.571↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => L 1.585↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 2.513↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 170 ECL2 S => T 1.38↑ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.38x39 174 TM5 I => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.40x41 176 TM5 A => T 1.148↑ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.148↑ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => L 1.585↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 1.072↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.949↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.44x45 180 TM5 F => L 1.549↑ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.45x46 181 TM5 L => F 3.165↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 333.333↓ pK(i) (Binding - Radioligand competition/displacement) VUF 8430 Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) JNJ 7777120 Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => N Abolished effect K(d) (Binding - Radioligand saturation) JNJ 7777120 Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 1.267↑ K(d) (Binding - Radioligand saturation) JNJ 7777120 Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => H 3.984↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.60x61 150 TM4 M => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 156 ECL2 S => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => L 1.259↑ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 2.137↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.38x39 174 TM5 I => V 1.0 pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.39x40 175 TM5 L => V 15.873↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.39x40 175 TM5 L => V 20.0↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 5.43x44 179 TM5 S => L 3.165↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 4.169↑ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.175↑ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.45x46 181 TM5 L => F 1.0 pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 1.585↓ pK(i) (Binding - Radioligand competition/displacement) JNJ 7777120 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 5.39x40 175 TM5 L => V 3.984↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL129199 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 5.46x461 182 TM5 E => Q 2.513↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL129199 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 3.40x40 102 TM3 V => A 1.259↓ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => Y 1.996↓ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 3.311↓ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.42x43 178 TM5 T => A 3.162↑ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 1.479↓ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 3.891↓ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 6.329↓ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 6.55x55 323 TM6 T => M 5.012↑ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 7.42x41 347 TM7 Q => L 7.943↑ pK(i) (Binding - Radioligand competition/displacement) clobenpropit Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 1.818↓ pK(i) (Binding - Radioligand competition/displacement) immepip Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 1.949↓ pK(i) (Binding - Radioligand competition/displacement) immepip Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.739↓ pK(i) (Binding - Radioligand competition/displacement) immepip Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 1.698↑ pK(i) (Binding - Radioligand competition/displacement) thioperamide Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 3.89↑ pK(i) (Binding - Radioligand competition/displacement) thioperamide Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.202↓ pK(i) (Binding - Radioligand competition/displacement) thioperamide Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 4.51x51 141 TM4 V => I 1.445↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => H 50.0↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.60x61 150 TM4 M => V 1.585↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.63x64 153 TM4 V => A 1.318↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 155 ECL2 E => D 1.318↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 156 ECL2 S => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 6.757↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => L 5.0↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 4.673↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 170 ECL2 S => T 2.137↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.38x39 174 TM5 I => V 1.585↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.39x40 175 TM5 L => V 3.981↑ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.40x41 176 TM5 A => T 1.479↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.202↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => L 1.585↑ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 2.57↑ pK(i) (Binding - Radioligand competition/displacement) clozapine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.514↑ pK(i) (Binding - Radioligand competition/displacement) clozapine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.44x45 180 TM5 F => L 1.047↑ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.45x46 181 TM5 L => F 1.996↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 1.259↓ pK(i) (Binding - Radioligand competition/displacement) clozapine Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 3.40x40 102 TM3 V => A 1.996↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL43934 Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => Y 10.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL43934 Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 5.42x43 178 TM5 T => A 2.512↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL43934 Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 5.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL43934 Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 6.55x55 323 TM6 T => M 2.512↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL43934 Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 7.42x41 347 TM7 Q => L 2.512↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL43934 Istyastono EP et al (2011) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 1.024↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL475621 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 1.148↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL475621 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.23↑ pK(i) (Binding - Radioligand competition/displacement) CHEMBL475621 Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.39x40 175 TM5 L => V 3.984↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL492884 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 5.46x461 182 TM5 E => Q 12.658↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL492884 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 5.39x40 175 TM5 L => V 31.25↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL493720 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 5.46x461 182 TM5 E => Q 100.0↓ pK(i) (Binding - Radioligand competition/displacement) CHEMBL493720 Schultes S et al (2013) Vass M et al (2019)
hrh4_human 169 ECL2 F => V 7.576↓ pK(i) (Binding - Radioligand competition/displacement) ISOLOXAPINE Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 3.467↑ pK(i) (Binding - Radioligand competition/displacement) ISOLOXAPINE Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.23↑ pK(i) (Binding - Radioligand competition/displacement) ISOLOXAPINE Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) histamine Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => N Abolished effect K(d) (Binding - Radioligand saturation) histamine Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 1.805↓ K(d) (Binding - Radioligand saturation) histamine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 1.326↓ K(d) (Binding - Radioligand saturation) histamine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 1.595↓ K(d) (Binding - Radioligand saturation) histamine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q Abolished effect K(d) (Binding - Radioligand saturation) histamine Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => A Abolished effect K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => E Abolished effect K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 3.32x32 94 TM3 D => N Abolished effect K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 3.36x36 98 TM3 C => S 7.937↓ pK(i) (Binding - Radioligand competition/displacement) histamine Nijmeijer S et al (2013) Kooistra AJ et al (2013)
hrh4_human 3.36x36 98 TM3 C => S 3.861↓ K(d) (Binding - Radioligand saturation) histamine Nijmeijer S et al (2013) Kooistra AJ et al (2013)
hrh4_human 4.51x51 141 TM4 V => I 1.698↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 4.51x51 141 TM4 V => I 1.167↓ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => A 4.464↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => T 2.053↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => H 3.165↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.57x57 147 TM4 N => H 5.682↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.60x61 150 TM4 M => V 1.259↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.60x61 150 TM4 M => V 1.555↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 4.63x64 153 TM4 V => A 1.479↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 4.63x64 153 TM4 V => A 1.433↓ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 155 ECL2 E => D 1.905↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 155 ECL2 E => D 1.233↓ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 156 ECL2 S => A Abolished effect pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 156 ECL2 S => A Abolished effect K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 5.882↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 4.717↓ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => L 1.259↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => L 2.0↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 169 ECL2 F => V 1.996↓ pK(i) (Binding - Radioligand competition/displacement) histamine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 170 ECL2 S => T 1.175↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 170 ECL2 S => T 1.323↓ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.38x39 174 TM5 I => V 1.0 pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.38x39 174 TM5 I => V 1.111↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.39x40 175 TM5 L => V 1.259↑ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.39x40 175 TM5 L => V 1.111↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.40x41 176 TM5 A => T 1.35↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.40x41 176 TM5 A => T 1.059↑ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.42x43 178 TM5 T => A 3.135↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 2.247↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 2.088↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 2.0↓ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => L 1.585↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => L 1.333↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => A 1.905↓ pK(i) (Binding - Radioligand competition/displacement) histamine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.43x44 179 TM5 S => M 2.513↓ pK(i) (Binding - Radioligand competition/displacement) histamine Wifling D et al (2015) Kooistra AJ et al (2013)
hrh4_human 5.44x45 180 TM5 F => L 1.479↑ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.44x45 180 TM5 F => L 1.154↑ K(d) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2008) Kooistra AJ et al (2013)
hrh4_human 5.45x46 181 TM5 L => F 1.259↓ pK(i) (Binding - Radioligand competition/displacement) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.45x46 181 TM5 L => F 1.89↓ K(d) (Binding - Radioligand saturation) histamine Lim HD et al (2010) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => A Abolished effect K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => D 10.0↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q Abolished effect K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 5.46x461 182 TM5 E => Q 500.0↓ pK(i) (Binding - Radioligand competition/displacement) histamine Jongejan A et al (2008) Kooistra AJ et al (2013)
hrh4_human 6.52x52 320 TM6 S => A 2.096↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 6.52x52 320 TM6 S => F 4.975↓ K(d) (Binding - Radioligand saturation) histamine Shin N et al (2002) Kooistra AJ et al (2013)
hrh4_human 3.36x36 98 TM3 C => S 2.512↑ pK(i) (Binding - Radioligand competition/displacement) VUF14481 Nijmeijer S et al (2013) Kooistra AJ et al (2013)
hrh4_human 3.36x36 98 TM3 C => S 3.165↓ pK(i) (Binding - Radioligand competition/displacement) VUF14480 Nijmeijer S et al (2013) Kooistra AJ et al (2013)
Protein name Generic number Segment Position Mutation FoldChange or Qual Exp Type Ligand Reference Review


Residue

Diagrams

ICL1 K N L R ICL1ECL1 F E W D F ECL1ICL2 A V S Y R T Q H T ICL2ECL2 S E S W K D E G S E C E P G F F S ECL2ICL3 H P G L T A V S S N I C G H S F R G R L S S R R S L S A S T E V P A S F H S E R Q R R K S S L M F S S R T K M N S N T I A S K M G S F S Q S D S V A L H Q R E ICL3ECL3 S S A T G P ECL3N-term M P D T N S T I N L N-termC-term K K Q P L P S Q H S R S V S S C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y K S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
Download: PNG | SVG Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7
Download: PNG | SVG




Residue Table


GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x32 3.32x32 D94
3x36 3.36x36 C98
3x40 3.40x40 V102
3x50 3.50x50 R112
TM4
4x51 4.51x51 V141
4x57 4.57x57 N147
4x61 4.60x61 M150
4x64 4.63x64 V153
TM5
5x39 5.38x39 I174
5x40 5.39x40 L175
5x41 5.40x41 A176
5x43 5.42x43 T178
5x44 5.43x44 S179
5x45 5.44x45 F180
5x46 5.45x46 L181
5x461 5.46x461 E182
TM6
6x30 6.30x30 A298
6x52 6.52x52 S320
6x55 6.55x55 T323
TM7
7x41 7.42x41 Q347